The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses
Abstract
Abstract Ginseng polysaccharides (GPS) have been well known as an immune modulator. This study was conducted to investigate the effects of dietary supplemental GPS on the immune responses involved in sow’s milk‐derived exosomal shuttle RNAs (esRNAs) using RNA‐Seq and miRNA‐Seq. Of the 213 identified miRNA types, a total of 26 conserved miRNAs were differently expressed in response to GPS supplementation, including 10 up‐regulated and 16 down‐regulated miRNAs in GPS feeding group. In addition, exosomal transcriptome analysis identified 14,696 protein‐coding genes in sow’s milk exosomes, and 283 genes with 204 and 79 candidates showing up and down‐regulation were significantly responded to GPS supplementation. Integrated analysis of each differently expressed miRNA with significantly expressed genes further revealed the presence of 51 highly conserved miRNA–gene interactions that were annotated to be related to immunoregulatory functions. This work provided an important advance in the functional identification of dietary GPS supplementation and more fundamental information about how GPS promoted the immune response and healthy growth of the infant from mothers at molecular levels.
- Authors:
-
[1];
- Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, National Engineering Research Center for Breeding Swine Industry South China Agricultural University Guangzhou Guangdong China
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1481312
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Journal of Animal Physiology and Animal Nutrition
- Additional Journal Information:
- Journal Name: Journal of Animal Physiology and Animal Nutrition Journal Volume: 103 Journal Issue: 1; Journal ID: ISSN 0931-2439
- Publisher:
- Wiley-Blackwell
- Country of Publication:
- Germany
- Language:
- English
Citation Formats
Sun, Jiajie, Xiong, Jiali, Yao, Liyuan, Chen, Ting, Luo, Junyi, Xi, Qianyun, and Zhang, Yongliang. The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses. Germany: N. p., 2018.
Web. doi:10.1111/jpn.12993.
Sun, Jiajie, Xiong, Jiali, Yao, Liyuan, Chen, Ting, Luo, Junyi, Xi, Qianyun, & Zhang, Yongliang. The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses. Germany. https://doi.org/10.1111/jpn.12993
Sun, Jiajie, Xiong, Jiali, Yao, Liyuan, Chen, Ting, Luo, Junyi, Xi, Qianyun, and Zhang, Yongliang. Thu .
"The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses". Germany. https://doi.org/10.1111/jpn.12993.
@article{osti_1481312,
title = {The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses},
author = {Sun, Jiajie and Xiong, Jiali and Yao, Liyuan and Chen, Ting and Luo, Junyi and Xi, Qianyun and Zhang, Yongliang},
abstractNote = {Abstract Ginseng polysaccharides (GPS) have been well known as an immune modulator. This study was conducted to investigate the effects of dietary supplemental GPS on the immune responses involved in sow’s milk‐derived exosomal shuttle RNAs (esRNAs) using RNA‐Seq and miRNA‐Seq. Of the 213 identified miRNA types, a total of 26 conserved miRNAs were differently expressed in response to GPS supplementation, including 10 up‐regulated and 16 down‐regulated miRNAs in GPS feeding group. In addition, exosomal transcriptome analysis identified 14,696 protein‐coding genes in sow’s milk exosomes, and 283 genes with 204 and 79 candidates showing up and down‐regulation were significantly responded to GPS supplementation. Integrated analysis of each differently expressed miRNA with significantly expressed genes further revealed the presence of 51 highly conserved miRNA–gene interactions that were annotated to be related to immunoregulatory functions. This work provided an important advance in the functional identification of dietary GPS supplementation and more fundamental information about how GPS promoted the immune response and healthy growth of the infant from mothers at molecular levels.},
doi = {10.1111/jpn.12993},
journal = {Journal of Animal Physiology and Animal Nutrition},
number = 1,
volume = 103,
place = {Germany},
year = {Thu Nov 08 00:00:00 EST 2018},
month = {Thu Nov 08 00:00:00 EST 2018}
}
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