Representing Kidney Development Using the Gene Ontology
Abstract
Gene Ontology (GO) provides dynamic controlled vocabularies to aid in the description of the functional biological attributes and subcellular locations of gene products from all taxonomic groups (www.geneontology.org). Here we describe collaboration between the renal biomedical research community and the GO Consortium to improve the quality and quantity of GO terms describing renal development. In the associated annotation activity, the new and revised terms were associated with gene products involved in renal development and function. This project resulted in a total of 522 GO terms being added to the ontology and the creation of approximately 9,600 kidney-related GO term associations to 940 UniProt Knowledgebase (UniProtKB) entries, covering 66 taxonomic groups. We demonstrate the impact of these improvements on the interpretation of GO term analyses performed on genes differentially expressed in kidney glomeruli affected by diabetic nephropathy. In summary, we have produced a resource that can be utilized in the interpretation of data from small- and large-scale experiments investigating molecular mechanisms of kidney function and development and thereby help towards alleviating renal disease.
- Authors:
-
- Wellcome Trust Genome Campus, Cambridge (United Kingdom). European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
- The Jackson Lab., Bar Harbor, ME (United States)
- Univ. of Cambridge (United Kingdom). Cambridge Systems Biology Centre. Dept. of Biochemistry
- Univ. of Cambridge (United Kingdom). Dept. of Genetics. FlyBase
- Univ. of Oregon, Eugene, OR (United States). The Zebrafish Model Organism Database (ZFIN)
- Univ. Paris-Sud, Orsay (France). Centre National de la Recherche Scientifique (CNRS). IR4M UMR8081
- Western General Hospital, Edinburgh (United Kingdom). Inst. of Genetics and Molecular Medicine. MRC Human Genetics Unit
- Univ. of Manchester (United Kingdom). Faculty of Medical and Human Sciences. Inst. of Human Development
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Genomics Division
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
- OSTI Identifier:
- 1627704
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS ONE
- Additional Journal Information:
- Journal Volume: 9; Journal Issue: 6; Journal ID: ISSN 1932-6203
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Science & Technology - Other Topics
Citation Formats
Alam-Faruque, Yasmin, Hill, David P., Dimmer, Emily C., Harris, Midori A., Foulger, Rebecca E., Tweedie, Susan, Attrill, Helen, Howe, Douglas G., Thomas, Stephen Randall, Davidson, Duncan, Woolf, Adrian S., Blake, Judith A., Mungall, Christopher J., O’Donovan, Claire, Apweiler, Rolf, and Huntley, Rachael P. Representing Kidney Development Using the Gene Ontology. United States: N. p., 2014.
Web. doi:10.1371/journal.pone.0099864.
Alam-Faruque, Yasmin, Hill, David P., Dimmer, Emily C., Harris, Midori A., Foulger, Rebecca E., Tweedie, Susan, Attrill, Helen, Howe, Douglas G., Thomas, Stephen Randall, Davidson, Duncan, Woolf, Adrian S., Blake, Judith A., Mungall, Christopher J., O’Donovan, Claire, Apweiler, Rolf, & Huntley, Rachael P. Representing Kidney Development Using the Gene Ontology. United States. https://doi.org/10.1371/journal.pone.0099864
Alam-Faruque, Yasmin, Hill, David P., Dimmer, Emily C., Harris, Midori A., Foulger, Rebecca E., Tweedie, Susan, Attrill, Helen, Howe, Douglas G., Thomas, Stephen Randall, Davidson, Duncan, Woolf, Adrian S., Blake, Judith A., Mungall, Christopher J., O’Donovan, Claire, Apweiler, Rolf, and Huntley, Rachael P. Wed .
"Representing Kidney Development Using the Gene Ontology". United States. https://doi.org/10.1371/journal.pone.0099864. https://www.osti.gov/servlets/purl/1627704.
@article{osti_1627704,
title = {Representing Kidney Development Using the Gene Ontology},
author = {Alam-Faruque, Yasmin and Hill, David P. and Dimmer, Emily C. and Harris, Midori A. and Foulger, Rebecca E. and Tweedie, Susan and Attrill, Helen and Howe, Douglas G. and Thomas, Stephen Randall and Davidson, Duncan and Woolf, Adrian S. and Blake, Judith A. and Mungall, Christopher J. and O’Donovan, Claire and Apweiler, Rolf and Huntley, Rachael P.},
abstractNote = {Gene Ontology (GO) provides dynamic controlled vocabularies to aid in the description of the functional biological attributes and subcellular locations of gene products from all taxonomic groups (www.geneontology.org). Here we describe collaboration between the renal biomedical research community and the GO Consortium to improve the quality and quantity of GO terms describing renal development. In the associated annotation activity, the new and revised terms were associated with gene products involved in renal development and function. This project resulted in a total of 522 GO terms being added to the ontology and the creation of approximately 9,600 kidney-related GO term associations to 940 UniProt Knowledgebase (UniProtKB) entries, covering 66 taxonomic groups. We demonstrate the impact of these improvements on the interpretation of GO term analyses performed on genes differentially expressed in kidney glomeruli affected by diabetic nephropathy. In summary, we have produced a resource that can be utilized in the interpretation of data from small- and large-scale experiments investigating molecular mechanisms of kidney function and development and thereby help towards alleviating renal disease.},
doi = {10.1371/journal.pone.0099864},
journal = {PLoS ONE},
number = 6,
volume = 9,
place = {United States},
year = {Wed Jun 18 00:00:00 EDT 2014},
month = {Wed Jun 18 00:00:00 EDT 2014}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Genome-wide gene expression profiling reveals renal genes regulated during metabolic acidosis
journal, February 2008
- Nowik, Marta; Lecca, M. Rita; Velic, Ana
- Physiological Genomics, Vol. 32, Issue 3
Gene expression profiling analysis in nephrology: towards molecular definition of renal disease
journal, June 2006
- Yasuda, Yoshinari; Cohen, Clemens D.; Henger, Anna
- Clinical and Experimental Nephrology, Vol. 10, Issue 2
Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution
journal, November 2008
- Brunskill, Eric W.; Aronow, Bruce J.; Georgas, Kylie
- Developmental Cell, Vol. 15, Issue 5
Differential Protein Expressions in Renal Cell Carcinoma: New Biomarker Discovery by Mass Spectrometry
journal, August 2009
- Siu, K. W. Michael; DeSouza, Leroi V.; Scorilas, Andreas
- Journal of Proteome Research, Vol. 8, Issue 8
Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry
journal, May 2007
- Tilton, Ronald G.; Haidacher, Sigmund J.; LeJeune, Wanda S.
- PROTEOMICS, Vol. 7, Issue 10
Proteomics in renal research
journal, February 2007
- Janech, Michael G.; Raymond, John R.; Arthur, John M.
- American Journal of Physiology-Renal Physiology, Vol. 292, Issue 2
Proteomic Analysis of Cellular Response to Osmotic Stress in Thick Ascending Limb of Henle’s Loop (TALH) Cells
journal, October 2005
- Dihazi, Hassan; Asif, Abdul R.; Agarwal, Nitin K.
- Molecular & Cellular Proteomics, Vol. 4, Issue 10
The GUDMAP database - an online resource for genitourinary research
journal, June 2011
- Harding, S. D.; Armit, C.; Armstrong, J.
- Development, Vol. 138, Issue 13
Drosophila provides rapid modeling of renal development, function, and disease
journal, December 2010
- Dow, Julian A. T.; Romero, Michael F.
- American Journal of Physiology-Renal Physiology, Vol. 299, Issue 6
A standard nomenclature for structures of the kidney
journal, January 1988
- Schafer, James A.; Andreoli, Thomas E.; Thurau, Klaus
- Kidney International, Vol. 33, Issue 1, p. 1-7
A high-resolution anatomical ontology of the developing murine genitourinary tract
journal, June 2007
- Little, Melissa H.; Brennan, Jane; Georgas, Kylie
- Gene Expression Patterns, Vol. 7, Issue 6
The Renal Gene Ontology Annotation Initiative
journal, April 2010
- Alam-Faruque, Yasmin; Dimmer, Emily C.; Huntley, Rachael P.
- Organogenesis, Vol. 6, Issue 2
Logical Development of the Cell Ontology
journal, January 2011
- Meehan, Terrence F.; Masci, Anna Maria; Abdulla, Amina
- BMC Bioinformatics, Vol. 12, Issue 1
Uberon, an integrative multi-species anatomy ontology
journal, January 2012
- Mungall, Christopher J.; Torniai, Carlo; Gkoutos, Georgios V.
- Genome Biology, Vol. 13, Issue 1
Cross-product extensions of the Gene Ontology
journal, February 2011
- Mungall, Christopher J.; Bada, Michael; Berardini, Tanya Z.
- Journal of Biomedical Informatics, Vol. 44, Issue 1
A MOD(ern) perspective on literature curation
journal, March 2010
- Hirschman, Jodi; Berardini, Tanya Z.; Drabkin, Harold J.
- Molecular Genetics and Genomics, Vol. 283, Issue 5
A guide to best practices for Gene Ontology (GO) manual annotation
journal, January 2013
- Balakrishnan, R.; Harris, M. A.; Huntley, R.
- Database, Vol. 2013, Issue 0
Analysis Tool Web Services from the EMBL-EBI
journal, May 2013
- McWilliam, Hamish; Li, Weizhong; Uludag, Mahmut
- Nucleic Acids Research, Vol. 41, Issue W1
EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates
journal, December 2008
- Vilella, A. J.; Severin, J.; Ureta-Vidal, A.
- Genome Research, Vol. 19, Issue 2
The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse
journal, November 2013
- Blake, Judith A.; Bult, Carol J.; Eppig, Janan T.
- Nucleic Acids Research, Vol. 42, Issue D1
FlyBase 102—advanced approaches to interrogating FlyBase
journal, November 2013
- St. Pierre, Susan E.; Ponting, Laura; Stefancsik, Raymund
- Nucleic Acids Research, Vol. 42, Issue D1
ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics
journal, October 2012
- Howe, Douglas G.; Bradford, Yvonne M.; Conlin, Tom
- Nucleic Acids Research, Vol. 41, Issue D1
MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data
journal, January 2003
- Doniger, Scott W.; Salomonis, Nathan; Dahlquist, Kam D.
- Genome Biology, Vol. 4, Issue 1, p. R7
GO-Elite: a flexible solution for pathway and ontology over-representation
journal, June 2012
- Zambon, Alexander C.; Gaj, Stan; Ho, Isaac
- Bioinformatics, Vol. 28, Issue 16
Ontologizer 2.0--a multifunctional tool for GO term enrichment analysis and data exploration
journal, May 2008
- Bauer, S.; Grossmann, S.; Vingron, M.
- Bioinformatics, Vol. 24, Issue 14
Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy
journal, April 2004
- Baelde, Hans J.; Eikmans, Michael; Doran, Peter P.
- American Journal of Kidney Diseases, Vol. 43, Issue 4
The representation of heart development in the gene ontology
journal, June 2011
- Khodiyar, Varsha K.; Hill, David P.; Howe, Doug
- Developmental Biology, Vol. 354, Issue 1
Muscle Research and Gene Ontology: New standards for improved data integration
journal, January 2009
- Feltrin, Erika; Campanaro, Stefano; Diehl, Alexander D.
- BMC Medical Genomics, Vol. 2, Issue 1
Organization of the pronephric kidney revealed by large-scale gene expression mapping
journal, January 2008
- Raciti, Daniela; Reggiani, Luca; Geffers, Lars
- Genome Biology, Vol. 9, Issue 5
Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells
journal, August 2006
- James, R. G.
- Development, Vol. 133, Issue 15
Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis
journal, July 2004
- Lan, Y.
- Development, Vol. 131, Issue 13
Odd-skipped genes encode repressors that control kidney development
journal, January 2007
- Tena, Juan J.; Neto, Ana; de la Calle-Mustienes, Elisa
- Developmental Biology, Vol. 301, Issue 2
Pax2 and Pax8 Regulate Branching Morphogenesis and Nephron Differentiation in the Developing Kidney
journal, February 2007
- Narlis, Melina; Grote, David; Gaitan, Yaned
- Journal of the American Society of Nephrology, Vol. 18, Issue 4
PAX2 mutations in oligomeganephronia
journal, February 2001
- Salomon, Rémi; Tellier, Anne-Lorraine; Attie-Bitach, Tania
- Kidney International, Vol. 59, Issue 2
Synergism between Pax-8 and lim-1 in Embryonic Kidney Development
journal, October 1999
- Carroll, Thomas J.; Vize, Peter D.
- Developmental Biology, Vol. 214, Issue 1
The HNF1β transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations: HNF1β in nephrogenesis
journal, August 2004
- Wu, Guizhi; Bohn, Silvia; Ryffel, Gerhart U.
- European Journal of Biochemistry, Vol. 271, Issue 18
Suppression of Ureteric Bud Apoptosis Rescues Nephron Endowment and Adult Renal Function in Pax2 Mutant Mice
journal, May 2006
- Dziarmaga, Alison; Eccles, Michael; Goodyer, Paul
- Journal of the American Society of Nephrology, Vol. 17, Issue 6
A dual requirement for Iroquois genes during Xenopus kidney development
journal, August 2008
- Alarcon, P.; Rodriguez-Seguel, E.; Fernandez-Gonzalez, A.
- Development, Vol. 135, Issue 19
The prepattern transcription factor Irx3 directs nephron segment identity
journal, September 2007
- Reggiani, L.; Raciti, D.; Airik, R.
- Genes & Development, Vol. 21, Issue 18
Apoptosis in the kidneys of patients with type II diabetic nephropathy
journal, November 2007
- Verzola, D.; Gandolfo, M. T.; Ferrario, F.
- Kidney International, Vol. 72, Issue 10
Targeted Glomerular Angiopoietin-1 Therapy for Early Diabetic Kidney Disease
journal, September 2013
- Dessapt-Baradez, Cecile; Woolf, Adrian S.; White, Kathryn E.
- Journal of the American Society of Nephrology, Vol. 25, Issue 1
The Impact of Focused Gene Ontology Curation of Specific Mammalian Systems
journal, December 2011
- Alam-Faruque, Yasmin; Huntley, Rachael P.; Khodiyar, Varsha K.
- PLoS ONE, Vol. 6, Issue 12
Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function
journal, October 2010
- Welsh, Gavin I.; Hale, Lorna J.; Eremina, Vera
- Cell Metabolism, Vol. 12, Issue 4
Nitric oxide deficiency in chronic kidney disease
journal, January 2008
- Baylis, Chris
- American Journal of Physiology-Renal Physiology, Vol. 294, Issue 1
Diabetic Endothelial Nitric Oxide Synthase Knockout Mice Develop Advanced Diabetic Nephropathy
journal, January 2007
- Nakagawa, Takahiko; Sato, Waichi; Glushakova, Olena
- Journal of the American Society of Nephrology, Vol. 18, Issue 2
Ontological analysis of gene expression data: current tools, limitations, and open problems
journal, June 2005
- Khatri, P.; Draghici, S.
- Bioinformatics, Vol. 21, Issue 18
Synergism between Pax-8 and lim-1 in Embryonic Kidney Development
journal, October 1999
- Carroll, Thomas J.; Vize, Peter D.
- Developmental Biology, Vol. 214, Issue 1
A MOD(ern) perspective on literature curation
journal, March 2010
- Hirschman, Jodi; Berardini, Tanya Z.; Drabkin, Harold J.
- Molecular Genetics and Genomics, Vol. 283, Issue 5
Gene expression profiling analysis in nephrology: towards molecular definition of renal disease
journal, June 2006
- Yasuda, Yoshinari; Cohen, Clemens D.; Henger, Anna
- Clinical and Experimental Nephrology, Vol. 10, Issue 2
An IRKO in the Podo: Impaired Insulin Signaling in Podocytes and the Pathogenesis of Diabetic Nephropathy
journal, October 2010
- Gurley, Susan B.; Coffman, Thomas M.
- Cell Metabolism, Vol. 12, Issue 4
The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy
journal, July 2011
- Hills, Claire E.; Squires, Paul E.
- Cytokine & Growth Factor Reviews
Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution
journal, November 2008
- Brunskill, Eric W.; Aronow, Bruce J.; Georgas, Kylie
- Developmental Cell, Vol. 15, Issue 5
Cross-product extensions of the Gene Ontology
journal, February 2011
- Mungall, Christopher J.; Bada, Michael; Berardini, Tanya Z.
- Journal of Biomedical Informatics, Vol. 44, Issue 1
A high-resolution anatomical ontology of the developing murine genitourinary tract
journal, June 2007
- Little, Melissa H.; Brennan, Jane; Georgas, Kylie
- Gene Expression Patterns, Vol. 7, Issue 6
Odd-skipped genes encode repressors that control kidney development
journal, January 2007
- Tena, Juan J.; Neto, Ana; de la Calle-Mustienes, Elisa
- Developmental Biology, Vol. 301, Issue 2
Pax2 and Pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney
journal, June 2007
- Grote, David; Narlis, Melina; Gaitan, Yaned
- Developmental Biology, Vol. 306, Issue 1
The representation of heart development in the gene ontology
journal, June 2011
- Khodiyar, Varsha K.; Hill, David P.; Howe, Doug
- Developmental Biology, Vol. 354, Issue 1
Differential Protein Expressions in Renal Cell Carcinoma: New Biomarker Discovery by Mass Spectrometry
journal, August 2009
- Siu, K. W. Michael; DeSouza, Leroi V.; Scorilas, Andreas
- Journal of Proteome Research, Vol. 8, Issue 8
Evidence of apoptosis in human diabetic kidney
journal, April 2004
- Kumar, Dinender; Robertson, Susan; Burns, Kevin D.
- Molecular and Cellular Biochemistry, Vol. 259, Issue 1/2
Apoptosis in the kidneys of patients with type II diabetic nephropathy
journal, November 2007
- Verzola, D.; Gandolfo, M. T.; Ferrario, F.
- Kidney International, Vol. 72, Issue 10
PAX2 mutations in oligomeganephronia
journal, February 2001
- Salomon, Rémi; Tellier, Anne-Lorraine; Attie-Bitach, Tania
- Kidney International, Vol. 59, Issue 2
Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy
journal, April 2004
- Baelde, Hans J.; Eikmans, Michael; Doran, Peter P.
- American Journal of Kidney Diseases, Vol. 43, Issue 4
Ontologizer 2.0--a multifunctional tool for GO term enrichment analysis and data exploration
journal, May 2008
- Bauer, S.; Grossmann, S.; Vingron, M.
- Bioinformatics, Vol. 24, Issue 14
GO-Elite: a flexible solution for pathway and ontology over-representation
journal, June 2012
- Zambon, Alexander C.; Gaj, Stan; Ho, Isaac
- Bioinformatics, Vol. 28, Issue 16
A guide to best practices for Gene Ontology (GO) manual annotation
journal, January 2013
- Balakrishnan, R.; Harris, M. A.; Huntley, R.
- Database, Vol. 2013, Issue 0
ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics
journal, October 2012
- Howe, Douglas G.; Bradford, Yvonne M.; Conlin, Tom
- Nucleic Acids Research, Vol. 41, Issue D1
The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse
journal, November 2013
- Blake, Judith A.; Bult, Carol J.; Eppig, Janan T.
- Nucleic Acids Research, Vol. 42, Issue D1
Analysis Tool Web Services from the EMBL-EBI
journal, May 2013
- McWilliam, Hamish; Li, Weizhong; Uludag, Mahmut
- Nucleic Acids Research, Vol. 41, Issue W1
Endothelial Cell Apoptosis during Glomerular Capillary Lumen Formation In Vivo
journal, May 2003
- Fierlbeck, W.
- Journal of the American Society of Nephrology, Vol. 14, Issue 5
Podocytes, glucose and insulin
journal, January 2010
- Welsh, Gavin I.; Coward, Richard JM
- Current Opinion in Nephrology and Hypertension, Vol. 19, Issue 4
The prepattern transcription factor Irx3 directs nephron segment identity
journal, September 2007
- Reggiani, L.; Raciti, D.; Airik, R.
- Genes & Development, Vol. 21, Issue 18
Proteomics in renal research
journal, February 2007
- Janech, Michael G.; Raymond, John R.; Arthur, John M.
- American Journal of Physiology-Renal Physiology, Vol. 292, Issue 2
Nitric oxide deficiency in chronic kidney disease
journal, January 2008
- Baylis, Chris
- American Journal of Physiology-Renal Physiology, Vol. 294, Issue 1
Drosophila provides rapid modeling of renal development, function, and disease
journal, December 2010
- Dow, Julian A. T.; Romero, Michael F.
- American Journal of Physiology-Renal Physiology, Vol. 299, Issue 6
Uberon, an integrative multi-species anatomy ontology
journal, January 2012
- Mungall, Christopher J.; Torniai, Carlo; Gkoutos, Georgios V.
- Genome Biology, Vol. 13, Issue 1
Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis
journal, July 2004
- Lan, Y.
- Development, Vol. 131, Issue 13
A dual requirement for Iroquois genes during Xenopus kidney development
journal, October 2008
- Alarcón, Pilar; Rodríguez-Seguel, Elisa; Fernández-González, Ana
- Development, Vol. 135, Issue 20
Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells
journal, August 2006
- James, R. G.
- Development, Vol. 133, Issue 15
The GUDMAP database - an online resource for genitourinary research
journal, June 2011
- Harding, S. D.; Armit, C.; Armstrong, J.
- Development, Vol. 138, Issue 13
Activation of Tubular Epithelial Cells in Diabetic Nephropathy and the Role of the Peroxisome Proliferator–Activated Receptor-γ Agonist
journal, May 2006
- Tang, Sydney C. W.; Leung, Joseph C. K.; Chan, Loretta Y. Y.
- Journal of the American Society of Nephrology, Vol. 17, Issue 6
The Vasculature in Diabetic Nephropathy
journal, January 2014
- Maski, Manish R.; Parikh, Samir M.
- Journal of the American Society of Nephrology, Vol. 25, Issue 1
Muscle Research and Gene Ontology: New standards for improved data integration.
journalarticle, January 2009
- Feltrin, Erika; Campanaro, Stefano; Diehl, Alexander D.
- Springer Science and Business Media LLC
The Renal Gene Ontology Annotation Initiative
journal, April 2010
- Alam-Faruque, Yasmin; Dimmer, Emily C.; Huntley, Rachael P.
- Organogenesis, Vol. 6, Issue 2
Works referencing / citing this record:
The GOA database: Gene Ontology annotation updates for 2015
journal, November 2014
- Huntley, Rachael P.; Sawford, Tony; Mutowo-Meullenet, Prudence
- Nucleic Acids Research, Vol. 43, Issue D1
A statistical approach to identify, monitor, and manage incomplete curated data sets
journal, April 2018
- Howe, Douglas G.
- BMC Bioinformatics, Vol. 19, Issue 1
The Cell Ontology 2016: enhanced content, modularization, and ontology interoperability
journal, July 2016
- Diehl, Alexander D.; Meehan, Terrence F.; Bradford, Yvonne M.
- Journal of Biomedical Semantics, Vol. 7, Issue 1
Urinary MicroRNA Profiling Predicts the Development of Microalbuminuria in Patients with Type 1 Diabetes
journal, July 2015
- Argyropoulos, Christos; Wang, Kai; Bernardo, Jose
- Journal of Clinical Medicine, Vol. 4, Issue 7
The GOA database: Gene Ontology annotation updates for 2015
journal, November 2014
- Huntley, Rachael P.; Sawford, Tony; Mutowo-Meullenet, Prudence
- Nucleic Acids Research, Vol. 43, Issue D1
The Cell Ontology 2016: enhanced content, modularization, and ontology interoperability
journal, July 2016
- Diehl, Alexander D.; Meehan, Terrence F.; Bradford, Yvonne M.
- Journal of Biomedical Semantics, Vol. 7, Issue 1
Urinary MicroRNA Profiling Predicts the Development of Microalbuminuria in Patients with Type 1 Diabetes
journal, July 2015
- Argyropoulos, Christos; Wang, Kai; Bernardo, Jose
- Journal of Clinical Medicine, Vol. 4, Issue 7