Mechanism of Action of N -Acyl and N -Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum , a Causative Agent of Malaria

Girma, Misgina B.; Ball, Haley S.; Wang, Xu; Brothers, Robert C.; Jackson, Emily R.; Meyers, Marvin J.; Dowd, Cynthia S.; Couch, Robin D.

doi:10.1021/acsomega.1c01711

Title: Mechanism of Action of N -Acyl and N -Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum , a Causative Agent of Malaria

Journal Article · Fri Oct 15 00:00:00 UTC 2021 · ACS Omega

DOI: https://doi.org/10.1021/acsomega.1c01711 · OSTI ID:1826235

^[1]; Ball, Haley S. ^[1];

^[2]; Brothers, Robert C. ^[3]; Jackson, Emily R. ^[3]; Meyers, Marvin J. ^[4]; Dowd, Cynthia S. ^[3]; Couch, Robin D. ^[1]

Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States
Progenra Inc., Malvern, Pennsylvania 19355, United States
Department of Chemistry, The George Washington University, Washington, District of Columbia 20052, United States
Department of Chemistry, Saint Louis University, Saint Louis, Missouri 63103, United States

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Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: Military Infectious Disease Research Program; National Institutes of Health (NIH); US Army Medical Research and Development Command (USAMRDC); USDOE; USDOE Office of Science (SC)

Grant/Contract Number:: SC0014664

OSTI ID:: 1826235

Journal Information:: ACS Omega, Journal Name: ACS Omega Journal Issue: 42 Vol. 6; ISSN 2470-1343

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC Konzuch, Sarah; Umeda, Tomonobu; Held, Jana Journal of Medicinal Chemistry, Vol. 57, Issue 21 https://doi.org/10.1021/jm500850y	journal	October 2014
Synthesis and Bioactivity of β-Substituted Fosmidomycin Analogues Targeting 1-Deoxy- d -xylulose-5-phosphate Reductoisomerase Chofor, René; Sooriyaarachchi, Sanjeewani; Risseeuw, Martijn D. P. Journal of Medicinal Chemistry, Vol. 58, Issue 7 https://doi.org/10.1021/jm5014264	journal	March 2015
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parasites
peptides and proteins

Title: Mechanism of Action of N -Acyl and N -Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum , a Causative Agent of Malaria

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