Methanobactin from methanotrophs: genetics, structure, function and potential applications
Abstract
ABSTRACT Aerobic methane-oxidizing bacteria of the Alphaproteobacteria have been found to express a novel ribosomally synthesized post-translationally modified polypeptide (RiPP) termed methanobactin (MB). The primary function of MB in these microbes appears to be for copper uptake, but MB has been shown to have multiple capabilities, including oxidase, superoxide dismutase and hydrogen peroxide reductase activities, the ability to detoxify mercury species, as well as acting as an antimicrobial agent. Herein, we describe the diversity of known MBs as well as the genetics underlying MB biosynthesis. We further propose based on bioinformatics analyses that some methanotrophs may produce novel forms of MB that have yet to be characterized. We also discuss recent findings documenting that MBs play an important role in controlling copper availability to the broader microbial community, and as a result can strongly affect the activity of microbes that require copper for important enzymatic transformations, e.g. conversion of nitrous oxide to dinitrogen. Finally, we describe procedures for the detection/purification of MB, as well as potential medical and industrial applications of this intriguing RiPP.
- Authors:
-
- Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, MI, USA 48109-2125
- Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, USA 50011
- Publication Date:
- Research Org.:
- Univ. of Michigan, Ann Arbor, MI (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER); National Science Foundation (NSF)
- OSTI Identifier:
- 1615161
- Alternate Identifier(s):
- OSTI ID: 1691490
- Grant/Contract Number:
- SC0018059; SC0020174; 1724744; 1912482
- Resource Type:
- Published Article
- Journal Name:
- FEMS Microbiology Letters (Online)
- Additional Journal Information:
- Journal Name: FEMS Microbiology Letters (Online) Journal Volume: 367 Journal Issue: 5; Journal ID: ISSN 1574-6968
- Publisher:
- Federation of European Microbiological Societies
- Country of Publication:
- Netherlands
- Language:
- English
- Subject:
- 54 ENVIRONMENTAL SCIENCES; methanobactin; methanotroph; mercury; methylmercury; copper
Citation Formats
Semrau, Jeremy D., DiSpirito, Alan A., Obulisamy, Parthiba Karthikeyan, and Kang-Yun, Christina S. Methanobactin from methanotrophs: genetics, structure, function and potential applications. Netherlands: N. p., 2020.
Web. doi:10.1093/femsle/fnaa045.
Semrau, Jeremy D., DiSpirito, Alan A., Obulisamy, Parthiba Karthikeyan, & Kang-Yun, Christina S. Methanobactin from methanotrophs: genetics, structure, function and potential applications. Netherlands. doi:https://doi.org/10.1093/femsle/fnaa045
Semrau, Jeremy D., DiSpirito, Alan A., Obulisamy, Parthiba Karthikeyan, and Kang-Yun, Christina S. Fri .
"Methanobactin from methanotrophs: genetics, structure, function and potential applications". Netherlands. doi:https://doi.org/10.1093/femsle/fnaa045.
@article{osti_1615161,
title = {Methanobactin from methanotrophs: genetics, structure, function and potential applications},
author = {Semrau, Jeremy D. and DiSpirito, Alan A. and Obulisamy, Parthiba Karthikeyan and Kang-Yun, Christina S.},
abstractNote = {ABSTRACT Aerobic methane-oxidizing bacteria of the Alphaproteobacteria have been found to express a novel ribosomally synthesized post-translationally modified polypeptide (RiPP) termed methanobactin (MB). The primary function of MB in these microbes appears to be for copper uptake, but MB has been shown to have multiple capabilities, including oxidase, superoxide dismutase and hydrogen peroxide reductase activities, the ability to detoxify mercury species, as well as acting as an antimicrobial agent. Herein, we describe the diversity of known MBs as well as the genetics underlying MB biosynthesis. We further propose based on bioinformatics analyses that some methanotrophs may produce novel forms of MB that have yet to be characterized. We also discuss recent findings documenting that MBs play an important role in controlling copper availability to the broader microbial community, and as a result can strongly affect the activity of microbes that require copper for important enzymatic transformations, e.g. conversion of nitrous oxide to dinitrogen. Finally, we describe procedures for the detection/purification of MB, as well as potential medical and industrial applications of this intriguing RiPP.},
doi = {10.1093/femsle/fnaa045},
journal = {FEMS Microbiology Letters (Online)},
number = 5,
volume = 367,
place = {Netherlands},
year = {2020},
month = {3}
}
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Works referenced in this record:
Particulate methane monooxygenase contains only mononuclear copper centers
journal, May 2019
- Ross, Matthew O.; MacMillan, Fraser; Wang, Jingzhou
- Science, Vol. 364, Issue 6440
Methanotrophs and copper
journal, July 2010
- Semrau, Jeremy D.; DiSpirito, Alan A.; Yoon, Sukhwan
- FEMS Microbiology Reviews, Vol. 34, Issue 4
An Oxidized Tryptophan Facilitates Copper Binding in Methylococcus capsulatus -secreted Protein MopE
journal, March 2008
- Helland, Ronny; Fjellbirkeland, Anne; Karlsen, Odd Andre
- Journal of Biological Chemistry, Vol. 283, Issue 20
Enrichment, Isolation and Some Properties of Methane-utilizing Bacteria
journal, May 1970
- Whittenbury, R.; Phillips, K. C.; Wilkinson, J. F.
- Journal of General Microbiology, Vol. 61, Issue 2
Copper ions as inhibitors of protein C of soluble methane monooxygenase of Methylococcus capsulatus (Bath)
journal, November 1985
- Green, Jeffrey; Prior, Stephen D.; Dalton, Howard
- European Journal of Biochemistry, Vol. 153, Issue 1
Copper-Binding Properties and Structures of Methanobactins from Methylosinus trichosporium OB3b
journal, February 2011
- El Ghazouani, Abdelnasser; Baslé, Arnaud; Firbank, Susan J.
- Inorganic Chemistry, Vol. 50, Issue 4
Methanotrophic bacteria.
journal, January 1996
- Hanson, R. S.; Hanson, T. E.
- Microbiological reviews, Vol. 60, Issue 2
Methanobactin from Methylocystis sp. Strain SB2 Affects Gene Expression and Methane Monooxygenase Activity in Methylosinus trichosporium OB3b
journal, January 2015
- Farhan Ul-Haque, Muhammad; Kalidass, Bhagyalakshmi; Vorobev, Alexey
- Applied and Environmental Microbiology, Vol. 81, Issue 7
Spectral, Kinetic, and Thermodynamic Properties of Cu(I) and Cu(II) Binding by Methanobactin from Methylosinus trichosporium OB3b †
journal, February 2006
- Choi, Dong W.; Zea, Corbin J.; Do, Young S.
- Biochemistry, Vol. 45, Issue 5
Genome mining for methanobactins
journal, February 2013
- Kenney, Grace E.; Rosenzweig, Amy C.
- BMC Biology, Vol. 11, Issue 1
Methanobactin, a Copper-Acquisition Compound from Methane-Oxidizing Bacteria
journal, September 2004
- Kim, H. J.
- Science, Vol. 305, Issue 5690
Bacterial copper storage proteins
journal, February 2018
- Dennison, Christopher; David, Sholto; Lee, Jaeick
- Journal of Biological Chemistry, Vol. 293, Issue 13
Analysis of methanotrophic communities in landfill biofilters using diagnostic microarray
journal, May 2008
- Gebert, Julia; Stralis-Pavese, Nancy; Alawi, Mashal
- Environmental Microbiology, Vol. 10, Issue 5
The role of copper in the pMMO of Methylococcus capsulatus Bath: A structural vs. catalytic function
journal, June 1995
- Semrau, Jeremy D.; Zolandz, Dorothy; Lindstrom, Mary E.
- Journal of Inorganic Biochemistry, Vol. 58, Issue 4
Determination of copper at electrodes modified with ligands of varying coordination strength: a preamble to speciation studies
journal, February 1990
- Cha, Seong K.; Abruna, Hector D.
- Analytical Chemistry, Vol. 62, Issue 3
Metagenomic Approaches Unearth Methanotroph Phylogenetic and Metabolic Diversity
journal, January 2019
- Smith, Garrett J.; Wrighton, Kelly C.
- Current Issues in Molecular Biology
Activity and Identification of Methanotrophic Bacteria in Arable and No-Tillage Soils from Lublin Region (Poland)
journal, September 2018
- Szafranek-Nakonieczna, Anna; Wolińska, Agnieszka; Zielenkiewicz, Urszula
- Microbial Ecology, Vol. 77, Issue 3
Earthworm activity in a simulated landfill cover soil shifts the community composition of active methanotrophs
journal, December 2011
- Kumaresan, Deepak; Héry, Marina; Bodrossy, Levente
- Research in Microbiology, Vol. 162, Issue 10
Redox Potentiometry Studies of Particulate Methane Monooxygenase: Support for a Trinuclear Copper Cluster Active Site
journal, March 2007
- Chan, Sunney I.; Wang, Vincent C. -C.; Lai, Jeff C. -H.
- Angewandte Chemie International Edition, Vol. 46, Issue 12
Wilson's disease
journal, February 2007
- Ala, Aftab; Walker, Ann P.; Ashkan, Keyoumars
- The Lancet, Vol. 369, Issue 9559
Quantitative Proteomic Analysis of Metabolic Regulation by Copper Ions in Methylococcus capsulatus (Bath)
journal, September 2004
- Kao, Wei-Chun; Chen, Yet-Ran; Yi, Eugene C.
- Journal of Biological Chemistry, Vol. 279, Issue 49
Diversity and Habitat Preferences of Cultivated and Uncultivated Aerobic Methanotrophic Bacteria Evaluated Based on pmoA as Molecular Marker
journal, December 2015
- Knief, Claudia
- Frontiers in Microbiology, Vol. 6
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
journal, June 2006
- Gaggelli, Elena; Kozlowski, Henryk; Valensin, Daniela
- Chemical Reviews, Vol. 106, Issue 6
Universal chemical assay for the detection and determination of siderophores
journal, January 1987
- Schwyn, Bernhard; Neilands, J. B.
- Analytical Biochemistry, Vol. 160, Issue 1, p. 47-56
Copper-Binding Compounds from Methylosinus trichosporium OB3b
journal, July 1998
- DiSpirito, Alan A.; Zahn, James A.; Graham, David W.
- Journal of Bacteriology, Vol. 180, Issue 14
Copper is required for oncogenic BRAF signalling and tumorigenesis
journal, April 2014
- Brady, Donita C.; Crowe, Matthew S.; Turski, Michelle L.
- Nature, Vol. 509, Issue 7501
Spectral and copper binding properties of methanobactin from the facultative methanotroph Methylocystis strain SB2
journal, May 2012
- Bandow, Nathan; Gilles, Valerie S.; Freesmeier, Brittani
- Journal of Inorganic Biochemistry, Vol. 110
Methane oxidation by an extremely acidophilic bacterium of the phylum Verrucomicrobia
journal, November 2007
- Dunfield, Peter F.; Yuryev, Anton; Senin, Pavel
- Nature, Vol. 450, Issue 7171
Spatial and temporal diversity of methanotrophs in a landfill cover soil are differentially related to soil abiotic factors: Spatial and temporal diversity of methanotrophs
journal, August 2009
- Kumaresan, Deepak; Abell, Guy C. J.; Bodrossy, Levente
- Environmental Microbiology Reports, Vol. 1, Issue 5
Distribution and Selection of Poly-3-Hydroxybutyrate Production Capacity in Methanotrophic Proteobacteria
journal, May 2011
- Pieja, Allison J.; Rostkowski, Katherine H.; Criddle, Craig S.
- Microbial Ecology, Vol. 62, Issue 3
Bacterial cytosolic proteins with a high capacity for Cu(I) that protect against copper toxicity
journal, December 2016
- Vita, Nicolas; Landolfi, Gianpiero; Baslé, Arnaud
- Scientific Reports, Vol. 6, Issue 1
A TonB-Dependent Transporter Is Responsible for Methanobactin Uptake by Methylosinus trichosporium OB3b
journal, January 2016
- Gu, Wenyu; Farhan Ul Haque, Muhammad; Baral, Bipin S.
- Applied and Environmental Microbiology, Vol. 82, Issue 6
Alzheimer’s disease causation by copper toxicity and treatment with zinc
journal, May 2014
- Brewer, George J.
- Frontiers in Aging Neuroscience, Vol. 6
Field application of nitrogen and phenylacetylene to mitigate greenhouse gas emissions from landfill cover soils: effects on microbial community structure
journal, August 2010
- Im, Jeongdae; Lee, Sung-Woo; Bodrossy, Levente
- Applied Microbiology and Biotechnology, Vol. 89, Issue 1
Characterization of Methanobactin from Methylosinus sp. LW4
journal, August 2016
- Kenney, Grace E.; Goering, Anthony W.; Ross, Matthew O.
- Journal of the American Chemical Society, Vol. 138, Issue 35
Biological synthesis of metal nanoparticles by microbes
journal, April 2010
- Narayanan, Kannan Badri; Sakthivel, Natarajan
- Advances in Colloid and Interface Science, Vol. 156, Issue 1-2
Unusual Genomic Traits Suggest Methylocystis bryophila S285 to Be Well Adapted for Life in Peatlands
journal, January 2018
- Han, Dongfei; Dedysh, Svetlana N.; Liesack, Werner
- Genome Biology and Evolution, Vol. 10, Issue 2
Mercury binding by methanobactin from Methylocystis strain SB2
journal, December 2014
- Baral, Bipin S.; Bandow, Nathan L.; Vorobev, Alexy
- Journal of Inorganic Biochemistry, Vol. 141
Membrane-associated methane monooxygenase from Methylococcus capsulatus (Bath).
journal, February 1996
- Zahn, J. A.; DiSpirito, A. A.
- Journal of Bacteriology, Vol. 178, Issue 4
Toward Delineating the Structure and Function of the Particulate Methane Monooxygenase from Methanotrophic Bacteria †
journal, April 2004
- Chan, Sunney I.; Chen, Kelvin H. -C.; Yu, Steve S. -F.
- Biochemistry, Vol. 43, Issue 15
Public good dynamics drive evolution of iron acquisition strategies in natural bacterioplankton populations
journal, November 2012
- Cordero, O. X.; Ventouras, L. -A.; DeLong, E. F.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 49
Poly-3-Hydroxybutyrate Metabolism in the Type II Methanotroph Methylocystis parvus OBBP
journal, July 2011
- Pieja, Allison J.; Sundstrom, Eric R.; Criddle, Craig S.
- Applied and Environmental Microbiology, Vol. 77, Issue 17, p. 6012-6019
Siderophore cheating and cheating resistance shape competition for iron in soil and freshwater Pseudomonas communities
journal, September 2017
- Butaitė, Elena; Baumgartner, Michael; Wyder, Stefan
- Nature Communications, Vol. 8, Issue 1
Copper-responsive gene expression in the methanotroph Methylosinus trichosporium OB3b
journal, January 2016
- Kenney, Grace E.; Sadek, Monica; Rosenzweig, Amy C.
- Metallomics, Vol. 8, Issue 9
Variations in methanobactin structure influences copper utilization by methane-oxidizing bacteria
journal, May 2012
- El Ghazouani, A.; Basle, A.; Gray, J.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 22
Optimization of diagnostic microarray for application in analysing landfill methanotroph communities under different plant covers: Microarray analysis of landfill site methanotrophs
journal, February 2004
- Stralis-Pavese, Nancy; Sessitsch, Angela; Weilharter, Alexandra
- Environmental Microbiology, Vol. 6, Issue 4
Nitrite-driven anaerobic methane oxidation by oxygenic bacteria
journal, March 2010
- Ettwig, Katharina F.; Butler, Margaret K.; Le Paslier, Denis
- Nature, Vol. 464, Issue 7288
The origin of aerobic methanotrophy within the Proteobacteria
journal, May 2019
- Kang, Christina S.; Dunfield, Peter F.; Semrau, Jeremy D.
- FEMS Microbiology Letters, Vol. 366, Issue 9
The Membrane-Associated Methane Monooxygenase (pMMO) and pMMO-NADH:Quinone Oxidoreductase Complex from Methylococcus capsulatus Bath
journal, September 2003
- Choi, Dong-W.; Kunz, Ryan C.; Boyd, Eric S.
- Journal of Bacteriology, Vol. 185, Issue 19
Microbial minorities modulate methane consumption through niche partitioning
journal, June 2013
- Bodelier, Paul LE; Meima-Franke, Marion; Hordijk, Cornelis A.
- The ISME Journal, Vol. 7, Issue 11
Recent biomedical applications of gold nanoparticles: A review
journal, July 2018
- Elahi, Narges; Kamali, Mehdi; Baghersad, Mohammad Hadi
- Talanta, Vol. 184
The quest for atmospheric methane oxidizers in forest soils: Atmospheric methane-oxidizing methanotrophs in forest soils
journal, July 2009
- Kolb, Steffen
- Environmental Microbiology Reports, Vol. 1, Issue 5
In vitro activation of ammonia monooxygenase from Nitrosomonas europaea by copper.
journal, April 1993
- Ensign, S. A.; Hyman, M. R.; Arp, D. J.
- Journal of Bacteriology, Vol. 175, Issue 7
Methanotrophy below pH 1 by a new Verrucomicrobia species
journal, November 2007
- Pol, Arjan; Heijmans, Klaas; Harhangi, Harry R.
- Nature, Vol. 450, Issue 7171
The genomic landscape of the verrucomicrobial methanotroph Methylacidiphilum fumariolicum SolV
journal, January 2014
- Anvar, Seyed; Frank, Jeroen; Pol, Arjan
- BMC Genomics, Vol. 15, Issue 1
Optical properties and biomedical applications of plasmonic nanoparticles
journal, January 2010
- Khlebtsov, Nikolai G.; Dykman, Lev A.
- Journal of Quantitative Spectroscopy and Radiative Transfer, Vol. 111, Issue 1
Characterization of the role of copCD in copper uptake and the ‘copper-switch’ in Methylosinus trichosporium OB3b
journal, May 2017
- Gu, Wenyu; Farhan Ul Haque, Muhammad; Semrau, Jeremy D.
- FEMS Microbiology Letters, Vol. 364, Issue 10
Methane oxidation at 55 C and pH 2 by a thermoacidophilic bacterium belonging to the Verrucomicrobia phylum
journal, January 2008
- Islam, T.; Jensen, S.; Reigstad, L. J.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 1, p. 300-304
Alkane Oxidation: Methane Monooxygenases, Related Enzymes, and Their Biomimetics
journal, February 2017
- Wang, Vincent C. -C.; Maji, Suman; Chen, Peter P. -Y.
- Chemical Reviews, Vol. 117, Issue 13
Physical disturbance to ecological niches created by soil structure alters community composition of methanotrophs: Ecological niches and methanotroph diversity
journal, August 2011
- Kumaresan, Deepak; Stralis-Pavese, Nancy; Abell, Guy C. J.
- Environmental Microbiology Reports, Vol. 3, Issue 5
The Particulate Methane Monooxygenase from Methylococcus capsulatus (Bath) Is a Novel Copper-containing Three-subunit Enzyme : ISOLATION AND CHARACTERIZATION
journal, April 1998
- Nguyen, Hiep-Hoa T.; Elliott, Sean J.; Yip, John Hon-Kay
- Journal of Biological Chemistry, Vol. 273, Issue 14
Spectral and thermodynamic properties of Ag(I), Au(III), Cd(II), Co(II), Fe(III), Hg(II), Mn(II), Ni(II), Pb(II), U(IV), and Zn(II) binding by methanobactin from Methylosinus trichosporium OB3b
journal, December 2006
- Choi, Dong W.; Do, Young S.; Zea, Corbin J.
- Journal of Inorganic Biochemistry, Vol. 100, Issue 12, p. 2150-2161
Detoxification of Mercury by Methanobactin from Methylosinus trichosporium OB3b
journal, July 2013
- Vorobev, Alexey; Jagadevan, Sheeja; Baral, Bipin S.
- Applied and Environmental Microbiology, Vol. 79, Issue 19
Oxidase, superoxide dismutase, and hydrogen peroxide reductase activities of methanobactin from types I and II methanotrophs
journal, August 2008
- Choi, Dong W.; Semrau, Jeremy D.; Antholine, William E.
- Journal of Inorganic Biochemistry, Vol. 102, Issue 8
Methanobactin reverses acute liver failure in a rat model of Wilson disease
journal, June 2016
- Lichtmannegger, Josef; Leitzinger, Christin; Wimmer, Ralf
- Journal of Clinical Investigation, Vol. 126, Issue 7
The Methylococcus capsulatus (Bath) Secreted Protein, MopE*, Binds Both Reduced and Oxidized Copper
journal, August 2012
- Ve, Thomas; Mathisen, Karina; Helland, Ronny
- PLoS ONE, Vol. 7, Issue 8
X-ray Absorption and EPR Studies on the Copper Ions Associated with the Particulate Methane Monooxygenase from Methylococcus capsulatus (Bath). Cu(I) Ions and Their Implications
journal, January 1996
- Nguyen, Hiep-Hoa T.; Nakagawa, Kent H.; Hedman, Britt
- Journal of the American Chemical Society, Vol. 118, Issue 50
Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity
journal, September 2015
- Gamez, Patrick; Caballero, Ana B.
- AIP Advances, Vol. 5, Issue 9
Repurposed HisC Aminotransferases Complete the Biosynthesis of Some Methanobactins
journal, April 2018
- Park, Yun Ji; Kenney, Grace E.; Schachner, Luis F.
- Biochemistry, Vol. 57, Issue 25
Quantum Refinement Does Not Support Dinuclear Copper Sites in Crystal Structures of Particulate Methane Monooxygenase
journal, December 2017
- Cao, Lili; Caldararu, Octav; Rosenzweig, Amy C.
- Angewandte Chemie International Edition, Vol. 57, Issue 1
A four-helix bundle stores copper for methane oxidation
journal, August 2015
- Vita, Nicolas; Platsaki, Semeli; Baslé, Arnaud
- Nature, Vol. 525, Issue 7567
An assay for screening microbial cultures for chalkophore production
journal, April 2010
- Yoon, Sukhwan; Kraemer, Stephan M.; DiSpirito, Alan A.
- Environmental Microbiology Reports, Vol. 2, Issue 2
Effect of Exogenous Siderophores on Iron Uptake Activity of Marine Bacteria under Iron-Limited Conditions
journal, April 2001
- Guan, L. L.; Kanoh, K.; Kamino, K.
- Applied and Environmental Microbiology, Vol. 67, Issue 4
Effect of earthworms on the community structure of active methanotrophic bacteria in a landfill cover soil
journal, November 2007
- Héry, Marina; Singer, Andrew C.; Kumaresan, Deepak
- The ISME Journal, Vol. 2, Issue 1
Growth yields of methanotrophs 2. A theoretical analysis
journal, March 1986
- Leak, David J.; Dalton, Howard
- Applied Microbiology and Biotechnology, Vol. 23, Issue 6
Growth yields of methanotrophs: 1. Effect of copper on the energetics of methane oxidation
journal, March 1986
- Leak, David J.; Dalton, Howard
- Applied Microbiology and Biotechnology, Vol. 23, Issue 6
Mössbauer Studies of the Membrane-Associated Methane Monooxygenase from Methylococcus capsulatus Bath: Evidence for a Diiron Center
journal, December 2007
- Martinho, Marlène; Choi, Dong W.; DiSpirito, Alan A.
- Journal of the American Chemical Society, Vol. 129, Issue 51
Liver transplantation for Wilson's disease: Liver transplantation for Wilson's disease
journal, May 2014
- Schilsky, Michael L.
- Annals of the New York Academy of Sciences, Vol. 1315, Issue 1
Methanobactin and the Link between Copper and Bacterial Methane Oxidation
journal, March 2016
- DiSpirito, Alan A.; Semrau, Jeremy D.; Murrell, J. Colin
- Microbiology and Molecular Biology Reviews, Vol. 80, Issue 2
TIGRFAMs and Genome Properties in 2013
journal, November 2012
- Haft, Daniel H.; Selengut, Jeremy D.; Richter, Roland A.
- Nucleic Acids Research, Vol. 41, Issue D1
Characterization of a novel facultative Methylocystis species capable of growth on methane, acetate and ethanol: Facultative methanotrophy in a Methylocystis sp.
journal, August 2010
- Im, Jeongdae; Lee, Sung-Woo; Yoon, Sukhwan
- Environmental Microbiology Reports, Vol. 3, Issue 2
Genome Sequence of the Methanotrophic Alphaproteobacterium Methylocystis sp. Strain Rockwell (ATCC 49242)
journal, March 2011
- Stein, L. Y.; Bringel, F.; DiSpirito, A. A.
- Journal of Bacteriology, Vol. 193, Issue 10
Current Trends in Methylotrophy
journal, August 2018
- Chistoserdova, Ludmila; Kalyuzhnaya, Marina G.
- Trends in Microbiology, Vol. 26, Issue 8
NMR, Mass Spectrometry and Chemical Evidence Reveal a Different Chemical Structure for Methanobactin That Contains Oxazolone Rings
journal, September 2008
- Behling, Lee A.; Hartsel, Scott C.; Lewis, David E.
- Journal of the American Chemical Society, Vol. 130, Issue 38
Methylocystis bryophila sp. nov., a facultatively methanotrophic bacterium from acidic Sphagnum peat, and emended description of the genus Methylocystis (ex Whittenbury et al. 1970) Bowman et al. 1993
journal, June 2012
- Belova, S. E.; Kulichevskaya, I. S.; Bodelier, P. L. E.
- INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol. 63, Issue Pt 3
Wilson’s Disease
journal, August 2005
- Ferenci, Peter
- Clinical Gastroenterology and Hepatology, Vol. 3, Issue 8
Methanotrophic bacteria in oilsands tailings ponds of northern Alberta
journal, December 2012
- Saidi-Mehrabad, Alireza; He, Zhiguo; Tamas, Ivica
- The ISME Journal, Vol. 7, Issue 5
Acquisition of iron by the non-siderophore-producing Pseudomonas fragi
journal, May 1996
- Champomier-Verges, M. -C.; Stintzi, A.; Meyer, J. -M.
- Microbiology, Vol. 142, Issue 5
Low-copper diet as a preventive strategy for Alzheimer's disease
journal, September 2014
- Squitti, Rosanna; Siotto, Mariacristina; Polimanti, Renato
- Neurobiology of Aging, Vol. 35
Drug Development Based on the Metals Hypothesis of Alzheimer's Disease
journal, October 2008
- Bush, Ashley I.
- Journal of Alzheimer's Disease, Vol. 15, Issue 2
Biosynthesis of gold nanoparticles by two bacterial and fungal strains, Bacillus cereus and Fusarium oxysporum, and assessment and comparison of their nanotoxicity in vitro by direct and indirect assays
journal, September 2017
- Pourali, Parastoo; Badiee, Seyyed Hossein; Manafi, Sahebali
- Electronic Journal of Biotechnology, Vol. 29
Treatment of Wilson’s disease: What are the relative roles of penicillamine, trientine, and zinc supplementation?
journal, February 2001
- Schilsky, Michael L.
- Current Gastroenterology Reports, Vol. 3, Issue 1
Copper dysfunction in Alzheimer's disease: From meta-analysis of biochemical studies to new insight into genetics
journal, June 2012
- Squitti, Rosanna
- Journal of Trace Elements in Medicine and Biology, Vol. 26, Issue 2-3
Oxidation of methane by a biological dicopper centre
journal, April 2010
- Balasubramanian, Ramakrishnan; Smith, Stephen M.; Rawat, Swati
- Nature, Vol. 465, Issue 7294
Nitric Oxide Dismutase (nod) Genes as a Functional Marker for the Diversity and Phylogeny of Methane-Driven Oxygenic Denitrifiers
journal, July 2019
- Zhu, Baoli; Wang, Jiaqi; Bradford, Lauren M.
- Frontiers in Microbiology, Vol. 10
Chalkophores
journal, June 2018
- Kenney, Grace E.; Rosenzweig, Amy C.
- Annual Review of Biochemistry, Vol. 87, Issue 1
High spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment
journal, September 2018
- Müller, Jennifer-Christin; Lichtmannegger, Josef; Zischka, Hans
- Journal of Trace Elements in Medicine and Biology, Vol. 49
The Surface-Associated and Secreted MopE Protein of Methylococcus capsulatus (Bath) Responds to Changes in the Concentration of Copper in the Growth Medium
journal, April 2003
- Karlsen, O. A.; Berven, F. S.; Stafford, G. P.
- Applied and Environmental Microbiology, Vol. 69, Issue 4
Effect of Copper on Methylomonas albus BG8 †
journal, January 1991
- Collins, Mary Lynne Perille; Buchholz, Lorie A.; Remsen, Charles C.
- Applied and Environmental Microbiology, Vol. 57, Issue 4
Environmental, genomic and taxonomic perspectives on methanotrophic Verrucomicrobia : Perspectives on methanotrophic
journal, March 2009
- Op den Camp, Huub J. M.; Islam, Tajul; Stott, Matthew B.
- Environmental Microbiology Reports, Vol. 1, Issue 5
Effect of nutrient and selective inhibitor amendments on methane oxidation, nitrous oxide production, and key gene presence and expression in landfill cover soils: characterization of the role of methanotrophs, nitrifiers, and denitrifiers
journal, September 2009
- Lee, Sung-Woo; Im, Jeongdae; DiSpirito, Alan A.
- Applied Microbiology and Biotechnology, Vol. 85, Issue 2
Methylmercury uptake and degradation by methanotrophs
journal, May 2017
- Lu, Xia; Gu, Wenyu; Zhao, Linduo
- Science Advances, Vol. 3, Issue 5
Metals and Methanotrophy
journal, January 2018
- Semrau, Jeremy D.; DiSpirito, Alan A.; Gu, Wenyu
- Applied and Environmental Microbiology, Vol. 84, Issue 6
Isolation of Copper Biochelates fromMethylosinus trichosporium OB3b and Soluble Methane Monooxygenase Mutants
journal, March 1998
- Téllez, Carlos M.; Gaus, Kristen P.; Graham, David W.
- Applied and Environmental Microbiology, Vol. 64, Issue 3
Aerobic proteobacterial methylotrophs in Movile Cave: genomic and metagenomic analyses
journal, January 2018
- Kumaresan, Deepak; Stephenson, Jason; Doxey, Andrew C.
- Microbiome, Vol. 6, Issue 1
A Comparison of Methanobactins from Methylosinus trichosporium OB3b and Methylocystis Strain SB2 Predicts Methanobactins Are Synthesized from Diverse Peptide Precursors Modified To Create a Common Core for Binding and Reducing Copper Ions
journal, November 2010
- Krentz, Benjamin D.; Mulheron, Heidi J.; Semrau, Jeremy D.
- Biochemistry, Vol. 49, Issue 47
Insight into Metal Removal from Peptides that Sequester Copper for Methane Oxidation
journal, February 2018
- Baslé, Arnaud; El Ghazouani, Abdelnasser; Lee, Jaeick
- Chemistry – A European Journal, Vol. 24, Issue 18
Activity and community structure of methane-oxidising bacteria in a wet meadow soil
journal, September 2002
- Horz, Hans-Peter; Raghubanshi, Akhilesh S.; Heyer, Jürgen
- FEMS Microbiology Ecology, Vol. 41, Issue 3
Archaeal nitrification is constrained by copper complexation with organic matter in municipal wastewater treatment plants
journal, October 2019
- Gwak, Joo-Han; Jung, Man-Young; Hong, Heeji
- The ISME Journal, Vol. 14, Issue 2
Spectral and thermodynamic properties of methanobactin from γ-proteobacterial methane oxidizing bacteria: A case for copper competition on a molecular level
journal, December 2010
- Choi, Dong W.; Bandow, Nathan L.; McEllistrem, Marcus T.
- Journal of Inorganic Biochemistry, Vol. 104, Issue 12
Copper stress underlies the fundamental change in intracellular location of methane mono-oxygenase in methane-oxidizing organisms: Studies in batch and continuous cultures
journal, July 1983
- Stanley, S. H.; Prior, S. D.; Leak, D. J.
- Biotechnology Letters, Vol. 5, Issue 7
Intracytoplasmic membrane formation in Methylomicrobium album BG8 is stimulated by copper in the growth medium
journal, July 1997
- Brantner, Christine A.; Buchholz, Lorie A.; McSwain, Claudia L.
- Canadian Journal of Microbiology, Vol. 43, Issue 7
Controls on bacterial and archaeal community structure and greenhouse gas production in natural, mined, and restored Canadian peatlands
journal, January 2013
- Basiliko, Nathan; Henry, Kevin; Gupta, Varun
- Frontiers in Microbiology, Vol. 4
Methanobactin from Methylosinus trichosporium OB3b inhibits N2O reduction in denitrifiers
journal, January 2018
- Chang, Jin; Gu, Wenyu; Park, Doyoung
- The ISME Journal, Vol. 12, Issue 8
Molecular Ecology Techniques for the Study of Aerobic Methanotrophs
journal, December 2007
- McDonald, I. R.; Bodrossy, L.; Chen, Y.
- Applied and Environmental Microbiology, Vol. 74, Issue 5
The nature of the copper ions in the membranes containing the particulate methane monooxygenase from Methylococcus capsulatus (Bath).
journal, May 1994
- Nguyen, H. H.; Shiemke, A. K.; Jacobs, S. J.
- Journal of Biological Chemistry, Vol. 269, Issue 21
The biosynthesis of methanobactin
journal, March 2018
- Kenney, Grace E.; Dassama, Laura M. K.; Pandelia, Maria-Eirini
- Science, Vol. 359, Issue 6382
Diversity and activity of methanotrophs in alkaline soil from a Chinese coal mine
journal, November 2009
- Han, Bing; Chen, Yin; Abell, Guy
- FEMS Microbiology Ecology, Vol. 70, Issue 2
Alpha- and Gammaproteobacterial Methanotrophs Codominate the Active Methane-Oxidizing Communities in an Acidic Boreal Peat Bog
journal, February 2016
- Esson, Kaitlin C.; Lin, Xueju; Kumaresan, Deepak
- Applied and Environmental Microbiology, Vol. 82, Issue 8
Uncultivated Methylocystis Species in Paddy Soil Include Facultative Methanotrophs that Utilize Acetate
journal, December 2014
- Leng, Lingqin; Chang, Jiali; Geng, Kan
- Microbial Ecology, Vol. 70, Issue 1
Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice
journal, May 2001
- Cherny, Robert A.; Atwood, Craig S.; Xilinas, Michel E.
- Neuron, Vol. 30, Issue 3