Title: The Efficacy and Safety of Mesalamine and Probiotics in Mild-to-Moderate Ulcerative Colitis: A Systematic Review and Meta-Analysis

Abstract

Objective . To evaluate the efficacy and safety of mesalamine in conjunction with probiotics for ulcerative colitis. Methods . Random controlled trials (RCTs) were searched in PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and VIP (VIP Database for Chinese Technical Periodicals) from inception to October 2019. Methodological quality was assessed by the Cochrane Collaboration tool. The quality of evidence was rated by the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). Data analysis was carried out in Review Manager 5.3. Results . A total of fifteen studies met the criteria for inclusion. Thirteen studies reported the clinical efficacy, three studies provided data on the clinical symptom scores, two trials reported disease activity index, four studies evaluated endoscopic score, and twelve studies reported adverse events. For ulcerative colitis (UC), mesalamine and probiotics had better clinical efficacy than mesalamine alone (≤8 weeks: RR = 1.12, 95% CI: 1.07–1.18, $P<0.0001$ ; >8 weeks: RR = 1.25, 95% CI: 1.11–1.41, $P=0.0003$ ). On the clinical symptom scores, disease activity index, and endoscopic score, UC patients receiving mesalamine and probiotics had significant difference than patients receiving mesalazine alone (MD = −2.02, 95% CI: −3.28 to −0.76, $P=0.002$ ; MD = −1.20, 95% CI: −1.76 to −0.65, $P<0.001$ ; and MD = −0.42, 95% CI: −0.61 to −0.23, $P<0.0001$ , respectively). There was no statistically significant difference in adverse events between the two groups (RR = 0.88, 95% CI: 0.54 to 1.43, $P=0.60$ ). Conclusion . Our meta-analysis results supported that mesalamine and probiotics were effective and safe in treating ulcerative colitis.

Authors:

Tian, Chunying ^[1]; Huang, Yang ^[1]; Wu, Xiaoxia ^[1]; Xu, Chuhan ^[1]; Bu, Huaien  ^[1];

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• Search DOE PAGES for ORCID "0000-0001-6616-2959"

Wang, Hongwu  ^[1]

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• Search DOE PAGES for ORCID "0000-0003-0449-715X"

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+ Show Author Affiliations

1. Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China

Publication Date:

Sat Mar 28 00:00:00 EDT 2020

Sponsoring Org.:

USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI Identifier:

1607584

Grant/Contract Number:  

2011CB505406

Resource Type:

Published Article

Journal Name:

Evidence-Based Complementary and Alternative Medicine

Additional Journal Information:

Journal Name: Evidence-Based Complementary and Alternative Medicine Journal Volume: 2020; Journal ID: ISSN 1741-427X

Publisher:

Hindawi Publishing Corporation

Country of Publication:

United Kingdom

Language:

English