Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

Ivanov, Alexander S.; Simms, Megan E.; Bryantsev, Vyacheslav S.; Benny, Paul D.; Griswold, Justin R.; Delmau, Laetitia H.; Thiele, Nikki A.

doi:10.1039/d2cc03156f

Title: Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

Journal Article · Fri Aug 19 00:00:00 UTC 2022 · ChemComm

DOI: https://doi.org/10.1039/d2cc03156f · OSTI ID:1885318

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Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

The coordination chemistry of Ra₂₊ is poorly defined, hampering efforts to design effective chelators for ²²³Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra²⁺ with the biomedically-relevant chelators DOTA and macropa. Our work reveals the highest affinity chelator to date for Ra²⁺ and advances our understanding of key factors underlying complex stability and selectivity for this underexplored ion.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE; USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1885318

Journal Information:: ChemComm, Journal Name: ChemComm Journal Issue: 71 Vol. 58; ISSN 1359-7345

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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