A hypothesis for temporal coding of young and mature granule cells
Abstract
While it has been hypothesized that adult neurogenesis (NG) plays a role in the encoding of temporal information at long time-scales, the temporal relationship of immature cells to the highly rhythmic network activity of the hippocampus has been largely unexplored. Here, we present a theory for how the activity of immature adult-born granule cells relates to hippocampal oscillations. Our hypothesis is that theta rhythmic (5–10 Hz) excitatory and inhibitory inputs into the hippocampus could differentially affect young and mature granule cells due to differences in intrinsic physiology and synaptic inhibition between the two cell populations. Consequently, immature cell activity may occur at broader ranges of theta phase than the activity of their mature counterparts. We describe how this differential influence on young and mature granule cells could separate the activity of differently aged neurons in a temporal coding regime. Notably, this process could have considerable implications on how the downstream CA3 region interprets the information conveyed by young and mature granule cells. To begin to investigate the phasic behavior of granule cells, we analyzed in vivo recordings of the rat dentate gyrus (DG), observing that the temporal behavior of granule cells with respect to the theta rhythm is different betweenmore »
- Authors:
-
- University of California, San Diego, CA (United States)
- Salk Institute for Biological Studies, La Jolla, CA (United States)
- Sandia National Laboratory (SNL-NM), Albuquerque, NM (United States)
- Publication Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA); James S. McDonnell Foundation; National Science Foundation (NSF); USDOE Laboratory Directed Research and Development (LDRD) Program
- OSTI Identifier:
- 1628202
- Grant/Contract Number:
- NA0003525; SBE0542013; AC04-94AL85000.
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Frontiers in Neuroscience (Online)
- Additional Journal Information:
- Journal Name: Frontiers in Neuroscience (Online); Journal Volume: 7; Journal ID: ISSN 1662-453X
- Publisher:
- Frontiers Research Foundation
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; adult neurogenesis; oscillations; dentate gyrus; hippocampus; temporal coding; granule cells
Citation Formats
Rangel, Lara M., Quinn, Laleh K., Chiba, Andrea A., Gage, Fred H., and Aimone, James B. A hypothesis for temporal coding of young and mature granule cells. United States: N. p., 2013.
Web. doi:10.3389/fnins.2013.00075.
Rangel, Lara M., Quinn, Laleh K., Chiba, Andrea A., Gage, Fred H., & Aimone, James B. A hypothesis for temporal coding of young and mature granule cells. United States. https://doi.org/10.3389/fnins.2013.00075
Rangel, Lara M., Quinn, Laleh K., Chiba, Andrea A., Gage, Fred H., and Aimone, James B. Tue .
"A hypothesis for temporal coding of young and mature granule cells". United States. https://doi.org/10.3389/fnins.2013.00075. https://www.osti.gov/servlets/purl/1628202.
@article{osti_1628202,
title = {A hypothesis for temporal coding of young and mature granule cells},
author = {Rangel, Lara M. and Quinn, Laleh K. and Chiba, Andrea A. and Gage, Fred H. and Aimone, James B.},
abstractNote = {While it has been hypothesized that adult neurogenesis (NG) plays a role in the encoding of temporal information at long time-scales, the temporal relationship of immature cells to the highly rhythmic network activity of the hippocampus has been largely unexplored. Here, we present a theory for how the activity of immature adult-born granule cells relates to hippocampal oscillations. Our hypothesis is that theta rhythmic (5–10 Hz) excitatory and inhibitory inputs into the hippocampus could differentially affect young and mature granule cells due to differences in intrinsic physiology and synaptic inhibition between the two cell populations. Consequently, immature cell activity may occur at broader ranges of theta phase than the activity of their mature counterparts. We describe how this differential influence on young and mature granule cells could separate the activity of differently aged neurons in a temporal coding regime. Notably, this process could have considerable implications on how the downstream CA3 region interprets the information conveyed by young and mature granule cells. To begin to investigate the phasic behavior of granule cells, we analyzed in vivo recordings of the rat dentate gyrus (DG), observing that the temporal behavior of granule cells with respect to the theta rhythm is different between rats with normal and impaired levels of NG. Specifically, in control animals, granule cells exhibit both strong and weak coupling to the phase of the theta rhythm. In contrast, the distribution of phase relationships in NG-impaired rats is shifted such that they are significantly stronger. These preliminary data support our hypothesis that immature neurons could distinctly affect the temporal dynamics of hippocampal encoding.},
doi = {10.3389/fnins.2013.00075},
journal = {Frontiers in Neuroscience (Online)},
number = ,
volume = 7,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2013},
month = {Tue Jan 01 00:00:00 EST 2013}
}
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