Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways

Zhang, Yang; Chang, Yuansen; Cao, Haijing; Xu, Wenping; Li, Zhong; Tao, Liming

doi:10.1080/09540105.2017.1373271

Title: Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways

Authors:

Zhang, Yang ^[1]; Chang, Yuansen ^[1]; Cao, Haijing ^[1]; Xu, Wenping ^[1]; Li, Zhong ^[1]; Tao, Liming ^[1]

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People’s Republic of China

Publication Date:: Thu Sep 07 00:00:00 EDT 2017

Sponsoring Org.:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI Identifier:: 1483306

Grant/Contract Number:: 2011BAE06B04

Resource Type:: Published Article

Journal Name:: Food and Agricultural Immunology

Additional Journal Information:: Journal Name: Food and Agricultural Immunology Journal Volume: 29 Journal Issue: 1; Journal ID: ISSN 0954-0105

Publisher:: Informa UK Limited

Country of Publication:: Country unknown/Code not available

Language:: English

Citation Formats


                    Zhang, Yang, Chang, Yuansen, Cao, Haijing, Xu, Wenping, Li, Zhong, and Tao, Liming. Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways.  Country unknown/Code not available: N. p., 2017. 
Web.  doi:10.1080/09540105.2017.1373271.

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                    Zhang, Yang, Chang, Yuansen, Cao, Haijing, Xu, Wenping, Li, Zhong, & Tao, Liming. Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways.  Country unknown/Code not available.  https://doi.org/10.1080/09540105.2017.1373271

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                    Zhang, Yang, Chang, Yuansen, Cao, Haijing, Xu, Wenping, Li, Zhong, and Tao, Liming. Thu .  
"Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways".  Country unknown/Code not available.  https://doi.org/10.1080/09540105.2017.1373271.

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@article{osti_1483306,

  title        = {Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways},

  author       = {Zhang, Yang and Chang, Yuansen and Cao, Haijing and Xu, Wenping and Li, Zhong and Tao, Liming},

  abstractNote = {},

  doi          = {10.1080/09540105.2017.1373271},

  journal      = {Food and Agricultural Immunology},

  number       = 1,

  volume       = 29,

  place        = {Country unknown/Code not available},

  year         = {Thu Sep 07 00:00:00 EDT 2017},

  month        = {Thu Sep 07 00:00:00 EDT 2017}

}

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https://doi.org/10.1080/09540105.2017.1373271

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Works referenced in this record:

The biochemistry of programmed cell death.
journal, October 1995

Kroemer, G.; Petit, P.; Zamzami, N.
The FASEB Journal, Vol. 9, Issue 13
DOI: 10.1096/fasebj.9.13.7557017

Apoptosis by Death Factor
journal, February 1997

Nagata, Shigekazu
Cell, Vol. 88, Issue 3
DOI: 10.1016/S0092-8674(00)81874-7

Apoptosis: A Review of Programmed Cell Death
journal, June 2007

Elmore, Susan
Toxicologic Pathology, Vol. 35, Issue 4
DOI: 10.1080/01926230701320337

Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos
journal, September 2012

Lee, Jeong Eun; Park, Jae Hyeon; Shin, In Chul
Toxicology and Applied Pharmacology, Vol. 263, Issue 2
DOI: 10.1016/j.taap.2012.06.005

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis
journal, May 2011

Hüttemann, Maik; Pecina, Petr; Rainbolt, Matthew
Mitochondrion, Vol. 11, Issue 3
DOI: 10.1016/j.mito.2011.01.010

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis
journal, May 2000

Li, Kang; Li, Yucheng; Shelton, John M.
Cell, Vol. 101, Issue 4
DOI: 10.1016/S0092-8674(00)80849-1

Mitochondrial dynamics in cell death and neurodegeneration
journal, June 2010

Cho, Dong-Hyung; Nakamura, Tomohiro; Lipton, Stuart A.
Cellular and Molecular Life Sciences, Vol. 67, Issue 20
DOI: 10.1007/s00018-010-0435-2

Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release
journal, May 2000

Koya, Richard Chikara; Fujita, Hisakazu; Shimizu, Shigeomi
Journal of Biological Chemistry, Vol. 275, Issue 20
DOI: 10.1074/jbc.275.20.15343

Mechanisms of cytochrome c release from mitochondria
journal, May 2006

Garrido, C.; Galluzzi, L.; Brunet, M.
Cell Death & Differentiation, Vol. 13, Issue 9
DOI: 10.1038/sj.cdd.4401950

Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells
journal, December 2015

Jang, Yoonjeong; Lee, Ah Young; Jeong, Sang-Hee
Toxicology, Vol. 338
DOI: 10.1016/j.tox.2015.09.006

Cancer-A matter of life and cell death
journal, May 1997

Evan, Gerard
International Journal of Cancer, Vol. 71, Issue 5
DOI: 10.1002/(SICI)1097-0215(19970529)71:5<709::AID-IJC2>3.0.CO;2-V

An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis: CYTOCHROME
journal, July 2002

Morishima, Nobuhiro; Nakanishi, Keiko; Takenouchi, Hiromi
Journal of Biological Chemistry, Vol. 277, Issue 37
DOI: 10.1074/jbc.M204973200

Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamins C and E
journal, April 2008

Yu, Fu; Wang, Ziren; Ju, Bao
Experimental and Toxicologic Pathology, Vol. 59, Issue 6
DOI: 10.1016/j.etp.2007.11.007

Mitochondrial Membrane Potential in Living Cells
journal, November 1988

Chen, Lan Bo
Annual Review of Cell Biology, Vol. 4, Issue 1
DOI: 10.1146/annurev.cb.04.110188.001103

Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells
journal, March 2015

Zhang, Baoyan; Xu, Zhiping; Zhang, Yixi
Pesticide Biochemistry and Physiology, Vol. 119
DOI: 10.1016/j.pestbp.2015.01.019

Cleavage of DFF-45/ICAD by Multiple Caspases Is Essential for Its Function during Apoptosis
journal, October 1998

Tang, Damu; Kidd, Vincent J.
Journal of Biological Chemistry, Vol. 273, Issue 44
DOI: 10.1074/jbc.273.44.28549

Apoptosis: controlled demolition at the cellular level
journal, March 2008

Taylor, Rebecca C.; Cullen, Sean P.; Martin, Seamus J.
Nature Reviews Molecular Cell Biology, Vol. 9, Issue 3
DOI: 10.1038/nrm2312

Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells
journal, January 2001

Antonsson, Bruno; Montessuit, Sylvie; Sanchez, Belen
Journal of Biological Chemistry, Vol. 276, Issue 15
DOI: 10.1074/jbc.M010810200

NF-κB and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope
journal, March 2004

Perfettini, Jean-Luc; Roumier, Thomas; Castedo, Maria
The Journal of Experimental Medicine, Vol. 199, Issue 5
DOI: 10.1084/jem.20031216

Accumulation, histopathological effects and response of biochemical markers in the spleens and head kidneys of common carp exposed to atrazine and chlorpyrifos
journal, December 2013

Wang, Xu; Xing, Houjuan; Jiang, Yan
Food and Chemical Toxicology, Vol. 62
DOI: 10.1016/j.fct.2013.08.044

Rotenone Inhibits the Mitochondrial Permeability Transition-induced Cell Death in U937 and KB Cells
journal, August 2001

Chauvin, Christiane; De Oliveira, Frédéric; Ronot, Xavier
Journal of Biological Chemistry, Vol. 276, Issue 44
DOI: 10.1074/jbc.M106417200

Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence
journal, February 1999

Petronilli, Valeria; Miotto, Giovanni; Canton, Marcella
Biophysical Journal, Vol. 76, Issue 2, p. 725-734
DOI: 10.1016/S0006-3495(99)77239-5

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
journal, July 1996

Liu, Xuesong; Kim, Caryn Naekyung; Yang, Jie
Cell, Vol. 86, Issue 1
DOI: 10.1016/S0092-8674(00)80085-9

Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives
journal, January 1999

Scaduto, Russell C.; Grotyohann, Lee W.
Biophysical Journal, Vol. 76, Issue 1
DOI: 10.1016/S0006-3495(99)77214-0

Effects of atrazine and chlorpyrifos on cytochrome P450 in common carp liver
journal, June 2014

Xing, Houjuan; Zhang, Ziwei; Yao, Haidong
Chemosphere, Vol. 104
DOI: 10.1016/j.chemosphere.2014.01.002

Intracellular Bax Translocation after Transient Cerebral Ischemia: Implications for a Role of the Mitochondrial Apoptotic Signaling Pathway in Ischemic Neuronal Death
journal, April 2001

Cao, Guodong; Minami, Manabu; Pei, Wei
Journal of Cerebral Blood Flow & Metabolism, Vol. 21, Issue 4
DOI: 10.1097/00004647-200104000-00001

Cytochrome c release from mitochondria proceeds by a two-step process
journal, January 2002

Ott, M.; Robertson, J. D.; Gogvadze, V.
Proceedings of the National Academy of Sciences, Vol. 99, Issue 3
DOI: 10.1073/pnas.241655498

JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis
journal, April 2013

Ki, Yeo-Woon; Park, Jae Hyeon; Lee, Jeong Eun
Toxicology Letters, Vol. 218, Issue 3
DOI: 10.1016/j.toxlet.2013.02.003

BCL-2 family members and the mitochondria in apoptosis
journal, August 1999

Gross, A.; McDonnell, J. M.; Korsmeyer, S. J.
Genes & Development, Vol. 13, Issue 15
DOI: 10.1101/gad.13.15.1899

Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells
journal, May 2009

Saulsbury, Marilyn D.; Heyliger, Simone O.; Wang, Kaiyu
Toxicology, Vol. 259, Issue 1-2
DOI: 10.1016/j.tox.2008.12.026

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
journal, October 1996

Susin, S. A.
Journal of Experimental Medicine, Vol. 184, Issue 4
DOI: 10.1084/jem.184.4.1331

Programmed Cell Death in Animal Development and Disease
journal, December 2011

Fuchs, Yaron; Steller, Hermann
Cell, Vol. 147, Issue 7
DOI: 10.1016/j.cell.2011.11.045

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
journal, August 1972

Kerr, J. F. R.; Wyllie, A. H.; Currie, A. R.
British Journal of Cancer, Vol. 26, Issue 4
DOI: 10.1038/bjc.1972.33

Genotoxic effects of the carbamate insecticide, methomyl. II. In vivo studies with pure compound and the technical formulation, “lannate 25”
journal, January 1994

Bolognesi, Claudia; Peluso, Marco; Degan, Paolo
Environmental and Molecular Mutagenesis, Vol. 24, Issue 3
DOI: 10.1002/em.2850240313

Dose–response and time-course of neurobehavioral changes following oral chlorpyrifos in rats of different ages
journal, September 2000

Moser, Virginia C.
Neurotoxicology and Teratology, Vol. 22, Issue 5
DOI: 10.1016/S0892-0362(00)00087-8

Drosophila Pro-apoptotic Bcl-2/Bax Homologue Reveals Evolutionary Conservation of Cell Death Mechanisms
journal, September 2000

Zhang, Hong; Huang, Qihong; Ke, Ning
Journal of Biological Chemistry, Vol. 275, Issue 35
DOI: 10.1016/S0021-9258(19)61510-3

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Title: Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways

Citation Formats

The biochemistry of programmed cell death. journal, October 1995

Apoptosis by Death Factor journal, February 1997

Apoptosis: A Review of Programmed Cell Death journal, June 2007

Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos journal, September 2012

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis journal, May 2011

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis journal, May 2000

Mitochondrial dynamics in cell death and neurodegeneration journal, June 2010

Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release journal, May 2000

Mechanisms of cytochrome c release from mitochondria journal, May 2006

Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells journal, December 2015

Cancer-A matter of life and cell death journal, May 1997

An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis: CYTOCHROME journal, July 2002

Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamins C and E journal, April 2008

Mitochondrial Membrane Potential in Living Cells journal, November 1988

Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells journal, March 2015

Cleavage of DFF-45/ICAD by Multiple Caspases Is Essential for Its Function during Apoptosis journal, October 1998

Apoptosis: controlled demolition at the cellular level journal, March 2008

Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells journal, January 2001

NF-κB and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope journal, March 2004

Accumulation, histopathological effects and response of biochemical markers in the spleens and head kidneys of common carp exposed to atrazine and chlorpyrifos journal, December 2013

Rotenone Inhibits the Mitochondrial Permeability Transition-induced Cell Death in U937 and KB Cells journal, August 2001

Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence journal, February 1999

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c journal, July 1996

Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives journal, January 1999

Effects of atrazine and chlorpyrifos on cytochrome P450 in common carp liver journal, June 2014

Intracellular Bax Translocation after Transient Cerebral Ischemia: Implications for a Role of the Mitochondrial Apoptotic Signaling Pathway in Ischemic Neuronal Death journal, April 2001

Cytochrome c release from mitochondria proceeds by a two-step process journal, January 2002

JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis journal, April 2013

BCL-2 family members and the mitochondria in apoptosis journal, August 1999

Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells journal, May 2009

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease journal, October 1996

Programmed Cell Death in Animal Development and Disease journal, December 2011

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics journal, August 1972

Genotoxic effects of the carbamate insecticide, methomyl. II. In vivo studies with pure compound and the technical formulation, “lannate 25” journal, January 1994

Dose–response and time-course of neurobehavioral changes following oral chlorpyrifos in rats of different ages journal, September 2000

Drosophila Pro-apoptotic Bcl-2/Bax Homologue Reveals Evolutionary Conservation of Cell Death Mechanisms journal, September 2000

The biochemistry of programmed cell death.
journal, October 1995

Apoptosis by Death Factor
journal, February 1997

Apoptosis: A Review of Programmed Cell Death
journal, June 2007

Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos
journal, September 2012

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis
journal, May 2011

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis
journal, May 2000

Mitochondrial dynamics in cell death and neurodegeneration
journal, June 2010

Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release
journal, May 2000

Mechanisms of cytochrome c release from mitochondria
journal, May 2006

Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells
journal, December 2015

Cancer-A matter of life and cell death
journal, May 1997

An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis: CYTOCHROME
journal, July 2002

Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamins C and E
journal, April 2008

Mitochondrial Membrane Potential in Living Cells
journal, November 1988

Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells
journal, March 2015

Cleavage of DFF-45/ICAD by Multiple Caspases Is Essential for Its Function during Apoptosis
journal, October 1998

Apoptosis: controlled demolition at the cellular level
journal, March 2008

Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells
journal, January 2001

NF-κB and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope
journal, March 2004

Accumulation, histopathological effects and response of biochemical markers in the spleens and head kidneys of common carp exposed to atrazine and chlorpyrifos
journal, December 2013

Rotenone Inhibits the Mitochondrial Permeability Transition-induced Cell Death in U937 and KB Cells
journal, August 2001

Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence
journal, February 1999

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
journal, July 1996

Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives
journal, January 1999

Effects of atrazine and chlorpyrifos on cytochrome P450 in common carp liver
journal, June 2014

Intracellular Bax Translocation after Transient Cerebral Ischemia: Implications for a Role of the Mitochondrial Apoptotic Signaling Pathway in Ischemic Neuronal Death
journal, April 2001

Cytochrome c release from mitochondria proceeds by a two-step process
journal, January 2002

JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis
journal, April 2013

BCL-2 family members and the mitochondria in apoptosis
journal, August 1999

Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells
journal, May 2009

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
journal, October 1996

Programmed Cell Death in Animal Development and Disease
journal, December 2011

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
journal, August 1972

Genotoxic effects of the carbamate insecticide, methomyl. II. In vivo studies with pure compound and the technical formulation, “lannate 25”
journal, January 1994

Dose–response and time-course of neurobehavioral changes following oral chlorpyrifos in rats of different ages
journal, September 2000

Drosophila Pro-apoptotic Bcl-2/Bax Homologue Reveals Evolutionary Conservation of Cell Death Mechanisms
journal, September 2000