Core Metabolism Shifts during Growth on Methanol versus Methane in the Methanotroph Methylomicrobium buryatense 5GB1
- Department of Chemical Engineering, University of Washington, Seattle, Washington, USA
- Department of Chemical Engineering, University of Washington, Seattle, Washington, USA, eScience Institute, University of Washington, Seattle, Washington, USA
- Department of Chemical Engineering, University of Washington, Seattle, Washington, USA, Department of Microbiology, University of Washington, Seattle, Washington, USA
One-carbon compounds such as methane and methanol are of increasing interest as sustainable substrates for biological production of fuels and industrial chemicals. The bacteria that carry out these conversions have been studied for many decades, but gaps exist in our knowledge of their metabolic pathways. One such gap is the difference between growth on methane and growth on methanol. Understanding such metabolism is important, since each has advantages and disadvantages as a feedstock for production of chemicals and fuels. The significance of our research is in the demonstration that the metabolic network is substantially altered in each case and in the delineation of these changes. The resulting new insights into the core metabolism of this bacterium now provide an improved basis for future strain design.
- Research Organization:
- University of Washington, Seattle, WA (United States)
- Sponsoring Organization:
- USDOE; USDOE Advanced Research Projects Agency - Energy (ARPA-E)
- Grant/Contract Number:
- AR0000350
- OSTI ID:
- 1505657
- Journal Information:
- mBio, Journal Name: mBio Journal Issue: 2 Vol. 10; ISSN 2161-2129
- Publisher:
- American Society for MicrobiologyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Similar Records
The oxidative TCA cycle operates during methanotrophic growth of the Type I methanotroph Methylomicrobium buryatense 5GB1
MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense