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Title: The importance of structure property relationship for the designing of biomaterials using liquid crystal elastomers

Journal Article · · Materials Advances
DOI: https://doi.org/10.1039/D2MA00401A · OSTI ID:1873192
ORCiD logo [1]; ORCiD logo [2]
  1. Advanced Materials and Liquid Crystal Institute (AMLCI), Kent State University (KSU), Kent, OH 44242-0001, USA, Materials Science Graduate Program, KSU, Kent, OH 44242-0001, USA
  2. Advanced Materials and Liquid Crystal Institute (AMLCI), Kent State University (KSU), Kent, OH 44242-0001, USA, Materials Science Graduate Program, KSU, Kent, OH 44242-0001, USA, Department of Biological Sciences, KSU, Kent, OH 44242-0001, USA, Brain Health Research Institute (BHRI), KSU, Kent, OH 44242-0001, USA

In this perspective, we presented our group’s journey to design biomaterials using LCEs and as inks for 3D printing. We addressed properties sought in a scaffold that address cells’ specific needs, and how we used the intrinsic properties of LCEs to influence on cell behavior.

Sponsoring Organization:
USDOE
OSTI ID:
1873192
Journal Information:
Materials Advances, Journal Name: Materials Advances Journal Issue: 14 Vol. 3; ISSN MAADC9; ISSN 2633-5409
Publisher:
Royal Society of Chemistry (RSC)Copyright Statement
Country of Publication:
United Kingdom
Language:
English

References (98)

Thermotropic Liquid Crystals as Substrates for Imaging the Reorganization of Matrigel by Human Embryonic Stem Cells journal March 2006
Liquid Crystal-Induced Myoblast Alignment journal January 2019
Light-Driven Side-On Nematic Elastomer Actuators journal April 2003
A Novel Family of Biodegradable Poly(ester amide) Elastomers journal March 2011
Liquid-Crystalline Elastomer Microvalve for Microfluidics journal September 2011
Self-Regulating Iris Based on Light-Actuated Liquid Crystal Elastomer journal June 2017
3D Printing of Liquid Crystal Elastomeric Actuators with Spatially Programed Nematic Order journal January 2018
A Zero‐Power Optical, ppt‐ to ppm‐Level Toxic Gas and Vapor Sensor with Image, Text, and Analytical Capabilities journal April 2020
Seeing the Unseen: The Role of Liquid Crystals in Gas‐Sensing Technologies journal April 2020
Light‐Powered Microrobots: Challenges and Opportunities for Hard and Soft Responsive Microswimmers journal February 2021
Photomobile Polymer Materials: Towards Light-Driven Plastic Motors journal June 2008
Influence of the nanofiber dimensions on the properties of nanocellulose/poly(vinyl alcohol) aerogels journal December 2014
Thermally activated shape memory behavior of melt-mixed polyurethane/cellulose nanocrystal composites journal March 2017
Channeled scaffolds implanted in adult rat brain
  • Martínez‐Ramos, Cristina; Vallés‐Lluch, Ana; Verdugo, José Manuel García
  • Journal of Biomedical Materials Research Part A, Vol. 100A, Issue 12 https://doi.org/10.1002/jbm.a.34273
journal June 2012
Cell alignment by smectic liquid crystal elastomer coatings with nanogrooves journal May 2020
3D Cell Culture Systems: Advantages and Applications: 3D CELL CULTURE SYSTEMS journal September 2014
Extracellular matrix and traumatic brain injury journal January 2018
Biocompatible, Biodegradable and Porous Liquid Crystal Elastomer Scaffolds for Spatial Cell Cultures: Biocompatible, Biodegradable and Porous LC Elastomers journal October 2014
Effects of Structural Variations on the Cellular Response and Mechanical Properties of Biocompatible, Biodegradable, and Porous Smectic Liquid Crystal Elastomers journal November 2016
Effects of Freezing/Thawing Cycles and Cellulose Nanowhiskers on Structure and Properties of Biocompatible Starch/PVA Sponges: Effects of Freezing/Thawing Cycles and Cellulose Nanowhiskers … journal November 2009
3D Porous Liquid Crystal Elastomer Foams Supporting Long‐term Neuronal Cultures journal January 2020
Phase diagrams of thermally stable, polymer-dispersed liquid crystals: Exploring the impact of chain length and chemical structure journal January 2016
Liquid Crystalline Networks toward Regenerative Medicine and Tissue Repair journal October 2017
Shear modulus of polydomain, mono-domain and non-mesomorphic side-chain elastomers: Influence of the nematic order journal March 2001
Peptide conjugated cellulose nanocrystals with sensitive human neutrophil elastase sensor activity journal March 2013
Review: current international research into cellulose nanofibres and nanocomposites journal January 2010
Mechanisms of polymer degradation and erosion journal January 1996
Helicoidal self-ordering of cellulose microfibrils in aqueous suspension journal June 1992
Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat journal November 1999
Oriented surfaces of adsorbed cellulose nanowhiskers promote skeletal muscle myogenesis journal January 2013
A biomechanical perspective on stress fiber structure and function journal November 2015
Synthesis, characterization and in vitro degradation of a biodegradable elastomer journal October 2004
Functional cardiac cell constructs on cellulose-based scaffolding journal November 2004
Bioreactors for tissue mass culture: Design, characterization, and recent advances journal December 2005
Improving the mechanical and thermal properties of gelatin hydrogels cross-linked by cellulose nanowhiskers journal January 2013
BioCell Printing : Integrated automated assembly system for tissue engineering constructs journal January 2011
Bioinspired lubricating films of cellulose nanofibrils and hyaluronic acid journal February 2016
Study on friction and wear of Cellulose Nanocrystal (CNC) nanoparticle as lubricating additive in engine oil journal March 2019
Mechanical behavior of a cellulose-reinforced scaffold in vascular tissue engineering journal March 2012
Monotonic and cyclic loading behavior of porous scaffolds made from poly(para-phenylene) for orthopedic applications journal January 2015
Mechanosensation in traumatic brain injury journal January 2021
Bionanocomposites from lignocellulosic resources: Properties, applications and future trends for their use in the biomedical field journal October 2013
Production and Characterization of a Camelid Single Domain Antibody–Urease Enzyme Conjugate for the Treatment of Cancer journal May 2015
Self-Assembly of Aqueous Soft Matter Patterned by Liquid-Crystal Polymer Networks for Controlling the Dynamics of Bacteria journal March 2020
Reactive 3D Printing of Shape-Programmable Liquid Crystal Elastomer Actuators journal June 2020
Liquid Crystal Elastomer Microspheres as Three-Dimensional Cell Scaffolds Supporting the Attachment and Proliferation of Myoblasts journal June 2015
Four-dimensional Printing of Liquid Crystal Elastomers journal October 2017
Designing Highly Luminescent Cellulose Nanocrystals with Modulated Morphology for Multifunctional Bioimaging Materials journal December 2019
Biocompatible 3D Liquid Crystal Elastomer Cell Scaffolds and Foams with Primary and Secondary Porous Architecture journal December 2015
Effect of Surface Charge on the Cellular Uptake and Cytotoxicity of Fluorescent Labeled Cellulose Nanocrystals journal October 2010
TEMPO-Oxidized Nanocellulose Participating as Crosslinking Aid for Alginate-Based Sponges journal August 2012
Physiologically Responsive, Mechanically Adaptive Bio-Nanocomposites for Biomedical Applications journal February 2013
Development of Biodegradable Injectable Thermoplastic Oligomers journal January 2004
Printable Optical Sensors Based on H-Bonded Supramolecular Cholesteric Liquid Crystal Networks journal April 2012
Imaging Biological Cells Using Liquid Crystals journal April 2003
Surface-Structured Bacterial Cellulose with Guided Assembly-Based Biolithography (GAB) journal December 2014
Liquid Crystal Systems from Fibrillar Polysaccharides journal August 1959
Cell mechanics and the cytoskeleton journal January 2010
A 3D bioprinting system to produce human-scale tissue constructs with structural integrity journal February 2016
Liquid-crystal materials find a new order in biomedical applications journal November 2007
Printed artificial cilia from liquid-crystal network actuators modularly driven by light journal June 2009
Experimental verification of homogeneity in polymer gels journal May 2014
Polar jets of swimming bacteria condensed by a patterned liquid crystal journal March 2020
Facile tuning of the mechanical properties of a biocompatible soft material journal May 2019
Tailorable and programmable liquid-crystalline elastomers using a two-stage thiol–acrylate reaction journal January 2015
Bioinks for 3D bioprinting: an overview journal January 2018
Liquid crystal elastomer foams with elastic properties specifically engineered as biodegradable brain tissue scaffolds journal January 2018
Mechanically tunable elastomer and cellulose nanocrystal composites as scaffolds for in vitro cell studies journal January 2021
Applications of liquid crystals in biosensing journal January 2021
Cellulose nanomaterials review: structure, properties and nanocomposites journal January 2011
Probing inhibitory effects of nanocrystalline cellulose: inhibition versus surface charge journal January 2012
Les cristaux liquides journal January 1909
Extracellular matrix and the brain: components and function journal July 2000
Bioprinted 3D vascularized tissue model for drug toxicity analysis journal July 2017
Processing advances in liquid crystal elastomers provide a path to biomedical applications journal October 2020
Processing and reprocessing liquid crystal elastomer actuators journal April 2021
Three-dimensional bioprinting of thick vascularized tissues journal March 2016
Alignment of polymer network-stabilized ferroelectric liquid crystal using a magnetic field journal November 2000
Biphenyl-based liquid crystals for elevated temperature processing with polymers journal May 2014
Solid‐state Polyelectrolyte Complexes of Branched Poly(ethylenimine) and Sodium Lauryl Sulfate journal February 2006
Cradle-to-cradle: designing biomaterials to fit as truly biomimetic cell scaffolds– a review journal July 2020
Improvement of mechanical properties of elastic materials by chemical methods journal January 2020
Chemical and biological sensing using liquid crystals journal June 2013
Indentation Versus Tensile Measurements of Young's Modulus for Soft Biological Tissues journal June 2011
Voxelated liquid crystal elastomers journal February 2015
Tissue engineering journal May 1993
Untethered soft robotic matter with passive control of shape morphing and propulsion journal August 2019
Cytotoxicity and Cellular Uptake of Cellulose Nanocrystals journal September 2012
Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans journal March 2019
Viscoelastic Retraction of Single Living Stress Fibers and Its Impact on Cell Shape, Cytoskeletal Organization, and Extracellular Matrix Mechanics journal May 2006
An ecotoxicological characterization of nanocrystalline cellulose (NCC) journal March 2010
Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation journal May 2022
Role of Surfactant during Microemulsion Photopolymerization for the Creation of Three-Dimensional Liquid Crystal Elastomer Microsphere Spatial Cell Scaffolds journal June 2016
Synchrotron Microbeam Diffraction Studies on the Alignment within 3D-Printed Smectic-A Liquid Crystal Elastomer Filaments during Extrusion journal May 2021
Actin Stress Fibers Response and Adaptation under Stretch journal May 2022
Liquid Crystal Elastomers—A Path to Biocompatible and Biodegradable 3D-LCE Scaffolds for Tissue Regeneration journal March 2018
Aqueous Colloidal Solutions of Cellulose Micelles. journal January 1949
Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling journal December 2019