Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial
Abstract
Neutralizing and non-neutralizing antibodies to linear epitopes on HIV-1 envelope glycoproteins have potential to mediate antiviral effector functions that could be beneficial to vaccine-induced protection. Here, plasma IgG responses were assessed in three HIV-1 gp120 vaccine efficacy trials (RV144, Vax003, Vax004) and in HIV-1- infected individuals by using arrays of overlapping peptides spanning the entire consensus gp160 of all major genetic subtypes and circulating recombinant forms (CRFs) of the virus. In RV144, where 31.2% efficacy against HIV-1 infection was seen, dominant responses targeted the C1, V2, V3 and C5 regions of gp120. An analysis of RV144 case-control samples showed that IgG to V2 CRF01_AE significantly inversely correlated with infection risk (OR= 0.54, p=0.0042), as did the response to other V2 subtypes (OR=0.60-0.63, p=0.016-0.025). The response to V3 CRF01_AE also inversely correlated with infection risk but only in vaccine recipients who had lower levels of other antibodies, especially Env-specific plasma IgA (OR=0.49, p=0.007) and neutralizing antibodies (OR=0.5, p=0.008). Responses to C1 and C5 showed no significant correlation with infection risk. In Vax003 and Vax004, where no significant protection was seen, serum IgG responses targeted the same epitopes as in RV144 with the exception of an additional C1 reactivity in Vax003 andmore »
- Authors:
-
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- Fred Hutchinson Cancer Research Center, Seattle, WA (United States)
- National Institutes of Health (NIH), Bethesda, MD (United States)
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Duke University, Durham, NC (United States)
- PT Peptide Technologies GmbH, Berlin (Germany)
- Santa Clara Univesity, Santa Clara, CA (United States)
- Global Solutions for Infectious Diseases, South San Francisco, CA (United States)
- US Army Medical Component, AFRIMS, Bangkok (Thailand)
- Ministry of Public Health, Nonthaburi (Thailand)
- Mahidol University, Bangkok (Thailand)
- Sanofi Pasteur, Swiftwater, PA (United States)
- Walter Reed Army Institute of Research, Silver Spring, MD (United States)
- Veterans Affairs New York Harbor Healthcare System, New York, NY (United States); New York University (NYU), NY (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER) US Department of Defense; New York University School of Medicine; Bill & Melinda Gates Foundation; Henry M. Jackson Foundation
- OSTI Identifier:
- 1627640
- Grant/Contract Number:
- AC52-06NA25396; W81XWH-07-2-0067; 692526; 38619
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS ONE
- Additional Journal Information:
- Journal Volume: 8; Journal Issue: 9; Journal ID: ISSN 1932-6203
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; HIV vaccines; medical risk factors; HIV-1; antibodies; vaccine development; viral vaccines; medicine and health sciences; immune response
Citation Formats
Gottardo, Raphael, Bailer, Robert T., Korber, Bette T., Gnanakaran, S., Phillips, Joshua, Shen, Xiaoying, Tomaras, Georgia D., Turk, Ellen, Imholte, Gregory, Eckler, Larry, Wenschuh, Holger, Zerweck, Johannes, Greene, Kelli, Gao, Hongmei, Berman, Phillip W., Francis, Donald, Sinangil, Faruk, Lee, Carter, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Tartaglia, James, Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Zolla-Pazner, Susan, Haynes, Barton F., Mascola, John R., Self, Steve, Gilbert, Peter, and Montefiori, David C. Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial. United States: N. p., 2013.
Web. doi:10.1371/journal.pone.0075665.
Gottardo, Raphael, Bailer, Robert T., Korber, Bette T., Gnanakaran, S., Phillips, Joshua, Shen, Xiaoying, Tomaras, Georgia D., Turk, Ellen, Imholte, Gregory, Eckler, Larry, Wenschuh, Holger, Zerweck, Johannes, Greene, Kelli, Gao, Hongmei, Berman, Phillip W., Francis, Donald, Sinangil, Faruk, Lee, Carter, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Tartaglia, James, Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Zolla-Pazner, Susan, Haynes, Barton F., Mascola, John R., Self, Steve, Gilbert, Peter, & Montefiori, David C. Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial. United States. https://doi.org/10.1371/journal.pone.0075665
Gottardo, Raphael, Bailer, Robert T., Korber, Bette T., Gnanakaran, S., Phillips, Joshua, Shen, Xiaoying, Tomaras, Georgia D., Turk, Ellen, Imholte, Gregory, Eckler, Larry, Wenschuh, Holger, Zerweck, Johannes, Greene, Kelli, Gao, Hongmei, Berman, Phillip W., Francis, Donald, Sinangil, Faruk, Lee, Carter, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Tartaglia, James, Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Zolla-Pazner, Susan, Haynes, Barton F., Mascola, John R., Self, Steve, Gilbert, Peter, and Montefiori, David C. Thu .
"Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial". United States. https://doi.org/10.1371/journal.pone.0075665. https://www.osti.gov/servlets/purl/1627640.
@article{osti_1627640,
title = {Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial},
author = {Gottardo, Raphael and Bailer, Robert T. and Korber, Bette T. and Gnanakaran, S. and Phillips, Joshua and Shen, Xiaoying and Tomaras, Georgia D. and Turk, Ellen and Imholte, Gregory and Eckler, Larry and Wenschuh, Holger and Zerweck, Johannes and Greene, Kelli and Gao, Hongmei and Berman, Phillip W. and Francis, Donald and Sinangil, Faruk and Lee, Carter and Nitayaphan, Sorachai and Rerks-Ngarm, Supachai and Kaewkungwal, Jaranit and Pitisuttithum, Punnee and Tartaglia, James and Robb, Merlin L. and Michael, Nelson L. and Kim, Jerome H. and Zolla-Pazner, Susan and Haynes, Barton F. and Mascola, John R. and Self, Steve and Gilbert, Peter and Montefiori, David C.},
abstractNote = {Neutralizing and non-neutralizing antibodies to linear epitopes on HIV-1 envelope glycoproteins have potential to mediate antiviral effector functions that could be beneficial to vaccine-induced protection. Here, plasma IgG responses were assessed in three HIV-1 gp120 vaccine efficacy trials (RV144, Vax003, Vax004) and in HIV-1- infected individuals by using arrays of overlapping peptides spanning the entire consensus gp160 of all major genetic subtypes and circulating recombinant forms (CRFs) of the virus. In RV144, where 31.2% efficacy against HIV-1 infection was seen, dominant responses targeted the C1, V2, V3 and C5 regions of gp120. An analysis of RV144 case-control samples showed that IgG to V2 CRF01_AE significantly inversely correlated with infection risk (OR= 0.54, p=0.0042), as did the response to other V2 subtypes (OR=0.60-0.63, p=0.016-0.025). The response to V3 CRF01_AE also inversely correlated with infection risk but only in vaccine recipients who had lower levels of other antibodies, especially Env-specific plasma IgA (OR=0.49, p=0.007) and neutralizing antibodies (OR=0.5, p=0.008). Responses to C1 and C5 showed no significant correlation with infection risk. In Vax003 and Vax004, where no significant protection was seen, serum IgG responses targeted the same epitopes as in RV144 with the exception of an additional C1 reactivity in Vax003 and infrequent V2 reactivity in Vax004. In HIV-1 infected subjects, dominant responses targeted the V3 and C5 regions of gp120, as well as the immunodominant domain, heptad repeat 1 (HR-1) and membrane proximal external region (MPER) of gp41. These results highlight the presence of several dominant linear B cell epitopes on the HIV-1 envelope glycoproteins. They also generate the hypothesis that IgG to linear epitopes in the V2 and V3 regions of gp120 are part of a complex interplay of immune responses that contributed to protection in RV144.},
doi = {10.1371/journal.pone.0075665},
journal = {PLoS ONE},
number = 9,
volume = 8,
place = {United States},
year = {Thu Sep 26 00:00:00 EDT 2013},
month = {Thu Sep 26 00:00:00 EDT 2013}
}
Works referenced in this record:
Electrostatics of nanosystems: Application to microtubules and the ribosome
journal, August 2001
- Baker, N. A.; Sept, D.; Joseph, S.
- Proceedings of the National Academy of Sciences, Vol. 98, Issue 18, p. 10037-10041
The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2G12 Recognizes a Cluster of 1->2 Mannose Residues on the Outer Face of gp120
journal, July 2002
- Scanlan, C. N.; Pantophlet, R.; Wormald, M. R.
- Journal of Virology, Vol. 76, Issue 14
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
journal, September 2012
- Huang, Jinghe; Ofek, Gilad; Laub, Leo
- Nature, Vol. 491, Issue 7424
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
journal, November 2011
- McLellan, Jason S.; Pancera, Marie; Carrico, Chris
- Nature, Vol. 480, Issue 7377
A direct approach to false discovery rates
journal, August 2002
- Storey, John D.
- Journal of the Royal Statistical Society: Series B (Statistical Methodology), Vol. 64, Issue 3
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
journal, January 2001
- Mascola, John R.; Stiegler, Gabriela; VanCott, Thomas C.
- AIDS, Vol. 15
Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity
journal, March 2010
- Diskin, Ron; Marcovecchio, Paola M.; Bjorkman, Pamela J.
- Nature Structural & Molecular Biology, Vol. 17, Issue 5
Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41
journal, November 2001
- Zwick, M. B.; Labrijn, A. F.; Wang, M.
- Journal of Virology, Vol. 75, Issue 22
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
journal, July 2012
- Klein, Florian; Gaebler, Christian; Mouquet, Hugo
- The Journal of Experimental Medicine, Vol. 209, Issue 8
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
journal, June 2009
- Hessell, Ann J.; Poignard, Pascal; Hunter, Meredith
- Nature Medicine, Vol. 15, Issue 8
Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial
journal, April 2012
- Haynes, Barton F.; Gilbert, Peter B.; McElrath, M. Juliana
- New England Journal of Medicine, Vol. 366, Issue 14
Secretory IgA Specific for a Conserved Epitope on gp41 Envelope Glycoprotein Inhibits Epithelial Transcytosis of HIV-1
journal, May 2001
- Alfsen, Annette; Iniguez, Pierre; Bouguyon, Edwige
- The Journal of Immunology, Vol. 166, Issue 10
Structure of a V3-Containing HIV-1 gp120 Core
journal, November 2005
- Huang, C. -c.
- Science, Vol. 310, Issue 5750
Genetic Signatures in the Envelope Glycoproteins of HIV-1 that Associate with Broadly Neutralizing Antibodies
journal, October 2010
- Gnanakaran, S.; Daniels, Marcus G.; Bhattacharya, Tanmoy
- PLoS Computational Biology, Vol. 6, Issue 10
Memory B Cell Antibodies to HIV-1 gp140 Cloned from Individuals Infected with Clade A and B Viruses
journal, September 2011
- Mouquet, Hugo; Klein, Florian; Scheid, Johannes F.
- PLoS ONE, Vol. 6, Issue 9
Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein
journal, September 1989
- Javaherian, K.; Langlois, A. J.; McDanal, C.
- Proceedings of the National Academy of Sciences, Vol. 86, Issue 17
Structures of HIV-1 gp120 Envelope Glycoproteins from Laboratory-Adapted and Primary Isolates
journal, February 2001
- Kwong, Peter D.; Wyatt, Richard; Majeed, Shahzad
- Structure, Vol. 9, Issue 2
Solution structure of the HIV gp120 C5 Domain: HIV Gp120 C5 solution structure
journal, September 2002
- Guilhaudis, Laure; Jacobs, Amy; Caffrey, Michael
- European Journal of Biochemistry, Vol. 269, Issue 19
Antigenic specificity of antibody-dependent cell-mediated cytotoxicity directed against human immunodeficiency virus in antibody-positive sera.
journal, January 1989
- Koup, R. A.; Sullivan, J. L.; Levine, P. H.
- Journal of Virology, Vol. 63, Issue 2
How well does a restrained electrostatic potential (RESP) model perform in calculating conformational energies of organic and biological molecules?
journal, January 2000
- Wang, Junmei; Cieplak, Piotr; Kollman, Peter A.
- Journal of Computational Chemistry, Vol. 21, Issue 12
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility
journal, December 2009
- Pancera, M.; Majeed, S.; Ban, Y. -E. A.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 3
Correlates of Protection Induced by Vaccination
journal, May 2010
- Plotkin, Stanley A.
- Clinical and Vaccine Immunology, Vol. 17, Issue 7
Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG
journal, May 2013
- Tomaras, G. D.; Ferrari, G.; Shen, X.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 22
Anti-V3 Monoclonal Antibodies Display Broad Neutralizing Activities against Multiple HIV-1 Subtypes
journal, April 2010
- Hioe, Catarina E.; Wrin, Terri; Seaman, Michael S.
- PLoS ONE, Vol. 5, Issue 4
Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
journal, December 2009
- Rerks-Ngarm, Supachai; Pitisuttithum, Punnee; Nitayaphan, Sorachai
- New England Journal of Medicine, Vol. 361, Issue 23
Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16
journal, August 2010
- Doores, Katie J.; Burton, Dennis R.
- Journal of Virology, Vol. 84, Issue 20
Human Antibody Responses to HIV Type 1 Glycoprotein 41 Cloned in Phage Display Libraries Suggest Three Major Epitopes Are Recognized and Give Evidence for Conserved Antibody Motifs in Antigen Binding
journal, July 1996
- Binley, James M.; Ditzel, Henrik J.; Barbas, Carlos F.
- AIDS Research and Human Retroviruses, Vol. 12, Issue 10
Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
journal, December 1983
- Kabsch, Wolfgang; Sander, Christian
- Biopolymers, Vol. 22, Issue 12
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
journal, January 2004
- Smyth, Gordon K.
- Statistical Applications in Genetics and Molecular Biology, Vol. 3, Issue 1
Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial
journal, January 2013
- Zolla-Pazner, Susan; deCamp, Allan C.; Cardozo, Timothy
- PLoS ONE, Vol. 8, Issue 1
Correlation between Immunologic Responses to a Recombinant Glycoprotein 120 Vaccine and Incidence of HIV‐1 Infection in a Phase 3 HIV‐1 Preventive Vaccine Trial
journal, March 2005
- Gilbert, Peter B.; Peterson, Michael L.; Follmann, Dean
- The Journal of Infectious Diseases, Vol. 191, Issue 5
HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells
journal, February 2008
- Arthos, James; Cicala, Claudia; Martinelli, Elena
- Nature Immunology, Vol. 9, Issue 3
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1.
journal, January 1993
- Muster, T.; Steindl, F.; Purtscher, M.
- Journal of Virology, Vol. 67, Issue 11
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops
journal, March 2012
- Kwon, Y. D.; Finzi, A.; Wu, X.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 15
Human amniotic IgA inhibits natural IgG autoantibodies of maternal or unrelated origin
journal, December 1998
- Quan, Canh P.; Watanabe, Shinichiro; Forestier, François
- European Journal of Immunology, Vol. 28, Issue 12
IgA antibody, antibody-dependent cellular cytotoxicity and prognosis in patients with nasopharyngeal carcinoma
journal, February 1981
- Mathew, Gregory D.; Qualtiere, Louis F.; Neel, H. Bryan
- International Journal of Cancer, Vol. 27, Issue 2
Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single-Genome Amplification and Sequencing
text, January 2008
- B., Guffey, M.; A., Anderson, J.; M., Korber, B. T.
- The University of North Carolina at Chapel Hill University Libraries
Map of Sequential B Cell Epitopes of the HIV-1 Transmembrane Protein Using Human Antibodies as Probe
journal, January 1990
- Goudsmit, Jaap; Meloen, Rob H.; Brasseur, Robert
- Intervirology, Vol. 31, Issue 6
Structures of HIV-1 gp120 Envelope Glycoproteins from Laboratory-Adapted and Primary Isolates
journal, December 2000
- Kwong, Peter D.; Wyatt, Richard; Majeed, Shahzad
- Structure, Vol. 8, Issue 12
VMD: Visual molecular dynamics
journal, February 1996
- Humphrey, William; Dalke, Andrew; Schulten, Klaus
- Journal of Molecular Graphics, Vol. 14, Issue 1
Mass Spectrometric Characterization of a Discontinuous Epitope of the HIV Envelope Protein HIV-gp120 Recognized by the Human Monoclonal Antibody 1331A
journal, April 2000
- Hochleitner, Elisabeth O.; Gorny, Miroslaw K.; Zolla-Pazner, Susan
- The Journal of Immunology, Vol. 164, Issue 8
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
journal, February 2004
- Huang, C. -c.; Venturi, M.; Majeed, S.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 9
Determinants Of Antibody Response After Recombinant Gp160 Boosting In Vaccinia-Naive Volunteers Primed With Gp160-Recombinant Vaccinia Virus
journal, October 1994
- Graham, B. S.; Gorse, G. J.; Schwartz, D. H.
- Journal of Infectious Diseases, Vol. 170, Issue 4
Genetic Signatures in the Envelope Glycoproteins of HIV-1 that Associate with Broadly Neutralizing Antibodies
text, January 2010
- Hongmei, Gao,; Tanmoy, Bhattacharya,; S., Cohen, Myron
- The University of North Carolina at Chapel Hill University Libraries
Broad neutralization coverage of HIV by multiple highly potent antibodies
journal, September 2011
- Walker, Laura M.; Huber, Michael; Doores, Katie J.
- Nature, Vol. 477, Issue 7365
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
journal, February 2000
- Mascola, John R.; Stiegler, Gabriela; VanCott, Thomas C.
- Nature Medicine, Vol. 6, Issue 2
Randomized, Double‐Blind, Placebo‐Controlled Efficacy Trial of a Bivalent Recombinant Glycoprotein 120 HIV‐1 Vaccine among Injection Drug Users in Bangkok, Thailand
journal, December 2006
- Pitisuttithum, Punnee; Gilbert, Peter; Gurwith, Marc
- The Journal of Infectious Diseases, Vol. 194, Issue 12
The Role of Antibodies in HIV Vaccines
journal, March 2010
- Mascola, John R.; Montefiori, David C.
- Annual Review of Immunology, Vol. 28, Issue 1
The Mannose-Dependent Epitope for Neutralizing Antibody 2G12 on Human Immunodeficiency Virus Type 1 Glycoprotein gp120
journal, July 2002
- Sanders, R. W.; Venturi, M.; Schiffner, L.
- Journal of Virology, Vol. 76, Issue 14
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2
journal, September 2012
- Rolland, Morgane; Edlefsen, Paul T.; Larsen, Brendan B.
- Nature, Vol. 490, Issue 7420
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2
journal, January 2013
- Liao, Hua-Xin; Bonsignori, Mattia; Alam, S. Munir
- Immunity, Vol. 38, Issue 1
The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120
journal, November 2012
- Karasavvas, Nicos; Billings, Erik; Rao, Mangala
- AIDS Research and Human Retroviruses, Vol. 28, Issue 11
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
journal, July 2010
- Wu, X.; Yang, Z. -Y.; Li, Y.
- Science, Vol. 329, Issue 5993
A comparison of background correction methods for two-colour microarrays
journal, August 2007
- Ritchie, M. E.; Silver, J.; Oshlack, A.
- Bioinformatics, Vol. 23, Issue 20
A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope.
journal, April 1987
- Palker, T. J.; Matthews, T. J.; Clark, M. E.
- Proceedings of the National Academy of Sciences, Vol. 84, Issue 8
Humoral Immune Responses to Homologous Envelope Peptides in Vaccinees and Lab Workers Infected with HIV
journal, August 1992
- Pincus, Seth H.; Messer, Katherine
- AIDS Research and Human Retroviruses, Vol. 8, Issue 8
PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical p K a Predictions
journal, December 2010
- Olsson, Mats H. M.; Søndergaard, Chresten R.; Rostkowski, Michal
- Journal of Chemical Theory and Computation, Vol. 7, Issue 2
Placebo-Controlled Phase 3 Trial Of A Recombinant Glycoprotein 120 Vaccine To Prevent Hiv-1 Infection
text, January 2005
- Group, The Rgp120 HIV Vaccine Study
- Zenodo
Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials
journal, May 2012
- Montefiori, D. C.; Karnasuta, C.; Huang, Y.
- Journal of Infectious Diseases, Vol. 206, Issue 3
PGV04, an HIV-1 gp120 CD4 Binding Site Antibody, Is Broad and Potent in Neutralization but Does Not Induce Conformational Changes Characteristic of CD4
journal, February 2012
- Falkowska, Emilia; Ramos, Alejandra; Feng, Yu
- Journal of Virology, Vol. 86, Issue 8
Placebo-Controlled Phase 3 Trial of a Recombinant Glycoprotein 120 Vaccine to Prevent HIV-1 Infection
journalarticle, January 2005
- Group, The Rgp120 HIV Vaccine Study
- Zenodo
Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
journal, September 2009
- Walker, L. M.; Phogat, S. K.; Chan-Hui, P. -Y.
- Science, Vol. 326, Issue 5950
Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
journal, January 2010
- Corti, Davide; Langedijk, Johannes P. M.; Hinz, Andreas
- PLoS ONE, Vol. 5, Issue 1
Recognition by Human Monoclonal Antibodies of Free and Complexed Peptides Representing the Prefusogenic and Fusogenic Forms of Human Immunodeficiency Virus Type 1 gp41
journal, July 2000
- Gorny, Miroslaw K.; Zolla-Pazner, Susan
- Journal of Virology, Vol. 74, Issue 13
Intraepithelial Cell Neutralization of HIV-1 Replication by IgA
journal, April 2005
- Huang, Yung T.; Wright, Alison; Gao, Xing
- The Journal of Immunology, Vol. 174, Issue 8
Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses
journal, July 2012
- Burton, D. R.; Poignard, P.; Stanfield, R. L.
- Science, Vol. 337, Issue 6091
Placebocontrolled Phase 3 Trial of a Recombinant Glycoprotein 120 Vaccine to Prevent HIV-1 Infection
journal, January 2006
- Sydman, D. R.
- Yearbook of Medicine, Vol. 2006
Efficient inhibition of HIV-1 replication in human immature monocyte-derived dendritic cells by purified anti–HIV-1 IgG without induction of maturation
journal, June 2006
- Holl, Vincent; Peressin, Maryse; Schmidt, Sylvie
- Blood, Vol. 107, Issue 11
PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations
journal, May 2007
- Dolinsky, T. J.; Czodrowski, P.; Li, H.
- Nucleic Acids Research, Vol. 35, Issue Web Server
Conserved structural elements in the V3 crown of HIV-1 gp120
journal, July 2010
- Jiang, Xunqing; Burke, Valicia; Totrov, Maxim
- Nature Structural & Molecular Biology, Vol. 17, Issue 8
Neutralizing antibody directed against the HIV–1 envelope glycoprotein can completely block HIV–1/SIV chimeric virus infections of macaque monkeys
journal, February 1999
- Shibata, Riri; Igarashi, Tatsuhiko; Haigwood, Nancy
- Nature Medicine, Vol. 5, Issue 2
Structural definition of a conserved neutralization epitope on HIV-1 gp120
journal, February 2007
- Zhou, Tongqing; Xu, Ling; Dey, Barna
- Nature, Vol. 445, Issue 7129
VMD: Visual molecular dynamics
journal, February 1996
- Humphrey, William; Dalke, Andrew; Schulten, Klaus
- Journal of Molecular Graphics, Vol. 14, Issue 1
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2
journal, January 2013
- Liao, Hua-Xin; Bonsignori, Mattia; Alam, S. Munir
- Immunity, Vol. 38, Issue 1
A computational framework for the analysis of peptide microarray antibody binding data with application to HIV vaccine profiling
journal, September 2013
- Imholte, Greg C.; Sauteraud, Renan; Korber, Bette
- Journal of Immunological Methods, Vol. 395, Issue 1-2
Intracellular Neutralization of HIV Transcytosis across Tight Epithelial Barriers by Anti-HIV Envelope Protein dIgA or IgM
journal, August 1998
- Bomsel, Morgane; Heyman, Martine; Hocini, Hakim
- Immunity, Vol. 9, Issue 2
Neutralizing antibody directed against the HIV–1 envelope glycoprotein can completely block HIV–1/SIV chimeric virus infections of macaque monkeys
journal, February 1999
- Shibata, Riri; Igarashi, Tatsuhiko; Haigwood, Nancy
- Nature Medicine, Vol. 5, Issue 2
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
journal, November 2011
- McLellan, Jason S.; Pancera, Marie; Carrico, Chris
- Nature, Vol. 480, Issue 7377
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2
journal, September 2012
- Rolland, Morgane; Edlefsen, Paul T.; Larsen, Brendan B.
- Nature, Vol. 490, Issue 7420
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
journal, September 2012
- Huang, Jinghe; Ofek, Gilad; Laub, Leo
- Nature, Vol. 491, Issue 7424
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
journal, June 2009
- Hessell, Ann J.; Poignard, Pascal; Hunter, Meredith
- Nature Medicine, Vol. 15, Issue 8
Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity
journal, March 2010
- Diskin, Ron; Marcovecchio, Paola M.; Bjorkman, Pamela J.
- Nature Structural & Molecular Biology, Vol. 17, Issue 5
Conserved structural elements in the V3 crown of HIV-1 gp120
journal, July 2010
- Jiang, Xunqing; Burke, Valicia; Totrov, Maxim
- Nature Structural & Molecular Biology, Vol. 17, Issue 8
A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope.
journal, April 1987
- Palker, T. J.; Matthews, T. J.; Clark, M. E.
- Proceedings of the National Academy of Sciences, Vol. 84, Issue 8
Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein
journal, September 1989
- Javaherian, K.; Langlois, A. J.; McDanal, C.
- Proceedings of the National Academy of Sciences, Vol. 86, Issue 17
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
journal, July 2012
- Klein, Florian; Gaebler, Christian; Mouquet, Hugo
- The Journal of Experimental Medicine, Vol. 209, Issue 8
Randomized, Double‐Blind, Placebo‐Controlled Efficacy Trial of a Bivalent Recombinant Glycoprotein 120 HIV‐1 Vaccine among Injection Drug Users in Bangkok, Thailand
journal, December 2006
- Pitisuttithum, Punnee; Gilbert, Peter; Gurwith, Marc
- The Journal of Infectious Diseases, Vol. 194, Issue 12
Humoral Immune Responses to Homologous Envelope Peptides in Vaccinees and Lab Workers Infected with HIV
journal, August 1992
- Pincus, Seth H.; Messer, Katherine
- AIDS Research and Human Retroviruses, Vol. 8, Issue 8
A comparison of background correction methods for two-colour microarrays
journal, August 2007
- Ritchie, M. E.; Silver, J.; Oshlack, A.
- Bioinformatics, Vol. 23, Issue 20
Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials
journal, May 2012
- Montefiori, D. C.; Karnasuta, C.; Huang, Y.
- Journal of Infectious Diseases, Vol. 206, Issue 3
Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
journal, September 2009
- Walker, L. M.; Phogat, S. K.; Chan-Hui, P. -Y.
- Science, Vol. 326, Issue 5950
An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum
journal, May 2011
- Ferrari, G.; Pollara, J.; Kozink, D.
- Journal of Virology, Vol. 85, Issue 14
Antibody-Dependent Cellular Cytotoxicity against Primary HIV-Infected CD4 + T Cells Is Directly Associated with the Magnitude of Surface IgG Binding
journal, June 2012
- Smalls-Mantey, Adjoa; Doria-Rose, Nicole; Klein, Rachel
- Journal of Virology, Vol. 86, Issue 16
Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells
journal, May 2006
- Holl, V.; Peressin, M.; Decoville, T.
- Journal of Virology, Vol. 80, Issue 12
Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design
journal, February 2012
- Bonsignori, Mattia; Montefiori, David C.; Wu, Xueling
- Journal of Virology, Vol. 86, Issue 8
Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus.
journal, January 1987
- Gnann, J. W.; Nelson, J. A.; Oldstone, M. B.
- Journal of Virology, Vol. 61, Issue 8
Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies.
journal, January 1991
- Xu, J. Y.; Gorny, M. K.; Palker, T.
- Journal of Virology, Vol. 65, Issue 9
Identification and characterization of a neutralization site within the second variable region of human immunodeficiency virus type 1 gp120.
journal, January 1992
- Fung, M. S.; Sun, C. R.; Gordon, W. L.
- Journal of Virology, Vol. 66, Issue 2
Conserved and Exposed Epitopes on Intact, Native, Primary Human Immunodeficiency Virus Type 1 Virions of Group M
journal, August 2000
- Nyambi, P. N.; Mbah, H. A.; Burda, S.
- Journal of Virology, Vol. 74, Issue 15
Antibody from Patients with Acute Human Immunodeficiency Virus (HIV) Infection Inhibits Primary Strains of HIV Type 1 in the Presence of Natural-Killer Effector Cells
journal, August 2001
- Forthal, Donald N.; Landucci, Gary; Daar, Eric S.
- Journal of Virology, Vol. 75, Issue 15
Fine Mapping of the Interaction of Neutralizing and Nonneutralizing Monoclonal Antibodies with the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120
journal, January 2003
- Pantophlet, R.; Ollmann Saphire, E.; Poignard, P.
- Journal of Virology, Vol. 77, Issue 1
Nature of Nonfunctional Envelope Proteins on the Surface of Human Immunodeficiency Virus Type 1
journal, February 2006
- Moore, P. L.; Crooks, E. T.; Porter, L.
- Journal of Virology, Vol. 80, Issue 5
The Role of Antibodies in HIV Vaccines
journal, March 2010
- Mascola, John R.; Montefiori, David C.
- Annual Review of Immunology, Vol. 28, Issue 1
Map of Sequential B Cell Epitopes of the HIV-1 Transmembrane Protein Using Human Antibodies as Probe
journal, January 1990
- Goudsmit, Jaap; Meloen, Rob H.; Brasseur, Robert
- Intervirology, Vol. 31, Issue 6
Differences in the antibody response to human immunodeficiency virus-1 envelope glycoprotein (gp160) in infected laboratory workers and vaccinees.
journal, May 1993
- Pincus, S. H.; Messer, K. G.; Schwartz, D. H.
- Journal of Clinical Investigation, Vol. 91, Issue 5
Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
journal, January 2010
- Corti, Davide; Langedijk, Johannes P. M.; Hinz, Andreas
- PLoS ONE, Vol. 5, Issue 1
Anti-V3 Monoclonal Antibodies Display Broad Neutralizing Activities against Multiple HIV-1 Subtypes
journal, April 2010
- Hioe, Catarina E.; Wrin, Terri; Seaman, Michael S.
- PLoS ONE, Vol. 5, Issue 4
Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial
journal, January 2013
- Zolla-Pazner, Susan; deCamp, Allan C.; Cardozo, Timothy
- PLoS ONE, Vol. 8, Issue 1
HIV-1 rational vaccine design: molecular details of b12–gp120 complex structure
journal, June 2007
- Phogat, Sanjay K.; Kaminsky, Stephen M.; Koff, Wayne C.
- Expert Review of Vaccines, Vol. 6, Issue 3
osDesign: AnRPackage for the Analysis, Evaluation, and Design of Two-Phase and Case-Control Studies
journal, January 2011
- Haneuse, Sebastien; Saegusa, Takumi; Lumley, Thomas
- Journal of Statistical Software, Vol. 43, Issue 11
Mass Spectrometric Characterization of a Discontinuous Epitope of the HIV Envelope Protein HIV-gp120 Recognized by the Human Monoclonal Antibody 1331A
journal, April 2000
- Hochleitner, Elisabeth O.; Gorny, Miroslaw K.; Zolla-Pazner, Susan
- The Journal of Immunology, Vol. 164, Issue 8
Secretory IgA Specific for a Conserved Epitope on gp41 Envelope Glycoprotein Inhibits Epithelial Transcytosis of HIV-1
journal, May 2001
- Alfsen, Annette; Iniguez, Pierre; Bouguyon, Edwige
- The Journal of Immunology, Vol. 166, Issue 10
Intraepithelial Cell Neutralization of HIV-1 Replication by IgA
journal, April 2005
- Huang, Yung T.; Wright, Alison; Gao, Xing
- The Journal of Immunology, Vol. 174, Issue 8
Works referencing / citing this record:
Prospects from systems serology research
journal, December 2017
- Arnold, Kelly B.; Chung, Amy W.
- Immunology, Vol. 153, Issue 3
An Enhanced Synthetic Multiclade DNA Prime Induces Improved Cross-Clade-Reactive Functional Antibodies when Combined with an Adjuvanted Protein Boost in Nonhuman Primates
journal, June 2015
- Wise, Megan C.; Hutnick, Natalie A.; Pollara, Justin
- Journal of Virology, Vol. 89, Issue 18
Complex immune correlates of protection in HIV-1 vaccine efficacy trials
journal, January 2017
- Tomaras, Georgia D.; Plotkin, Stanley A.
- Immunological Reviews, Vol. 275, Issue 1
Immune correlates of vaccine protection against HIV-1 acquisition
journal, October 2015
- Corey, Lawrence; Gilbert, Peter B.; Tomaras, Georgia D.
- Science Translational Medicine, Vol. 7, Issue 310
HIV-1 Vaccine Sequences Impact V1V2 Antibody Responses: A Comparison of Two Poxvirus Prime gp120 Boost Vaccine Regimens
journal, February 2020
- Shen, Xiaoying; Laher, Fatima; Moodie, Zoe
- Scientific Reports, Vol. 10, Issue 1
Modification of the Association Between T-Cell Immune Responses and Human Immunodeficiency Virus Type 1 Infection Risk by Vaccine-Induced Antibody Responses in the HVTN 505 Trial
journal, January 2018
- Fong, Youyi; Shen, Xiaoying; Ashley, Vicki C.
- The Journal of Infectious Diseases, Vol. 217, Issue 8
Infant HIV Type 1 gp120 Vaccination Elicits Robust and Durable Anti-V1V2 Immunoglobulin G Responses and Only Rare Envelope-Specific Immunoglobulin A Responses
journal, August 2014
- Fouda, Genevieve G.; Cunningham, Coleen K.; McFarland, Elizabeth J.
- The Journal of Infectious Diseases, Vol. 211, Issue 4
Novel prime-boost vaccine strategies against HIV-1
journal, July 2019
- Excler, Jean-Louis; Kim, Jerome H.
- Expert Review of Vaccines, Vol. 18, Issue 8
Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes
journal, May 2019
- Nelson, Ashley N.; Goswami, Ria; Dennis, Maria
- Journal of Virology, Vol. 93, Issue 15
Sustained virologic control in SIV+ macaques after antiretroviral and 4 7 antibody therapy
journal, October 2016
- Byrareddy, S. N.; Arthos, J.; Cicala, C.
- Science, Vol. 354, Issue 6309
Simplified steps to heterologous prime-boost HIV vaccine development?
journal, September 2019
- Michael, Nelson L.
- Journal of Clinical Investigation, Vol. 129, Issue 11
Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant
journal, April 2018
- Wen, Yingxia; Trinh, Hung V.; Linton, Christine E.
- PLOS ONE, Vol. 13, Issue 4
Immunogenicity and Efficacy of a Novel Multi-Antigenic Peptide Vaccine Based on Cross-Reactivity between Feline and Human Immunodeficiency Viruses
journal, February 2019
- Sahay, Bikash; Aranyos, Alek; Mishra, Meerambika
- Viruses, Vol. 11, Issue 2
Revisiting the Correlate of Reduced HIV Infection Risk in the Rv144 Vaccine Trial
journal, September 2019
- Zolla-Pazner, Susan; Gilbert, Peter B.
- Journal of Virology, Vol. 93, Issue 17
Randomized, Double-Blind Evaluation of Late Boost Strategies for HIV-Uninfected Vaccine Recipients in the RV144 HIV Vaccine Efficacy Trial
journal, February 2017
- Rerks-Ngarm, Supachai; Pitisuttithum, Punnee; Excler, Jean-Louis
- The Journal of Infectious Diseases, Vol. 215, Issue 8
Liposome-Encapsulated Human Immunodeficiency Virus-1 gp120 Induces Potent V1V2-Specific Antibodies in Humans
journal, June 2018
- Rao, Mangala; Onkar, Sayali; Peachman, Kristina K.
- The Journal of Infectious Diseases, Vol. 218, Issue 10
A critical question for HIV vaccine development: Which antibodies to induce?
journal, July 2014
- Zolla-Pazner, S.
- Science, Vol. 345, Issue 6193
Correction: ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type
journal, April 2020
- Schifanella, Luca; Barnett, Susan W.; Bissa, Massimiliano
- PLOS Pathogens, Vol. 16, Issue 4
Towards conformational fidelity of a quaternary HIV-1 epitope: computational design and directed evolution of a minimal V1V2 antigen
journal, April 2018
- Lai, Jennifer I.; Verma, Deeptak; Bailey-Kellogg, Chris
- Protein Engineering, Design and Selection, Vol. 31, Issue 4
A Plant-Derived Multi-HIV Antigen Induces Broad Immune Responses in Orally Immunized Mice
journal, March 2015
- Rubio-Infante, Néstor; Govea-Alonso, Dania O.; Romero-Maldonado, Andrea
- Molecular Biotechnology, Vol. 57, Issue 7
HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
journal, February 2019
- Jones, Andrew T.; Shen, Xiaoying; Walter, Korey L.
- Nature Communications, Vol. 10, Issue 1
Enhancing poxvirus vectors vaccine immunogenicity
journal, May 2014
- García-Arriaza, Juan; Esteban, Mariano
- Human Vaccines & Immunotherapeutics, Vol. 10, Issue 8
Distinct Mechanisms Regulate Exposure of Neutralizing Epitopes in the V2 and V3 Loops of HIV-1 Envelope
journal, August 2014
- Upadhyay, C.; Mayr, L. M.; Zhang, J.
- Journal of Virology, Vol. 88, Issue 21
Maternal Binding and Neutralizing IgG Responses Targeting the C-Terminal Region of the V3 Loop Are Predictive of Reduced Peripartum HIV-1 Transmission Risk
journal, February 2017
- Martinez, David R.; Vandergrift, Nathan; Douglas, Ayooluwa O.
- Journal of Virology, Vol. 91, Issue 9
Rationally Designed Vaccines Targeting the V2 Region of HIV-1 gp120 Induce a Focused, Cross-Clade-Reactive, Biologically Functional Antibody Response
journal, September 2016
- Zolla-Pazner, Susan; Powell, Rebecca; Yahyaei, Sara
- Journal of Virology, Vol. 90, Issue 24
Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial
text, January 2015
- Unknown, (:Unkn)
- My University
ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type
journal, December 2019
- Schifanella, Luca; Barnett, Susan W.; Bissa, Massimiliano
- PLOS Pathogens, Vol. 15, Issue 12
HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis
journal, January 2018
- Wills, Saintedym; Hwang, Kwan-Ki; Liu, Pinghuang
- Journal of Virology, Vol. 92, Issue 7
HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Specific B and T Cell Immune Functions in Nonhuman Primates
journal, May 2017
- García-Arriaza, Juan; Perdiguero, Beatriz; Heeney, Jonathan L.
- Journal of Virology, Vol. 91, Issue 9
Maternal HIV-1 envelope–specific antibody responses and reduced risk of perinatal transmission
journal, June 2015
- Permar, Sallie R.; Fong, Youyi; Vandergrift, Nathan
- Journal of Clinical Investigation, Vol. 125, Issue 7
Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India
journal, August 2018
- Munusamy Ponnan, Sivasankaran; Swaminathan, Soumya; Tiruvengadam, Kannan
- PLOS ONE, Vol. 13, Issue 8
Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence
journal, April 2019
- Nadai, Yuka; Held, Kathrin; Joseph, Sarah
- Frontiers in Immunology, Vol. 10
A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes
journal, February 2017
- Joseph, Sarah; Quinn, Killian; Greenwood, Aldona
- Frontiers in Immunology, Vol. 8
Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies
journal, April 2018
- Doran, Rachel C.; Tatsuno, Gwen P.; O’Rourke, Sara M.
- PLOS ONE, Vol. 13, Issue 4
Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition
journal, May 2016
- Vaccari, Monica; Gordon, Shari N.; Fourati, Slim
- Nature Medicine, Vol. 22, Issue 7
Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIV mac251 Acquisition
journal, September 2016
- Gordon, Shari N.; Liyanage, Namal P. M.; Doster, Melvin N.
- The Journal of Immunology, Vol. 197, Issue 7
Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques
journal, October 2017
- Phillips, Bonnie; Fouda, Genevieve G.; Eudailey, Josh
- Clinical and Vaccine Immunology, Vol. 24, Issue 10
Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice
journal, December 2016
- Wiehe, Kevin; Nicely, Nathan I.; Lockwood, Bradley
- The Journal of Immunology, Vol. 198, Issue 3
A Chimeric HIV-1 gp120 Fused with Vaccinia Virus 14K (A27) Protein as an HIV Immunogen
journal, July 2015
- Vijayan, Aneesh; García-Arriaza, Juan; C. Raman, Suresh
- PLOS ONE, Vol. 10, Issue 7
Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization
text, January 2016
- E., Giorgi, Elena; S., Seaman, Michael; C., Montefiori, David
- The University of North Carolina at Chapel Hill University Libraries
Reduced Cell-Associated DNA and Improved Viral Control in Macaques following Passive Transfer of a Single Anti-V2 Monoclonal Antibody and Repeated Simian/Human Immunodeficiency Virus Challenges
journal, March 2018
- Hessell, Ann J.; Shapiro, Mariya B.; Powell, Rebecca
- Journal of Virology, Vol. 92, Issue 11
Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap
journal, June 2016
- Gray, Glenda E.; Mayer, Kenneth H.; Elizaga, Marnie L.
- Clinical and Vaccine Immunology, Vol. 23, Issue 6
IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells
journal, September 2018
- Blasi, Maria; Negri, Donatella; LaBranche, Celia
- Communications Biology, Vol. 1, Issue 1
Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial
journal, October 2014
- Edlefsen, Paul T.; Rolland, Morgane; Hertz, Tomer
- AIDS Research and Human Retroviruses, Vol. 30, Issue S1
Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector
journal, December 2019
- Giel-Moloney, M.; Esteban, M.; Oakes, B. H.
- Scientific Reports, Vol. 9, Issue 1
Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates
journal, May 2015
- Shen, Xiaoying; Duffy, Ryan; Howington, Robert
- Journal of Virology, Vol. 89, Issue 16
HIV vaccine delayed boosting increases Env variable region 2–specific antibody effector functions
journal, January 2020
- Easterhoff, David; Pollara, Justin; Luo, Kan
- JCI Insight, Vol. 5, Issue 2
Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization
journal, July 2016
- Rademeyer, Cecilia; Korber, Bette; Seaman, Michael S.
- PLOS Pathogens, Vol. 12, Issue 7
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations
journal, July 2019
- Han, Qifeng; Jones, Julia A.; Nicely, Nathan I.
- Nature Communications, Vol. 10, Issue 1
Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa
journal, September 2019
- Gray, Glenda E.; Huang, Ying; Grunenberg, Nicole
- Science Translational Medicine, Vol. 11, Issue 510
Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials
journal, January 2018
- Balasubramanian, Preetha; Williams, Constance; Shapiro, Mariya B.
- Scientific Reports, Vol. 8, Issue 1
HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees
journal, January 2018
- Yates, Nicole L.; deCamp, Allan C.; Korber, Bette T.
- Journal of Virology, Vol. 92, Issue 8
Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques
journal, December 2016
- Luo, Kan; Liao, Hua-Xin; Zhang, Ruijun
- JCI Insight, Vol. 1, Issue 20
Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates
journal, February 2018
- Saunders, Kevin O.; Santra, Sampa; Parks, Robert
- Journal of Virology, Vol. 92, Issue 8
HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine
journal, January 2018
- McGuire, Erin P.; Fong, Youyi; Toote, Christopher
- Journal of Virology, Vol. 92, Issue 1
Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques
text, January 2017
- Camden, Bay,; G., Fouda, Genevieve; Josh, Eudailey,
- The University of North Carolina at Chapel Hill University Libraries
Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial
journal, February 2015
- Edlefsen, Paul T.; Rolland, Morgane; Hertz, Tomer
- PLOS Computational Biology, Vol. 11, Issue 2
Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates
journal, June 2015
- García-Arriaza, Juan; Perdiguero, Beatriz; Heeney, Jonathan
- Journal of Virology, Vol. 89, Issue 16
Coadministration of CH31 Broadly Neutralizing Antibody Does Not Affect Development of Vaccine-Induced Anti-HIV-1 Envelope Antibody Responses in Infant Rhesus Macaques
journal, December 2018
- Dennis, Maria; Eudailey, Joshua; Pollara, Justin
- Journal of Virology, Vol. 93, Issue 5
Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01
journal, November 2019
- Pinto, Dora; Fenwick, Craig; Caillat, Christophe
- Cell Host & Microbe, Vol. 26, Issue 5
Characterization of a monoclonal antibody to a novel glycan-dependent epitope in the V1/V2 domain of the HIV-1 envelope protein, gp120
journal, November 2014
- Doran, Rachel C.; Morales, Javier F.; To, Briana
- Molecular Immunology, Vol. 62, Issue 1
HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
journal, February 2019
- Jones, Andrew T.; Shen, Xiaoying; Walter, Korey L.
- Nature Communications, Vol. 10, Issue 1
Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials
journal, January 2018
- Balasubramanian, Preetha; Williams, Constance; Shapiro, Mariya B.
- Scientific Reports, Vol. 8, Issue 1
Projected effectiveness and added value of HIV vaccination campaigns in South Africa: A modeling study
journal, April 2018
- de Montigny, Simon; Adamson, Blythe J. S.; Mâsse, Benoît R.
- Scientific Reports, Vol. 8, Issue 1
Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector
journal, December 2019
- Giel-Moloney, M.; Esteban, M.; Oakes, B. H.
- Scientific Reports, Vol. 9, Issue 1
HIV-1 Vaccine Sequences Impact V1V2 Antibody Responses: A Comparison of Two Poxvirus Prime gp120 Boost Vaccine Regimens
journal, February 2020
- Shen, Xiaoying; Laher, Fatima; Moodie, Zoe
- Scientific Reports, Vol. 10, Issue 1
Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial
journal, October 2014
- Edlefsen, Paul T.; Rolland, Morgane; Hertz, Tomer
- AIDS Research and Human Retroviruses, Vol. 30, Issue S1
IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens
journal, November 2015
- Karasavvas, Nicos; Karnasuta, Chitraporn; Savadsuk, Hathairat
- AIDS Research and Human Retroviruses, Vol. 31, Issue 11
Comparison of Antibody Responses Induced by RV144, VAX003, and VAX004 Vaccination Regimens
journal, May 2017
- Karnasuta, Chitraporn; Akapirat, Siriwat; Madnote, Sirinan
- AIDS Research and Human Retroviruses, Vol. 33, Issue 5
Modification of the Association Between T-Cell Immune Responses and Human Immunodeficiency Virus Type 1 Infection Risk by Vaccine-Induced Antibody Responses in the HVTN 505 Trial
journal, January 2018
- Fong, Youyi; Shen, Xiaoying; Ashley, Vicki C.
- The Journal of Infectious Diseases, Vol. 217, Issue 8
Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap
journal, June 2016
- Gray, Glenda E.; Mayer, Kenneth H.; Elizaga, Marnie L.
- Clinical and Vaccine Immunology, Vol. 23, Issue 6
Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques
journal, October 2017
- Shen, Xiaoying; Bogers, Willy M.; Yates, Nicole L.
- Journal of Virology, Vol. 91, Issue 19
An Enhanced Synthetic Multiclade DNA Prime Induces Improved Cross-Clade-Reactive Functional Antibodies when Combined with an Adjuvanted Protein Boost in Nonhuman Primates
journal, June 2015
- Wise, Megan C.; Hutnick, Natalie A.; Pollara, Justin
- Journal of Virology, Vol. 89, Issue 18
HIV-1 gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine
journal, October 2017
- Shen, Xiaoying; Basu, Rahul; Sawant, Sheetal
- Journal of Virology, Vol. 91, Issue 24
A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques
journal, March 2018
- Jones, Andrew T.; Chamcha, Venkateswarlu; Kesavardhana, Sannula
- Journal of Virology, Vol. 92, Issue 5
Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design
journal, September 2017
- Routy, Jean-Pierre; Mehraj, Vikram
- AIDS Research and Therapy, Vol. 14, Issue 1
Effect of Glycosylation on an Immunodominant Region in the V1V2 Variable Domain of the HIV-1 Envelope gp120 Protein
journal, October 2016
- Tian, Jianhui; López, Cesar A.; Derdeyn, Cynthia A.
- PLOS Computational Biology, Vol. 12, Issue 10
Biocompatible Anionic Polymeric Microspheres as Priming Delivery System for Effetive HIV/AIDS Tat-Based Vaccines
journal, October 2014
- Titti, Fausto; Maggiorella, Maria T.; Ferrantelli, Flavia
- PLoS ONE, Vol. 9, Issue 10
Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor
journal, December 2015
- Peachman, Kristina K.; Karasavvas, Nicos; Chenine, Agnes-Laurence
- PLOS ONE, Vol. 10, Issue 12
Immunogenicity of a novel Clade B HIV-1 vaccine combination: Results of phase 1 randomized placebo controlled trial of an HIV-1 GM-CSF-expressing DNA prime with a modified vaccinia Ankara vaccine boost in healthy HIV-1 uninfected adults
journal, July 2017
- Buchbinder, Susan P.; Grunenberg, Nicole A.; Sanchez, Brittany J.
- PLOS ONE, Vol. 12, Issue 7
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques
journal, August 2015
- Santra, Sampa; Tomaras, Georgia D.; Warrier, Ranjit
- PLOS Pathogens, Vol. 11, Issue 8
Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization
journal, July 2016
- Rademeyer, Cecilia; Korber, Bette; Seaman, Michael S.
- PLOS Pathogens, Vol. 12, Issue 7
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journal, April 2020
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Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines
journal, January 2013
- Chin’ombe, Nyasha
- The Open Virology Journal, Vol. 7, Issue 1
Which Antibody Functions are Important for an HIV Vaccine?
journal, June 2014
- Su, Bin; Moog, Christiane
- Frontiers in Immunology, Vol. 5
Immunogenicity and Efficacy of a Novel Multi-Antigenic Peptide Vaccine Based on Cross-Reactivity between Feline and Human Immunodeficiency Viruses
journal, February 2019
- Sahay, Bikash; Aranyos, Alek; Mishra, Meerambika
- Viruses, Vol. 11, Issue 2
Advancing Toward HIV-1 Vaccine Efficacy through the Intersections of Immune Correlates
journal, December 2013
- Tomaras, Georgia; Haynes, Barton
- Vaccines, Vol. 2, Issue 1
HIV DNA Vaccine: Stepwise Improvements Make a Difference
journal, May 2014
- Felber, Barbara; Valentin, Antonio; Rosati, Margherita
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V2-Specific Antibodies in HIV-1 Vaccine Research and Natural Infection: Controllers or Surrogate Markers
journal, August 2019
- Duerr, Ralf; Gorny, Miroslaw K.
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Conserved HIV Epitopes for an Effective HIV Vaccine
journal, January 2017
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