Title: PET imaging of glucose and fatty acid metabolism for NAFLD patients

Abstract

The study presented in this issue of the Journal by Tang and colleagues illuminate the deficiency in our knowledge of the reciprocal metabolic relationship between liver and heart in health and disease. The results presented in this paper used a large number of previously acquired ¹⁸F-FDG PET studies to investigate the association between non-alcoholic fatty liver disease (NAFLD) (Figure 1A) and myocardial glucose uptake. Previous work published by Lee and colleagues in Metabolism, had found a significant correlation between NAFLD and vascular inflammation using ¹⁸F-FDG PET to measure maximum target-to-background uptake in the carotid arteries; however, the present study is the first to elicit through imaging the correlation between NAFLD and potential cardiac metabolic abnormalities. Patients with NAFLD have a high risk of related cardiovascular disease (CVD). It has been pointed out that the leading cause of death in NAFLD patients is CVD rather than liver-associated complications, of which only 5% of NAFLD patients die from liver-related diseases. ¹⁸F-FGD PET is an important indicator of cardiac glucose metabolism and its alteration in the presence of disease; however, to systematically understand the relation between NAFLD and the risk of cardiovascular disease, other probes, in addition to ¹⁸FDG, should be used tomore » study the complex and dynamic pathways of energy substrate metabolism in the heart in health and disease and their relationship to the metabolic pathways of other body organs.« less

Authors:

Gullberg, Grant T. ^[1]; Shrestha, Uttam M. ^[1]; Seo, Youngho ^[1]

---

+ Show Author Affiliations

1. Univ. of California, San Francisco, CA (United States)

Publication Date:

Thu Dec 13 00:00:00 EST 2018

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE Office of Science (SC)

OSTI Identifier:

1506391

Grant/Contract Number:  

AC02-05CH11231

Resource Type:

Accepted Manuscript

Journal Name:

Journal of Nuclear Cardiology

Additional Journal Information:

Journal Volume: 27; Journal ID: ISSN 1071-3581

Publisher:

Springer Nature

Country of Publication:

United States

Language:

English

Subject:

62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES