Association between maternal occupational exposure to polycyclic aromatic hydrocarbons and rare birth defects of the face and central nervous system
Abstract
Abstract Background Previous studies suggested associations between maternal smoking, a source of exposure to polycyclic aromatic hydrocarbons (PAHs) and other chemicals, and central nervous system and face birth defects; however, no previous studies have evaluated maternal occupational PAH exposure itself. Methods Jobs held in the periconceptional period were retrospectively assigned for occupational PAH exposures. Associations between maternal occupational PAH exposure and selected rare defects of the face (cataracts, microphthalmia, glaucoma, microtia, and choanal atresia) and central nervous system (holoprosencephaly, hydrocephaly, cerebellar hypoplasia, and Dandy‐Walker malformation) were evaluated using data from the National Birth Defects Prevention Study, a population‐based case–control study in the United States. Crude and adjusted odds ratios (ORs) with 95% confidence intervals were calculated to estimate associations between each evaluated defect and PAH exposure using multivariable logistic regression. Results Food and beverage serving, as well as cooks and food preparation occupations, were among the most frequent jobs held by exposed mothers. Cataracts, microtia, microphthalmia, and holoprosencephaly were significantly associated with PAH exposure with evidence of dose–response ( P ‐values for trend ≤.05). Hydrocephaly was associated with any PAH exposure, but not significant for trend. Sensitivity analyses that reduced possible sources of exposure misclassification tended to strengthen associations. Conclusionsmore »
- Authors:
-
- Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Cincinnati Ohio
- College of Public Health, University of Kentucky Lexington Kentucky
- Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services Austin Texas
- Centers for Disease Control and Prevention National Center on Birth Defects and Developmental Disabilities Atlanta Georgia
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1582691
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Birth Defects Research
- Additional Journal Information:
- Journal Name: Birth Defects Research Journal Volume: 112 Journal Issue: 5; Journal ID: ISSN 2472-1727
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Citation Formats
Santiago‐Colón, Albeliz, Rocheleau, Carissa M., Chen, I‐Chen, Sanderson, Wayne, Waters, Martha A., Lawson, Christina C., Langlois, Peter H., Cragan, Janet D., Reefhuis, Jennita, and the National Birth Defects Prevention Study. Association between maternal occupational exposure to polycyclic aromatic hydrocarbons and rare birth defects of the face and central nervous system. Country unknown/Code not available: N. p., 2020.
Web. doi:10.1002/bdr2.1643.
Santiago‐Colón, Albeliz, Rocheleau, Carissa M., Chen, I‐Chen, Sanderson, Wayne, Waters, Martha A., Lawson, Christina C., Langlois, Peter H., Cragan, Janet D., Reefhuis, Jennita, & the National Birth Defects Prevention Study. Association between maternal occupational exposure to polycyclic aromatic hydrocarbons and rare birth defects of the face and central nervous system. Country unknown/Code not available. https://doi.org/10.1002/bdr2.1643
Santiago‐Colón, Albeliz, Rocheleau, Carissa M., Chen, I‐Chen, Sanderson, Wayne, Waters, Martha A., Lawson, Christina C., Langlois, Peter H., Cragan, Janet D., Reefhuis, Jennita, and the National Birth Defects Prevention Study. Tue .
"Association between maternal occupational exposure to polycyclic aromatic hydrocarbons and rare birth defects of the face and central nervous system". Country unknown/Code not available. https://doi.org/10.1002/bdr2.1643.
@article{osti_1582691,
title = {Association between maternal occupational exposure to polycyclic aromatic hydrocarbons and rare birth defects of the face and central nervous system},
author = {Santiago‐Colón, Albeliz and Rocheleau, Carissa M. and Chen, I‐Chen and Sanderson, Wayne and Waters, Martha A. and Lawson, Christina C. and Langlois, Peter H. and Cragan, Janet D. and Reefhuis, Jennita and the National Birth Defects Prevention Study},
abstractNote = {Abstract Background Previous studies suggested associations between maternal smoking, a source of exposure to polycyclic aromatic hydrocarbons (PAHs) and other chemicals, and central nervous system and face birth defects; however, no previous studies have evaluated maternal occupational PAH exposure itself. Methods Jobs held in the periconceptional period were retrospectively assigned for occupational PAH exposures. Associations between maternal occupational PAH exposure and selected rare defects of the face (cataracts, microphthalmia, glaucoma, microtia, and choanal atresia) and central nervous system (holoprosencephaly, hydrocephaly, cerebellar hypoplasia, and Dandy‐Walker malformation) were evaluated using data from the National Birth Defects Prevention Study, a population‐based case–control study in the United States. Crude and adjusted odds ratios (ORs) with 95% confidence intervals were calculated to estimate associations between each evaluated defect and PAH exposure using multivariable logistic regression. Results Food and beverage serving, as well as cooks and food preparation occupations, were among the most frequent jobs held by exposed mothers. Cataracts, microtia, microphthalmia, and holoprosencephaly were significantly associated with PAH exposure with evidence of dose–response ( P ‐values for trend ≤.05). Hydrocephaly was associated with any PAH exposure, but not significant for trend. Sensitivity analyses that reduced possible sources of exposure misclassification tended to strengthen associations. Conclusions This is the first population‐based case–control study to evaluate associations between maternal occupational PAH exposures and these rare birth defects of the central nervous system and face.},
doi = {10.1002/bdr2.1643},
journal = {Birth Defects Research},
number = 5,
volume = 112,
place = {Country unknown/Code not available},
year = {Tue Jan 14 00:00:00 EST 2020},
month = {Tue Jan 14 00:00:00 EST 2020}
}
https://doi.org/10.1002/bdr2.1643
Web of Science
Works referenced in this record:
Risk factors for cytogenetically normal holoprosencephaly in California: A population-based case-control study
journal, February 2000
- Croen, Lisa A.; Shaw, Gary M.; Lammer, Edward J.
- American Journal of Medical Genetics, Vol. 90, Issue 4
Prepregnancy Obesity as a Risk Factor for Structural Birth Defects
journal, August 2007
- Waller, D. Kim
- Archives of Pediatrics & Adolescent Medicine, Vol. 161, Issue 8
Risk factors for Dandy-Walker malformation: A population-based assessment
journal, May 2015
- Reeder, Matthew R.; Botto, Lorenzo D.; Keppler-Noreuil, Kim M.
- American Journal of Medical Genetics Part A, Vol. 167, Issue 9
Inter-Rater Reliability of Assessed Prenatal Maternal Occupational Exposures to Solvents, Polycyclic Aromatic Hydrocarbons, and Heavy Metals
journal, December 2011
- Rocheleau, Carissa M.; Lawson, Christina C.; Waters, Martha A.
- Journal of Occupational and Environmental Hygiene, Vol. 8, Issue 12
Epidemiologic characteristics of anotia and microtia in California, 1989-1997
journal, July 2004
- Shaw, Gary M.; Carmichael, Suzan L.; Kaidarova, Zhanna
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 70, Issue 7
Control Selection and Participation in an Ongoing, Population-based, Case-Control Study of Birth Defects
journal, September 2009
- Cogswell, Mary E.; Bitsko, Rebecca H.; Anderka, Marlene
- American Journal of Epidemiology, Vol. 170, Issue 8
Agreement between qualitative exposure estimates and quantitative exposure measurements
journal, January 1987
- Kromhout, Hans; Oostendorp, Yvette; Heederik, Dick
- American Journal of Industrial Medicine, Vol. 12, Issue 5
Population-based case-control study of isolated congenital cataract
journal, December 2005
- Vogt, Gábor; Puhó, Erzsébet; Czeizel, Andrew E.
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 73, Issue 12
Maternal Overweight and Obesity and the Risk of Congenital Anomalies: A Systematic Review and Meta-analysis
journal, February 2009
- Stothard, Katherine J.; Tennant, Peter W. G.; Bell, Ruth
- JAMA, Vol. 301, Issue 6
The National Birth Defects Prevention Study
journal, January 2001
- Yoon, Pw; Rasmussen, Sa; Lynberg, Mc
- Public Health Reports, Vol. 116, Issue 1_suppl
A review on polycyclic aromatic hydrocarbons: Source, environmental impact, effect on human health and remediation
journal, March 2016
- Abdel-Shafy, Hussein I.; Mansour, Mona S. M.
- Egyptian Journal of Petroleum, Vol. 25, Issue 1
Descriptive and risk factor analysis for choanal atresia: The National Birth Defects Prevention Study, 1997–2007
journal, April 2014
- Kancherla, Vijaya; Romitti, Paul A.; Sun, Lixian
- European Journal of Medical Genetics, Vol. 57, Issue 5
Maternal environmental risk factors for congenital hydrocephalus: a systematic review
journal, November 2016
- Kalyvas, Aristotelis V.; Kalamatianos, Theodosis; Pantazi, Mantha
- Neurosurgical Focus, Vol. 41, Issue 5
Maternal Pre-Pregnancy Body Mass Index and Risk of Selected Birth Defects: Evidence of a Dose-Response Relationship: Pre-pregnancy BMI and risk of birth defects
journal, October 2013
- Block, Suzanne R.; Watkins, Sharon M.; Salemi, Jason L.
- Paediatric and Perinatal Epidemiology, Vol. 27, Issue 6
Epidemiologic features and clinical subgroups of anotia/microtia in Texas
journal, November 2009
- Canfield, Mark A.; Langlois, Peter H.; Nguyen, Ly M.
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 85, Issue 11
Descriptive Epidemiology of Infantile Cataracts in Metropolitan Atlanta, Ga, 1968-1998
journal, April 2003
- Bhatti, Tricia R.; Dott, Mary; Yoon, Paula W.
- Archives of Pediatrics & Adolescent Medicine, Vol. 157, Issue 4
Maternal Obesity and Risk for Birth Defects
journal, May 2003
- Watkins, Margaret L.; Rasmussen, Sonja A.; Honein, Margaret A.
- Pediatrics, Vol. 111, Issue Supplement_1
Maternal Obesity, Gestational Diabetes, and Central Nervous System Birth Defects
journal, January 2005
- Anderson, James L.; Waller, D. Kim; Canfield, Mark A.
- Epidemiology, Vol. 16, Issue 1
The relationship between prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAHs) and PAH–DNA adducts in cord blood
journal, January 2013
- Jedrychowski, Wieslaw A.; Perera, Frederica P.; Tang, Deliang
- Journal of Exposure Science & Environmental Epidemiology, Vol. 23, Issue 4
Holoprosencephaly: Epidemiologic and clinical characteristics of a California population
journal, August 1996
- Croen, Lisa A.; Shaw, Gary M.; Lammer, Edward J.
- American Journal of Medical Genetics, Vol. 64, Issue 3
Epidemiology and genetics of microtia-anotia: a registry based study on over one million births.
journal, June 1995
- Mastroiacovo, P.; Corchia, C.; Botto, L. D.
- Journal of Medical Genetics, Vol. 32, Issue 6
Assessment of Risk Factors for Infantile Cataracts Using a Case-Control Study
journal, August 2010
- Prakalapakorn, Sasapin G.; Rasmussen, Sonja A.; Lambert, Scott R.
- Ophthalmology, Vol. 117, Issue 8
Risk factors for non-syndromic holoprosencephaly in the National Birth Defects Prevention Study
journal, February 2010
- Miller, Eric A.; Rasmussen, Sonja A.; Siega-Riz, Anna Maria
- American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Vol. 154C, Issue 1
The national birth defects prevention study: A review of the methods: NBDPS METHODS REVIEW
journal, June 2015
- Reefhuis, Jennita; Gilboa, Suzanne M.; Anderka, Marlene
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 103, Issue 8
Risk factors for congenital hydrocephalus: a nationwide, register-based, cohort study
journal, March 2014
- Munch, T. N.; Rasmussen, M. -L. H.; Wohlfahrt, J.
- Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85, Issue 11
Maternal occupational exposure to polycyclic aromatic hydrocarbons and risk of neural tube defect-affected pregnancies
journal, July 2012
- Langlois, Peter H.; Hoyt, Adrienne T.; Lupo, Philip J.
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 94, Issue 9
Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Risk of Oral Cleft-Affected Pregnancies
journal, May 2013
- Langlois, Peter H.; Hoyt, Adrienne T.; Lupo, Philip J.
- The Cleft Palate-Craniofacial Journal, Vol. 50, Issue 3
Evaluation of reports of periconceptual occupational exposure: Maternal-assessed versus industrial hygienist-assessed exposure
journal, November 1999
- Bauer, Eric P.; Romitti, Paul A.; Reynolds, Stephen J.
- American Journal of Industrial Medicine, Vol. 36, Issue 5
Descriptive epidemiology of holoprosencephaly and arhinencephaly in metropolitan Atlanta, 1968–1992
journal, December 1996
- Rasmussen, Sonja A.; Moore, Cynthia A.; Khoury, Muin J.
- American Journal of Medical Genetics, Vol. 66, Issue 3
Polycyclic Aromatic Hydrocarbon (PAH) Exposure and DNA Adduct Semi-Quantitation in Archived Human Tissues
journal, June 2011
- Pratt, M. Margaret; John, Kaarthik; MacLean, Allan B.
- International Journal of Environmental Research and Public Health, Vol. 8, Issue 7
Maternal occupation and the risk of birth defects: an overview from the National Birth Defects Prevention Study
journal, December 2009
- Herdt-Losavio, M. L.; Lin, S.; Chapman, B. R.
- Occupational and Environmental Medicine, Vol. 67, Issue 1
Environmental and Genetic Factors Associated with Congenital Microtia: A Case-Control Study in Jiangsu, China, 2004 to 2007
journal, January 2009
- Zhang, Qing-guo; Zhang, Jiao; Yu, Pei
- Plastic and Reconstructive Surgery, Vol. 124, Issue 4
Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the national birth defects prevention study: MATERNAL EXPOSURE TO PAHs AND CRANIOSYNOSTOSIS
journal, June 2015
- O'Brien, Jacqueline L.; Langlois, Peter H.; Lawson, Christina C.
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 106, Issue 1
A population-based case-control study of isolated primary congenital glaucoma
journal, January 2006
- Vogt, Gábor; Horváth-Puhó, Erzsébet; Czeizel, Andrew E.
- American Journal of Medical Genetics Part A, Vol. 140A, Issue 11
Epidemiology of holoprosencephaly and phenotypic characteristics of affected children: New York state, 1984–1989
journal, December 1997
- Olsen, Carolyn L.; Hughes, Jeffery P.; Youngblood, Lois G.
- American Journal of Medical Genetics, Vol. 73, Issue 2
Descriptive epidemiology of anophthalmia and microphthalmia, Hawaii, 1986–2001
journal, January 2006
- Forrester, Mathias B.; Merz, Ruth D.
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 76, Issue 3
Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls
journal, July 2011
- Hackshaw, A.; Rodeck, C.; Boniface, S.
- Human Reproduction Update, Vol. 17, Issue 5
Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring
journal, June 2014
- Langlois, Peter H.; Hoyt, Adrienne T.; Desrosiers, Tania A.
- Occupational and Environmental Medicine, Vol. 71, Issue 8
Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons: Effects on Gastroschisis among Offspring in the National Birth Defects Prevention Study
journal, June 2012
- Lupo, Philip J.; Langlois, Peter H.; Reefhuis, Jennita
- Environmental Health Perspectives, Vol. 120, Issue 6
Non-genetic risk factors for holoprosencephaly
journal, February 2010
- Johnson, Candice Y.; Rasmussen, Sonja A.
- American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Vol. 154C, Issue 1
Differential risks to males and females for congenital malformations among 2.5 million California births, 1989-1997
journal, December 2003
- Shaw, Gary M.; Carmichael, Suzan L.; Kaidarova, Zhanna
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol. 67, Issue 12
Inhibitory effects of cigarette smoke extract on neural crest migration occur through suppression of R-spondin1 expression via aryl hydrocarbon receptor
journal, September 2009
- Sanbe, Atsushi; Mizutani, Reiko; Miyauchi, Noriko
- Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 380, Issue 6