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Title: Distinct properties underlie flavin-based electron bifurcation in a novel electron transfer flavoprotein FixAB from Rhodopseudomonas palustris

Journal Article · · Journal of Biological Chemistry

Not Available

Sponsoring Organization:
USDOE
Grant/Contract Number:
SC0012518; AC36-08GO28308
OSTI ID:
1769425
Journal Information:
Journal of Biological Chemistry, Journal Name: Journal of Biological Chemistry Journal Issue: 13 Vol. 293; ISSN 0021-9258
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (70)

Barrier Compression Enhances an Enzymatic Hydrogen-Transfer Reaction journal February 2009
Redox bifurcations: Mechanisms and importance to life now, and at its origin: A widespread means of energy conversion in biology unfolds… journal November 2011
Structure of methylene blue-DNA complexes studied by linear and circular dichroism spectroscopy: METHYLENE BLUE-DNA COMPLEXES journal September 1982
Ultraviolet absorption spectra of adenosine-5′-triphosphate and related 5′-ribonucleotides journal June 1956
Oxidation-reduction potentials and stoichiometry of electron transfer in ferredoxins journal April 1968
Charge-transfer complexes of nicotinamide-adenine dinucleotide analogues and flavin mononucleotide journal March 1966
Interaction of phenols with old yellow enzyme. Physical evidence for charge-transfer complexes. journal September 1976
Expression and characterization of human and chimeric human-Paracoccus denitrificans electron transfer flavoproteins. journal December 1994
Oxidation-Reduction Potentials of the Diphosphopyridine Nucleotide System journal April 1955
Energetics of beta-oxidation. Reduction potentials of general fatty acyl-CoA dehydrogenase, electron transfer flavoprotein, and fatty acyl-CoA substrates. journal June 1986
Redox potentiometry: Determination of midpoint potentials of oxidation-reduction components of biological electron-transfer systems book January 1978
The functions of the flavin contact residues, αArg249 and βTyr16, in human electron transfer flavoprotein journal August 1999
The electron transfer flavoprotein: Ubiquinone oxidoreductases journal December 2010
Mutational hotspots in electron transfer flavoprotein underlie defective folding and function in multiple acyl-CoA dehydrogenase deficiency journal November 2010
Excited State Dynamics Can Be Used to Probe Donor-Acceptor Distances for H-Tunneling Reactions Catalyzed by Flavoproteins journal December 2013
Electron bifurcation journal April 2016
Electron hopping through proteins journal November 2012
A simple method for the determination of reduction potentials in heme proteins journal January 2014
Electron Bifurcation: Thermodynamics and Kinetics of Two-Electron Brokering in Biological Redox Chemistry journal August 2017
The Electron Bifurcating FixABCX Protein Complex from Azotobacter vinelandii : Generation of Low-Potential Reducing Equivalents for Nitrogenase Catalysis journal August 2017
Unusual redox properties of electron-transfer flavoprotein from Methylophilus methylotrophus journal October 1989
Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase journal March 1990
Aspartate 120 of Escherichia coli Methylenetetrahydrofolate Reductase:  Evidence for Major Roles in Folate Binding and Catalysis and a Minor Role in Flavin Reactivity , journal May 2005
Modulation of the Redox Properties of the Flavin Cofactor through Hydrogen-Bonding Interactions with the N(5) Atom:  Role of αSer254 in the Electron-Transfer Flavoprotein from the Methylotrophic Bacterium W3A1 journal March 2007
Structure and Mechanism of Styrene Monooxygenase Reductase: New Insight into the FAD-Transfer Reaction journal August 2013
An Exposed Tyrosine on the Surface of Trimethylamine Dehydrogenase Facilitates Electron Transfer to Electron Transferring Flavoprotein:  Kinetics of Transfer in Wild-Type and Mutant Complexes journal January 1997
αT244M Mutation Affects the Redox, Kinetic, and in Vitro Folding Properties of Paracoccus denitrificans Electron Transfer Flavoprotein journal April 1997
Crystal Structure of Paracoccus denitrificans Electron Transfer Flavoprotein:  Structural and Electrostatic Analysis of a Conserved Flavin Binding Domain , journal February 1999
2,3-Difluorotyrosine at Position 356 of Ribonucleotide Reductase R2:  A Probe of Long-Range Proton-Coupled Electron Transfer journal September 2003
Interfacial pH at an Isolated Silica−Water Surface journal February 2005
Mutagenesis of Morphinone Reductase Induces Multiple Reactive Configurations and Identifies Potential Ambiguity in Kinetic Analysis of Enzyme Tunneling Mechanisms journal November 2007
Site-Specific Insertion of 3-Aminotyrosine into Subunit α2 of E. coli Ribonucleotide Reductase:  Direct Evidence for Involvement of Y 730 and Y 731 in Radical Propagation journal December 2007
Electron Tunneling Pathways and Role of Adenine in Repair of Cyclobutane Pyrimidine Dimer by DNA Photolyase journal April 2012
Femtosecond Fluorescence Dynamics of Flavoproteins:  Comparative Studies on Flavodoxin, Its Site-Directed Mutants, and Riboflavin Binding Protein Regarding Ultrafast Electron Transfer in Protein Nanospaces journal September 2002
Mechanistic insights into energy conservation by flavin-based electron bifurcation journal April 2017
A new method for preparing flavin-adenine dinucleotide journal June 1953
Electron transfer flavoprotein from pig liver mitochondria. A simple purification and re-evaluation of some of the molecular properties journal February 1983
Measurement of the oxidation-reduction potentials for one-electron and two-electron reduction of electron-transfer flavoprotein from pig liver journal May 1984
Purification and characterization of a flavoprotein involved in the degradation of epoxyalkanes by Xanthobacter Py2 journal October 1998
The effects of pH and semiquinone formation on the oxidation-reduction potentials of flavin mononucleotide. A reappraisal journal October 1999
Tryptophan-mediated charge-resonance stabilization in the bis-Fe(IV) redox state of MauG journal May 2013
Hole hopping through tyrosine/tryptophan chains protects proteins from oxidative damage journal July 2015
Deficiency of electron transfer flavoprotein or electron transfer flavoprotein:ubiquinone oxidoreductase in glutaric acidemia type II fibroblasts. journal July 1985
Expression and Characterization of Two Pathogenic Mutations in Human Electron Transfer Flavoprotein journal October 1997
Identification of the Naturally Occurring Flavin of Nitroalkane Oxidase from Fusarium oxysporum as a 5-Nitrobutyl-FAD and Conversion of the Enzyme to the Active FAD-containing Form journal February 1997
αArg-237 in Methylophilus methylotrophus (sp. W 3 A 1 ) Electron-transferring Flavoprotein Affords ∼200-Millivolt Stabilization of the FAD Anionic Semiquinone and a Kinetic Block on Full Reduction to the Dihydroquinone journal April 2001
Suppression of Electron Transfer to Dioxygen by Charge Transfer and Electron Transfer Complexes in the FAD-dependent Reductase Component of Toluene Dioxygenase journal September 2012
Redox Modulation of Flavin and Tyrosine Determines Photoinduced Proton-coupled Electron Transfer and Photoactivation of BLUF Photoreceptors journal July 2012
Studies on the Mechanism of Electron Bifurcation Catalyzed by Electron Transferring Flavoprotein (Etf) and Butyryl-CoA Dehydrogenase (Bcd) of Acidaminococcus fermentans journal December 2013
Insights into Flavin-based Electron Bifurcation via the NADH-dependent Reduced Ferredoxin:NADP Oxidoreductase Structure journal July 2015
Transient Kinetic Analysis of Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone Oxidoreductase journal August 2015
Reduction of Flavodoxin by Electron Bifurcation and Sodium Ion-dependent Reoxidation by NAD + Catalyzed by Ferredoxin-NAD + Reductase (Rnf) journal April 2016
Equilibrium and ultrafast kinetic studies manipulating electron transfer: A short-lived flavin semiquinone is not sufficient for electron bifurcation journal June 2017
Phenol Hydroxylase from Bacillus thermoglucosidasius A7, a Two-protein Component Monooxygenase with a Dual Role for FAD journal September 2003
Sulfite Oxidase Catalyzes Single-Electron Transfer at Molybdenum Domain to Reduce Nitrite to Nitric Oxide journal August 2015
Molar Absorptivities of β-NADH and β-NAD at 260 nm journal June 1975
Purification of Electron-Transferring Flavoprotein from Megasphaera elsdenii and Binding of Additional FAD with an Unusual Absorption Spectrum journal November 2003
Interaction between NADH and electron-transferring flavoprotein from Megasphaera elsdenii journal March 2013
In Vitro Refolding and Unfolding of Subunits of Electron-Transferring Flavoprotein: Characterization of the Folding Intermediates and the Effects of FAD and AMP on the Folding Reaction journal August 1996
The Binding of Adenine Nucleotides to Apo-Electron-Transferring Flavoprotein1 journal December 1992
Electron-Transferring Flavoprotein Has an AMP-Binding Site in Addition to the FAD-Binding Site1 journal August 1993
Reduction of ferredoxin or oxygen by flavin-based electron bifurcation in Megasphaera elsdenii journal May 2015
The Redox Potential of Dithionite and SO-2 from Equilibrium Reactions with Flavodoxins, Methyl Viologen and Hydrogen plus Hydrogenase journal April 1978
Dynamics driving function − new insights from electron transferring flavoproteins and partner complexes: ETF and partners - structure, function and dynamics journal October 2007
Excited-State Dynamics of Fully Reduced Flavins and Flavoenzymes Studied at Subpicosecond Time Resolution journal August 1998
Production of Hydrogen Gas from Light and the Inorganic Electron Donor Thiosulfate by Rhodopseudomonas palustris journal October 2010
Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family journal August 2017
Energy Conservation via Electron-Transferring Flavoprotein in Anaerobic Bacteria journal November 2007
Genetic and structural analysis of the Rhizobium meliloti fixA, fixB, fixC, and fixX genes. journal March 1987
The fixABCX Genes in Rhodospirillum rubrum Encode a Putative Membrane Complex Participating in Electron Transfer to Nitrogenase journal March 2004