Enhanced mitochondrial inhibition by 3,4‐dihydroxyphenyl‐acetaldehyde (DOPAL)‐oligomerized α‐synuclein
- Authors:
-
- Department of Psychiatry &, Biobehavioral Sciences, David Geffen School of Medicine at UCLA UCLA Los Angeles California
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1564448
- Grant/Contract Number:
- FC02-02ER63421
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Journal of Neuroscience Research
- Additional Journal Information:
- Journal Name: Journal of Neuroscience Research; Journal ID: ISSN 0360-4012
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Sarafian, Theodore A., Yacoub, Amneh, Kunz, Anastasia, Aranki, Burkan, Serobyan, Grigor, Cohn, Whitaker, Whitelegge, Julian P., and Watson, Joseph B. Enhanced mitochondrial inhibition by 3,4‐dihydroxyphenyl‐acetaldehyde (DOPAL)‐oligomerized α‐synuclein. United States: N. p., 2019.
Web. doi:10.1002/jnr.24513.
Sarafian, Theodore A., Yacoub, Amneh, Kunz, Anastasia, Aranki, Burkan, Serobyan, Grigor, Cohn, Whitaker, Whitelegge, Julian P., & Watson, Joseph B. Enhanced mitochondrial inhibition by 3,4‐dihydroxyphenyl‐acetaldehyde (DOPAL)‐oligomerized α‐synuclein. United States. https://doi.org/10.1002/jnr.24513
Sarafian, Theodore A., Yacoub, Amneh, Kunz, Anastasia, Aranki, Burkan, Serobyan, Grigor, Cohn, Whitaker, Whitelegge, Julian P., and Watson, Joseph B. Fri .
"Enhanced mitochondrial inhibition by 3,4‐dihydroxyphenyl‐acetaldehyde (DOPAL)‐oligomerized α‐synuclein". United States. https://doi.org/10.1002/jnr.24513.
@article{osti_1564448,
title = {Enhanced mitochondrial inhibition by 3,4‐dihydroxyphenyl‐acetaldehyde (DOPAL)‐oligomerized α‐synuclein},
author = {Sarafian, Theodore A. and Yacoub, Amneh and Kunz, Anastasia and Aranki, Burkan and Serobyan, Grigor and Cohn, Whitaker and Whitelegge, Julian P. and Watson, Joseph B.},
abstractNote = {},
doi = {10.1002/jnr.24513},
journal = {Journal of Neuroscience Research},
number = ,
volume = ,
place = {United States},
year = {Fri Aug 16 00:00:00 EDT 2019},
month = {Fri Aug 16 00:00:00 EDT 2019}
}
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Works referenced in this record:
The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species
journal, March 2017
- Bordt, Evan A.; Clerc, Pascaline; Roelofs, Brian A.
- Developmental Cell, Vol. 40, Issue 6
A Water Soluble CoQ10 Formulation Improves Intracellular Distribution and Promotes Mitochondrial Respiration in Cultured Cells
journal, March 2012
- Bergamini, Christian; Moruzzi, Noah; Sblendido, Antonella
- PLoS ONE, Vol. 7, Issue 3
Ginsenoside Rd Protects SH-SY5Y Cells against 1-Methyl-4-phenylpyridinium Induced Injury
journal, June 2015
- Liu, Yang; Zhang, Ren-Yu; Zhao, Jun
- International Journal of Molecular Sciences, Vol. 16, Issue 12
Mitochondrial dysfunction in Parkinson's disease
journal, August 2016
- Bose, Anindita; Beal, M. Flint
- Journal of Neurochemistry, Vol. 139
Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s disease
journal, August 2017
- Bido, Simone; Soria, Federico N.; Fan, Rebecca Z.
- Scientific Reports, Vol. 7, Issue 1
V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis
journal, January 1999
- Lemasters, John J.
- American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 276, Issue 1
Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease
journal, December 2012
- Fitzmaurice, A. G.; Rhodes, S. L.; Lulla, A.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 2
Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein: Fibrillated α-Syn Enhances Synaptic Glutamate
journal, January 2017
- Sarafian, Theodore A.; Littlejohn, Kaitlyn; Yuan, Sarah
- Journal of Neuroscience Research, Vol. 95, Issue 9
Stabilization of Alpha-Synuclein Oligomers In Vitro by the Neurotransmitters, Dopamine and Norepinephrine: The Effect of Oxidized Catecholamines
journal, May 2015
- Fischer, Andrew F.; Matera, Kathryn Mansfield
- Neurochemical Research, Vol. 40, Issue 7
The genetics and neuropathology of Parkinson’s disease
journal, July 2012
- Houlden, Henry; Singleton, Andrew B.
- Acta Neuropathologica, Vol. 124, Issue 3
S-methyl N-butylthiocarbamate sulfoxide
journal, November 1999
- Staub, Richard E.; Quistad, Gary B.; Casida, John E.
- Biochemical Pharmacology, Vol. 58, Issue 9
Ginsenoside Re protects against phencyclidine-induced behavioral changes and mitochondrial dysfunction via interactive modulation of glutathione peroxidase-1 and NADPH oxidase in the dorsolateral cortex of mice
journal, December 2017
- Tran, The-Vinh; Shin, Eun-Joo; Dang, Duy-Khanh
- Food and Chemical Toxicology, Vol. 110
High Stability and Cooperative Unfolding of α-Synuclein Oligomers
journal, September 2014
- Paslawski, Wojciech; Andreasen, Maria; Nielsen, Søren Bang
- Biochemistry, Vol. 53, Issue 39
Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human α-Synuclein
journal, May 2013
- Sarafian, Theodore A.; Ryan, Christopher M.; Souda, Puneet
- PLoS ONE, Vol. 8, Issue 5
Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils
journal, February 2015
- Ardah, Mustafa T.; Paleologou, Katerina E.; Lv, Guohua
- Neurobiology of Disease, Vol. 74
Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity
journal, March 2007
- Leung, K. W.; Yung, K. K. L.; Mak, N. K.
- Neuropharmacology, Vol. 52, Issue 3
Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
journal, March 2015
- Gallegos, Scarlet; Pacheco, Carla; Peters, Christian
- Frontiers in Neuroscience, Vol. 9
Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria
journal, April 2001
- Kristal, B.
- Free Radical Biology and Medicine, Vol. 30, Issue 8
Cytotoxic and genotoxic potential of dopamine
journal, March 1999
- Stokes, Alan H.; Hastings, Teresa G.; Vrana, Kent E.
- Journal of Neuroscience Research, Vol. 55, Issue 6
Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions
journal, March 2010
- Zhou, Wenbo; Long, Chunmei; Reaney, Stephen H.
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1802, Issue 3
Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
journal, February 2008
- Devi, Latha; Raghavendran, Vijayendran; Prabhu, Badanavalu M.
- Journal of Biological Chemistry, Vol. 283, Issue 14
Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease
journal, October 2012
- Goldstein, David S.; Sullivan, Patti; Cooney, Adele
- Journal of Neurochemistry, Vol. 123, Issue 6
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
journal, June 2015
- Peelaerts, W.; Bousset, L.; Van der Perren, A.
- Nature, Vol. 522, Issue 7556
Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential
journal, December 2015
- Hong, Minho; Song, Ki Duk; Lee, Hak-Kyo
- In Vitro Cellular & Developmental Biology - Animal, Vol. 52, Issue 3
The Convergence of Dopamine and α-Synuclein: Implications for Parkinson’s Disease
journal, January 2018
- Mor, Danielle E.; Ischiropoulos, Harry
- Journal of Experimental Neuroscience, Vol. 12
Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein
journal, October 2014
- Subramaniam, Sudhakar Raja; Vergnes, Laurent; Franich, Nicholas R.
- Neurobiology of Disease, Vol. 70
Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein
journal, May 2016
- Werner-Allen, Jon W.; DuMond, Jenna F.; Levine, Rodney L.
- Angewandte Chemie International Edition, Vol. 55, Issue 26
Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo
journal, August 2008
- Nakajima, Yoshimi; Inokuchi, Yuta; Nishi, Masahiro
- Brain Research, Vol. 1226
Parkinson’s Disease: Mitochondrial Molecular Pathology, Inflammation, Statins, and Therapeutic Neuroprotective Nutrition
journal, August 2010
- Kones, Richard
- Nutrition in Clinical Practice, Vol. 25, Issue 4
Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified α-synuclein
journal, October 2018
- Carmo-Gonçalves, Phelippe; do Nascimento, Lucas Alex; Cortines, Juliana R.
- Biochemical and Biophysical Research Communications, Vol. 505, Issue 1
Parkinson's Disease
journal, September 2003
- Dauer, William; Przedborski, Serge
- Neuron, Vol. 39, Issue 6
Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson’s Disease
journal, November 2017
- Helley, Martin P.; Pinnell, Jennifer; Sportelli, Carolina
- Frontiers in Genetics, Vol. 8
Reversible Inhibition of α-Synuclein Fibrillization by Dopaminochrome-mediated Conformational Alterations
journal, April 2005
- Norris, Erin H.; Giasson, Benoit I.; Hodara, Roberto
- Journal of Biological Chemistry, Vol. 280, Issue 22
Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson’s disease: a case for the selective vulnerability of the substantia nigra
journal, June 2006
- Galvin, James E.
- Acta Neuropathologica, Vol. 112, Issue 2
To mdivi-1 or not to mdivi-1: Is that the question?: mdivi-1 as a Fission Inhibitor
journal, August 2017
- Smith, George; Gallo, Gianluca
- Developmental Neurobiology, Vol. 77, Issue 11
Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane
journal, February 2015
- Pacheco, Carla R.; Morales, Camila N.; Ramírez, Alejandra E.
- Journal of Neurochemistry, Vol. 132, Issue 6
Mitochondrial association of alpha-synuclein causes oxidative stress
journal, February 2008
- Parihar, M. S.; Parihar, A.; Fujita, M.
- Cellular and Molecular Life Sciences, Vol. 65, Issue 7-8
DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function
journal, January 2017
- Plotegher, N.; Berti, G.; Ferrari, E.
- Scientific Reports, Vol. 7, Issue 1
In vivo demonstration that -synuclein oligomers are toxic
journal, February 2011
- Winner, B.; Jappelli, R.; Maji, S. K.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 10
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
journal, June 2016
- Di Maio, Roberto; Barrett, Paul J.; Hoffman, Eric K.
- Science Translational Medicine, Vol. 8, Issue 342
Protein Reactivity of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite, Is Dependent on Both the Aldehyde and the Catechol
journal, July 2009
- Rees, Jennifer N.; Florang, Virginia R.; Eckert, Laurie L.
- Chemical Research in Toxicology, Vol. 22, Issue 7
The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes
journal, December 2013
- Lorenzen, Nikolai; Lemminger, Lasse; Pedersen, Jannik Nedergaard
- FEBS Letters, Vol. 588, Issue 3
Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity
journal, December 2014
- Luth, Eric S.; Bartels, Tim; Dettmer, Ulf
- Biochemistry, Vol. 54, Issue 2
Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease
journal, July 2014
- Casida, John E.; Ford, Breanna; Jinsmaa, Yunden
- Chemical Research in Toxicology, Vol. 27, Issue 8
α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease
journal, June 2015
- Rostovtseva, Tatiana K.; Gurnev, Philip A.; Protchenko, Olga
- Journal of Biological Chemistry, Vol. 290, Issue 30
New insights into the complex role of mitochondria in Parkinson’s disease
journal, June 2019
- Grünewald, Anne; Kumar, Kishore R.; Sue, Carolyn M.
- Progress in Neurobiology, Vol. 177
Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
journal, July 2015
- Mahul-Mellier, A-L; Vercruysse, F.; Maco, B.
- Cell Death & Differentiation, Vol. 22, Issue 12
A new method for purification of recombinant human α-synuclein in Escherichia coli
journal, July 2005
- Huang, Chunjuan; Ren, Guoping; Zhou, Hui
- Protein Expression and Purification, Vol. 42, Issue 1
Products of Cu( ii )-catalyzed oxidation of α-synuclein fragments containing M 1 -D 2 and H 50 residues in the presence of hydrogen peroxide
journal, January 2008
- Kowalik-Jankowska, Teresa; Rajewska, Anna; Jankowska, Elżbieta
- Dalton Trans., Issue 6
Fenofibrate Impairs Rat Mitochondrial Function by Inhibition of Respiratory Complex I
journal, May 2004
- Brunmair, Barbara; Lest, Andrea; Staniek, Katrin
- Journal of Pharmacology and Experimental Therapeutics, Vol. 311, Issue 1
High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria
journal, July 2011
- Rogers, George W.; Brand, Martin D.; Petrosyan, Susanna
- PLoS ONE, Vol. 6, Issue 7
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
journal, June 2018
- Ludtmann, Marthe H. R.; Angelova, Plamena R.; Horrocks, Mathew H.
- Nature Communications, Vol. 9, Issue 1
Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein
journal, March 2015
- Roberts, Hazel; Brown, David
- Biomolecules, Vol. 5, Issue 2
Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease
journal, July 2013
- Goldstein, David S.; Sullivan, Patti; Holmes, Courtney
- Journal of Neurochemistry, Vol. 126, Issue 5
Methionine oxidation, α-synuclein and Parkinson's disease
journal, January 2005
- Glaser, Charles B.; Yamin, Ghiam; Uversky, Vladimir N.
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1703, Issue 2
Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?
journal, March 2018
- Post, Michael R.; Lieberman, Ori J.; Mosharov, Eugene V.
- Frontiers in Neuroscience, Vol. 12
Neuropathology of Parkinsonʼs Disease
journal, January 1996
- Forno, Lysia S.
- Journal of Neuropathology and Experimental Neurology, Vol. 55, Issue 3
Catechols in post-mortem brain of patients with Parkinson disease: Brain catechols in Parkinson disease
journal, November 2010
- Goldstein, D. S.; Sullivan, P.; Holmes, C.
- European Journal of Neurology, Vol. 18, Issue 5
Kinetic Stabilization of the alpha -Synuclein Protofibril by a Dopamine-alpha -Synuclein Adduct
journal, November 2001
- Conway, K. A.
- Science, Vol. 294, Issue 5545
3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson’s disease pathogenesis
journal, November 2003
- Burke, William J.; Li, Shu Wen; Williams, Evelyn A.
- Brain Research, Vol. 989, Issue 2
Alterations in corticostriatal synaptic plasticity in mice overexpressing human α-synuclein
journal, March 2009
- Watson, J. B.; Hatami, A.; David, H.
- Neuroscience, Vol. 159, Issue 2
Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca 2+ -induced Mitochondrial Dysfunction
journal, June 2014
- Luth, Eric S.; Stavrovskaya, Irina G.; Bartels, Tim
- Journal of Biological Chemistry, Vol. 289, Issue 31
Function of the asparagine 74 residue of the inhibitory γ-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivo
journal, October 2011
- Tsang, Stephen H.; Woodruff, Michael L.; Hsu, Chun Wei
- Cellular Signalling, Vol. 23, Issue 10
Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of α-Synuclein
journal, February 2018
- Werner-Allen, Jonathan W.; Monti, Sarah; DuMond, Jenna F.
- Biochemistry, Vol. 57, Issue 9
Aggregation of α-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine
journal, October 2007
- Burke, William J.; Kumar, Vijaya B.; Pandey, Neeraj
- Acta Neuropathologica, Vol. 115, Issue 2
Therapeutic use of coenzyme Q 10 and coenzyme Q 10 -related compounds and formulations
journal, March 2010
- Villalba, Jose M.; Parrado, Cristina; Santos-Gonzalez, Monica
- Expert Opinion on Investigational Drugs, Vol. 19, Issue 4
C-Terminal Turn Stability Determines Assembly Differences between Aβ40 and Aβ42
journal, January 2013
- Roychaudhuri, Robin; Yang, Mingfeng; Deshpande, Atul
- Journal of Molecular Biology, Vol. 425, Issue 2
Coenzyme Q<sub>10</sub> Therapy
journal, January 2014
- Garrido-Maraver, Juan; Cordero, Mario D.; Oropesa-Ávila, Manuel
- Molecular Syndromology, Vol. 5, Issue 3-4
Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease
journal, March 2018
- Zhang, Yun-Long; Liu, Yan; Kang, Xin-Pan
- Neuropharmacology, Vol. 131
A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death
journal, June 2016
- Kim, Hwajin; Lee, Jong Youl; Park, Keon Jae
- BMC Neuroscience, Vol. 17, Issue 1
The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease
journal, December 2016
- Al-Hilaly, Youssra K.; Biasetti, Luca; Blakeman, Ben J. F.
- Scientific Reports, Vol. 6, Issue 1
ANS Binding Reveals Common Features of Cytotoxic Amyloid Species
journal, June 2010
- Bolognesi, Benedetta; Kumita, Janet R.; Barros, Teresa P.
- ACS Chemical Biology, Vol. 5, Issue 8
Assessing mitochondrial dysfunction in cells
journal, March 2011
- Brand, Martin D.; Nicholls, David G.
- Biochemical Journal, Vol. 435, Issue 2
Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols
journal, November 2013
- Camilleri, Angelique; Zarb, Claire; Caruana, Mario
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1828, Issue 11
Cytosolic Catechols Inhibit -Synuclein Aggregation and Facilitate the Formation of Intracellular Soluble Oligomeric Intermediates
journal, September 2006
- Mazzulli, J. R.; Mishizen, A. J.; Giasson, B. I.
- Journal of Neuroscience, Vol. 26, Issue 39
Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases
journal, December 2018
- Joshi, Amit U.; Mochly-Rosen, Daria
- Pharmacological Research, Vol. 138
The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis
journal, December 2010
- Panneton, W. Michael; Kumar, V. B.; Gan, Qi
- PLoS ONE, Vol. 5, Issue 12
Metal-Catalyzed Oxidation of α-Synuclein in the Presence of Copper(II) and Hydrogen Peroxide
journal, June 2000
- Paik, Seung R.; Shin, Hyun-Ju; Lee, Ju-Hyun
- Archives of Biochemistry and Biophysics, Vol. 378, Issue 2
3,4-Dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: possible role in Parkinson’s disease pathogenesis
journal, September 2001
- Li, Shu Wen; Lin, Tien-Sung; Minteer, Shelly
- Molecular Brain Research, Vol. 93, Issue 1
Mdivi-1 Protects Adult Rat Hippocampal Neural Stem Cells against Palmitate-Induced Oxidative Stress and Apoptosis
journal, September 2017
- Kim, Sehee; Kim, Chanyang; Park, Seungjoon
- International Journal of Molecular Sciences, Vol. 18, Issue 9
Understanding Parkinson's Disease
journal, January 1997
- Youdim, Moussa B. H.; Riederer, Peter
- Scientific American, Vol. 276, Issue 1
Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity
journal, September 2018
- Manczak, Maria; Kandimalla, Ramesh; Yin, Xiangling
- Human Molecular Genetics, Vol. 28, Issue 2
Superoxide is the critical driver of DOPAL autoxidation, lysyl adduct formation, and crosslinking of α-synuclein
journal, May 2017
- Werner-Allen, Jon W.; Levine, Rodney L.; Bax, Ad
- Biochemical and Biophysical Research Communications, Vol. 487, Issue 2
Oxidation of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopaminergic Metabolite, to a Semiquinone Radical and an ortho -Quinone
journal, June 2011
- Anderson, David G.; Mariappan, S. V. Santhana; Buettner, Garry R.
- Journal of Biological Chemistry, Vol. 286, Issue 30
Current perspective of mitochondrial biology in Parkinson's disease
journal, July 2018
- Ammal Kaidery, Navneet; Thomas, Bobby
- Neurochemistry International, Vol. 117
Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis
journal, May 2017
- Mahdaviani, Kiana; Benador, Ilan Y.; Su, Shi
- EMBO reports, Vol. 18, Issue 7
Mitochondrial Complex I Deficiency in Parkinson's Disease
journal, March 1990
- Schapira, A. H. V.; Cooper, J. M.; Dexter, D.
- Journal of Neurochemistry, Vol. 54, Issue 3
The usual suspects, dopamine and alpha‐synuclein, conspire to cause neurodegeneration
journal, January 2019
- Mor, Danielle E.; Daniels, Malcolm J.; Ischiropoulos, Harry
- Movement Disorders, Vol. 34, Issue 2
Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL)
journal, September 2015
- Follmer, Cristian; Coelho-Cerqueira, Eduardo; Yatabe-Franco, Danilo Y.
- Journal of Biological Chemistry, Vol. 290, Issue 46
Ginsenosides Rd and Re co-treatments improve rotenone-induced oxidative stress and mitochondrial impairment in SH-SY5Y neuroblastoma cells
journal, November 2017
- González-Burgos, E.; Fernández-Moriano, Carlos; Lozano, R.
- Food and Chemical Toxicology, Vol. 109
Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity
journal, July 2014
- Coelho-Cerqueira, Eduardo; Pinheiro, Anderson S.; Follmer, Cristian
- Bioorganic & Medicinal Chemistry Letters, Vol. 24, Issue 14