A far-red cyanobacteriochrome lineage specific for verdins
Abstract
Significance Cyanobacteriochrome (CBCR) photoreceptors leverage light-triggered photoisomerization of bound bilin chromophores to regulate gene expression, directional movement, and cell–cell communication in cyanobacteria. CBCRs responding to far-red light provide an emerging class of small reagents for applications in synthetic biology. We have found CBCRs that use 18 1 ,18 2 -dihydrobiliverdin or biliverdin chromophore precursors to sense far-red light. This lineage is distinguished from others by exclusion of phycobilins, the normal CBCR chromophores. Owing to the deep penetrance of far-red light in mammalian tissue and availability of biliverdin therein, this lineage of CBCRs holds great potential for developing synthetic biology tools of biomedical interest.
- Authors:
-
[1];
[1];
[1];
[2];
[1]
- Department of Molecular and Cellular Biology, University of California, Davis, CA 95616,
- Department of Molecular and Cellular Biology, University of California, Davis, CA 95616,, Department of Chemistry, University of California, Davis, CA 95616
- Publication Date:
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1690274
- Grant/Contract Number:
- FG02-09ER16117; SC0002395
- Resource Type:
- Published Article
- Journal Name:
- Proceedings of the National Academy of Sciences of the United States of America
- Additional Journal Information:
- Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Volume: 117 Journal Issue: 45; Journal ID: ISSN 0027-8424
- Publisher:
- Proceedings of the National Academy of Sciences
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Moreno, Marcus V., Rockwell, Nathan C., Mora, Manuel, Fisher, Andrew J., and Lagarias, J. Clark. A far-red cyanobacteriochrome lineage specific for verdins. United States: N. p., 2020.
Web. doi:10.1073/pnas.2016047117.
Moreno, Marcus V., Rockwell, Nathan C., Mora, Manuel, Fisher, Andrew J., & Lagarias, J. Clark. A far-red cyanobacteriochrome lineage specific for verdins. United States. https://doi.org/10.1073/pnas.2016047117
Moreno, Marcus V., Rockwell, Nathan C., Mora, Manuel, Fisher, Andrew J., and Lagarias, J. Clark. Mon .
"A far-red cyanobacteriochrome lineage specific for verdins". United States. https://doi.org/10.1073/pnas.2016047117.
@article{osti_1690274,
title = {A far-red cyanobacteriochrome lineage specific for verdins},
author = {Moreno, Marcus V. and Rockwell, Nathan C. and Mora, Manuel and Fisher, Andrew J. and Lagarias, J. Clark},
abstractNote = {Significance Cyanobacteriochrome (CBCR) photoreceptors leverage light-triggered photoisomerization of bound bilin chromophores to regulate gene expression, directional movement, and cell–cell communication in cyanobacteria. CBCRs responding to far-red light provide an emerging class of small reagents for applications in synthetic biology. We have found CBCRs that use 18 1 ,18 2 -dihydrobiliverdin or biliverdin chromophore precursors to sense far-red light. This lineage is distinguished from others by exclusion of phycobilins, the normal CBCR chromophores. Owing to the deep penetrance of far-red light in mammalian tissue and availability of biliverdin therein, this lineage of CBCRs holds great potential for developing synthetic biology tools of biomedical interest.},
doi = {10.1073/pnas.2016047117},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 45,
volume = 117,
place = {United States},
year = {Mon Oct 26 00:00:00 EDT 2020},
month = {Mon Oct 26 00:00:00 EDT 2020}
}
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