Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol
Abstract
Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or “omics,” quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of themore »
- Authors:
-
more »
- Univ. of Iowa, Iowa City, IA (United States)
- St. Ambrose Univ., Davenport, IA (United States)
- Rush Univ. Medical Center, Chicago, IL (United States)
- Univ. of Illinois, Chicago, IL (United States)
- NorthShore University HealthSystem, Skokie, IL (United States)
- Univ. of Chicago, IL (United States)
- Univ. of Michigan, Ann Arbor, MI (United States)
- Univ. of California, San Diego, CA (United States)
- Wake Forest Univ., Winston-Salem, NC (United States)
- Univ. of California, Davis, CA (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Univ. of Pittsburgh, PA (United States)
- Johns Hopkins Univ., Baltimore, MD (United States)
- Univ. of Texas, Austin, TX (United States)
- Dartmouth College, Hanover, NH (United States)
- National Institutes of Health (NIH), Bethesda, MD (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- Contributing Org.:
- The Acute to Chronic Pain Signatures Consortium
- OSTI Identifier:
- 1882664
- Report Number(s):
- PNNL-SA-169089
Journal ID: ISSN 2296-858X
- Grant/Contract Number:
- AC05-76RL01830; UO1NS077179; UO1NS077352; U54DA049116; U54DA049115; U54DA09113; UM1NS112874; UM1NS118922; U24NS112873-03S2; K08 HL159327
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Frontiers in Medicine
- Additional Journal Information:
- Journal Volume: 9; Journal ID: ISSN 2296-858X
- Publisher:
- Frontiers Media S.A.
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; pain; postsurgical pain; biomarker; risk factors; protocol; total knee arthroplasty; thoracic surgery
Citation Formats
Berardi, Giovanni, Frey-Law, Laura, Sluka, Kathleen A., Bayman, Emine O., Coffey, Christopher S., Ecklund, Dixie, Vance, Carol G. T., Dailey, Dana L., Burns, John, Buvanendran, Asokumar, McCarthy, Robert J., Jacobs, Joshua, Zhou, Xiaohong Joe, Wixson, Richard, Balach, Tessa, Brummett, Chad M., Clauw, Daniel, Colquhoun, Douglas, Harte, Steven E., Harris, Richard E., Williams, David A., Chang, Andrew C., Waljee, Jennifer, Fisch, Kathleen M., Jepsen, Kristen, Laurent, Louise C., Olivier, Michael, Langefeld, Carl D., Howard, Timothy D., Fiehn, Oliver, Jacobs, Jon M., Dakup, Panshak P., Qian, Wei-Jun, Swensen, Adam C., Lokshin, Anna, Lindquist, Martin, Caffo, Brian S., Crainiceanu, Ciprian, Zeger, Scott, Kahn, Ari, Wager, Tor, Taub, Margaret, Ford, James, Sutherland, Stephani P., and Wandner, Laura D. Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol. United States: N. p., 2022.
Web. doi:10.3389/fmed.2022.849214.
Berardi, Giovanni, Frey-Law, Laura, Sluka, Kathleen A., Bayman, Emine O., Coffey, Christopher S., Ecklund, Dixie, Vance, Carol G. T., Dailey, Dana L., Burns, John, Buvanendran, Asokumar, McCarthy, Robert J., Jacobs, Joshua, Zhou, Xiaohong Joe, Wixson, Richard, Balach, Tessa, Brummett, Chad M., Clauw, Daniel, Colquhoun, Douglas, Harte, Steven E., Harris, Richard E., Williams, David A., Chang, Andrew C., Waljee, Jennifer, Fisch, Kathleen M., Jepsen, Kristen, Laurent, Louise C., Olivier, Michael, Langefeld, Carl D., Howard, Timothy D., Fiehn, Oliver, Jacobs, Jon M., Dakup, Panshak P., Qian, Wei-Jun, Swensen, Adam C., Lokshin, Anna, Lindquist, Martin, Caffo, Brian S., Crainiceanu, Ciprian, Zeger, Scott, Kahn, Ari, Wager, Tor, Taub, Margaret, Ford, James, Sutherland, Stephani P., & Wandner, Laura D. Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol. United States. https://doi.org/10.3389/fmed.2022.849214
Berardi, Giovanni, Frey-Law, Laura, Sluka, Kathleen A., Bayman, Emine O., Coffey, Christopher S., Ecklund, Dixie, Vance, Carol G. T., Dailey, Dana L., Burns, John, Buvanendran, Asokumar, McCarthy, Robert J., Jacobs, Joshua, Zhou, Xiaohong Joe, Wixson, Richard, Balach, Tessa, Brummett, Chad M., Clauw, Daniel, Colquhoun, Douglas, Harte, Steven E., Harris, Richard E., Williams, David A., Chang, Andrew C., Waljee, Jennifer, Fisch, Kathleen M., Jepsen, Kristen, Laurent, Louise C., Olivier, Michael, Langefeld, Carl D., Howard, Timothy D., Fiehn, Oliver, Jacobs, Jon M., Dakup, Panshak P., Qian, Wei-Jun, Swensen, Adam C., Lokshin, Anna, Lindquist, Martin, Caffo, Brian S., Crainiceanu, Ciprian, Zeger, Scott, Kahn, Ari, Wager, Tor, Taub, Margaret, Ford, James, Sutherland, Stephani P., and Wandner, Laura D. Mon .
"Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol". United States. https://doi.org/10.3389/fmed.2022.849214. https://www.osti.gov/servlets/purl/1882664.
@article{osti_1882664,
title = {Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol},
author = {Berardi, Giovanni and Frey-Law, Laura and Sluka, Kathleen A. and Bayman, Emine O. and Coffey, Christopher S. and Ecklund, Dixie and Vance, Carol G. T. and Dailey, Dana L. and Burns, John and Buvanendran, Asokumar and McCarthy, Robert J. and Jacobs, Joshua and Zhou, Xiaohong Joe and Wixson, Richard and Balach, Tessa and Brummett, Chad M. and Clauw, Daniel and Colquhoun, Douglas and Harte, Steven E. and Harris, Richard E. and Williams, David A. and Chang, Andrew C. and Waljee, Jennifer and Fisch, Kathleen M. and Jepsen, Kristen and Laurent, Louise C. and Olivier, Michael and Langefeld, Carl D. and Howard, Timothy D. and Fiehn, Oliver and Jacobs, Jon M. and Dakup, Panshak P. and Qian, Wei-Jun and Swensen, Adam C. and Lokshin, Anna and Lindquist, Martin and Caffo, Brian S. and Crainiceanu, Ciprian and Zeger, Scott and Kahn, Ari and Wager, Tor and Taub, Margaret and Ford, James and Sutherland, Stephani P. and Wandner, Laura D.},
abstractNote = {Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or “omics,” quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.},
doi = {10.3389/fmed.2022.849214},
journal = {Frontiers in Medicine},
number = ,
volume = 9,
place = {United States},
year = {Mon Apr 25 00:00:00 EDT 2022},
month = {Mon Apr 25 00:00:00 EDT 2022}
}
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