Caged luciferins for bioluminescent activity-based sensing
Abstract
Bioluminescence imaging is a powerful modality for in vivo imaging owing to its low background and high signal-to-noise ratio. Because bioluminescent emission occurs only upon the catalytic reaction between the luciferase enzyme and its luciferin substrate, caging luciferins with analyte-reactive triggers offers a general approach for activity-based sensing of specific biochemical processes in living systems across cell, tissue, and animal models. In this review, we summarize recent efforts in the development of synthetic caged luciferins for tracking enzyme, small molecule, and metal ion activity and their contributions to physiological and pathological processes.
- Authors:
-
[1];
[1];
[2]
- Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
- Univ. of California, Berkeley, CA (United States). Dept. of Chemistry, Dept. of Molecular and Cell Biology, Helen Willis Neuroscience Institute, and Howard Hughes Medical Institute
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Institutes of Health (NIH)
- OSTI Identifier:
- 1559227
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Current Opinion in Biotechnology
- Additional Journal Information:
- Journal Volume: 60; Journal Issue: C; Journal ID: ISSN 0958-1669
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Su, Timothy A., Bruemmer, Kevin J., and Chang, Christopher J. Caged luciferins for bioluminescent activity-based sensing. United States: N. p., 2019.
Web. doi:10.1016/j.copbio.2019.05.002.
Su, Timothy A., Bruemmer, Kevin J., & Chang, Christopher J. Caged luciferins for bioluminescent activity-based sensing. United States. https://doi.org/10.1016/j.copbio.2019.05.002
Su, Timothy A., Bruemmer, Kevin J., and Chang, Christopher J. Tue .
"Caged luciferins for bioluminescent activity-based sensing". United States. https://doi.org/10.1016/j.copbio.2019.05.002. https://www.osti.gov/servlets/purl/1559227.
@article{osti_1559227,
title = {Caged luciferins for bioluminescent activity-based sensing},
author = {Su, Timothy A. and Bruemmer, Kevin J. and Chang, Christopher J.},
abstractNote = {Bioluminescence imaging is a powerful modality for in vivo imaging owing to its low background and high signal-to-noise ratio. Because bioluminescent emission occurs only upon the catalytic reaction between the luciferase enzyme and its luciferin substrate, caging luciferins with analyte-reactive triggers offers a general approach for activity-based sensing of specific biochemical processes in living systems across cell, tissue, and animal models. In this review, we summarize recent efforts in the development of synthetic caged luciferins for tracking enzyme, small molecule, and metal ion activity and their contributions to physiological and pathological processes.},
doi = {10.1016/j.copbio.2019.05.002},
journal = {Current Opinion in Biotechnology},
number = C,
volume = 60,
place = {United States},
year = {Tue Jun 11 00:00:00 EDT 2019},
month = {Tue Jun 11 00:00:00 EDT 2019}
}
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