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Title: Vanadium Dioxide Circuits Emulate Neurological Disorders

Abstract

Information in the central nervous system (CNS) is conducted via electrical signals known as action potentials and is encoded in time. Several neurological disorders including depression, Attention Deficit Hyperactivity Disorder (ADHD), originate in faulty brain signaling frequencies. Here, we present a Hodgkin-Huxley model analog for a strongly correlated VO2 artificial neuron system that undergoes an electrically-driven insulator-metal transition. We demonstrate that tuning of the insulating phase resistance in VO2 threshold switch circuits can enable direct mimicry of neuronal origins of disorders in the CNS. The results introduce use of circuits based on quantum materials as complementary to model animal studies for neuroscience, especially when precise measurements of local electrical properties or competing parallel paths for conduction in complex neural circuits can be a challenge to identify onset of breakdown or diagnose early symptoms of disease.

Authors:
 [1];  [1];  [2]
+ Show Author Affiliations
  1. Argonne National Lab. (ANL), Argonne, IL (United States). Center for Nanoscale Materials; Univ. of Chicago, IL (United States). Inst. for Molecular Engineering
  2. Purdue Univ., West Lafayette, IN (United States). School of Materials Engineering, and School of Electrical and Computer Engineering
Publication Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES); National Science Foundation (NSF); (NSF); Semiconductor Research Corporation (SRC)
OSTI Identifier:
1490214
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Accepted Manuscript
Journal Name:
Frontiers in Neuroscience (Online)
Additional Journal Information:
Journal Name: Frontiers in Neuroscience (Online); Journal Volume: 12; Journal ID: ISSN 1662-453X
Publisher:
Frontiers Research Foundation
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Hodgkin-Huxley model; VO2; artificial neurons; central nervous system diseases; strongly correlated systems

Citation Formats

Lin, Jianqiang, Guha, Supratik, and Ramanathan, Shriram. Vanadium Dioxide Circuits Emulate Neurological Disorders. United States: N. p., 2018. Web. doi:10.3389/fnins.2018.00856.
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Lin, Jianqiang, Guha, Supratik, & Ramanathan, Shriram. Vanadium Dioxide Circuits Emulate Neurological Disorders. United States. https://doi.org/10.3389/fnins.2018.00856
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Lin, Jianqiang, Guha, Supratik, and Ramanathan, Shriram. Fri . "Vanadium Dioxide Circuits Emulate Neurological Disorders". United States. https://doi.org/10.3389/fnins.2018.00856. https://www.osti.gov/servlets/purl/1490214.
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@article{osti_1490214,
title = {Vanadium Dioxide Circuits Emulate Neurological Disorders},
author = {Lin, Jianqiang and Guha, Supratik and Ramanathan, Shriram},
abstractNote = {Information in the central nervous system (CNS) is conducted via electrical signals known as action potentials and is encoded in time. Several neurological disorders including depression, Attention Deficit Hyperactivity Disorder (ADHD), originate in faulty brain signaling frequencies. Here, we present a Hodgkin-Huxley model analog for a strongly correlated VO2 artificial neuron system that undergoes an electrically-driven insulator-metal transition. We demonstrate that tuning of the insulating phase resistance in VO2 threshold switch circuits can enable direct mimicry of neuronal origins of disorders in the CNS. The results introduce use of circuits based on quantum materials as complementary to model animal studies for neuroscience, especially when precise measurements of local electrical properties or competing parallel paths for conduction in complex neural circuits can be a challenge to identify onset of breakdown or diagnose early symptoms of disease.},
doi = {10.3389/fnins.2018.00856},
journal = {Frontiers in Neuroscience (Online)},
number = ,
volume = 12,
place = {United States},
year = {Fri Nov 30 00:00:00 EST 2018},
month = {Fri Nov 30 00:00:00 EST 2018}
}
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Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.3389/fnins.2018.00856
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Cited by: 15 works
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Figures / Tables:

FIGURE 1 FIGURE 1: Experimental details for the VO2 device. (A) The schematic of the VO2 devices under DC probing. (B) The top view of the lateral VO2 device with a “neck-down” layout. The “neck-down” layout leads to lower forward critical transition voltage (Vc) and lower power in the switching operation. (C)more » The typical current vs. voltage characteristic in DC measurement. The voltage sweep is in the sequence of forward (0–0.9 V) and reverse (0.8–0 V) direction. The switch is reversible. The forward critical voltage and reverse voltage are denoted. A current compliance is set at 5mA. Simulation shows a nice match with experiment.« less
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Works referenced in this record:

A scalable neuristor built with Mott memristors
journal, December 2012

  • Pickett, Matthew D.; Medeiros-Ribeiro, Gilberto; Williams, R. Stanley
  • Nature Materials, Vol. 12, Issue 2
  • DOI: 10.1038/nmat3510

Voltage-gated potassium channels as therapeutic targets
journal, December 2009

  • Wulff, Heike; Castle, Neil A.; Pardo, Luis A.
  • Nature Reviews Drug Discovery, Vol. 8, Issue 12
  • DOI: 10.1038/nrd2983

Emulating the Electrical Activity of the Neuron Using a Silicon Oxide RRAM Cell
journal, February 2016

The action potential in mammalian central neurons
journal, June 2007

  • Bean, Bruce P.
  • Nature Reviews Neuroscience, Vol. 8, Issue 6
  • DOI: 10.1038/nrn2148

Multiple neural spike train data analysis: state-of-the-art and future challenges
journal, April 2004

  • Brown, Emery N.; Kass, Robert E.; Mitra, Partha P.
  • Nature Neuroscience, Vol. 7, Issue 5
  • DOI: 10.1038/nn1228

Oxide Interfaces--An Opportunity for Electronics
journal, March 2010

Intrinsic plasticity: an emerging player in addiction
journal, February 2015

  • Kourrich, Saïd; Calu, Donna J.; Bonci, Antonello
  • Nature Reviews Neuroscience, Vol. 16, Issue 3
  • DOI: 10.1038/nrn3877

Correlated neuronal activity and the flow of neural information
journal, August 2001

  • Salinas, Emilio; Sejnowski, Terrence J.
  • Nature Reviews Neuroscience, Vol. 2, Issue 8
  • DOI: 10.1038/35086012

Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory
journal, October 2004

Growth and splitting of neural sequences in songbird vocal development
journal, November 2015

  • Okubo, Tatsuo S.; Mackevicius, Emily L.; Payne, Hannah L.
  • Nature, Vol. 528, Issue 7582
  • DOI: 10.1038/nature15741

Excellent Selector Characteristics of Nanoscale $ \hbox{VO}_{2}$ for High-Density Bipolar ReRAM Applications
journal, November 2011

  • Son, Myungwoo; Lee, Joonmyoung; Park, Jubong
  • IEEE Electron Device Letters, Vol. 32, Issue 11
  • DOI: 10.1109/LED.2011.2163697

A calcium channel mutant mouse model of hypokalemic periodic paralysis
journal, November 2012

  • Wu, Fenfen; Mi, Wentao; Hernández-Ochoa, Erick O.
  • Journal of Clinical Investigation, Vol. 122, Issue 12
  • DOI: 10.1172/JCI66091

Electrically Driven Insulator–Metal Transition-Based Devices—Part I: The Electrothermal Model and Experimental Analysis for the DC Characteristics
journal, September 2018

  • Lin, Jianqiang; Ramanathan, Shriram; Guha, Supratik
  • IEEE Transactions on Electron Devices, Vol. 65, Issue 9
  • DOI: 10.1109/TED.2018.2859180

Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience
journal, April 2014

Mechanisms of Neuropathic Pain
journal, October 2006

Stochastic phase-change neurons
journal, May 2016

  • Tuma, Tomas; Pantazi, Angeliki; Le Gallo, Manuel
  • Nature Nanotechnology, Vol. 11, Issue 8
  • DOI: 10.1038/nnano.2016.70

A quantitative description of membrane current and its application to conduction and excitation in nerve
journal, August 1952

<em>In Vivo</em> Electrophysiological Measurements on Mouse Sciatic Nerves
journal, January 2014

  • Schulz, Alexander; Walther, Christian; Morrison, Helen
  • Journal of Visualized Experiments, Issue 86
  • DOI: 10.3791/51181

Neuronal Mechanisms Underlying Attention Deficit Hyperactivity Disorder
journal, May 2008

  • Brennan, Avis R.; Arnsten, Amy F. T.
  • Annals of the New York Academy of Sciences, Vol. 1129, Issue 1
  • DOI: 10.1196/annals.1417.007

Steep-Slope Metal–Insulator-Transition VO 2 Switches With Temperature-Stable High $I_{\mathrm{{\scriptscriptstyle ON}}}$
journal, September 2015

  • Vitale, Wolfgang A.; Moldovan, Clara F.; Tamagnone, Michele
  • IEEE Electron Device Letters, Vol. 36, Issue 9
  • DOI: 10.1109/LED.2015.2454535

Physics and technology of electronic insulator-to-metal transition (E-IMT) for record high on/off ratio and low voltage in device applications
conference, December 2017

  • Lin, Jianqiang; Alam, Khan; Ocola, Leonidas
  • 2017 IEEE International Electron Devices Meeting (IEDM)
  • DOI: 10.1109/IEDM.2017.8268446

Mott Memory and Neuromorphic Devices
journal, August 2015

A direct-to-drive neural data acquisition system
journal, September 2015

  • Kinney, Justin P.; Bernstein, Jacob G.; Meyer, Andrew J.
  • Frontiers in Neural Circuits, Vol. 9
  • DOI: 10.3389/fncir.2015.00046

Leaky Integrate and Fire Neuron by Charge-Discharge Dynamics in Floating-Body MOSFET
journal, August 2017

Electrical switching dynamics and broadband microwave characteristics of VO 2 radio frequency devices
journal, May 2013

  • Ha, Sieu D.; Zhou, You; Fisher, Christopher J.
  • Journal of Applied Physics, Vol. 113, Issue 18
  • DOI: 10.1063/1.4803688

Mitral Cells of the Olfactory Bulb Perform Metabolic Sensing and Are Disrupted by Obesity at the Level of the Kv1.3 Ion Channel
journal, September 2011

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice
journal, July 2009

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders
journal, August 2015

Reconfigurable anisotropy and functional transformations with VO 2 -based metamaterial electric circuits
journal, April 2015

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders
journal, August 2015

A scalable neuristor built with Mott memristors
journal, December 2012

  • Pickett, Matthew D.; Medeiros-Ribeiro, Gilberto; Williams, R. Stanley
  • Nature Materials, Vol. 12, Issue 2
  • DOI: 10.1038/nmat3510

Multiple neural spike train data analysis: state-of-the-art and future challenges
journal, April 2004

  • Brown, Emery N.; Kass, Robert E.; Mitra, Partha P.
  • Nature Neuroscience, Vol. 7, Issue 5
  • DOI: 10.1038/nn1228

Stochastic phase-change neurons
journal, May 2016

  • Tuma, Tomas; Pantazi, Angeliki; Le Gallo, Manuel
  • Nature Nanotechnology, Vol. 11, Issue 8
  • DOI: 10.1038/nnano.2016.70

Voltage-gated potassium channels as therapeutic targets
journal, December 2009

  • Wulff, Heike; Castle, Neil A.; Pardo, Luis A.
  • Nature Reviews Drug Discovery, Vol. 8, Issue 12
  • DOI: 10.1038/nrd2983

Electrical switching dynamics and broadband microwave characteristics of VO 2 radio frequency devices
journal, May 2013

  • Ha, Sieu D.; Zhou, You; Fisher, Christopher J.
  • Journal of Applied Physics, Vol. 113, Issue 18
  • DOI: 10.1063/1.4803688

A quantitative description of membrane current and its application to conduction and excitation in nerve
journal, August 1952

Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory
journal, October 2004

Oxide Interfaces--An Opportunity for Electronics
journal, March 2010

Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience
journal, April 2014

Leaky channels make weak muscles
journal, November 2012

  • George, Alfred L.
  • Journal of Clinical Investigation, Vol. 122, Issue 12
  • DOI: 10.1172/jci66535

Neuronal Mechanisms Underlying Attention Deficit Hyperactivity Disorder
journal, May 2008

  • Brennan, Avis R.; Arnsten, Amy F. T.
  • Annals of the New York Academy of Sciences, Vol. 1129, Issue 1
  • DOI: 10.1196/annals.1417.007

Network Excitability Dysfunction in Alzheimer's Disease: Insights from In Vitro and In Vivo Models
journal, January 2010

A direct-to-drive neural data acquisition system
journal, September 2015

  • Kinney, Justin P.; Bernstein, Jacob G.; Meyer, Andrew J.
  • Frontiers in Neural Circuits, Vol. 9
  • DOI: 10.3389/fncir.2015.00046

<em>In Vivo</em> Electrophysiological Measurements on Mouse Sciatic Nerves
journal, January 2014

  • Schulz, Alexander; Walther, Christian; Morrison, Helen
  • Journal of Visualized Experiments, Issue 86
  • DOI: 10.3791/51181
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    Works referencing / citing this record:

    Functional Oxides for Photoneuromorphic Engineering: Toward a Solar Brain
    journal, June 2019

    Organismic materials for beyond von Neumann machines
    journal, March 2020

    • Zhang, Hai-Tian; Panda, Priyadarshini; Lin, Jerome
    • Applied Physics Reviews, Vol. 7, Issue 1
    • DOI: 10.1063/1.5113574

    Switch Elements with S-Shaped Current-Voltage Characteristic in Models of Neural Oscillators
    journal, August 2019

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