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Title: Utility of Human In Vitro Data in Risk Assessments of Influenza A Virus Using the Ferret Model

Journal Article · · Journal of Virology
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  1. Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  2. Emory University, Atlanta, Georgia, USA
  3. Department of Physics, Ryerson University, Toronto, Canada, Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS) at RIKEN, Wako, Japan
+ Show Author Affiliations

Both in vitro and in vivo models are employed for assessing the pandemic potential of novel and emerging influenza A viruses in laboratory settings, but systematic examinations of how well viral titer measurements obtained in vitro align with results from in vivo experimentation are not frequently performed. We show that certain viral titer measurements following infection of a human bronchial epithelial cell line are positively correlated with viral titers in specimens collected from virus-inoculated ferrets and employ mathematical modeling to identify commonalities between viral infection progression between both models.

Research Organization:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE; USDOE Office of Science (SC)
Grant/Contract Number:
SC0014664
OSTI ID:
1908010
Journal Information:
Journal of Virology, Journal Name: Journal of Virology Journal Issue: 1 Vol. 97; ISSN 0022-538X
Publisher:
American Society for MicrobiologyCopyright Statement
Country of Publication:
United States
Language:
English

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60 APPLIED LIFE SCIENCES
Virology
epithelial cells
ferret
influenza
risk assessment
virus replication