Microevolution in the pansecondary metabolome of Aspergillus flavus and its potential macroevolutionary implications for filamentous fungi

Drott, Milton T.; Rush, Tomás A.; Satterlee, Tatum R.; Giannone, Richard J.; Abraham, Paul E.; Greco, Claudio; Venkatesh, Nandhitha; Skerker, Jeffrey M.; Glass, N. Louise; Labbé, Jesse L.; Milgroom, Michael G.; Keller, Nancy P.

doi:10.1073/pnas.2021683118

Title: Microevolution in the pansecondary metabolome of Aspergillus flavus and its potential macroevolutionary implications for filamentous fungi

Journal Article · Thu May 20 00:00:00 UTC 2021 · Proceedings of the National Academy of Sciences of the United States of America

DOI: https://doi.org/10.1073/pnas.2021683118 · OSTI ID:1847996

^[1];

^[2]; Satterlee, Tatum R. ^[3];

^[2]; Abraham, Paul E. ^[2];

^[4]; Venkatesh, Nandhitha ^[5]; Skerker, Jeffrey M. ^[6];

^[7];

^[2];

^[8];

^[9]

Department of Bacteriology, University of Wisconsin–Madison, Madison, WI 53703,
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830,
Department of Genetics, University of Wisconsin–Madison, Madison, WI 53703,
Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, United Kingdom,
Department of Medical Microbiology and Immunology, University of Wisconsin–Madison, Madison, WI 53703,, Department of Plant Pathology, University of Wisconsin–Madison, Madison, WI 53706,
Innovative Genomics Institute, University of California, Berkeley, CA 94720,
Innovative Genomics Institute, University of California, Berkeley, CA 94720,, Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720,, Environmental Genomics and Systems Biology, The Lawrence Berkeley National Laboratory, Berkeley, CA 94720,
School of Integrative Plant Science, Cornell University, Ithaca, NY 14853
Department of Bacteriology, University of Wisconsin–Madison, Madison, WI 53703,, Department of Medical Microbiology and Immunology, University of Wisconsin–Madison, Madison, WI 53703,

Significance Secondary metabolites (SMs) produced by fungi mediate ecological interactions, define fungal niches, and are of profound pharmacological importance to humans. Most work on SMs has focused on a small number of individuals from each species, not fully reflecting the importance of intraspecific diversity. We demonstrate that even in one of the best-studied model fungi, the carcinogen-producing Aspergillus flavus , more than 25% of SM-producing biosynthetic gene clusters (BGCs) are novel and/or show population-specific variants. These results support the finding that the organization of BGC diversity into population-specific patterns may sometimes result from ecologically important interactions and may inform evolutionary and etiological inferences of SM capacities within a species. Importantly, our work also presents a vision of sources of potential pharmaceuticals.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDA; USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1847996

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Issue: 21 Vol. 118; ISSN 0027-8424

Publisher:: Proceedings of the National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
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Title: Microevolution in the pansecondary metabolome of Aspergillus flavus and its potential macroevolutionary implications for filamentous fungi

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