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Title: Cytoprotective metal-organic frameworks for anaerobic bacteria

Abstract

We report a strategy to uniformly wrap Morella thermoacetica bacteria with a metal-organic framework (MOF) monolayer of nanometer thickness for cytoprotection in artificial photosynthesis. The catalytic activity of the MOF enclosure toward decomposition of reactive oxygen species (ROS) reduces the death of strictly anaerobic bacteria by fivefold in the presence of 21% O 2, and enables the cytoprotected bacteria to continuously produce acetate from CO 2 fixation under oxidative stress. The high definition of the MOF–bacteria interface involving direct bonding between phosphate units on the cell surface and zirconium clusters on MOF monolayer, provides for enhancement of life throughout reproduction. The dynamic nature of the MOF wrapping allows for cell elongation and separation, including spontaneous covering of the newly grown cell surface. Finally, the open-metal sites on the zirconium clusters lead to 600 times more efficient ROS decomposition compared with zirconia nanoparticles.

Authors:
 [1];  [2];  [2];  [3];  [4]
  1. Univ. of California, Berkeley, CA (United States). Dept. of Chemistry; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division; Kavli Energy NanoSciences Inst., Berkeley, CA (United States)
  2. Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
  3. Univ. of California, Berkeley, CA (United States). Dept. of Chemistry; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division; King Abdulaziz City of Science and Technology, Riyadh (Saudi Arabia)
  4. Univ. of California, Berkeley, CA (United States). Dept. of Chemistry; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division; Univ. of California, Berkeley, CA (United States). Dept. of Materials Science and Engineering; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). fChemical Sciences Division
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC); National Aeronautics and Space Administration (NASA)
OSTI Identifier:
1561896
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 115; Journal Issue: 42; Journal ID: ISSN 0027-8424
Publisher:
National Academy of Sciences, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; cell wrapping; metal-organic frameworks; anaerobic bacteria; artificial photosynthesis; reactive oxygen species

Citation Formats

Ji, Zhe, Zhang, Hao, Liu, Hao, Yaghi, Omar M., and Yang, Peidong. Cytoprotective metal-organic frameworks for anaerobic bacteria. United States: N. p., 2018. Web. doi:10.1073/pnas.1808829115.
Ji, Zhe, Zhang, Hao, Liu, Hao, Yaghi, Omar M., & Yang, Peidong. Cytoprotective metal-organic frameworks for anaerobic bacteria. United States. doi:10.1073/pnas.1808829115.
Ji, Zhe, Zhang, Hao, Liu, Hao, Yaghi, Omar M., and Yang, Peidong. Mon . "Cytoprotective metal-organic frameworks for anaerobic bacteria". United States. doi:10.1073/pnas.1808829115. https://www.osti.gov/servlets/purl/1561896.
@article{osti_1561896,
title = {Cytoprotective metal-organic frameworks for anaerobic bacteria},
author = {Ji, Zhe and Zhang, Hao and Liu, Hao and Yaghi, Omar M. and Yang, Peidong},
abstractNote = {We report a strategy to uniformly wrap Morella thermoacetica bacteria with a metal-organic framework (MOF) monolayer of nanometer thickness for cytoprotection in artificial photosynthesis. The catalytic activity of the MOF enclosure toward decomposition of reactive oxygen species (ROS) reduces the death of strictly anaerobic bacteria by fivefold in the presence of 21% O2, and enables the cytoprotected bacteria to continuously produce acetate from CO2 fixation under oxidative stress. The high definition of the MOF–bacteria interface involving direct bonding between phosphate units on the cell surface and zirconium clusters on MOF monolayer, provides for enhancement of life throughout reproduction. The dynamic nature of the MOF wrapping allows for cell elongation and separation, including spontaneous covering of the newly grown cell surface. Finally, the open-metal sites on the zirconium clusters lead to 600 times more efficient ROS decomposition compared with zirconia nanoparticles.},
doi = {10.1073/pnas.1808829115},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 42,
volume = 115,
place = {United States},
year = {2018},
month = {10}
}

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