Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity
Abstract
Plants produce phylogenetically and spatially restricted, as well as structurally diverse specialized metabolites via multistep metabolic pathways. Hallmarks of specialized metabolic evolution include enzymatic promiscuity and recruitment of primary metabolic enzymes and examples of genomic clustering of pathway genes. Solanaceae glandular trichomes produce defensive acylsugars, with sidechains that vary in length across the family. We describe a tomato gene cluster on chromosome 7 involved in medium chain acylsugar accumulation due to trichome specific acyl-CoA synthetase and enoyl-CoA hydratase genes. This cluster co-localizes with a tomato steroidal alkaloid gene cluster and is syntenic to a chromosome 12 region containing another acylsugar pathway gene. We reconstructed the evolutionary events leading to this gene cluster and found that its phylogenetic distribution correlates with medium chain acylsugar accumulation across the Solanaceae. This work reveals insights into the dynamics behind gene cluster evolution and cell-type specific metabolite diversity.
- Authors:
-
[1];
[2];
[1];
[2];
[3];
[1];
[4];
[5];
[5];
[6];
[7]
- Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States
- Department of Plant Biology, Michigan State University, East Lansing, United States
- Department of Plant Biology, Michigan State University, East Lansing, United States, University of Wisconsin, Madison, United States
- Division of Biological Sciences, University of Missouri, Columbus, United States
- Department of Plant Biology, Michigan State University, East Lansing, United States, MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, United States
- Department of Plant Biology, Michigan State University, East Lansing, United States, Department of Computational Mathematics, Science, and Engineering, Michigan State University, East Lansing, United States
- Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, United States, Department of Plant Biology, Michigan State University, East Lansing, United States
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1635731
- Alternate Identifier(s):
- OSTI ID: 1635732; OSTI ID: 1803407
- Grant/Contract Number:
- SC0018409
- Resource Type:
- Published Article
- Journal Name:
- eLife
- Additional Journal Information:
- Journal Name: eLife Journal Volume: 9; Journal ID: ISSN 2050-084X
- Publisher:
- eLife Sciences Publications, Ltd.
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; biochemistry and chemical biology; plant biology; Solanum lycopersicum; Solanum quitoense; Solanum pennellii
Citation Formats
Fan, Pengxiang, Wang, Peipei, Lou, Yann-Ru, Leong, Bryan J., Moore, Bethany M., Schenck, Craig A., Combs, Rachel, Cao, Pengfei, Brandizzi, Federica, Shiu, Shin-Han, and Last, Robert L. Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity. United States: N. p., 2020.
Web. doi:10.7554/eLife.56717.
Fan, Pengxiang, Wang, Peipei, Lou, Yann-Ru, Leong, Bryan J., Moore, Bethany M., Schenck, Craig A., Combs, Rachel, Cao, Pengfei, Brandizzi, Federica, Shiu, Shin-Han, & Last, Robert L. Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity. United States. https://doi.org/10.7554/eLife.56717
Fan, Pengxiang, Wang, Peipei, Lou, Yann-Ru, Leong, Bryan J., Moore, Bethany M., Schenck, Craig A., Combs, Rachel, Cao, Pengfei, Brandizzi, Federica, Shiu, Shin-Han, and Last, Robert L. Thu .
"Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity". United States. https://doi.org/10.7554/eLife.56717.
@article{osti_1635731,
title = {Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity},
author = {Fan, Pengxiang and Wang, Peipei and Lou, Yann-Ru and Leong, Bryan J. and Moore, Bethany M. and Schenck, Craig A. and Combs, Rachel and Cao, Pengfei and Brandizzi, Federica and Shiu, Shin-Han and Last, Robert L.},
abstractNote = {Plants produce phylogenetically and spatially restricted, as well as structurally diverse specialized metabolites via multistep metabolic pathways. Hallmarks of specialized metabolic evolution include enzymatic promiscuity and recruitment of primary metabolic enzymes and examples of genomic clustering of pathway genes. Solanaceae glandular trichomes produce defensive acylsugars, with sidechains that vary in length across the family. We describe a tomato gene cluster on chromosome 7 involved in medium chain acylsugar accumulation due to trichome specific acyl-CoA synthetase and enoyl-CoA hydratase genes. This cluster co-localizes with a tomato steroidal alkaloid gene cluster and is syntenic to a chromosome 12 region containing another acylsugar pathway gene. We reconstructed the evolutionary events leading to this gene cluster and found that its phylogenetic distribution correlates with medium chain acylsugar accumulation across the Solanaceae. This work reveals insights into the dynamics behind gene cluster evolution and cell-type specific metabolite diversity.},
doi = {10.7554/eLife.56717},
journal = {eLife},
number = ,
volume = 9,
place = {United States},
year = {Thu Jul 02 00:00:00 EDT 2020},
month = {Thu Jul 02 00:00:00 EDT 2020}
}
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