Regulation of Yeast-to-Hyphae Transition in Yarrowia lipolytica

Pomraning, Kyle R.; Bredeweg, Erin L.; Kerkhoven, Eduard J.; Barry, Kerrie; Haridas, Sajeet; Hundley, Hope; LaButti, Kurt; Lipzen, Anna; Yan, Mi; Magnuson, Jon K.; Simmons, Blake A.; Grigoriev, Igor V.; Nielsen, Jens; Baker, Scott E.; Mitchell, ed., Aaron P.

doi:10.1128/mSphere.00541-18

Title: Regulation of Yeast-to-Hyphae Transition in Yarrowia lipolytica

Journal Article · Wed Dec 26 00:00:00 UTC 2018 · mSphere

DOI: https://doi.org/10.1128/mSphere.00541-18 · OSTI ID:1484405

Pomraning, Kyle R. ^[1]; Bredeweg, Erin L. ^[2]; Kerkhoven, Eduard J. ^[3]; Barry, Kerrie ^[4]; Haridas, Sajeet ^[4]; Hundley, Hope ^[4]; LaButti, Kurt ^[4]; Lipzen, Anna ^[4]; Yan, Mi ^[4]; Magnuson, Jon K. ^[5]; Simmons, Blake A. ^[6]; Grigoriev, Igor V. ^[4];

^[7];

^[8]; Mitchell, ed., Aaron P.

Chemical &, Biological Process Development Group, Pacific Northwest National Laboratory, Richland, Washington, USA
Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA
Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden
DOE Joint Genome Institute, Walnut Creek, California, USA
Chemical &, Biological Process Development Group, Pacific Northwest National Laboratory, Richland, Washington, USA, Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark
Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA, Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Berkeley, California, USA

Many yeasts undergo a morphological transition from yeast-to-hyphal growth in response to environmental conditions. We used forward and reverse genetic techniques to identify genes regulating this transition in Yarrowia lipolytica . We confirmed that the transcription factor Yl msn2 is required for the transition to hyphal growth and found that signaling by the histidine kinases Yl chk1 and Yl nik1 as well as the MAP kinases of the HOG pathway (Yl ssk2 , Yl pbs2 , and Yl hog1 ) regulates the transition to hyphal growth. These results suggest that Y. lipolytica transitions to hyphal growth in response to stress through multiple kinase pathways. Intriguingly, we found that a repetitive portion of the genome containing telomere-like and rDNA repeats may be involved in the transition to hyphal growth, suggesting a link between this region and the general stress response.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: AC02-05CH11231; AC05-76RL01830; SC0008744

OSTI ID:: 1484405

Report Number(s):: PNNL-SA--131456; e00541-18

Journal Information:: mSphere, Journal Name: mSphere Journal Issue: 6 Vol. 3; ISSN 2379-5042

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

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dimorphic
genomics
molecular genetics
morphology
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Title: Regulation of Yeast-to-Hyphae Transition in Yarrowia lipolytica

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