Overexpression of a Prefoldin β subunit gene reduces biomass recalcitrance in the bioenergy crop Populus

Zhang, Jin; Xie, Meng; Li, Mi; Ding, Jinhua; Pu, Yunqiao; Bryan, Anthony C.; Rottmann, William; Winkeler, Kimberly A.; Collins, Cassandra M.; Singan, Vasanth; Lindquist, Erika A.; Jawdy, Sara S.; Gunter, Lee E.; Engle, Nancy L.; Yang, Xiaohan; Barry, Kerrie; Tschaplinski, Timothy J.; Schmutz, Jeremy; Tuskan, Gerald A.; Muchero, Wellington; Chen, Jin‐Gui

doi:10.1111/pbi.13254

Title: Overexpression of a Prefoldin β subunit gene reduces biomass recalcitrance in the bioenergy crop Populus

Journal Article · 09 September 2019 · Plant Biotechnology Journal

DOI: https://doi.org/10.1111/pbi.13254 · OSTI ID:1566924

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^[1]; Schmutz, Jeremy ^[7];

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Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
Univ. of Tennessee, Knoxville, TN (United States)
Univ. of Tennessee, Knoxville, TN (United States); Donghua Univ., Shanghai (China)
ArborGen Inc., Ridgeville, SC (United States)
USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States)
USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); HudsonAlpha Inst. for Biotechnology, Huntsville, AL (United States)

Prefoldin (PFD) is a group II chaperonin that is ubiquitously present in the eukaryotic kingdom. Six subunits (PFD1-6) form a jellyfish-like heterohexameric PFD complex and function in protein folding and cytoskeleton organization. However, little is known about its function in plant cell wall-related processes. Here, we report the functional characterization of a PFD gene from Populus deltoides, designated as PdPFD2.2. There are two copies of PFD2 in Populus, and PdPFD2.2 was ubiquitously expressed with high transcript abundance in the cambial region. PdPFD2.2 can physically interact with DELLA protein RGA1_8g, and its subcellular localization is affected by the interaction. In P. deltoides transgenic plants overexpressing PdPFD2.2, the lignin syringyl/guaiacyl ratio was increased, but cellulose content and crystallinity index were unchanged. In addition, the total released sugar (glucose and xylose) amounts were increased by 7.6% and 6.1%, respectively, in two transgenic lines. Transcriptomic and metabolomic analyses revealed that secondary metabolic pathways, including lignin and flavonoid biosynthesis, were affected by overexpressing PdPFD2.2. A total of eight hub transcription factors (TFs) were identified based on TF binding sites of differentially expressed genes in Populus transgenic plants overexpressing PdPFD2.2. In addition, several known cell wall-related TFs, such as MYB3, MYB4, MYB7, TT8 and XND1, were affected by overexpression of PdPFD2.2. These results suggest that overexpression of PdPFD2.2 can reduce biomass recalcitrance and PdPFD2.2 is a promising target for genetic engineering to improve feedstock characteristics to enhance biofuel conversion and reduce the cost of lignocellulosic biofuel production.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231; AC05-00OR22725; AC02‐05CH1123; AC02‐05CH11231; AC05‐00OR22725

OSTI ID:: 1566924

Alternate ID(s):: OSTI ID: 1561676; OSTI ID: 1566925; OSTI ID: 1616121

Journal Information:: Plant Biotechnology Journal, Vol. 18, Issue 3; ISSN 1467-7644

Publisher:: Society for Experimental Biology; Association of Applied BiologyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 14 works

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59 BASIC BIOLOGICAL SCIENCES
Populus
prefoldin
biofuels
cell wall reclcitrance
lignin
S/G ratio
transcriptome
metabolome
09 BIOMASS FUELS
cell wall recalcitrance

Title: Overexpression of a Prefoldin β subunit gene reduces biomass recalcitrance in the bioenergy crop Populus

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