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Pancreas Organ Weight in Individuals With Disease-Associated Autoantibodies at Risk for Type 1 Diabetes
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journal
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December 2012 |
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Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
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journal
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October 2015 |
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Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer
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journal
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May 2010 |
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MAP3K11/GDF15 axis is a critical driver of cancer cachexia: MAP3K11/GDF15 axis is a driver of cancer cachexia
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journal
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October 2015 |
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MIC-1 is a novel TGF-β superfamily cytokine associated with macrophage activation
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journal
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January 1999 |
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Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes—indication of an increased environmental pressure?
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journal
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March 2003 |
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Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
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journal
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January 2010 |
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Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes
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journal
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January 2017 |
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Current and future therapies for type 1 diabetes
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journal
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February 2021 |
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The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes
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journal
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July 2001 |
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GDF15, an update of the physiological and pathological roles it plays: a review
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journal
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September 2020 |
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What the HLA-I!—Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes
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journal
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December 2019 |
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Associations of GDF-15 and GDF-15/adiponectin ratio with odds of type 2 diabetes in the Chinese population
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journal
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March 2021 |
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Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials
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journal
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June 2013 |
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Type 1 diabetes
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journal
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June 2018 |
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PLAB, a novel placental bone morphogenetic protein
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journal
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October 1997 |
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Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta
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journal
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December 1997 |
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Hepatic GDF15 is regulated by CHOP of the unfolded protein response and alleviates NAFLD progression in obese mice
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journal
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April 2018 |
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Neural control of the endocrine pancreas
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journal
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October 2014 |
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GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance
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journal
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August 2019 |
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Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15
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journal
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February 2018 |
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GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
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journal
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August 2021 |
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AMPK: Sensing Glucose as well as Cellular Energy Status
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journal
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February 2018 |
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GDF15 Induces Anorexia through Nausea and Emesis
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journal
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February 2020 |
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Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention
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journal
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February 2020 |
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Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study
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journal
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March 2019 |
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Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses
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journal
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January 2017 |
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GDF15 reflects beta cell function in obese patients independently of the grade of impairment of glucose metabolism
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journal
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April 2019 |
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Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases
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journal
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June 2019 |
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Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond
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journal
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August 2018 |
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Insights Into Mechanisms of GDF15 and Receptor GFRAL: Therapeutic Targets
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journal
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December 2020 |
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Growth differentiation factor-15 promotes immune escape of ovarian cancer via targeting CD44 in dendritic cells
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journal
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May 2021 |
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NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism
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journal
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February 2014 |
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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
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journal
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June 2010 |
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Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
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journal
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September 2017 |
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Clinical development success rates for investigational drugs
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journal
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January 2014 |
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GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
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journal
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April 2011 |
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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
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journal
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August 2017 |
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The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
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journal
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August 2017 |
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GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
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journal
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August 2017 |
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How to improve R&D productivity: the pharmaceutical industry's grand challenge
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journal
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February 2010 |
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The role of inflammation in insulitis and β-cell loss in type 1 diabetes
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journal
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April 2009 |
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Growth/differentiation factor-15: prostate cancer suppressor or promoter?
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journal
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February 2012 |
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Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
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journal
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December 2020 |
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Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
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journal
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May 2020 |
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GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
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journal
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August 2021 |
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GDF15 mediates the effects of metformin on body weight and energy balance
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journal
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December 2019 |
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Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide
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journal
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April 2017 |
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Improving the odds of drug development success through human genomics: modelling study
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journal
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December 2019 |
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Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells
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journal
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January 2021 |
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Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation
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journal
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April 2021 |
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The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice
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journal
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July 2021 |
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Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss
|
journal
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December 2019 |
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Colchicine—an old dog with new tricks
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journal
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April 2021 |
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Cytokine signalling in the β-cell: a dual role for IFNγ
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journal
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May 2008 |
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Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum
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journal
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September 2018 |
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Type I Diabetes Mellitus
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journal
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May 1986 |
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Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
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journal
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March 2007 |
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The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines
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journal
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December 2011 |
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Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling
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journal
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January 2014 |
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Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice
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journal
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November 2017 |
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Emerging science of chronotherapy offers big opportunities to optimize drug delivery
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journal
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October 2019 |
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CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15 -deficient mice protects against abdominal sepsis
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journal
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May 2020 |
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MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
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journal
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October 1997 |
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Cloning and Characterization of a Novel Member of the Transforming Growth Factor-β/Bone Morphogenetic Protein Family
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journal
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May 1998 |
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STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation
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journal
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October 2010 |
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Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice
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journal
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October 2016 |
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Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities
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journal
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February 2010 |
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Temozolomide chronotherapy in patients with glioblastoma: a retrospective single-institute study
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journal
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January 2021 |
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Recent advances in the regulation of pancreatic secretion
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journal
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January 2014 |
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Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice
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journal
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July 2020 |
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The suprachiasmatic nucleus controls the daily variation of plasma glucose via the autonomic output to the liver: are the clock genes involved?
|
journal
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November 2005 |
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Death of a Beta Cell: Homicide or Suicide?
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journal
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March 1986 |
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Identification, expression and functional characterization of the GRAL gene
|
journal
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October 2005 |
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ISPAD Clinical Practice Consensus Guidelines 2018: Stages of type 1 diabetes in children and adolescents
|
journal
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October 2018 |
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Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys
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journal
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October 2017 |
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A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine
|
journal
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September 2018 |
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GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma
|
journal
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September 2021 |
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Chronopharmacology: New Insights and Therapeutic Implications
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journal
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January 2014 |
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Adipocyte differentiation induces dynamic changes in NF-κB expression and activity
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journal
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December 2004 |
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Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes
|
journal
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November 2013 |
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The Propeptide Mediates Formation of Stromal Stores of PROMIC-1: Role in Determining Prostate Cancer Outcome
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journal
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March 2005 |
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Role of Macrophage Inhibitory Cytokine-1 in Tumorigenesis and Diagnosis of Cancer: Figure 1.
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journal
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May 2006 |
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Macrophage Inhibitory Cytokine 1: A New Prognostic Marker in Prostate Cancer
|
journal
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October 2009 |
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GDF15/MIC-1 Functions As a Protective and Antihypertrophic Factor Released From the Myocardium in Association With SMAD Protein Activation
|
journal
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February 2006 |
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Growth Differentiation Factor 15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized With COVID-19
|
journal
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December 2020 |
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NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development
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journal
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September 2017 |
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Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives
|
journal
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January 2019 |
|
Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1
|
journal
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January 2018 |
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Clinical applications of liquid biopsy as prognostic and predictive biomarkers in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA
|
journal
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September 2018 |
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Review of the role of the nervous system in glucose homoeostasis and future perspectives towards the management of diabetes
|
journal
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July 2018 |
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Identification of Macrophage Inhibitory Cytokine-1 in Adipose Tissue and Its Secretion as an Adipokine by Human Adipocytes
|
journal
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December 2008 |
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Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets
|
journal
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April 2012 |
|
Adaptive Induction of Growth Differentiation Factor 15 Attenuates Endothelial Cell Apoptosis in Response to High Glucose Stimulus
|
journal
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June 2013 |
|
Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI
|
journal
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July 2015 |
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The Relationship between Insulin Resistance and the Cardiovascular Biomarker Growth Differentiation Factor-15 in Obese Patients
|
journal
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February 2011 |
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The nuclear receptor REV-ERB α represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells
|
journal
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January 2016 |
|
Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet
|
journal
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September 2009 |
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Macrophage inhibitory cytokine-1 is increased in individuals before type 2 diabetes diagnosis but is not an independent predictor of type 2 diabetes: the Whitehall II study
|
journal
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May 2010 |
|
Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial
|
journal
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November 2012 |
|
The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models
|
journal
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February 2018 |
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GDF15 promotes EMT and metastasis in colorectal cancer
|
journal
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October 2015 |
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Definition of High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Types Using Only Three Single Nucleotide Polymorphisms
|
journal
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May 2013 |
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The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions
|
journal
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April 2016 |
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Growth Differentiation Factor 15 Mediates Systemic Glucose Regulatory Action of T-Helper Type 2 Cytokines
|
journal
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September 2017 |
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The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower-Risk Human Leukocyte Antigen Genotypes
|
journal
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August 2008 |
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Plasma Growth Differentiation Factor-15 Independently Predicts All-Cause and Cardiovascular Mortality As Well As Deterioration of Kidney Function in Type 1 Diabetic Patients With Nephropathy
|
journal
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March 2010 |
|
The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism
|
journal
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August 2011 |
|
GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin
|
journal
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November 2020 |
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The Relationship Between Circulating Growth Differentiation Factor 15 Levels and Diabetic Retinopathy in Patients With Type 2 Diabetes
|
journal
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March 2021 |
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Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint
|
journal
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May 2020 |
|
A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat
|
journal
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January 2017 |
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Increased Growth Differentiation Factor 15 in Patients with Hypoleptinemia-Associated Lipodystrophy
|
journal
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September 2020 |
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Effect of Weight Loss by Low-Calorie Diet on Cardiovascular Health in Type 2 Diabetes: An Interventional Cohort Study
|
journal
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April 2021 |
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NSAID Activated Gene (NAG-1), a Modulator of Tumorigenesis
|
journal
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November 2006 |
|
Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI
|
dataset
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January 2015 |