Chemical logic of MraY inhibition by antibacterial nucleoside natural products

Mashalidis, Ellene H.; Kaeser, Benjamin; Terasawa, Yuma; Katsuyama, Akira; Kwon, Do-Yeon; Lee, Kiyoun; Hong, Jiyong; Ichikawa, Satoshi; Lee, Seok-Yong

doi:10.1038/s41467-019-10957-9

Title: Chemical logic of MraY inhibition by antibacterial nucleoside natural products

Journal Article · Tue Jul 02 04:00:00 UTC 2019 · Nature Communications

DOI: https://doi.org/10.1038/s41467-019-10957-9 · OSTI ID:1544864

Mashalidis, Ellene H. ^[1]; Kaeser, Benjamin ^[1]; Terasawa, Yuma ^[2];

^[2]; Kwon, Do-Yeon ^[3]; Lee, Kiyoun ^[4];

^[3]; Ichikawa, Satoshi ^[2];

^[1]

Duke Univ. Medical Center, Durham, NC (United States)
Hokkaido Univ., Sapporo (Japan)
Duke Univ., Durham, NC (United States)
The Catholic Univ. of Korea, Bucheon (Korea)

Novel antibacterial agents are needed to address the emergence of global antibiotic resistance. MraY is a promising candidate for antibiotic development because it is the target of five classes of naturally occurring nucleoside inhibitors with potent antibacterial activity. Although these natural products share a common uridine moiety, their core structures vary substantially and they exhibit different activity profiles. An incomplete understanding of the structural and mechanistic basis of MraY inhibition has hindered the translation of these compounds to the clinic. Here we present crystal structures of MraY in complex with representative members of the liposidomycin/caprazamycin, capuramycin, and mureidomycin classes of nucleoside inhibitors. Our structures reveal cryptic druggable hot spots in the shallow inhibitor binding site of MraY that were not previously appreciated. Structural analyses of nucleoside inhibitor binding provide insights into the chemical logic of MraY inhibition, which can guide novel approaches to MraY-targeted antibiotic design.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: National Institutes of Health (NIH); Japan Society for the Promotion of Science (JSPS); Astellas Foundation for Research on Metabolic Disorders; Ministry of Education, Culture, Sports, Science and Technology (MEXT); Japan Agency for Medical Research and Development (AMED)

OSTI ID:: 1544864

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 10; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit Heib, Anna; Niro, Giuliana; Weck, Stefanie C. Universität des Saarlandes https://doi.org/10.22028/d291-30135	collection	January 2019
Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit Heib, Anna; Niro, Giuliana; Weck, Stefanie C. Universität des Saarlandes https://doi.org/10.22028/d291-30135	collection	January 2019
Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit Heib, Anna; Niro, Giuliana; Weck, Stefanie C. Molecules, Vol. 25, Issue 1 https://doi.org/10.3390/molecules25010022	journal	December 2019

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