Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors

Kaieda, Akira; Takahashi, Masashi; Takai, Takafumi; Goto, Masayuki; Miyazaki, Takahiro; Hori, Yuri; Unno, Satoko; Kawamoto, Tomohiro; Tanaka, Toshimasa; Itono, Sachiko; Takagi, Terufumi; Hamada, Teruki; Shirasaki, Mikio; Okada, Kengo; Snell, Gyorgy; Bragstad, Ken; Sang, Bi-Ching; Uchikawa, Osamu; Miwatashi, Seiji

doi:10.1016/j.bmc.2017.12.031

Title: Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors

Journal Article · Thu Feb 01 00:00:00 UTC 2018 · Bioorganic and Medicinal Chemistry

DOI: https://doi.org/10.1016/j.bmc.2017.12.031 · OSTI ID:1548864

Kaieda, Akira;

;

; Goto, Masayuki; Miyazaki, Takahiro; Hori, Yuri; Unno, Satoko; Kawamoto, Tomohiro; Tanaka, Toshimasa; Itono, Sachiko; Takagi, Terufumi; Hamada, Teruki; Shirasaki, Mikio; Okada, Kengo; Snell, Gyorgy; Bragstad, Ken; Sang, Bi-Ching; Uchikawa, Osamu; Miwatashi, Seiji

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Sponsoring Organization:: USDOE

OSTI ID:: 1548864

Journal Information:: Bioorganic and Medicinal Chemistry, Journal Name: Bioorganic and Medicinal Chemistry Journal Issue: 3 Vol. 26; ISSN 0968-0896

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Identification, Synthesis, and Biological Evaluation of 6-[(6 R )-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5- a ]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2 H )-one (AS1940477), a Potent p38 MAP Kinase Inhibitor Asano, Toru; Yamazaki, Hitoshi; Kasahara, Chiyoshi Journal of Medicinal Chemistry, Vol. 55, Issue 17 https://doi.org/10.1021/jm3008008	journal	August 2012
Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia ^† † Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1). Verhoest, Patrick R.; Chapin, Douglas S.; Corman, Michael Journal of Medicinal Chemistry, Vol. 52, Issue 16 https://doi.org/10.1021/jm900521k	journal	August 2009
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Synthesis and Biological Activities of 4-Phenyl-5-pyridyl-1,3-thiazole Derivatives as p38 MAP Kinase Inhibitors Miwatashi, Seiji; Arikawa, Yasuyoshi; Naruo, Ken-ichi Chemical and Pharmaceutical Bulletin, Vol. 53, Issue 4 https://doi.org/10.1248/cpb.53.410	journal	January 2005
MAP Kinase p38Inhibitors: Clinical Results and an Intimate Look at Their Interactions with p38α Protein Lee, Matthew; Dominguez, Celia Current Medicinal Chemistry, Vol. 12, Issue 25 https://doi.org/10.2174/092986705774462914	journal	December 2005
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