Title: A prospective study on myocardial injury after BNT162b2 mRNA COVID ‐19 fourth dose vaccination in healthy persons

Abstract

Aims To prospectively evaluate the incidence of myocardial injury after the administration of the fourth dose BNT162b2 mRNA vaccine (Pfizer‐BioNTech) against COVID‐19. Methods and results Health care workers who received the BNT162b2 vaccine during the fourth dose campaign had blood samples collected for high‐sensitivity cardiac troponin (hs‐cTn) during vaccine administration and 2–4 days afterward. Vaccine‐related myocardial injury was defined as hs‐cTn elevation above the 99th percentile upper reference limit and >50% increase from baseline measurement. Participants with evidence of myocardial injury underwent assessment for possible myocarditis. Of 324 participants, 192 (59.2%) were female and the mean age was 51.8 ± 15.0 years. Twenty‐one (6.5%) participants had prior COVID‐19 infection, the mean number of prior vaccine doses was 2.9 ± 0.4, and the median time from the last dose was 147 (142–157) days. Reported vaccine‐related adverse reactions included local pain at injection site in 57 (17.59%), fatigue in 39 (12.04%), myalgia in 32 (9.88%), sore throat in 21 (6.48%), headache in 18 (5.5%), fever ≥38°C in 16 (4.94%), chest pain in 12 (3.7%), palpitations in 7 (2.16%), and shortness of breath in one (0.3%) participant. Vaccine‐related myocardial injury was demonstrated in two (0.62%) participants, one had mild symptoms and one was asymptomatic; both had a normal electrocardiogrammore » and echocardiography. Conclusion In a prospective investigation, an increase in serum troponin levels was documented among 0.62% of healthy health care workers receiving the fourth dose BNT162b2 vaccine. The two cases had mild or no symptoms and no clinical sequela. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT05308680.« less

Authors:

Levi, Nir  ^[1];

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Moravsky, Gil ^[2]; Weitsman, Tatyana ^[1]; Amsalem, Itshak ^[1]; Bar‐Sheshet Itach, Sarit ^[3]; Algur, Nurit ^[3]; Lapidus, Ira ^[2]; Mitz, Ofir ^[2]; Glikson, Michael ^[1]; Wiener‐Well, Yonit ^[4]; Hasin, Tal ^[1]

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+ Show Author Affiliations

1. Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Faculty of Medicine The Hebrew University Jerusalem Israel
2. Cardiology department Shamir Medical Center Tzrifin Israel
3. Clinical Biochemistry Laboratory Shaare Zedek Medical Center Jerusalem Israel
4. Infectious Disease Unit, Shaare Zedek Medical Center, Faculty of Medicine The Hebrew University Jerusalem Israel

Publication Date:

Wed Sep 28 00:00:00 EDT 2022

Sponsoring Org.:

USDOE

OSTI Identifier:

1889770

Resource Type:

Publisher's Accepted Manuscript

Journal Name:

European Journal of Heart Failure

Additional Journal Information:

Journal Name: European Journal of Heart Failure Journal Volume: 25 Journal Issue: 2; Journal ID: ISSN 1388-9842

Publisher:

Wiley Blackwell (John Wiley & Sons)

Country of Publication:

Country unknown/Code not available

Language:

English