Cross talk between RNA N6‐methyladenosine methyltransferase‐like 3 and miR‐186 regulates hepatoblastoma progression through Wnt/β‐catenin signalling pathway

doi:10.1111/cpr.12768

Title: Cross talk between RNA N6‐methyladenosine methyltransferase‐like 3 and miR‐186 regulates hepatoblastoma progression through Wnt/β‐catenin signalling pathway

Authors:

Cui, Xichun ^[1]; Wang, Zhifang ^[2]; Li, Jianhao ^[3]; Zhu, Jianming ^[3]; Ren, Zhigang ^[3]; Zhang, Dandan ^[4]; Zhao, Wei ^[1]; Fan, Yingzhong ^[1]; Zhang, Da ^[1];

^[3]

Pediatric Surgery Department The First Affiliated Hospital of Zhengzhou University Zhengzhou China
Endocrinology Department The First Affiliated Hospital of Zhengzhou University Zhengzhou China
Precision Medicine Center The First Affiliated Hospital of Zhengzhou University Zhengzhou China
Pathology Department The First Affiliated Hospital of Zhengzhou University Zhengzhou China

Publication Date:: 2020-01-22

Sponsoring Org.:: USDOE Office of Electricity Delivery and Energy Reliability (OE), Power Systems Engineering Research and Development (R&D) (OE-10)

OSTI Identifier:: 1593197

Alternate Identifier(s):: OSTI ID: 1593199

Grant/Contract Number:: 2018YFC2000500; 2017M610463; 2018M632814; NELIMSA2018P03

Resource Type:: Published Article

Journal Name:: Cell Proliferation

Additional Journal Information:: Journal Name: Cell Proliferation; Journal ID: ISSN 0960-7722

Publisher:: Wiley-Blackwell

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Cui, Xichun, Wang, Zhifang, Li, Jianhao, Zhu, Jianming, Ren, Zhigang, Zhang, Dandan, Zhao, Wei, Fan, Yingzhong, Zhang, Da, and Sun, Ranran. Cross talk between RNA N6‐methyladenosine methyltransferase‐like 3 and miR‐186 regulates hepatoblastoma progression through Wnt/β‐catenin signalling pathway.  United Kingdom: N. p., 2020. 
        Web.  doi:10.1111/cpr.12768.

Copy to clipboard


                    Cui, Xichun, Wang, Zhifang, Li, Jianhao, Zhu, Jianming, Ren, Zhigang, Zhang, Dandan, Zhao, Wei, Fan, Yingzhong, Zhang, Da, & Sun, Ranran. Cross talk between RNA N6‐methyladenosine methyltransferase‐like 3 and miR‐186 regulates hepatoblastoma progression through Wnt/β‐catenin signalling pathway.  United Kingdom.  doi:10.1111/cpr.12768.

Copy to clipboard


                    Cui, Xichun, Wang, Zhifang, Li, Jianhao, Zhu, Jianming, Ren, Zhigang, Zhang, Dandan, Zhao, Wei, Fan, Yingzhong, Zhang, Da, and Sun, Ranran. Wed .  
        "Cross talk between RNA N6‐methyladenosine methyltransferase‐like 3 and miR‐186 regulates hepatoblastoma progression through Wnt/β‐catenin signalling pathway".  United Kingdom.  doi:10.1111/cpr.12768.

Copy to clipboard


                    
@article{osti_1593197,

  title        = {Cross talk between RNA N6‐methyladenosine methyltransferase‐like 3 and miR‐186 regulates hepatoblastoma progression through Wnt/β‐catenin signalling pathway},

  author       = {Cui, Xichun and Wang, Zhifang and Li, Jianhao and Zhu, Jianming and Ren, Zhigang and Zhang, Dandan and Zhao, Wei and Fan, Yingzhong and Zhang, Da and Sun, Ranran},

  abstractNote = {},

  doi          = {10.1111/cpr.12768},

  journal      = {Cell Proliferation},

  number       = ,

  volume       = ,

  place        = {United Kingdom},

  year         = {2020},

  month        = {1}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Publisher's Version of Record
DOI: 10.1111/cpr.12768

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Critical Enzymatic Functions of FTO in Obesity and Cancer
journal, July 2018

Deng, Xiaolan; Su, Rui; Stanford, Savanna
Frontiers in Endocrinology, Vol. 9
DOI: 10.3389/fendo.2018.00396

Apoptosis induction in K562 human myelogenous leukaemia cells is connected to the modulation of Wnt/β-catenin signalling by BHX, a novel pyrazoline derivative
journal, January 2018

Bao, Hanmei; Zhang, Qing; Du, Yibo
Cell Proliferation, Vol. 51, Issue 3
DOI: 10.1111/cpr.12433

Caught up in a Wnt storm: Wnt signaling in cancer
journal, June 2003

Giles, Rachel H.; van Es, Johan H.; Clevers, Hans
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1653, Issue 1
DOI: 10.1016/S0304-419X(03)00005-2

miRNA-30e regulates abnormal differentiation of small intestinal epithelial cells in diabetic mice by downregulating Dll4 expression
journal, January 2016

Shan, Ti-Dong; Ouyang, Hui; Yu, Tao
Cell Proliferation, Vol. 49, Issue 1
DOI: 10.1111/cpr.12230

Dynamic RNA modifications in disease
journal, June 2014

Klungland, Arne; Dahl, John Arne
Current Opinion in Genetics & Development, Vol. 26
DOI: 10.1016/j.gde.2014.05.006

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification
journal, February 2018

Weng, Hengyou; Huang, Huilin; Wu, Huizhe
Cell Stem Cell, Vol. 22, Issue 2
DOI: 10.1016/j.stem.2017.11.016

N6-methyladenosine-dependent regulation of messenger RNA stability
journal, November 2013

Wang, Xiao; Lu, Zhike; Gomez, Adrian
Nature, Vol. 505, Issue 7481
DOI: 10.1038/nature12730

Wnt signaling and telomerase activation of hepatoblastoma: correlation with chemosensitivity and surgical resectability
journal, December 2011

Ueda, Yuka; Hiyama, Eiso; Kamimatsuse, Arata
Journal of Pediatric Surgery, Vol. 46, Issue 12
DOI: 10.1016/j.jpedsurg.2011.09.003

Natural Killer–Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms
journal, December 2018

Neviani, Paolo; Wise, Petra M.; Murtadha, Mariam
Cancer Research, Vol. 79, Issue 6
DOI: 10.1158/0008-5472.CAN-18-0779

MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance
journal, January 2019

Ecevit, Çiğdem Ö.; Aktaş, Safiye; Tosun Yildirim, Hülya
Journal of Pediatric Hematology/Oncology, Vol. 41, Issue 1
DOI: 10.1097/MPH.0000000000001234

Management of hepatoblastoma: an update
journal, January 2014

Kremer, Nathalie; Walther, Ashley E.; Tiao, Gregory M.
Current Opinion in Pediatrics, Vol. 26, Issue 3
DOI: 10.1097/MOP.0000000000000081

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
journal, May 2016

Lin, Shuibin; Choe, Junho; Du, Peng
Molecular Cell, Vol. 62, Issue 3
DOI: 10.1016/j.molcel.2016.03.021

RUNX3 regulates hepatocellular carcinoma cell metastasis via targeting miR-186/E-cadherin/EMT pathway
journal, June 2017

Gou, Yuli; Zhai, Fangbing; Zhang, Liang
Oncotarget, Vol. 8, Issue 37
DOI: 10.18632/oncotarget.18424

MicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer
journal, July 2016

Huang, Tonghai; She, Kelin; Peng, Guilin
International Journal of Oncology, Vol. 49, Issue 4
DOI: 10.3892/ijo.2016.3637

N6-methyladenosine marks primary microRNAs for processing
journal, March 2015

Alarcón, Claudio R.; Lee, Hyeseung; Goodarzi, Hani
Nature, Vol. 519, Issue 7544
DOI: 10.1038/nature14281

Wnt signaling and hepatocarcinogenesis: The hepatoblastoma model
journal, February 2011

Armengol, C.; Cairo, S.; Fabre, M.
The International Journal of Biochemistry & Cell Biology, Vol. 43, Issue 2
DOI: 10.1016/j.biocel.2009.07.012

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
journal, April 2018

Chen, Mengnuo; Wei, Lai; Law, Cheuk-Ting
Hepatology, Vol. 67, Issue 6
DOI: 10.1002/hep.29683

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
journal, March 2016

Zhang, Chuanzhao; Samanta, Debangshu; Lu, Haiquan
Proceedings of the National Academy of Sciences, Vol. 113, Issue 14
DOI: 10.1073/pnas.1602883113

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing
journal, June 2016

Roundtree, Ian A.; He, Chuan
Trends in Genetics, Vol. 32, Issue 6
DOI: 10.1016/j.tig.2016.03.006

Reduced m⁶A mRNA methylation is correlated with the progression of human cervical cancer
journal, October 2017

Wang, Xiuli; Li, Zenghui; Kong, Beihua
Oncotarget, Vol. 8, Issue 58
DOI: 10.18632/oncotarget.22041

miR‐186 inhibits proliferation, migration, and epithelial‐mesenchymal transition in breast cancer cells by targeting Twist1
journal, December 2018

Sun, Wen‐juan; Zhang, Ya‐na; Xue, Peng
Journal of Cellular Biochemistry, Vol. 120, Issue 6
DOI: 10.1002/jcb.28283

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway
journal, September 2019

Peng, Wen; Li, Jie; Chen, Ranran
Journal of Experimental & Clinical Cancer Research, Vol. 38, Issue 1
DOI: 10.1186/s13046-019-1408-4

Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer
journal, December 2017

Nishizawa, Yujiro; Konno, Masamitsu; Asai, Ayumu
Oncotarget, Vol. 9, Issue 7
DOI: 10.18632/oncotarget.23554

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
journal, May 2018

Yang, Ying; Hsu, Phillip J.; Chen, Yu-Sheng
Cell Research, Vol. 28, Issue 6
DOI: 10.1038/s41422-018-0040-8

Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: a Chinese population-based study
journal, September 2016

Liu, Wanbo; Chen, Sheng; Liu, Bing
Pediatric Surgery International, Vol. 32, Issue 11
DOI: 10.1007/s00383-016-3960-8

β-catenin regulates IRF3-mediated innate immune signalling in colorectal cancer
journal, July 2018

Ding, Chengming; He, Jun; Zhao, Jun
Cell Proliferation, Vol. 51, Issue 5
DOI: 10.1111/cpr.12464

MicroRNA expression and its clinical implications in Ewing's sarcoma
journal, December 2014

Li, Zheng; Yu, Xin; Shen, Jianxiong
Cell Proliferation, Vol. 48, Issue 1
DOI: 10.1111/cpr.12160

Increased N6-methyladenosine causes infertility is associated with FTO expression
journal, March 2018

Ding, Chenyue; Zou, Qinyan; Ding, Jie
Journal of Cellular Physiology, Vol. 233, Issue 9
DOI: 10.1002/jcp.26507

METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
journal, January 2016

Zhang, Zhe; Zhang, Guojun; Kong, Chuize
Scientific Reports, Vol. 6, Issue 1
DOI: 10.1038/srep19261

Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential
journal, May 2016

Sun, Ranran; Shen, Jacson; Gao, Yan
Oncotarget, Vol. 7, Issue 25
DOI: 10.18632/oncotarget.9518

MeT-DB V2.0: elucidating context-specific functions of N6-methyl-adenosine methyltranscriptome
journal, November 2017

Liu, Hui; Wang, Huaizhi; Wei, Zhen
Nucleic Acids Research, Vol. 46, Issue D1
DOI: 10.1093/nar/gkx1080

MiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1
journal, August 2015

Yao, Kun; He, Leye; Gan, Yu
Diagnostic Pathology, Vol. 10, Issue 1
DOI: 10.1186/s13000-015-0372-3

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6 ‐methyladenosine‐dependent primary MicroRNA processing
journal, December 2016

Ma, Jin‐zhao; Yang, Fu; Zhou, Chuan‐chuan
Hepatology, Vol. 65, Issue 2
DOI: 10.1002/hep.28885

HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g
journal, February 2018

Cai, Xiaoli; Wang, Xiao; Cao, Can
Cancer Letters, Vol. 415
DOI: 10.1016/j.canlet.2017.11.018

The Role of MicroRNAs in Hepatoblastoma Tumors
journal, March 2019

Cristóbal, Ion; Sanz-Álvarez, Marta; Luque, Melani
Cancers, Vol. 11, Issue 3
DOI: 10.3390/cancers11030409

MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma
journal, February 2011

von Frowein, Julia; Pagel, Philipp; Kappler, Roland
Hepatology, Vol. 53, Issue 3
DOI: 10.1002/hep.24125

MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma
journal, March 2016

Ruan, Tingyan; He, Xiaoting; Yu, Jun
Oncology Letters, Vol. 11, Issue 4
DOI: 10.3892/ol.2016.4312

Effects of Wnt/β-catenin signalling on proliferation and differentiation of apical papilla stem cells: Effects of Wnt/β-catenin signalling
journal, January 2012

Wang, J.; Liu, B.; Gu, S.
Cell Proliferation, Vol. 45, Issue 2
DOI: 10.1111/j.1365-2184.2012.00806.x

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
journal, January 2019

Cheng, Maosheng; Sheng, Lu; Gao, Qian
Oncogene, Vol. 38, Issue 19
DOI: 10.1038/s41388-019-0683-z

Long Noncoding RNA ANRIL Promotes Cervical Cancer Development by Acting as a Sponge of miR-186
journal, April 2018

Zhang, Jun-Jun; Wang, Dan-Dan; Du, Chen-Xiang
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Vol. 26, Issue 3
DOI: 10.3727/096504017X14953948675449

m6A Facilitates eIF4F-Independent mRNA Translation
journal, November 2017

Coots, Ryan A.; Liu, Xiao-Min; Mao, Yuanhui
Molecular Cell, Vol. 68, Issue 3
DOI: 10.1016/j.molcel.2017.10.002

Novel Advances in Understanding of Molecular Pathogenesis of Hepatoblastoma: A Wnt/β-Catenin Perspective
journal, February 2017

Bell, Danielle; Ranganathan, Sarangarajan; Tao, Junyan
Gene Expression, Vol. 17, Issue 2
DOI: 10.3727/105221616X693639

Similar records in OSTI.GOV collections:

Nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between GLI1 and β catenin through activation of GSK3β

Journal Article Nayak, Anmada ; Siddharth, Sumit ; Das, Sarita ; ... - Toxicology and Applied Pharmacology

Presences of cancer stem cells (CSCs) in a bulk of cancer cells are responsible for tumor relapse, metastasis and drug resistance in oral cancer. Due to high drug efflux, DNA repair and self-renewable capacity of CSCs, the conventional chemotherapeutic agents are unable to kill the CSCs. CSCs utilizes Hedgehog (HH-GLI), WNT-β catenin signalling for its growth and development. GSK3β negatively regulates both the pathways in CSCs. Here, we have shown that a nano-formulated bioactive small molecule inhibitor Quinacrine (NQC) caused apoptosis in oral cancer stem cells (OCSCs; isolated from different oral cancer cells and oral cancer patient derived primary cells)more »« less
DOI: 10.1016/J.TAAP.2017.07.008
Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer

Journal Article Tan, Min ; Wu, Junjie, E-mail: wujunjiesh@126.com ; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433 ; ... - Biochemical and Biophysical Research Communications

Highlights: •Dnmt3A and Dnmt3B are involved in the down-regulation of WIF-1 expression in non-small-cell lung cancer. •MiR-29 family members could restore WIF-1 expression through demethylation. •MiR-29s suppress Wnt/β-catenin signaling pathway and inhibit tumor growth. •The expression of miR-29a and miR-29b could be regulated partially in a positive feedback loop. -- Abstract: Wnt inhibitory factor-1 (WIF-1) silencing induced by promoter hypermethylation is a common mechanism of aberrant activation of the Wnt signaling pathway in non-small-cell lung cancer (NSCLC). However, the activity of regulators associated with the methylation of the WIF-1 gene remains unclear. Here, we investigated the role of three DNAmore »« less
DOI: 10.1016/J.BBRC.2013.07.123
Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis

Journal Article Li, Pengfei ; Guo, Youming ; Bledsoe, Grant ; ... - Experimental Cell Research

Kallistatin is an endogenous protein that regulates differential signaling pathways and biological functions. Our previous studies showed that kallistatin gene therapy inhibited angiogenesis, tumor growth and metastasis in mice, and kallistatin protein suppressed Wnt-mediated growth, migration and invasion by blocking Wnt/β-catenin signaling pathway in breast cancer cells. In this study, we show that kallistatin reduced cell viability, and increased apoptotic cell death and caspase-3 activity in MDA-MB-231 breast cancer cells. Kallistatin also induced cancer cell autophagy, as evidenced by increased LC3B levels and elevated Atg5 and Beclin-1 expression; however, co-administration of Wnt or PPARγ antagonist GW9662 abolished these effects. Moreover,more »« less
DOI: 10.1016/J.YEXCR.2016.01.004
Wnt signaling promotes androgen-independent prostate cancer cell proliferation through up-regulation of the hippo pathway effector YAP

Journal Article Seo, Won Ik ; Park, Seoyoung ; Gwak, Jungsug ; ... - Biochemical and Biophysical Research Communications

Aberrant up-regulation of Wnt/β-catenin signaling is associated with the development and progression of prostate cancer, but the underlying mechanism is unclear. Here we show that in the absence of androgens, the Wnt/β-catenin pathway activates AR-mediated transcription through up-regulation of the Hippo pathway effector Yes-associated protein (YAP). Wnt3a-conditioned medium (Wnt3a-CM) promotes the growth of LNCaP cells and increases AR and YAP protein levels. Moreover, Wnt3a-CM induces the nuclear translocation of YAP and the AR, but not β-catenin, thereby activating the expression of AR- and YAP-dependent genes, in an androgen-independent manner. In addition, depletion of YAP with small interfering RNA (siRNA) preventedmore »« less
DOI: 10.1016/J.BBRC.2017.03.158
Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression

Journal Article Xiao, Can ; Department of Stomatology, The First Affiliated Hospital of Soochow University, Suzhou 215006 ; Wang, Lili ; ... - Biochemical and Biophysical Research Communications

Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCCmore »« less
DOI: 10.1016/J.BBRC.2014.10.122

Similar Records

Title: Cross talk between RNA N6‐methyladenosine methyltransferase‐like 3 and miR‐186 regulates hepatoblastoma progression through Wnt/β‐catenin signalling pathway

Citation Formats

Critical Enzymatic Functions of FTO in Obesity and Cancer journal, July 2018

Apoptosis induction in K562 human myelogenous leukaemia cells is connected to the modulation of Wnt/β-catenin signalling by BHX, a novel pyrazoline derivative journal, January 2018

Caught up in a Wnt storm: Wnt signaling in cancer journal, June 2003

miRNA-30e regulates abnormal differentiation of small intestinal epithelial cells in diabetic mice by downregulating Dll4 expression journal, January 2016

Dynamic RNA modifications in disease journal, June 2014

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification journal, February 2018

N6-methyladenosine-dependent regulation of messenger RNA stability journal, November 2013

Wnt signaling and telomerase activation of hepatoblastoma: correlation with chemosensitivity and surgical resectability journal, December 2011

Natural Killer–Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms journal, December 2018

MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance journal, January 2019

Management of hepatoblastoma: an update journal, January 2014

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells journal, May 2016

RUNX3 regulates hepatocellular carcinoma cell metastasis via targeting miR-186/E-cadherin/EMT pathway journal, June 2017

MicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer journal, July 2016

N6-methyladenosine marks primary microRNAs for processing journal, March 2015

Wnt signaling and hepatocarcinogenesis: The hepatoblastoma model journal, February 2011

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2 journal, April 2018

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA journal, March 2016

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing journal, June 2016

Reduced m6A mRNA methylation is correlated with the progression of human cervical cancer journal, October 2017

miR‐186 inhibits proliferation, migration, and epithelial‐mesenchymal transition in breast cancer cells by targeting Twist1 journal, December 2018

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway journal, September 2019

Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer journal, December 2017

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism journal, May 2018

Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: a Chinese population-based study journal, September 2016

β-catenin regulates IRF3-mediated innate immune signalling in colorectal cancer journal, July 2018

MicroRNA expression and its clinical implications in Ewing's sarcoma journal, December 2014

Increased N6-methyladenosine causes infertility is associated with FTO expression journal, March 2018

METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion journal, January 2016

Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential journal, May 2016

MeT-DB V2.0: elucidating context-specific functions of N6-methyl-adenosine methyltranscriptome journal, November 2017

MiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1 journal, August 2015

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6 ‐methyladenosine‐dependent primary MicroRNA processing journal, December 2016

HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g journal, February 2018

The Role of MicroRNAs in Hepatoblastoma Tumors journal, March 2019

MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma journal, February 2011

MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma journal, March 2016

Effects of Wnt/β-catenin signalling on proliferation and differentiation of apical papilla stem cells: Effects of Wnt/β-catenin signalling journal, January 2012

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network journal, January 2019

Long Noncoding RNA ANRIL Promotes Cervical Cancer Development by Acting as a Sponge of miR-186 journal, April 2018

m6A Facilitates eIF4F-Independent mRNA Translation journal, November 2017

Novel Advances in Understanding of Molecular Pathogenesis of Hepatoblastoma: A Wnt/β-Catenin Perspective journal, February 2017

Critical Enzymatic Functions of FTO in Obesity and Cancer
journal, July 2018

Apoptosis induction in K562 human myelogenous leukaemia cells is connected to the modulation of Wnt/β-catenin signalling by BHX, a novel pyrazoline derivative
journal, January 2018

Caught up in a Wnt storm: Wnt signaling in cancer
journal, June 2003

miRNA-30e regulates abnormal differentiation of small intestinal epithelial cells in diabetic mice by downregulating Dll4 expression
journal, January 2016

Dynamic RNA modifications in disease
journal, June 2014

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification
journal, February 2018

N6-methyladenosine-dependent regulation of messenger RNA stability
journal, November 2013

Wnt signaling and telomerase activation of hepatoblastoma: correlation with chemosensitivity and surgical resectability
journal, December 2011

Natural Killer–Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms
journal, December 2018

MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance
journal, January 2019

Management of hepatoblastoma: an update
journal, January 2014

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
journal, May 2016

RUNX3 regulates hepatocellular carcinoma cell metastasis via targeting miR-186/E-cadherin/EMT pathway
journal, June 2017

MicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer
journal, July 2016

N6-methyladenosine marks primary microRNAs for processing
journal, March 2015

Wnt signaling and hepatocarcinogenesis: The hepatoblastoma model
journal, February 2011

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
journal, April 2018

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
journal, March 2016

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing
journal, June 2016

Reduced m⁶A mRNA methylation is correlated with the progression of human cervical cancer
journal, October 2017

miR‐186 inhibits proliferation, migration, and epithelial‐mesenchymal transition in breast cancer cells by targeting Twist1
journal, December 2018

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway
journal, September 2019

Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer
journal, December 2017

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
journal, May 2018

Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: a Chinese population-based study
journal, September 2016

β-catenin regulates IRF3-mediated innate immune signalling in colorectal cancer
journal, July 2018

MicroRNA expression and its clinical implications in Ewing's sarcoma
journal, December 2014

Increased N6-methyladenosine causes infertility is associated with FTO expression
journal, March 2018

METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
journal, January 2016

Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential
journal, May 2016

MeT-DB V2.0: elucidating context-specific functions of N6-methyl-adenosine methyltranscriptome
journal, November 2017

MiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1
journal, August 2015

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6 ‐methyladenosine‐dependent primary MicroRNA processing
journal, December 2016

HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g
journal, February 2018

The Role of MicroRNAs in Hepatoblastoma Tumors
journal, March 2019

MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma
journal, February 2011

MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma
journal, March 2016

Effects of Wnt/β-catenin signalling on proliferation and differentiation of apical papilla stem cells: Effects of Wnt/β-catenin signalling
journal, January 2012

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
journal, January 2019

Long Noncoding RNA ANRIL Promotes Cervical Cancer Development by Acting as a Sponge of miR-186
journal, April 2018

m6A Facilitates eIF4F-Independent mRNA Translation
journal, November 2017

Novel Advances in Understanding of Molecular Pathogenesis of Hepatoblastoma: A Wnt/β-Catenin Perspective
journal, February 2017