Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery
Abstract
Abstract Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal–organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well‐defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one‐pot process for versatile bioapplications. The MOP superassemblies are surface‐engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half‐life of 5.6 h and to undergo renal clearance—characteristics needed for nanomedicines.
- Authors:
-
[1]
- Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico Albuquerque NM 87131 USA
- ARC Centre of Excellence in Convergent Bio–Nano Science and Technology and The Department of Chemical Engineering The University of Melbourne Parkville Victoria 3010 Australia
- Department of Internal Medicine Molecular Medicine The University of New Mexico Albuquerque NM 87131 USA
- School of Energy and Environment City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong SAR P. R. China
- Sandia National Laboratories Applied Optical/Plasma Sciences P.O. Box 5800, MS 1411 Albuquerque NM 87185‐1411 USA
- College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 P. R. China
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1493080
- Grant/Contract Number:
- DENA‐0003525
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Advanced Materials
- Additional Journal Information:
- Journal Name: Advanced Materials Journal Volume: 31 Journal Issue: 12; Journal ID: ISSN 0935-9648
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Germany
- Language:
- English
Citation Formats
Zhu, Wei, Guo, Jimin, Ju, Yi, Serda, Rita E., Croissant, Jonas G., Shang, Jin, Coker, Eric, Agola, Jacob Ongudi, Zhong, Qi‐Zhi, Ping, Yuan, Caruso, Frank, and Brinker, C. Jeffrey. Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery. Germany: N. p., 2019.
Web. doi:10.1002/adma.201806774.
Zhu, Wei, Guo, Jimin, Ju, Yi, Serda, Rita E., Croissant, Jonas G., Shang, Jin, Coker, Eric, Agola, Jacob Ongudi, Zhong, Qi‐Zhi, Ping, Yuan, Caruso, Frank, & Brinker, C. Jeffrey. Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery. Germany. https://doi.org/10.1002/adma.201806774
Zhu, Wei, Guo, Jimin, Ju, Yi, Serda, Rita E., Croissant, Jonas G., Shang, Jin, Coker, Eric, Agola, Jacob Ongudi, Zhong, Qi‐Zhi, Ping, Yuan, Caruso, Frank, and Brinker, C. Jeffrey. Thu .
"Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery". Germany. https://doi.org/10.1002/adma.201806774.
@article{osti_1493080,
title = {Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery},
author = {Zhu, Wei and Guo, Jimin and Ju, Yi and Serda, Rita E. and Croissant, Jonas G. and Shang, Jin and Coker, Eric and Agola, Jacob Ongudi and Zhong, Qi‐Zhi and Ping, Yuan and Caruso, Frank and Brinker, C. Jeffrey},
abstractNote = {Abstract Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal–organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well‐defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one‐pot process for versatile bioapplications. The MOP superassemblies are surface‐engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half‐life of 5.6 h and to undergo renal clearance—characteristics needed for nanomedicines.},
doi = {10.1002/adma.201806774},
journal = {Advanced Materials},
number = 12,
volume = 31,
place = {Germany},
year = {Thu Jan 31 00:00:00 EST 2019},
month = {Thu Jan 31 00:00:00 EST 2019}
}
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https://doi.org/10.1002/adma.201806774
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