Modular design: Implementing proven engineering principles in biotechnology
Abstract
Modular design resides at the foundation of contemporary engineering, enabling rapid, efficient, and reproducible construction and maintenance of complex systems across applications. Remarkably, modularity has recently been discovered as a governing principle in natural biological systems from genes to proteins to complex networks within a cell and organism communities. The convergent knowledge of natural and engineered modular systems provides a key to drive modern biotechnology to address emergent challenges associated with health, food, energy, and the environment. Here, we first present the theory and application of modular design in traditional engineering fields. We further discuss the significance and impact of modular architectures on systems biology and biotechnology. Next, we focus on the very recent theoretical and experimental advances in modular cell engineering that seeks to enable rapid and systematic development of microbial catalysts capable of efficiently synthesizing a large space of useful chemicals. We conclude with an outlook towards theoretical and practical opportunities for a more systematic and effective application of modular engineering in biotechnology.
- Authors:
-
- Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Publication Date:
- Research Org.:
- Univ. of Tennessee, Knoxville, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER); National Science Foundation (NSF)
- OSTI Identifier:
- 1598476
- Alternate Identifier(s):
- OSTI ID: 1573281
- Grant/Contract Number:
- SC0019412
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Biotechnology Advances
- Additional Journal Information:
- Journal Volume: 37; Journal Issue: 7; Journal ID: ISSN 0734-9750
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Modular design; Modularity; Modular cell; Modular cell engineering; ModCell; Systems biology; Metabolic engineering; Synthetic biology; Robustness; Evolvability; Networks; Pareto optimality; Industrialization of biology; Microbial biocatalysis
Citation Formats
Garcia, Sergio, and Trinh, Cong T. Modular design: Implementing proven engineering principles in biotechnology. United States: N. p., 2019.
Web. doi:10.1016/j.biotechadv.2019.06.002.
Garcia, Sergio, & Trinh, Cong T. Modular design: Implementing proven engineering principles in biotechnology. United States. https://doi.org/10.1016/j.biotechadv.2019.06.002
Garcia, Sergio, and Trinh, Cong T. Fri .
"Modular design: Implementing proven engineering principles in biotechnology". United States. https://doi.org/10.1016/j.biotechadv.2019.06.002. https://www.osti.gov/servlets/purl/1598476.
@article{osti_1598476,
title = {Modular design: Implementing proven engineering principles in biotechnology},
author = {Garcia, Sergio and Trinh, Cong T.},
abstractNote = {Modular design resides at the foundation of contemporary engineering, enabling rapid, efficient, and reproducible construction and maintenance of complex systems across applications. Remarkably, modularity has recently been discovered as a governing principle in natural biological systems from genes to proteins to complex networks within a cell and organism communities. The convergent knowledge of natural and engineered modular systems provides a key to drive modern biotechnology to address emergent challenges associated with health, food, energy, and the environment. Here, we first present the theory and application of modular design in traditional engineering fields. We further discuss the significance and impact of modular architectures on systems biology and biotechnology. Next, we focus on the very recent theoretical and experimental advances in modular cell engineering that seeks to enable rapid and systematic development of microbial catalysts capable of efficiently synthesizing a large space of useful chemicals. We conclude with an outlook towards theoretical and practical opportunities for a more systematic and effective application of modular engineering in biotechnology.},
doi = {10.1016/j.biotechadv.2019.06.002},
journal = {Biotechnology Advances},
number = 7,
volume = 37,
place = {United States},
year = {Fri Jun 07 00:00:00 EDT 2019},
month = {Fri Jun 07 00:00:00 EDT 2019}
}
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