Transcriptional responses of Escherichia coli during recovery from inorganic or organic mercury exposure
Abstract
Background: The protean chemical properties of mercury have long made it attractive for diverse applications, but its toxicity requires great care in its use, disposal, and recycling. Mercury occurs in multiple chemical forms, and the molecular basis for the distinct toxicity of its various forms is only partly understood. Global transcriptomics applied over time can reveal how a cell recognizes a toxicant and what cellular subsystems it marshals to repair and recover from the damage. The longitudinal effects on the transcriptome of exponential phase E. coli were compared during sub-acute exposure to mercuric chloride (HgCl2) or to phenylmercuric acetate (PMA) using RNA-Seq. Results: Differential gene expression revealed common and distinct responses to the mercurials throughout recovery. Cultures exhibited growth stasis immediately after each mercurial exposure but returned to normal growth more quickly after PMA exposure than after HgCl2 exposure. Correspondingly, PMA rapidly elicited up-regulation of a large number of genes which continued for 30 min, whereas fewer genes were up-regulated early after HgCl2 exposure only some of which overlapped with PMA up-regulated genes. By 60 min gene expression in PMA-exposed cells was almost indistinguishable from unexposed cells, but HgCl2 exposed cells still had many differentially expressed genes. Relative expression ofmore »
- Authors:
- Publication Date:
- Research Org.:
- Univ. of Georgia, Athens, GA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1618556
- Alternate Identifier(s):
- OSTI ID: 1506472
- Grant/Contract Number:
- ER64408; ER65286; FG02-07ER64408
- Resource Type:
- Published Article
- Journal Name:
- BMC Genomics
- Additional Journal Information:
- Journal Name: BMC Genomics Journal Volume: 19 Journal Issue: 1; Journal ID: ISSN 1471-2164
- Publisher:
- Springer Science + Business Media
- Country of Publication:
- United Kingdom
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Longitudinal RNA-Seq; Transcriptomics; Toxic metals; Essential metals; Stress response; Biofilm; Phenylmercury; Antibiotic resistance
Citation Formats
LaVoie, Stephen P., and Summers, Anne O. Transcriptional responses of Escherichia coli during recovery from inorganic or organic mercury exposure. United Kingdom: N. p., 2018.
Web. doi:10.1186/s12864-017-4413-z.
LaVoie, Stephen P., & Summers, Anne O. Transcriptional responses of Escherichia coli during recovery from inorganic or organic mercury exposure. United Kingdom. https://doi.org/10.1186/s12864-017-4413-z
LaVoie, Stephen P., and Summers, Anne O. Tue .
"Transcriptional responses of Escherichia coli during recovery from inorganic or organic mercury exposure". United Kingdom. https://doi.org/10.1186/s12864-017-4413-z.
@article{osti_1618556,
title = {Transcriptional responses of Escherichia coli during recovery from inorganic or organic mercury exposure},
author = {LaVoie, Stephen P. and Summers, Anne O.},
abstractNote = {Background: The protean chemical properties of mercury have long made it attractive for diverse applications, but its toxicity requires great care in its use, disposal, and recycling. Mercury occurs in multiple chemical forms, and the molecular basis for the distinct toxicity of its various forms is only partly understood. Global transcriptomics applied over time can reveal how a cell recognizes a toxicant and what cellular subsystems it marshals to repair and recover from the damage. The longitudinal effects on the transcriptome of exponential phase E. coli were compared during sub-acute exposure to mercuric chloride (HgCl2) or to phenylmercuric acetate (PMA) using RNA-Seq. Results: Differential gene expression revealed common and distinct responses to the mercurials throughout recovery. Cultures exhibited growth stasis immediately after each mercurial exposure but returned to normal growth more quickly after PMA exposure than after HgCl2 exposure. Correspondingly, PMA rapidly elicited up-regulation of a large number of genes which continued for 30 min, whereas fewer genes were up-regulated early after HgCl2 exposure only some of which overlapped with PMA up-regulated genes. By 60 min gene expression in PMA-exposed cells was almost indistinguishable from unexposed cells, but HgCl2 exposed cells still had many differentially expressed genes. Relative expression of energy production and most metabolite uptake pathways declined with both compounds, but nearly all stress response systems were up-regulated by one or the other mercurial during recovery. Conclusions: Sub-acute exposure influenced expression of ~45% of all genes with many distinct responses for each compound, reflecting differential biochemical damage by each mercurial and the corresponding resources available for repair. This study is the first global, high-resolution view of the transcriptional responses to any common toxicant in a prokaryotic model system from exposure to recovery of active growth. The responses provoked by these two mercurials in this model bacterium also provide insights about how higher organisms may respond to these ubiquitous metal toxicants.},
doi = {10.1186/s12864-017-4413-z},
journal = {BMC Genomics},
number = 1,
volume = 19,
place = {United Kingdom},
year = {Tue Jan 16 00:00:00 EST 2018},
month = {Tue Jan 16 00:00:00 EST 2018}
}
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1186/s12864-017-4413-z
https://doi.org/10.1186/s12864-017-4413-z
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 12 works
Citation information provided by
Web of Science
Web of Science
Figures / Tables:
Fig. 1: Effects of sub-acute mercury exposure on growth of MG1655. a E. coli K12 MG1655 grown in MOPS minimal medium, unexposed (blue) or exposed to 3 μM HgCl2 (red) or 3 μM PMA (green) during mid-log phase. Asterisks indicate sampling times for RNA-seq. Error bars are standard error (SEM)more »
All figures and tables
(17 total)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
STRING: known and predicted protein-protein associations, integrated and transferred across organisms
journal, December 2004
- von Mering, C.
- Nucleic Acids Research, Vol. 33, Issue Database issue
The mar regulon: multiple resistance to antibiotics and other toxic chemicals
journal, October 1999
- Alekshun, Michael N.; Levy, Stuart B.
- Trends in Microbiology, Vol. 7, Issue 10
Alterations in renal cellular glutathione metabolism after in vivo administration of a subtoxic dose of mercuric chloride
journal, January 1996
- Lash, Lawrence H.; Zalups, Rudolfs K.
- Journal of Biochemical Toxicology, Vol. 11, Issue 1
Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions
journal, September 2015
- Schwechheimer, Carmen; Kuehn, Meta J.
- Nature Reviews Microbiology, Vol. 13, Issue 10
Displacement of zinc and copper from copper-induced metallothionein by cadmium and by mercury: In vivo and ex vivo studies
journal, January 1987
- Funk, Allen E.; Day, Frances A.; Brady, Frank O.
- Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, Vol. 86, Issue 1
Structure and Function of the Escherichia coli Protein YmgB: A Protein Critical for Biofilm Formation and Acid-resistance
journal, October 2007
- Lee, Jintae; Page, Rebecca; García-Contreras, Rodolfo
- Journal of Molecular Biology, Vol. 373, Issue 1
Mercury-Induced Apoptosis in Human Lymphoid Cells: Evidence That the Apoptotic Pathway Is Mercurial Species Dependent
journal, October 2000
- Shenker, Bruce J.; Guo, Tai L.; Shapiro, Irving M.
- Environmental Research, Vol. 84, Issue 2
The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase
journal, December 1997
- Rensing, C.; Mitra, B.; Rosen, B. P.
- Proceedings of the National Academy of Sciences, Vol. 94, Issue 26
Genome-wide Escherichia coli stress response and improved tolerance towards industrially relevant chemicals
journal, October 2016
- Rau, Martin Holm; Calero, Patricia; Lennen, Rebecca M.
- Microbial Cell Factories, Vol. 15, Issue 1
Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation
journal, January 2010
- Ung, Choong; Lam, Siew; Hlaing, Mya
- BMC Genomics, Vol. 11, Issue 1
Operator sequences of the aerobactin operon of plasmid ColV-K30 binding the ferric uptake regulation (fur) repressor.
journal, June 1987
- de Lorenzo, V.; Wee, S.; Herrero, M.
- Journal of Bacteriology, Vol. 169, Issue 6
Submicromolar hydrogen peroxide disrupts the ability of Fur protein to control free-iron levels in Escherichia coli
journal, May 2007
- Varghese, Shery; Wu, Amy; Park, Sunny
- Molecular Microbiology, Vol. 64, Issue 3
The RNA Degradosome of Escherichia coli : An mRNA-Degrading Machine Assembled on RNase E
journal, October 2007
- Carpousis, Agamemnon J.
- Annual Review of Microbiology, Vol. 61, Issue 1
Convergent Evolution of a New Arsenic Binding Site in the ArsR/SmtB Family of Metalloregulators
journal, October 2007
- Qin, J.; Fu, H. -L.; Ye, J.
- Journal of Biological Chemistry, Vol. 282, Issue 47
Oxygen, iron, carbon, and superoxide control of the fumarase fumA and fumC genes of Escherichia coli: role of the arcA, fnr, and soxR gene products.
journal, November 1995
- Park, S. J.; Gunsalus, R. P.
- Journal of Bacteriology, Vol. 177, Issue 21
Escherichia coli BdcA controls biofilm dispersal in Pseudomonas aeruginosa and Rhizobium meliloti
journal, October 2011
- Ma, Qun; Zhang, Guishan; Wood, Thomas K.
- BMC Research Notes, Vol. 4, Issue 1
Global Gene Expression Responses to Cadmium Toxicity in Escherichia coli
journal, April 2005
- Wang, A.; Crowley, D. E.
- Journal of Bacteriology, Vol. 187, Issue 9
Mercury(II) Complexes of Imidazole and Histidine
journal, May 1960
- Brooks, Philip; Davidson, Norman
- Journal of the American Chemical Society, Vol. 82, Issue 9
The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation: Manganese-dependent ribonucleotide reductase
journal, March 2011
- Martin, Julia E.; Imlay, James A.
- Molecular Microbiology, Vol. 80, Issue 2
The yliA, -B, -C, and -D Genes of Escherichia coli K-12 Encode a Novel Glutathione Importer with an ATP-Binding Cassette
journal, August 2005
- Suzuki, H.; Koyanagi, T.; Izuka, S.
- Journal of Bacteriology, Vol. 187, Issue 17
Roles of pgaABCD Genes in Synthesis, Modification, and Export of the Escherichia coli Biofilm Adhesin Poly- -1,6-N-Acetyl-D-Glucosamine
journal, March 2008
- Itoh, Y.; Rice, J. D.; Goller, C.
- Journal of Bacteriology, Vol. 190, Issue 10
Transcriptomic characterization of zebrafish larvae in response to mercury exposure
journal, February 2017
- Lu, Xing; Xiang, Ying; Yang, Guohua
- Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol. 192
Low dose mercury toxicity and human health
journal, September 2005
- Zahir, Farhana; Rizwi, Shamim J.; Haq, Soghra K.
- Environmental Toxicology and Pharmacology, Vol. 20, Issue 2
Iron–sulfur cluster biosynthesis
journal, November 2008
- Bandyopadhyay, Sibali; Chandramouli, Kala; Johnson, Michael K.
- Biochemical Society Transactions, Vol. 36, Issue 6
The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease
journal, March 2010
- Bissonnette, Sarah A.; Rivera-Rivera, Izarys; Sauer, Robert T.
- Molecular Microbiology, Vol. 75, Issue 6
RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more
journal, November 2012
- Salgado, Heladia; Peralta-Gil, Martin; Gama-Castro, Socorro
- Nucleic Acids Research, Vol. 41, Issue D1
Global regulation by the seven-component Pi signaling system
journal, April 2010
- Hsieh, Yi-Ju; Wanner, Barry L.
- Current Opinion in Microbiology, Vol. 13, Issue 2
Gold Mining as a Source of Mercury Exposure in the Brazilian Amazon
journal, May 1998
- Malm, Olaf
- Environmental Research, Vol. 77, Issue 2
baySeq: Empirical Bayesian methods for identifying differential expression in sequence count data
journal, August 2010
- Hardcastle, Thomas J.; Kelly, Krystyna A.
- BMC Bioinformatics, Vol. 11, Issue 1
Crystal structure of the [2Fe-2S] oxidative-stress sensor SoxR bound to DNA
journal, March 2008
- Watanabe, S.; Kita, A.; Kobayashi, K.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 11
Selenoproteins: Molecular Pathways and Physiological Roles
journal, July 2014
- Labunskyy, Vyacheslav M.; Hatfield, Dolph L.; Gladyshev, Vadim N.
- Physiological Reviews, Vol. 94, Issue 3
Metals, Toxicity and Oxidative Stress
journal, May 2005
- Valko, M.; Morris, H.; Cronin, M.
- Current Medicinal Chemistry, Vol. 12, Issue 10
Global Gene Expression Analysis of Long-Term Stationary Phase Effects in E. coli K12 MG1655
journal, May 2014
- Arunasri, Kotakonda; Adil, Mohammed; Khan, Pathan Akbar Ali
- PLoS ONE, Vol. 9, Issue 5
Role of the Major Heat Shock Proteins as Molecular Chaperones
journal, November 1993
- Georgopoulos, C.; Welch, W. J.
- Annual Review of Cell Biology, Vol. 9, Issue 1
Association of mercury resistance with antibiotic resistance in the gram-negative fecal bacteria of primates.
journal, January 1997
- Wireman, J.; Liebert, C. A.; Smith, T.
- Applied and environmental microbiology, Vol. 63, Issue 11
Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli
journal, May 2009
- Anjem, Adil; Varghese, Shery; Imlay, James A.
- Molecular Microbiology, Vol. 72, Issue 4
RNA snap ™: a rapid, quantitative and inexpensive, method for isolating total RNA from bacteria
journal, July 2012
- Stead, Mark B.; Agrawal, Ankit; Bowden, Katherine E.
- Nucleic Acids Research, Vol. 40, Issue 20
Comparative toxicology of mercurials in Caenorhabditis elegans
journal, July 2011
- McElwee, Matthew K.; Freedman, Jonathan H.
- Environmental Toxicology and Chemistry, Vol. 30, Issue 9
Disulfide bond formation by exported glutaredoxin indicates glutathione's presence in the E. coli periplasm
journal, January 2009
- Eser, M.; Masip, L.; Kadokura, H.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 5
Review: Environmental exposure to mercury and its toxicopathologic implications for public health
journal, January 2003
- Tchounwou, Paul B.; Ayensu, Wellington K.; Ninashvili, Nanuli
- Environmental Toxicology, Vol. 18, Issue 3
Ribose catabolism of Escherichia coli: characterization of the rpiB gene encoding ribose phosphate isomerase B and of the rpiR gene, which is involved in regulation of rpiB expression.
journal, February 1996
- Sørensen, K. I.; Hove-Jensen, B.
- Journal of Bacteriology, Vol. 178, Issue 4
Gene expression profiling of Escherichia coli growth transitions: an expanded stringent response model
journal, July 2002
- Chang, Dong-Eun; Smalley, Darren J.; Conway, Tyrrell
- Molecular Microbiology, Vol. 45, Issue 2
Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA
journal, March 2011
- Lemke, J. J.; Sanchez-Vazquez, P.; Burgos, H. L.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 14
Lipid A Modification Systems in Gram-Negative Bacteria
journal, June 2007
- Raetz, Christian R. H.; Reynolds, C. Michael; Trent, M. Stephen
- Annual Review of Biochemistry, Vol. 76, Issue 1
Advances in metal-induced oxidative stress and human disease
journal, May 2011
- Jomova, Klaudia; Valko, Marian
- Toxicology, Vol. 283, Issue 2-3
Structural Basis of the Redox Switch in the OxyR Transcription Factor
journal, April 2001
- Choi, Hee-Jung; Kim, Seung-Jun; Mukhopadhyay, Partha
- Cell, Vol. 105, Issue 1
The copper-inducible ComR (YcfQ) repressor regulates expression of ComC (YcfR), which affects copper permeability of the outer membrane of Escherichia coli
journal, November 2011
- Mermod, Mélanie; Magnani, David; Solioz, Marc
- BioMetals, Vol. 25, Issue 1
Inhibition of the Human Thioredoxin System
journal, March 2008
- Carvalho, Cristina M. L.; Chew, Eng-Hui; Hashemy, Seyed Isaac
- Journal of Biological Chemistry, Vol. 283, Issue 18
Roles of the Tn21 merT, merP, and merC gene products in mercury resistance and mercury binding.
journal, October 1992
- Hamlett, N. V.; Landale, E. C.; Davis, B. H.
- Journal of Bacteriology, Vol. 174, Issue 20
Molecular characterization of the soxRS genes of Escherichia coli : two genes control a superoxide stress regulon
journal, January 1991
- Amábile-Cuevas, Carlos F.; Demple, Bruce
- Nucleic Acids Research, Vol. 19, Issue 16
Modulation of the Fumarases of Escherichia coli in Response to Oxidative Stress
journal, March 1993
- Liochev, S. I.; Fridovich, I.
- Archives of Biochemistry and Biophysics, Vol. 301, Issue 2
The Formation Constants of Mercury(II)−Glutathione Complexes
journal, January 1996
- Oram, Paul D.; Fang, Xiaojun; Fernando, Quintus
- Chemical Research in Toxicology, Vol. 9, Issue 4
The Escherichia coli OxyS regulatory RNA represses fhlA translation by blocking ribosome binding
journal, October 1998
- Altuvia, S.
- The EMBO Journal, Vol. 17, Issue 20
EcoCyc: fusing model organism databases with systems biology
journal, November 2012
- Keseler, Ingrid M.; Mackie, Amanda; Peralta-Gil, Martin
- Nucleic Acids Research, Vol. 41, Issue D1
FieF (YiiP) from Escherichia coli mediates decreased cellular accumulation of iron and relieves iron stress
journal, November 2004
- Grass, Gregor; Otto, Markus; Fricke, Beate
- Archives of Microbiology, Vol. 183, Issue 1
STRING v10: protein–protein interaction networks, integrated over the tree of life
journal, October 2014
- Szklarczyk, Damian; Franceschini, Andrea; Wyder, Stefan
- Nucleic Acids Research, Vol. 43, Issue D1
Mercury as a Global Pollutant: Sources, Pathways, and Effects
journal, May 2013
- Driscoll, Charles T.; Mason, Robert P.; Chan, Hing Man
- Environmental Science & Technology, Vol. 47, Issue 10
The Pho regulon and the pathogenesis of Escherichia coli
journal, November 2011
- Crépin, Sébastien; Chekabab, Samuel-Mohammed; Le Bihan, Guillaume
- Veterinary Microbiology, Vol. 153, Issue 1-2
Structure, Function, and Formation of Biological Iron-Sulfur Clusters
journal, June 2005
- Johnson, Deborah C.; Dean, Dennis R.; Smith, Archer D.
- Annual Review of Biochemistry, Vol. 74, Issue 1
Ward’s Hierarchical Agglomerative Clustering Method: Which Algorithms Implement Ward’s Criterion?
journal, October 2014
- Murtagh, Fionn; Legendre, Pierre
- Journal of Classification, Vol. 31, Issue 3
Role of bacterial cell surface structures in Escherichia coli biofilm formation
journal, June 2005
- Van Houdt, Rob; Michiels, Chris W.
- Research in Microbiology, Vol. 156, Issue 5-6
Effect of diethylsulphoxide on growth, survival and ion exchange of Escherichia coli
journal, June 2002
- Markarian, S. A.; Poladyan, A. A.; Kirakosyan, G. R.
- Letters in Applied Microbiology, Vol. 34, Issue 6
Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential
journal, November 2015
- Pal, Chandan; Bengtsson-Palme, Johan; Kristiansson, Erik
- BMC Genomics, Vol. 16, Issue 1
Antagonistic regulation of motility and transcriptome expression by RpoN and RpoS in Escherichia coli: Antagonistic control by RpoS and RpoN
journal, November 2010
- Dong, Tao; Yu, Rosemary; Schellhorn, Herb
- Molecular Microbiology, Vol. 79, Issue 2
A complex network of small non-coding RNAs regulate motility in Escherichia coli : sRNA regulation of motility in
journal, September 2012
- De Lay, Nicholas; Gottesman, Susan
- Molecular Microbiology, Vol. 86, Issue 3
Genes of the GadX-GadW Regulon in Escherichia coli
journal, May 2003
- Tucker, D. L.; Tucker, N.; Ma, Z.
- Journal of Bacteriology, Vol. 185, Issue 10
Comparative toxicogenomic responses of mercuric and methyl-mercury
journal, January 2013
- McElwee, Matthew K.; Ho, Lindsey A.; Chou, Jeff W.
- BMC Genomics, Vol. 14, Issue 1
The Toxicology of Mercury and Its Chemical Compounds
journal, January 2006
- Clarkson, Thomas W.; Magos, Laszlo
- Critical Reviews in Toxicology, Vol. 36, Issue 8
Lysis of Escherichia coli by Sulfhydryl-Binding Reagents
journal, January 1962
- Schaechter, M.; Santomassino, Katherine A.
- Journal of Bacteriology, Vol. 84, Issue 2
Nickel transport systems in microorganisms
journal, January 2000
- Eitinger, T.; Mandrand-Berthelot, M. -A.
- Archives of Microbiology, Vol. 173, Issue 1
Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli.
journal, August 1990
- Greenberg, J. T.; Monach, P.; Chou, J. H.
- Proceedings of the National Academy of Sciences, Vol. 87, Issue 16
Ferric uptake regulation protein acts as a repressor, employing iron(II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli
journal, August 1987
- Bagg, Anne; Neilands, J. B.
- Biochemistry, Vol. 26, Issue 17
Regulation of the Synthesis of Ribosomes and Ribosomal Components
journal, June 1984
- Nomura, M.; Gourse, R.; Baughman, G.
- Annual Review of Biochemistry, Vol. 53, Issue 1
Effects of Cystine and Hydrogen Peroxide on Glutathione Status and Expression of Antioxidant Genes in Escherichia coli
journal, August 2005
- Smirnova, G. V.; Muzyka, N. G.; Oktyabrsky, O. N.
- Biochemistry (Moscow), Vol. 70, Issue 8
Silver(I), Mercury(II), Cadmium(II), and Zinc(II) Target Exposed Enzymic Iron-Sulfur Clusters when They Toxify Escherichia coli
journal, February 2012
- Xu, Fang Fang; Imlay, James A.
- Applied and Environmental Microbiology, Vol. 78, Issue 10
Modulation of mercury-induced mitochondria-dependent apoptosis by glycine in hepatocytes
journal, March 2011
- Pal, Pabitra Bikash; Pal, Sankhadeep; Das, Joydeep
- Amino Acids, Vol. 42, Issue 5
Nuclear magnetic resonance studies of the solution chemistry of metal complexes. 25. Hg(thiol)3 complexes and HG(II)-thiol ligand exchange kinetics
journal, September 1988
- Cheesman, Bruce V.; Arnold, Alan P.; Rabenstein, Dallas L.
- Journal of the American Chemical Society, Vol. 110, Issue 19
The Weird and Wonderful World of Bacterial Ribosome Regulation
journal, January 2007
- Wilson, Daniel N.; Nierhaus, Knud H.
- Critical Reviews in Biochemistry and Molecular Biology, Vol. 42, Issue 3
YcfR (BhsA) Influences Escherichia coli Biofilm Formation through Stress Response and Surface Hydrophobicity
journal, February 2007
- Zhang, X. -S.; Garcia-Contreras, R.; Wood, T. K.
- Journal of Bacteriology, Vol. 189, Issue 8
Iron and Hydrogen Peroxide Detoxification Properties of DNA-binding Protein from Starved Cells: A FERRITIN-LIKE DNA-BINDING PROTEIN OF
journal, May 2002
- Zhao, Guanghua; Ceci, Pierpaolo; Ilari, Andrea
- Journal of Biological Chemistry, Vol. 277, Issue 31
Export of glutathione by some widely used Salmonella typhimurium and Escherichia coli strains.
journal, October 1986
- Owens, R. A.; Hartman, P. E.
- Journal of Bacteriology, Vol. 168, Issue 1
Global transcriptomic responses of Escherichia coli K-12 to volatile organic compounds
journal, January 2016
- Yung, Pui Yi; Lo Grasso, Letizia; Mohidin, Abeed Fatima
- Scientific Reports, Vol. 6, Issue 1
Oxidative Stress Inactivates Cobalamin-Independent Methionine Synthase (MetE) in Escherichia coli
journal, October 2004
- Hondorp, Elise R.; Matthews, Rowena G.
- PLoS Biology, Vol. 2, Issue 11
soxR, a locus governing a superoxide response regulon in Escherichia coli K-12.
journal, August 1990
- Tsaneva, I. R.; Weiss, B.
- Journal of Bacteriology, Vol. 172, Issue 8
Bacterial glutathione S-transferases: what are they good for?
journal, March 1997
- Vuilleumier, S.
- Journal of Bacteriology, Vol. 179, Issue 5
Global Gene Expression Profiling in Escherichia coli K12 : THE EFFECTS OF OXYGEN AVAILABILITY AND FNR
journal, May 2003
- Salmon, Kirsty; Hung, She-pin; Mekjian, Kathy
- Journal of Biological Chemistry, Vol. 278, Issue 32
HTSeq--a Python framework to work with high-throughput sequencing data
journal, September 2014
- Anders, S.; Pyl, P. T.; Huber, W.
- Bioinformatics, Vol. 31, Issue 2
iPath2.0: interactive pathway explorer
journal, May 2011
- Yamada, Takuji; Letunic, Ivica; Okuda, Shujiro
- Nucleic Acids Research, Vol. 39, Issue suppl_2
A signal transducer for aerotaxis in Escherichia coli.
journal, June 1997
- Bibikov, S. I.; Biran, R.; Rudd, K. E.
- Journal of Bacteriology, Vol. 179, Issue 12
Comprehensive Mapping of the Escherichia coli Flagellar Regulatory Network
journal, October 2014
- Fitzgerald, Devon M.; Bonocora, Richard P.; Wade, Joseph T.
- PLoS Genetics, Vol. 10, Issue 10
Fast gapped-read alignment with Bowtie 2
journal, March 2012
- Langmead, Ben; Salzberg, Steven L.
- Nature Methods, Vol. 9, Issue 4
The Bacterial RecA Protein and the Recombinational DNA Repair of Stalled Replication Forks
journal, June 2002
- Lusetti, Shelley L.; Cox, Michael M.
- Annual Review of Biochemistry, Vol. 71, Issue 1
Long-Term Exposure to Methylmercury and Neurologic Signs in Minamata and Neighboring Communities
journal, January 2008
- Yorifuji, Takashi; Tsuda, Toshihide; Takao, Soshi
- Epidemiology, Vol. 19, Issue 1
Multiple layers of control govern expression of the Escherichia coli ibpAB heat-shock operon
journal, September 2010
- Gaubig, L. C.; Waldminghaus, T.; Narberhaus, F.
- Microbiology, Vol. 157, Issue 1
Characterization of Escherichia coli NrdH : A GLUTAREDOXIN-LIKE PROTEIN WITH A THIOREDOXIN-LIKE ACTIVITY PROFILE
journal, July 1997
- Jordan, Albert; Åslund, Fredrik; Pontis, Elisabet
- Journal of Biological Chemistry, Vol. 272, Issue 29
The biogeochemical cycling of elemental mercury: Anthropogenic influences
journal, August 1994
- Mason, R. P.; Fitzgerald, W. F.; Morel, F. M. M.
- Geochimica et Cosmochimica Acta, Vol. 58, Issue 15
Mercury exposure and risks from dental amalgam in the US population, post-2000
journal, September 2011
- Richardson, G. M.; Wilson, R.; Allard, D.
- Science of The Total Environment, Vol. 409, Issue 20
Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655
journal, August 2015
- Seo, Sang Woo; Kim, Donghyuk; Szubin, Richard
- Cell Reports, Vol. 12, Issue 8
Escherichia coli heat-shock proteins IbpA/B are involved in resistance to oxidative stress induced by copper
journal, June 2008
- Matuszewska, E.; Kwiatkowska, J.; Kuczynska-Wisnik, D.
- Microbiology, Vol. 154, Issue 6
The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium
journal, May 2013
- Imlay, James A.
- Nature Reviews Microbiology, Vol. 11, Issue 7
Observation of Unusual Organic Mercury Species in Soils and Sediments of Industrially Contaminated Sites
journal, July 1995
- Hintelmann, Holger.; Hempel, Maximilian.; Wilken, Rolf Dieter.
- Environmental Science & Technology, Vol. 29, Issue 7
Three Distinct-Type Glutathione S-Transferases from Escherichia coli Important for Defense against Oxidative Stress
journal, November 2006
- Kanai, Takuya; Takahashi, Kenji; Inoue, Hideshi
- The Journal of Biochemistry, Vol. 140, Issue 5
Cryptic prophages help bacteria cope with adverse environments
journal, December 2010
- Wang, Xiaoxue; Kim, Younghoon; Ma, Qun
- Nature Communications, Vol. 1, Issue 1
The Sequence Alignment/Map format and SAMtools
journal, June 2009
- Li, H.; Handsaker, B.; Wysoker, A.
- Bioinformatics, Vol. 25, Issue 16
Organic and inorganic mercurials have distinct effects on cellular thiols, metal homeostasis, and Fe-binding proteins in Escherichia coli
journal, October 2015
- LaVoie, Stephen P.; Mapolelo, Daphne T.; Cowart, Darin M.
- JBIC Journal of Biological Inorganic Chemistry, Vol. 20, Issue 8
Discovering Mercury Protein Modifications in Whole Proteomes Using Natural Isotope Distributions Observed in Liquid Chromatography-Tandem Mass Spectrometry
journal, April 2011
- Polacco, Benjamin J.; Purvine, Samuel O.; Zink, Erika M.
- Molecular & Cellular Proteomics, Vol. 10, Issue 8
TorC apocytochrome negatively autoregulates the trimethylamine N-oxide (TMAO) reductase operon in Escherichia coli
journal, July 1999
- Ansaldi, Mireille; Bordi, Christophe; Lepelletier, Michele
- Molecular Microbiology, Vol. 33, Issue 2
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation
journal, October 2009
- Cegelski, Lynette; Pinkner, Jerome S.; Hammer, Neal D.
- Nature Chemical Biology, Vol. 5, Issue 12
Heavy metal ions are potent inhibitors of protein folding
journal, July 2008
- Sharma, Sandeep K.; Goloubinoff, Pierre; Christen, Philipp
- Biochemical and Biophysical Research Communications, Vol. 372, Issue 2
Crosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomer
journal, September 2002
- Soskine, M.; Steiner-Mordoch, S.; Schuldiner, S.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 19
Mechanisms of iron–sulfur cluster assembly: the SUF machinery
journal, October 2005
- Fontecave, M.; Choudens, S. Ollagnier de; Py, B.
- JBIC Journal of Biological Inorganic Chemistry, Vol. 10, Issue 7
Works referencing / citing this record:
The role of cysteine and sulfide in the interplay between microbial Hg( ii ) uptake and sulfur metabolism
journal, January 2019
- Thomas, Sara A.; Catty, Patrice; Hazemann, Jean-Louis
- Metallomics, Vol. 11, Issue 7
Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.