A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications

Mastren, Tara; Akin, Andrew; Copping, Roy; Brugh, Mark; Wilbur, D. Scott; Birnbaum, Eva R.; Nortier, Francois M.; John, Kevin D.; Fassbender, Michael E.

doi:10.1016/j.nucmedbio.2020.09.006

Title: A reverse ²³⁰U/²²⁶Th radionuclide generator for targeted alpha therapy applications

Journal Article · Wed Sep 30 00:00:00 UTC 2020 · Nuclear Medicine and Biology

DOI: https://doi.org/10.1016/j.nucmedbio.2020.09.006 · OSTI ID:1671108

Mastren, Tara ^[1];

^[2]; Copping, Roy ^[3]; Brugh, Mark ^[2]; Wilbur, D. Scott ^[4];

^[2];

^[2]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of Utah, Salt Lake City, UT (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Univ. of Washington, Seattle, WA (United States)

Thorium-226 (half-life 30.6 m) is a radionuclide of interest for use in targeted alpha therapy applications. Additionally, due to its short half-life, ²²⁶Th must be provided through a radionuclide generator system from its parent ²³⁰U (20.8 d). Furthermore, as the half-life of ²²⁶Th is very short, it should be provided in a form that is directly amenable to use in biomedical applications.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1671108

Report Number(s):: LA-UR--20-25550

Journal Information:: Nuclear Medicine and Biology, Journal Name: Nuclear Medicine and Biology Vol. 90-91; ISSN 0969-8051

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (29)

Thorium chelators for targeted alpha therapy: Rapid chelation of thorium-226 Ferrier, Maryline G.; Li, Yawen; Chyan, Ming-Kuan Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 63, Issue 12 https://doi.org/10.1002/jlcr.3875	journal	September 2020
Anion exchange separation of uranium, thorium and bismuth Korkisch, J.; Tera, F. Fresenius' Zeitschrift f�r Analytische Chemie, Vol. 186, Issue 2 https://doi.org/10.1007/BF00626136	journal	January 1962
Separation of uranium(VI) as chloride complex by solvent extraction with dicyclohexyl-18-crown-6 Deorkar, N. V.; Khopkar, S. M. Journal of Radioanalytical and Nuclear Chemistry Articles, Vol. 130, Issue 2 https://doi.org/10.1007/BF02041362	journal	April 1989
Separation studies of uranium and thorium using tetra(2-ethylhexyl) diglycolamide (TEHDGA) as an extractant Sharma, J. N.; Ruhela, R.; Harindaran, K. N. Journal of Radioanalytical and Nuclear Chemistry, Vol. 278, Issue 1 https://doi.org/10.1007/s10967-007-7238-4	journal	June 2008
An overview of targeted alpha therapy Kim, Young-Seung; Brechbiel, Martin W. Tumor Biology, Vol. 33, Issue 3 https://doi.org/10.1007/s13277-011-0286-y	journal	December 2011
The mutual separation of thorium, protoactinium, and uranium by tributyl phosphate extraction from hydrochloric acid Peppard, D. F.; Mason, G. W.; Gergel, M. V. Journal of Inorganic and Nuclear Chemistry, Vol. 3, Issue 6 https://doi.org/10.1016/0022-1902(57)80044-X	journal	January 1957
Separation of thorium and uranium nitrates by anion exchange Carswell, D. J. Journal of Inorganic and Nuclear Chemistry, Vol. 3, Issue 6 https://doi.org/10.1016/0022-1902(57)80046-3	journal	January 1957
Application of ion-exchange separations to determination of trace elements in natural waters—IX Simultaneous isolation and determination of uranium and thorium Korkisch, J. Talanta, Vol. 23, Issue 4 https://doi.org/10.1016/0039-9140(76)80196-8	journal	April 1976
Kinetically and thermodynamically stable isomers of thorium chelates of polyaza polycarboxylic macrocycles Jacques, Vincent; Desreux, Jean F. Journal of Alloys and Compounds, Vol. 213-214 https://doi.org/10.1016/0925-8388(94)90917-2	journal	October 1994
Advancements in cancer therapy with alpha-emitters: a review Imam, Seyed K. International Journal of Radiation OncologyBiologyPhysics, Vol. 51, Issue 1 https://doi.org/10.1016/S0360-3016(01)01585-1	journal	September 2001
Separation of Th, U, Pa, Ra and Ac from natural uranium and thorium series Alhassanieh, O.; Abdul-Hadi, A.; Ghafar, M. Applied Radiation and Isotopes, Vol. 51, Issue 5 https://doi.org/10.1016/S0969-8043(99)00068-8	journal	November 1999
Production of 230Pa by proton irradiation of 232Th at the LANL isotope production facility: Precursor of 230U for targeted alpha therapy Friend, Mitchell T.; Mastren, Tara; Parker, T. Gannon Applied Radiation and Isotopes, Vol. 156 https://doi.org/10.1016/j.apradiso.2019.108973	journal	February 2020
An efficient chelator for complexation of thorium-227 Ramdahl, Thomas; Bonge-Hansen, Hanne T.; Ryan, Olav B. Bioorganic & Medicinal Chemistry Letters, Vol. 26, Issue 17 https://doi.org/10.1016/j.bmcl.2016.07.034	journal	September 2016
Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes Radchenko, V.; Engle, J. W.; Wilson, J. J. Journal of Chromatography A, Vol. 1380, p. 55-63 https://doi.org/10.1016/j.chroma.2014.12.045	journal	February 2015
In Vitro Cytotoxicity of Low-Dose-Rate Radioimmunotherapy by the Alpha-Emitting Radioimmunoconjugate Thorium-227–DOTA–Rituximab Dahle, Jostein; Krogh, Cecilie; Melhus, Katrine B. International Journal of Radiation OncologyBiologyPhysics, Vol. 75, Issue 3 https://doi.org/10.1016/j.ijrobp.2009.04.062	journal	November 2009
Sequential separation of lanthanides, thorium and uranium using novel solid phase extraction method from high acidic nuclear wastes Siva Kesava Raju, Ch.; Subramanian, M. S. Journal of Hazardous Materials, Vol. 145, Issue 1-2 https://doi.org/10.1016/j.jhazmat.2006.11.024	journal	June 2007
Use of o-phenylene dioxydiacetic acid impregnated in Amberlite XAD resin for separation and preconcentration of uranium(VI) and thorium(IV) Seyhan, Serap; Merdivan, Melek; Demirel, Nadir Journal of Hazardous Materials, Vol. 152, Issue 1 https://doi.org/10.1016/j.jhazmat.2007.06.065	journal	March 2008
Production of 230Pa from Proton-irradiated Thorium and Developing 230Pa/230U/226Th Tandem Generator Lapshina, Elena; Zhuikov, Boris; Vasiliev, Aleksandr Journal of Medical Imaging and Radiation Sciences, Vol. 50, Issue 4 https://doi.org/10.1016/j.jmir.2019.11.056	journal	December 2019
Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy Dahle, Jostein; Borrebæk, Jørgen; Melhus, Katrine B. Nuclear Medicine and Biology, Vol. 33, Issue 2 https://doi.org/10.1016/j.nucmedbio.2005.12.004	journal	February 2006
Distribution coefficients of 60 elements on TODGA resin: Application to Ca, Lu, Hf, U and Th isotope geochemistry Pourmand, Ali; Dauphas, Nicolas Talanta, Vol. 81, Issue 3 https://doi.org/10.1016/j.talanta.2010.01.008	journal	May 2010
Production of ²³⁰ U/ ²²⁶ Th for Targeted Alpha Therapy via Proton Irradiation of ²³¹ Pa Morgenstern, Alfred; Lebeda, Ondrej; Stursa, Jan Analytical Chemistry, Vol. 80, Issue 22 https://doi.org/10.1021/ac801304c	journal	November 2008
Separation of Thorium and Uranium from Silicate Rock Samples Using Two Commercial Extraction Chromatographic Resins Yokoyama, Tetsuya; Makishima, Akio; Nakamura, Eizo Analytical Chemistry, Vol. 71, Issue 1 https://doi.org/10.1021/ac9805807	journal	January 1999
Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins Mastren, Tara; Stein, Benjamin W.; Parker, T. Gannon Analytical Chemistry, Vol. 90, Issue 11 https://doi.org/10.1021/acs.analchem.8b01380	journal	April 2018
A Macrocyclic Chelator with Unprecedented Th ⁴⁺ Affinity Pham, Tiffany A.; Xu, Jide; Raymond, Kenneth N. Journal of the American Chemical Society, Vol. 136, Issue 25 https://doi.org/10.1021/ja503456r	journal	June 2014
Synthesis and radiometric evaluation of diglycolamide functionalized mesoporous silica for the chromatographic separation of actinides Th, Pa and U Hopkins, Philip D.; Mastren, Tara; Florek, Justyna Dalton Transactions, Vol. 47, Issue 15 https://doi.org/10.1039/C8DT00404H	journal	January 2018
Determination of uranium and thorium in geological materials using extraction chromatography Carter, Helen E.; Warwick, Peter; Cobb, John The Analyst, Vol. 124, Issue 3 https://doi.org/10.1039/a809781j	journal	January 1999
Separation Studies of Uranium and Thorium Using Di-2-Ethylhexyl Isobutyramide (D2EHIBA) Pathak, P. N.; Veeraraghavan, R.; Prabhu, D. R. Separation Science and Technology, Vol. 34, Issue 13 https://doi.org/10.1081/SS-100100793	journal	September 1999
Formation cross-sections and chromatographic separation of protactinium isotopes formed in proton-irradiated thorium metal Radchenko, Valery; Engle, Jonathan W.; Wilson, Justin J. Radiochimica Acta, Vol. 104, Issue 5 https://doi.org/10.1515/ract-2015-2486	journal	January 2016
Production of Alpha Emitters for Targeted Alpha Therapy Morgenstern, A.; Abbas, K.; Bruchertseifer, F. Current Radiopharmaceuticalse, Vol. 1, Issue 3 https://doi.org/10.2174/1874471010801030135	journal	September 2008

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