Engineering Plant Synthetic Pathways for the Biosynthesis of Novel Antifungals

Calgaro-Kozina, Amy; Vuu, Khanh M.; Keasling, Jay D.; Loqué, Dominique; Sattely, Elizabeth S.; Shih, Patrick M.

doi:10.1021/acscentsci.0c00241

Title: Engineering Plant Synthetic Pathways for the Biosynthesis of Novel Antifungals

Journal Article · Mon Jul 20 00:00:00 UTC 2020 · ACS Central Science

DOI: https://doi.org/10.1021/acscentsci.0c00241 · OSTI ID:1639141

Calgaro-Kozina, Amy ^[1]; Vuu, Khanh M. ^[2]; Keasling, Jay D. ^[3];

^[2];

^[4]; Shih, Patrick M. ^[5]

Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States
Joint BioEnergy Institute, Emeryville, California 94608, United States, Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, United States
Joint BioEnergy Institute, Emeryville, California 94608, United States, Department of Chemical and Biomolecular Engineering, UC Berkeley, Berkeley, California 94720, United States, Department of Bioengineering, UC Berkeley, Berkeley, California 94720, United States, Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, United States
Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, United States
Joint BioEnergy Institute, Emeryville, California 94608, United States, Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, United States, Department of Plant Biology, University of California, Davis, Davis, California 95616, United States, Genome Center, University of California, Davis, Davis, California 95616, United States

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Stanford Univ., CA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1639141

Journal Information:: ACS Central Science, Journal Name: ACS Central Science Journal Issue: 8 Vol. 6; ISSN 2374-7943

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (27)

Inhibition of Methionine Biosynthesis in Botrytis cinerea by the Anilinopyrimidine Fungicide Pyrimethanil Fritz, Rene; Lanen, Catherine; Colas, Virginie Pesticide Science, Vol. 49, Issue 1 https://doi.org/10.1002/(SICI)1096-9063(199701)49:1<40::AID-PS470>3.0.CO;2-Y	journal	January 1997
RadH: A Versatile Halogenase for Integration into Synthetic Pathways Menon, Binuraj R. K.; Brandenburger, Eileen; Sharif, Humera H. Angewandte Chemie International Edition, Vol. 56, Issue 39 https://doi.org/10.1002/anie.201706342	journal	August 2017
Mode of action of the anilino-pyrimidine fungicide pyrimethanil. 2. Effects on enzyme secretion in Botrytis cinerea Milling, Richard J.; Richardson, Caroline J. Pesticide Science, Vol. 45, Issue 1 https://doi.org/10.1002/ps.2780450107	journal	September 1995
Substrate Specificity of the Cytochrome P450 Enzymes CYP79A1 and CYP71E1 Involved in the Biosynthesis of the Cyanogenic Glucoside Dhurrin inSorghum bicolor(L.) Moench Kahn, Rachel Alice; Fahrendorf, Theodor; Halkier, Barbara Ann Archives of Biochemistry and Biophysics, Vol. 363, Issue 1 https://doi.org/10.1006/abbi.1998.1068	journal	March 1999
Adequacy of cellular phytoalexin concentrations in hypersensitively responding cotton leaves Pierce, M. L.; Cover, E. C.; Richardson, P. E. Physiological and Molecular Plant Pathology, Vol. 48, Issue 5 https://doi.org/10.1006/pmpp.1996.0025	journal	May 1996
Assessing the impact of pesticides on the environment van der Werf, Hayo M. G. Agriculture, Ecosystems & Environment, Vol. 60, Issue 2-3 https://doi.org/10.1016/S0167-8809(96)01096-1	journal	December 1996
Glucosinolate research in the Arabidopsis era Wittstock, Ute; Halkier, Barbara A. Trends in Plant Science, Vol. 7, Issue 6 https://doi.org/10.1016/S1360-1385(02)02273-2	journal	June 2002
Harnessing plant metabolic diversity Owen, Charlie; Patron, Nicola J.; Huang, Ancheng Current Opinion in Chemical Biology, Vol. 40 https://doi.org/10.1016/j.cbpa.2017.04.015	journal	October 2017
Non-indolyl cruciferous phytoalexins: Nasturlexins and tridentatols, a striking convergent evolution of defenses in terrestrial plants and marine animals? Pedras, M. Soledade C.; To, Q. Huy Phytochemistry, Vol. 113 https://doi.org/10.1016/j.phytochem.2014.07.024	journal	May 2015
A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules Reed, James; Stephenson, Michael J.; Miettinen, Karel Metabolic Engineering, Vol. 42 https://doi.org/10.1016/j.ymben.2017.06.012	journal	July 2017
Integrating carbon–halogen bond formation into medicinal plant metabolism Runguphan, Weerawat; Qu, Xudong; O’Connor, Sarah E. Nature, Vol. 468, Issue 7322 https://doi.org/10.1038/nature09524	journal	November 2010
Two cytochromes P450 catalyze S-heterocyclizations in cabbage phytoalexin biosynthesis Klein, Andrew P.; Sattely, Elizabeth S. Nature Chemical Biology, Vol. 11, Issue 11 https://doi.org/10.1038/nchembio.1914	journal	September 2015
The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes Liu, Shengyi; Liu, Yumei; Yang, Xinhua Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms4930	journal	May 2014
The genome of the mesopolyploid crop species Brassica rapa Wang, Xiaowu; Wang, Hanzhong; Wang, Jun Nature Genetics, Vol. 43, Issue 10 https://doi.org/10.1038/ng.919	journal	August 2011
A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase Banerjee, T.; DuHadaway, J. B.; Gaspari, P. Oncogene, Vol. 27, Issue 20 https://doi.org/10.1038/sj.onc.1210939	journal	November 2007
The phytoalexins from cultivated and wild crucifers: Chemistry and biology Pedras, M. Soledade C.; Yaya, Estifanos E.; Glawischnig, Erich Natural Product Reports, Vol. 28, Issue 8 https://doi.org/10.1039/c1np00020a	journal	January 2011
Metabolic engineering of p-hydroxybenzylglucosinolate in Arabidopsis by expression of the cyanogenic CYP79A1 from Sorghum bicolor Bak, Soren; Olsen, Carl Erik; Petersen, Bent Larsen The Plant Journal, Vol. 20, Issue 6 https://doi.org/10.1046/j.1365-313X.1999.00642.x	journal	December 1999
Biosynthesis of cabbage phytoalexins from indole glucosinolate Klein, Andrew P.; Sattely, Elizabeth S. Proceedings of the National Academy of Sciences, Vol. 114, Issue 8 https://doi.org/10.1073/pnas.1615625114	journal	February 2017
Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. Catalyzes the Conversion of l-Phenylalanine to Phenylacetaldoxime in the Biosynthesis of Benzylglucosinolate Wittstock, Ute; Halkier, Barbara Ann Journal of Biological Chemistry, Vol. 275, Issue 19 https://doi.org/10.1074/jbc.275.19.14659	journal	May 2000
Resistance to Fludioxonil in Botrytis cinerea Isolates from Blackberry and Strawberry Li, Xingpeng; Fernández-Ortuño, Dolores; Grabke, Anja Phytopathology®, Vol. 104, Issue 7 https://doi.org/10.1094/PHYTO-11-13-0308-R	journal	July 2014
Metabolic Engineering of Valine- and Isoleucine-Derived Glucosinolates in Arabidopsis Expressing CYP79D2 from Cassava Mikkelsen, Michael Dalgaard; Halkier, Barbara Ann Plant Physiology, Vol. 131, Issue 2 https://doi.org/10.1104/pp.013425	journal	February 2003
Biosynthesis of the Nitrile Glucosides Rhodiocyanoside A and D and the Cyanogenic Glucosides Lotaustralin and Linamarin in Lotus japonicus Forslund, Karin; Morant, Marc; Jørgensen, Bodil Plant Physiology, Vol. 135, Issue 1 https://doi.org/10.1104/pp.103.038059	journal	May 2004
Genetic Engineering for Disease Resistance in Plants: Recent Progress and Future Perspectives Dong, Oliver Xiaoou; Ronald, Pamela C. Plant Physiology, Vol. 180, Issue 1 https://doi.org/10.1104/pp.18.01224	journal	March 2019
The Top 10 fungal pathogens in molecular plant pathology: Top 10 fungal pathogens Dean, Ralph; Van Kan, Jan A. L.; Pretorius, Zacharias A. Molecular Plant Pathology, Vol. 13, Issue 4 https://doi.org/10.1111/j.1364-3703.2011.00783.x	journal	April 2012
Altering glucosinolate profiles modulates disease resistance in plants Brader, Günter; Mikkelsen, Michael Dalgaard; Halkier, Barbara Ann The Plant Journal, Vol. 46, Issue 5 https://doi.org/10.1111/j.1365-313X.2006.02743.x	journal	June 2006
pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants Sainsbury, Frank; Thuenemann, Eva C.; Lomonossoff, George P. Plant Biotechnology Journal, Vol. 7, Issue 7 https://doi.org/10.1111/j.1467-7652.2009.00434.x	journal	September 2009
Biology and Biochemistry of Glucosinolates Halkier, Barbara Ann; Gershenzon, Jonathan Annual Review of Plant Biology, Vol. 57, Issue 1 https://doi.org/10.1146/annurev.arplant.57.032905.105228	journal	June 2006

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