Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations
Abstract
"Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., triglycerides) is high or low relative to its distribution in the population. Quantile-specific offspring-parent regression slopes (βOP) were estimated by quantile regression for 6227 offspring-parent pairs. Quantile-specific heritability (h2), estimated by 2βOP/(1 + $$\Gamma$$ spouse), decreased 0.0047 ± 0.0007 (P = 2.9 × 10-14) for each one-percent decrement in fasting triglyceride concentrations, i.e., h2 ± SE were: 0.428 ± 0.059, 0.230 ± 0.030, 0.111 ± 0.015, 0.050 ± 0.016, and 0.033 ± 0.010 at the 90th, 75th, 50th, 25th, and 10th percentiles of the triglyceride distribution, respectively. Consistent with quantile-dependent expressivity, 11 drug studies report smaller genotype differences at lower (post-treatment) than higher (pre-treatment) triglyceride concentrations. This meant genotype-specific triglyceride changes could not move in parallel when triglycerides were decreased pharmacologically, so that subtracting pre-treatment from post-treatment triglyceride levels necessarily created a greater triglyceride decrease for the genotype with a higher pre-treatment value (purported precision-medicine genetic markers). In addition, sixty-five purported gene-environment interactions were found to be potentially attributable to triglyceride's quantile-dependent expressivity, including gene-adiposity (APOA5, APOB, APOE, GCKR, IRS-1, LPL, MTHFR, PCSK9, PNPLA3, PPARγ2), gene-exercise (APOA1, APOA2, LPL), gene-diet (APOA5, APOE, INSIG2, LPL, MYB, NXPH1, PER2, TNFA), gene-alcohol (ALDH2, APOA5, APOC3, CETP, LPL), gene-smoking (APOC3, CYBA, LPL, USF1), gene-pregnancy (LPL), and gene-insulin resistance interactions (APOE, LPL).
- Authors:
-
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Biophysics & Integrated Bioimaging Division
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Heart, Lung, and Blood Institute (NHLBI); Boston University; National Institutes of Health (NIH)
- OSTI Identifier:
- 1615321
- Grant/Contract Number:
- AC02-05CH11231; N01-HC-25195; HHSN268201500001I; R21ES020700
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Scientific Reports
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 2045-2322
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Williams, Paul T. Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations. United States: N. p., 2020.
Web. doi:10.1038/s41598-020-60965-9.
Williams, Paul T. Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations. United States. https://doi.org/10.1038/s41598-020-60965-9
Williams, Paul T. Wed .
"Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations". United States. https://doi.org/10.1038/s41598-020-60965-9. https://www.osti.gov/servlets/purl/1615321.
@article{osti_1615321,
title = {Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations},
author = {Williams, Paul T.},
abstractNote = {"Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., triglycerides) is high or low relative to its distribution in the population. Quantile-specific offspring-parent regression slopes (βOP) were estimated by quantile regression for 6227 offspring-parent pairs. Quantile-specific heritability (h2), estimated by 2βOP/(1 + $\Gamma$ spouse), decreased 0.0047 ± 0.0007 (P = 2.9 × 10-14) for each one-percent decrement in fasting triglyceride concentrations, i.e., h2 ± SE were: 0.428 ± 0.059, 0.230 ± 0.030, 0.111 ± 0.015, 0.050 ± 0.016, and 0.033 ± 0.010 at the 90th, 75th, 50th, 25th, and 10th percentiles of the triglyceride distribution, respectively. Consistent with quantile-dependent expressivity, 11 drug studies report smaller genotype differences at lower (post-treatment) than higher (pre-treatment) triglyceride concentrations. This meant genotype-specific triglyceride changes could not move in parallel when triglycerides were decreased pharmacologically, so that subtracting pre-treatment from post-treatment triglyceride levels necessarily created a greater triglyceride decrease for the genotype with a higher pre-treatment value (purported precision-medicine genetic markers). In addition, sixty-five purported gene-environment interactions were found to be potentially attributable to triglyceride's quantile-dependent expressivity, including gene-adiposity (APOA5, APOB, APOE, GCKR, IRS-1, LPL, MTHFR, PCSK9, PNPLA3, PPARγ2), gene-exercise (APOA1, APOA2, LPL), gene-diet (APOA5, APOE, INSIG2, LPL, MYB, NXPH1, PER2, TNFA), gene-alcohol (ALDH2, APOA5, APOC3, CETP, LPL), gene-smoking (APOC3, CYBA, LPL, USF1), gene-pregnancy (LPL), and gene-insulin resistance interactions (APOE, LPL).},
doi = {10.1038/s41598-020-60965-9},
journal = {Scientific Reports},
number = 1,
volume = 10,
place = {United States},
year = {2020},
month = {3}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 3 works
Citation information provided by
Web of Science
Web of Science
Figures / Tables:
Table 1: Traditional and quantile regression analyses of triglycerides and very low density lipoprotein (VLDL)cholesterol from the Offspring and Third Generation Framingham Cohorts. Triglycerides and log triglycerides: 1174 offspring with one parent and 2507 with two parents, and 6176 full siblings in 2187 sibships; VLDLcholesterol: 2840 full siblings in 1029more »
All figures and tables
(8 total)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Contribution of Apolipoprotein C-III Gene Variants to Determination of Triglyceride Levels and Interaction With Smoking in Middle-Aged Men
journal, December 2000
- Waterworth, Dawn M.; Talmud, Philippa J.; Bujac, Sarah R.
- Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 20, Issue 12
Relationship of abdominal adiposity and dyslipemic status in women with a common mutation in the lipoprotein lipase gene
journal, May 2000
- Sentı́, Mariano; Bosch, Mireia; Aubó, Clara
- Atherosclerosis, Vol. 150, Issue 1
Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 gene on lipid profile and adipokines levels in obese subjects
journal, June 2017
- Becer, E.; Çırakoğlu, A.
- Balkan Journal of Medical Genetics, Vol. 20, Issue 1
Interactions of Lipid Genetic Risk Scores With Estimates of Metabolic Health in a Danish Population
journal, June 2015
- Justesen, Johanne M.; Allin, Kristine H.; Sandholt, Camilla H.
- Circulation: Cardiovascular Genetics, Vol. 8, Issue 3
Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association
journal, May 2011
- Miller, Michael; Stone, Neil J.; Ballantyne, Christie
- Circulation, Vol. 123, Issue 20
Interactions between alcohol intake and the polymorphism of rs708272 on serum high-density lipoprotein cholesterol levels in the Guangxi Hei Yi Zhuang population
journal, November 2008
- Zhou, Yijiang; Yin, Ruixing; Deng, Yaju
- Alcohol, Vol. 42, Issue 7
Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia
journal, December 2011
- Brautbar, Ariel; Covarrubias, Daniel; Belmont, John
- Atherosclerosis, Vol. 219, Issue 2
Interaction of Insulin Resistance and Related Genetic Variants With Triglyceride-Associated Genetic Variants
journal, April 2016
- Klimentidis, Yann C.; Arora, Amit
- Circulation: Cardiovascular Genetics, Vol. 9, Issue 2
Polymorphism at the TNF ‐alpha gene interacts with M editerranean diet to influence triglyceride metabolism and inflammation status in metabolic syndrome patients: F rom the CORDIOPREV clinical trial
journal, April 2014
- Gomez‐Delgado, Francisco; Alcala‐Diaz, Juan Francisco; Garcia‐Rios, Antonio
- Molecular Nutrition & Food Research, Vol. 58, Issue 7
Consumption of whole grains and legumes modulates the genetic effect of the APOA5 -1131C variant on changes in triglyceride and apolipoprotein A-V concentrations in patients with impaired fasting glucose or newly diagnosed type 2 diabetes
journal, January 2014
- Kang, Ryungwoo; Kim, Minjoo; Chae, Jey
- Trials, Vol. 15, Issue 1
The Effect of Mediterranean Diet on Metabolic Syndrome and its Components
journal, March 2011
- Kastorini, Christina-Maria; Milionis, Haralampos J.; Esposito, Katherine
- Journal of the American College of Cardiology, Vol. 57, Issue 11
Biological, clinical and population relevance of 95 loci for blood lipids
journal, August 2010
- Teslovich, Tanya M.; Musunuru, Kiran; Smith, Albert V.
- Nature, Vol. 466, Issue 7307
Hind III polymorphism of the lipoprotein lipase gene and plasma lipid response to low calorie diet
journal, April 1997
- Jemaa, R.; Tuzet, S.; Betoulle, D.
- International Journal of Obesity, Vol. 21, Issue 4
Physical activity modulates the combined effect of a common variant of the lipoprotein lipase gene and smoking on serum triglyceride levels and high-density lipoprotein cholesterol in men
journal, September 2001
- Sentí, Mariano; Elosua, Roberto; Tomás, Marta
- Human Genetics, Vol. 109, Issue 4
U.K. consensus statement on safe clinical prescribing of bexarotene for patients with cutaneous T-cell lymphoma: Management of patients on bexarotene
journal, December 2012
- Scarisbrick, J. J.; Morris, S.; Azurdia, R.
- British Journal of Dermatology, Vol. 168, Issue 1
A Period 2 Genetic Variant Interacts with Plasma SFA to Modify Plasma Lipid Concentrations in Adults with Metabolic Syndrome
journal, May 2012
- Garcia-Rios, Antonio; Perez-Martinez, Pablo; Delgado-Lista, Javier
- The Journal of Nutrition, Vol. 142, Issue 7
Pharmacogenetic study of cholesteryl ester transfer protein gene and simvastatin treatment in hypercholesterolaemic subjects
journal, October 2007
- Anagnostopoulou, Katherine; Kolovou, Genovefa; Kostakou, Peggy
- Expert Opinion on Pharmacotherapy, Vol. 8, Issue 15
Life-Style and Serum Lipids and Lipoproteins
journal, January 2000
- Hata, Yoshiya; Nakajima, Kumiko
- Journal of Atherosclerosis and Thrombosis, Vol. 7, Issue 4
Sibling and parent--offspring correlation estimation with variable family size.
journal, May 1981
- Karlin, S.; Cameron, E. C.; Williams, P. T.
- Proceedings of the National Academy of Sciences, Vol. 78, Issue 5
Effect of genetic and environmental influences on cardiometabolic risk factors: a twin study
journal, January 2011
- Jermendy, György; Horváth, Tamás; Littvay, Levente
- Cardiovascular Diabetology, Vol. 10, Issue 1
Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study
journal, August 2010
- Wojczynski, Mary K.; Gao, Guimin; Borecki, Ingrid
- Journal of Lipid Research, Vol. 51, Issue 11
The interaction of Apolipoprotein A5 gene promoter region T-1131C polymorphism ( rs12286037 ) and lifestyle modification on plasma triglyceride levels in Japanese
journal, January 2015
- Yamasaki, Masayuki; Mutombo, Paulin Beya wa Bitadi; Iwamoto, Mamiko
- Nutrition Research and Practice, Vol. 9, Issue 4
Longitudinal interaction between APOA5 -1131T>C and overweight in the acceleration of age-related increase in arterial stiffness through the regulation of circulating triglycerides
journal, November 2018
- Kim, Minjoo; Yoo, Hye Jin; Lee, Hwa Jin
- Hypertension Research, Vol. 42, Issue 2
Lipoprotein lipase gene S447X polymorphism modulates the relation between central obesity and serum lipids, a twin study
journal, March 2006
- Huang, A. Q.; Hu, Y. H.; Zhan, S. Y.
- International Journal of Obesity, Vol. 30, Issue 12
Apolipoprotein E Polymorphisms and Postprandial Triglyceridemia Before and After Fenofibrate Treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study
journal, October 2010
- Irvin, Marguerite R.; Kabagambe, Edmond K.; Tiwari, Hemant K.
- Circulation: Cardiovascular Genetics, Vol. 3, Issue 5
Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on serum lipid levels in a Chinese Han population
journal, October 2016
- Zhi, Xueyuan; Yang, Boyi; Fan, Shujun
- Lipids in Health and Disease, Vol. 15, Issue 1
Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels
journal, September 2013
- Wu, Ying; Marvelle, Amanda F.; Li, Jin
- Journal of Lipid Research, Vol. 54, Issue 11
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, Recruitment, and Initial Examination
journal, April 2007
- Splansky, G. L.; Corey, D.; Yang, Q.
- American Journal of Epidemiology, Vol. 165, Issue 11
Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome
journal, April 2009
- Elder, Sonya J.; Lichtenstein, Alice H.; Pittas, Anastassios G.
- Journal of Lipid Research, Vol. 50, Issue 9
Genetic risk score and adiposity interact to influence triglyceride levels in a cohort of Filipino women
journal, June 2014
- Zubair, N.; Mayer-Davis, E. J.; Mendez, M. A.
- Nutrition & Diabetes, Vol. 4, Issue 6
Apolipoprotein E gene polymorphism alters lipids before pancreas transplantation
journal, January 2002
- Balakrishnan, Sajeev; Colling, Christopher; Burkman, Tab
- Transplantation, Vol. 74, Issue 7
Physical activity modulates effects of some genetic polymorphisms affecting cardiovascular risk in men aged over 40 years
journal, August 2003
- Pisciotta, L.; Cantafora, A.; Piana, A.
- Nutrition, Metabolism and Cardiovascular Diseases, Vol. 13, Issue 4
Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training
journal, March 2006
- Ruaño, Gualberto; Seip, Richard L.; Windemuth, Andreas
- Atherosclerosis, Vol. 185, Issue 1
INSIG2 variants, dietary patterns and metabolic risk in Samoa
journal, September 2012
- Baylin, A.; Deka, R.; Tuitele, J.
- European Journal of Clinical Nutrition, Vol. 67, Issue 1
The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
journal, February 2014
- Stojkovic, Ivana A.; Ericson, Ulrika; Rukh, Gull
- Genes & Nutrition, Vol. 9, Issue 2
Lipoprotein Lipase Variants D9N and N291S Are Associated With Increased Plasma Triglyceride and Lower High-Density Lipoprotein Cholesterol Concentrations: Studies in the Fasting and Postprandial States: The European Atherosclerosis Research Studies
journal, August 1997
- Gerdes, Christian; Fisher, Rachel M.; Nicaud, Viviane
- Circulation, Vol. 96, Issue 3
The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking
journal, June 2015
- Niemiec, Pawel; Nowak, Tomasz; Iwanicki, Tomasz
- International Journal of Molecular Sciences, Vol. 16, Issue 12
Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis
journal, August 1992
- Dattilo, A. M.; Kris-Etherton, P. M.
- The American Journal of Clinical Nutrition, Vol. 56, Issue 2
The response to lovastatin treatment in patients with heterozygous familial hypercholesterolemia is modulated by apolipoprotein E polymorphism
journal, July 1993
- Carmena, R.; Roederer, G.; Mailloux, H.
- Metabolism, Vol. 42, Issue 7
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
journal, January 2019
- de Vries, Paul S.; Brown, Michael R.; Bentley, Amy R.
- American Journal of Epidemiology, Vol. 188, Issue 6
Triglyceride Response to an Intensive Lifestyle Intervention Is Enhanced in Carriers of the GCKR Pro446Leu Polymorphism
journal, July 2011
- Pollin, Toni I.; Jablonski, Kathleen A.; McAteer, Jarred B.
- The Journal of Clinical Endocrinology & Metabolism, Vol. 96, Issue 7
Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels
journal, January 2012
- Yin, Rui-Xing; Wu, Dong-Feng; Miao, Lin
- Cardiovascular Diabetology, Vol. 11, Issue 1
Update on APOA5 Genetics: Toward a Better Understanding of Its Physiological Impact
journal, May 2017
- Guardiola, Montse; Ribalta, Josep
- Current Atherosclerosis Reports, Vol. 19, Issue 7
Association between the LPL-D9N mutation in the lipoprotein lipase gene and plasma lipid traits in myocardial infarction survivors from the ECTIM study
journal, April 1996
- Mailly, F.; Fisher, R. M.; Nicaud, V.
- Atherosclerosis, Vol. 122, Issue 1
Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1
journal, August 1995
- Clausen, J. O.; Hansen, T.; Bjørbaek, C.
- The Lancet, Vol. 346, Issue 8972
Genetic Variants Associated With Plasma Lipids Are Associated With the Lipid Response to Niacin
journal, October 2018
- Tuteja, Sony; Qu, Liming; Vujkovic, Marijana
- Journal of the American Heart Association, Vol. 7, Issue 19
Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Triglyceride and High-Density Lipoprotein Cholesterol Levels
journal, January 2004
- Czerwinski, Stefan A.; Mahaney, Michael C.; Rainwater, David Luther
- Human Biology, Vol. 76, Issue 6
Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate
journal, October 2012
- Aslibekyan, Stella; Goodarzi, Mark O.; Frazier-Wood, Alexis C.
- PLoS ONE, Vol. 7, Issue 10
Apolipoprotein E polymorphism in the Tunisian population: Frequency and effect on lipid parameters
journal, August 2006
- Jemaa, R.; Elasmi, M.; Naouali, C.
- Clinical Biochemistry, Vol. 39, Issue 8
Adiposity significantly modifies genetic risk for dyslipidemia
journal, September 2014
- Cole, Christopher B.; Nikpay, Majid; Lau, Paulina
- Journal of Lipid Research, Vol. 55, Issue 11
DNA polymorphisms of the apoprotein B gene are associated with altered plasma lipoprotein concentrations but not with perceived risk of cardiovascular disease: European Atherosclerosis Research Study
journal, August 1995
- Turner, P.
- Atherosclerosis, Vol. 116, Issue 2
Genetic factors affecting the consistency and magnitude of changes in plasma cholesterol in response to dietary challenge
journal, September 1996
- Humphries, S. E.; Talmud, P. J.; Cox, C.
- QJM, Vol. 89, Issue 9
Gene-environment interaction in the conversion of a mild-to-severe phenotype in a patient homozygous for a Ser172-->Cys mutation in the lipoprotein lipase gene.
journal, May 1993
- Ma, Y.; Liu, M. S.; Ginzinger, D.
- Journal of Clinical Investigation, Vol. 91, Issue 5
Quantile-dependent expressivity of postprandial lipemia
journal, February 2020
- Williams, Paul T.
- PLOS ONE, Vol. 15, Issue 2
Adiposity and Genetic Factors in Relation to Triglycerides and Triglyceride-Rich Lipoproteins in the Women's Genome Health Study
journal, January 2018
- Ahmad, Shafqat; Mora, Samia; Franks, Paul W.
- Clinical Chemistry, Vol. 64, Issue 1
Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner
journal, September 2001
- Pedro-Botet, Juan; Schaefer, Ernst J.; Bakker-Arkema, Rebecca G.
- Atherosclerosis, Vol. 158, Issue 1
No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population
journal, October 2013
- Dumitrescu, Logan; Carty, Cara L.; Franceschini, Nora
- Human Genetics, Vol. 132, Issue 12
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
journal, December 2008
- Perez-Martinez, Pablo; Corella, Dolores; Shen, Jian
- The American Journal of Clinical Nutrition, Vol. 89, Issue 1
Exercise Training-Induced Blood Pressure and Plasma Lipid Improvements in Hypertensives May Be Genotype Dependent
journal, July 1999
- Hagberg, James M.; Ferrell, Robert E.; Dengel, Donald R.
- Hypertension, Vol. 34, Issue 1
Interactions of the Apolipoprotein A5 Gene Polymorphisms and Alcohol Consumption on Serum Lipid Levels
journal, March 2011
- Yin, Rui-Xing; Li, Yi-Yang; Liu, Wan-Ying
- PLoS ONE, Vol. 6, Issue 3
A genome-wide association and gene–environment interaction study for serum triglycerides levels in a healthy Chinese male population
journal, December 2011
- Tan, Aihua; Sun, Jielin; Xia, Ning
- Human Molecular Genetics, Vol. 21, Issue 7
Association of APOA5 and APOC3 Genetic Polymorphisms With Severity of Hypertriglyceridemia in Patients With Cutaneous T-Cell Lymphoma Treated With Bexarotene
journal, December 2018
- Cabello, Irene; Alia, Pedro; Pintó, Xavier
- JAMA Dermatology, Vol. 154, Issue 12
An Investigation of Coronary Heart Disease in Families
journal, September 1979
- Kannel, William B.; Feinleib, Manning; McNAMARA, Patricia M.
- American Journal of Epidemiology, Vol. 110, Issue 3
Do Genetic Factors Modify the Relationship Between Obesity and Hypertriglyceridemia?: Findings From the GLACIER and the MDC Studies
journal, April 2016
- Ali, Ashfaq; Varga, Tibor V.; Stojkovic, Ivana A.
- Circulation: Cardiovascular Genetics, Vol. 9, Issue 2
The −1131T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: A postprandial study
journal, September 2009
- Cardona, Fernando; Guardiola, Montserrat; Queipo-Ortuño, María Isabel
- Atherosclerosis, Vol. 206, Issue 1
Interactions of the apolipoprotein C-III 3238C>G polymorphism and alcohol consumption on serum triglyceride levels
journal, August 2010
- Ruixing, Yin; Yiyang, Li; Meng, Li
- Lipids in Health and Disease, Vol. 9, Issue 1
Apolipoprotein E polymorphism in non-insulin-dependent diabetics of Mumbai, India and its effect on plasma lipids and lipoproteins
journal, March 2000
- Inamdar, P. A.; Kelkar, S. M.; Devasagayam, T. P. A.
- Diabetes Research and Clinical Practice, Vol. 47, Issue 3
Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster
journal, March 2013
- Hsu, M-C; Chang, C-S; Lee, K-T
- Nutrition & Diabetes, Vol. 3, Issue 3
The Lipoprotein Lipase Hin dIII Polymorphism Modulates Plasma Triglyceride Levels in Visceral Obesity
journal, May 1995
- Vohl, Marie-Claude; Lamarche, Benoı̂t; Moorjani, Sital
- Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 15, Issue 5
Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation
journal, January 2016
- Vallée Marcotte, Bastien; Cormier, Hubert; Guénard, Frédéric
- Journal of Nutrigenetics and Nutrigenomics, Vol. 9, Issue 1
Polygenic risk for hypertriglyceridemia is attenuated in Japanese men with high fitness levels
journal, March 2014
- Tanisawa, Kumpei; Ito, Tomoko; Sun, Xiaomin
- Physiological Genomics, Vol. 46, Issue 6
Linkage and association studies of the lipoprotein lipase gene with postheparin plasma lipase activities, body fat, and plasma lipid and lipoprotein concentrations : The HERITAGE family study
journal, April 2000
- Garenc, Christophe; Pérusse, Louis; Gagnon, Jacques
- Metabolism, Vol. 49, Issue 4
Smoking Dose Modifies the Association between C242T Polymorphism and Prevalence of Metabolic Syndrome in a Chinese Population
journal, March 2012
- Ge, Jiyong; Ding, Zhijian; Song, Yu
- PLoS ONE, Vol. 7, Issue 3
Elevated Levels of Triglyceride and Triglyceride-Rich Lipoprotein Triglyceride Induced by a High-Carbohydrate Diet Is Associated with Polymorphisms of APOA5-1131T>C and APOC3-482C>T in Chinese Healthy Young Adults
journal, January 2011
- Lin, Jia; Fang, Ding Zhi; Du, Juan
- Annals of Nutrition and Metabolism, Vol. 58, Issue 2
APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults
journal, November 2012
- Carvalho-Wells, Andrew L.; Jackson, Kim G.; Lockyer, Stacey
- The American Journal of Clinical Nutrition, Vol. 96, Issue 6
Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials
journal, May 2003
- Mensink, Ronald P.; Zock, Peter L.; Kester, Arnold DM
- The American Journal of Clinical Nutrition, Vol. 77, Issue 5
Variation at the lipoprotein lipase and apolipoprotein AI-CIII gene loci are associated with fasting lipid and lipoprotein traits in a population sample from Iceland: Interaction between genotype, gender, and smoking status
journal, January 1997
- Peacock, Rachel E.; Temple, Anne; Gudnason, Vilmundur
- Genetic Epidemiology, Vol. 14, Issue 3
Apolipoprotein A-V Genetic Variation and Plasma Lipoprotein Response to Fibrates
journal, June 2007
- Hegele, Robert A.; Pollex, Rebecca L.
- Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 27, Issue 6
The insulin resistance syndrome and postprandial lipid intolerance in smokers
journal, February 1997
- Eliasson, Björn; Mero, Niina; Taskinen, Marja-Riitta
- Atherosclerosis, Vol. 129, Issue 1
Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study
journal, January 2012
- Pyun, Jung-A; Kim, Sunshin; Park, KyungChae
- Genomics & Informatics, Vol. 10, Issue 2
Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism
journal, October 2011
- Garcia-Rios, Antonio; Delgado-Lista, Javier; Perez-Martinez, Pablo
- Atherosclerosis, Vol. 218, Issue 2
The G972R variant of the Insulin Receptor Substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance
journal, March 2001
- Baroni, M. G.; Arca, M.; Sentinelli, F.
- Diabetologia, Vol. 44, Issue 3
Quantile Regression
journal, November 2001
- Koenker, Roger; Hallock, Kevin F.
- Journal of Economic Perspectives, Vol. 15, Issue 4
Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study
journal, June 2007
- Lai, Chao-Qiang; Arnett, Donna K.; Corella, Dolores
- Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 27, Issue 6
Quantile-Specific Heritability may Account for Gene–Environment Interactions Involving Coffee Consumption
journal, January 2020
- Williams, Paul T.
- Behavior Genetics, Vol. 50, Issue 2
Quantile-Specific Penetrance of Genes Affecting Lipoproteins, Adiposity and Height
journal, January 2012
- Williams, Paul T.
- PLoS ONE, Vol. 7, Issue 1
Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.