Crystal Growth, Single Crystal Structure, and Biological Activity of Thiazolo-Pyridine Dicarboxylic Acid Derivatives

Ben yahia, Hamdi; Sabri, Souhir; Essehli, Rachid; El bali, Brahim; Kasak, Peter; Drogosz-Stachowicz, Joanna

doi:10.1021/acsomega.0c01769

Title: Crystal Growth, Single Crystal Structure, and Biological Activity of Thiazolo-Pyridine Dicarboxylic Acid Derivatives

Journal Article · Thu Oct 22 00:00:00 UTC 2020 · ACS Omega

DOI: https://doi.org/10.1021/acsomega.0c01769 · OSTI ID:1694381

^[1]; Sabri, Souhir ^[1]; Essehli, Rachid ^[2];

^[3];

^[4]; Drogosz-Stachowicz, Joanna ^[5]

Hamad Bin Khalifa Univ., Doha (Qatar). Qatar Environment and Energy Research Inst. (QEERI)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Independent Scientist, Oujda (Morocco)
Qatar Univ., Doha (Qatar). Center for Advanced Materials (CAM)
Medical Univ. of Lodz, Lodz (Poland)

Four novel TPDCA derivatives were prepared via a supersaturation method combining TPDCA with water, N-methyl-2-pyrrolidone (NMP), Na(PO₂H₂), and ammonia solution: 2(C₉H₇NO₅S)H₂O (1), (C₉H₇NO₅S)C₅H₉NO (2), (C₉H₇NO₅S)Na(PO₂H₂) (3), and (C₉H₅NO₅S)(NH₄)2(H₂O) (4). Their crystal structures were determined by single-crystal X-ray diffraction. Compounds (1) and (2) crystallize in the monoclinic space groups P2₁ and P2₁/c, respectively, whereas compounds (3) and (4) crystallize in the triclinic space group P1^-. Weak and moderate hydrogen bonds were detected in the four compounds. In the biological tests, (1) and (3) exhibited significant antibacterial activity against Escherichia coli and Staphylococcus aureus; in addition, (1) was cytotoxic against leukemia HL-60 cells with the IC₅₀ value of 158.5 ± 12.5 μM.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: Qatar Foundation; USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1694381

Journal Information:: ACS Omega, Journal Name: ACS Omega Journal Issue: 43 Vol. 5; ISSN 2470-1343

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Crystal structure
Hydrogen
Molecules
Noncovalent interactions
Space group

CCDC 1985955: Experimental Crystal Structure Determination Ben, Yahia, amdi; Souhir, Sabri,; Rachid, Essehli, https://doi.org/10.5517/ccdc.csd.cc24nk2g The current record is supplemented by this dataset	dataset	January 2020
CCDC 1985956: Experimental Crystal Structure Determination Ben, Yahia, amdi; Souhir, Sabri,; Rachid, Essehli, https://doi.org/10.5517/ccdc.csd.cc24nk3h The current record is supplemented by this dataset	dataset	January 2020
CCDC 1985957: Experimental Crystal Structure Determination Ben, Yahia, amdi; Souhir, Sabri,; Rachid, Essehli, https://doi.org/10.5517/ccdc.csd.cc24nk4j The current record is supplemented by this dataset	dataset	January 2020
CCDC 1985958: Experimental Crystal Structure Determination Ben, Yahia, amdi; Souhir, Sabri,; Rachid, Essehli, https://doi.org/10.5517/ccdc.csd.cc24nk5k The current record is supplemented by this dataset	dataset	January 2020

Title: Crystal Growth, Single Crystal Structure, and Biological Activity of Thiazolo-Pyridine Dicarboxylic Acid Derivatives

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