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Title: Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

Authors:
; ; ; ; ; ; ; ; ; ; ; ; ORCiD logo
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE; National Inst. of Health (NIH) (United States)
OSTI Identifier:
1466428
Alternate Identifier(s):
OSTI ID: 1477421
Grant/Contract Number:  
[AC02-05CH11231; AC02-06CH11357; GM114056; EB009998; UL1TR000439; GM103622]
Resource Type:
Published Article
Journal Name:
Nature Communications
Additional Journal Information:
[Journal Name: Nature Communications Journal Volume: 9 Journal Issue: 1]; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United Kingdom
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; computational biophysics; nuclear receptors; SAXS

Citation Formats

Huang, Wei, Peng, Yi, Kiselar, Janna, Zhao, Xuan, Albaqami, Aljawharah, Mendez, Daniel, Chen, Yinghua, Chakravarthy, Srinivas, Gupta, Sayan, Ralston, Corie, Kao, Hung-Ying, Chance, Mark R., and Yang, Sichun. Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains. United Kingdom: N. p., 2018. Web. doi:10.1038/s41467-018-06034-2.
Huang, Wei, Peng, Yi, Kiselar, Janna, Zhao, Xuan, Albaqami, Aljawharah, Mendez, Daniel, Chen, Yinghua, Chakravarthy, Srinivas, Gupta, Sayan, Ralston, Corie, Kao, Hung-Ying, Chance, Mark R., & Yang, Sichun. Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains. United Kingdom. doi:10.1038/s41467-018-06034-2.
Huang, Wei, Peng, Yi, Kiselar, Janna, Zhao, Xuan, Albaqami, Aljawharah, Mendez, Daniel, Chen, Yinghua, Chakravarthy, Srinivas, Gupta, Sayan, Ralston, Corie, Kao, Hung-Ying, Chance, Mark R., and Yang, Sichun. Thu . "Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains". United Kingdom. doi:10.1038/s41467-018-06034-2.
@article{osti_1466428,
title = {Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains},
author = {Huang, Wei and Peng, Yi and Kiselar, Janna and Zhao, Xuan and Albaqami, Aljawharah and Mendez, Daniel and Chen, Yinghua and Chakravarthy, Srinivas and Gupta, Sayan and Ralston, Corie and Kao, Hung-Ying and Chance, Mark R. and Yang, Sichun},
abstractNote = {},
doi = {10.1038/s41467-018-06034-2},
journal = {Nature Communications},
number = [1],
volume = [9],
place = {United Kingdom},
year = {2018},
month = {8}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1038/s41467-018-06034-2

Citation Metrics:
Cited by: 8 works
Citation information provided by
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Works referenced in this record:

SASBDB, a repository for biological small-angle scattering data
journal, October 2014

  • Valentini, Erica; Kikhney, Alexey G.; Previtali, Gianpietro
  • Nucleic Acids Research, Vol. 43, Issue D1
  • DOI: 10.1093/nar/gku1047

Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
journal, May 1998

  • Tanenbaum, D. M.; Wang, Y.; Williams, S. P.
  • Proceedings of the National Academy of Sciences, Vol. 95, Issue 11
  • DOI: 10.1073/pnas.95.11.5998

Integrated genomic characterization of endometrial carcinoma
journal, May 2013


DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex
journal, April 2011

  • Zhang, Jun; Chalmers, Michael J.; Stayrook, Keith R.
  • Nature Structural & Molecular Biology, Vol. 18, Issue 5
  • DOI: 10.1038/nsmb.2046

CRYSOL – a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates
journal, December 1995

  • Svergun, D.; Barberato, C.; Koch, M. H. J.
  • Journal of Applied Crystallography, Vol. 28, Issue 6
  • DOI: 10.1107/S0021889895007047

Estrogen receptors and human disease
journal, March 2006

  • Deroo, B. J.
  • Journal of Clinical Investigation, Vol. 116, Issue 3
  • DOI: 10.1172/JCI27987

The Amber biomolecular simulation programs
journal, January 2005

  • Case, David A.; Cheatham, Thomas E.; Darden, Tom
  • Journal of Computational Chemistry, Vol. 26, Issue 16
  • DOI: 10.1002/jcc.20290

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma
journal, April 2016


The palindromic DNA-bound USP/EcR nuclear receptor adopts an asymmetric organization with allosteric domain positioning
journal, June 2014

  • Maletta, Massimiliano; Orlov, Igor; Roblin, Pierre
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms5139

Small-Angle X-Ray Scattering- and Nuclear Magnetic Resonance-Derived Conformational Ensemble of the Highly Flexible Antitoxin PaaA2
journal, June 2014


Proteins in dynamic equilibrium
journal, December 2010

  • Bernadó, Pau; Blackledge, Martin
  • Nature, Vol. 468, Issue 7327
  • DOI: 10.1038/4681046a

Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor α
journal, April 2002

  • Wärnmark, Anette; Treuter, Eckardt; Gustafsson, Jan-Åke
  • Journal of Biological Chemistry, Vol. 277, Issue 24
  • DOI: 10.1074/jbc.M200764200

Methods for SAXS-Based Structure Determination of Biomolecular Complexes
journal, May 2014


Fast-SAXS-pro : A unified approach to computing SAXS profiles of DNA, RNA, protein, and their complexes
journal, January 2013

  • Ravikumar, Krishnakumar M.; Huang, Wei; Yang, Sichun
  • The Journal of Chemical Physics, Vol. 138, Issue 2
  • DOI: 10.1063/1.4774148

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA
journal, November 2008

  • Chandra, Vikas; Huang, Pengxiang; Hamuro, Yoshitomo
  • Nature, Vol. 456, Issue 7220
  • DOI: 10.1038/nature07413

Refined solution structure of the 82-kDa enzyme malate synthase G from joint NMR and synchrotron SAXS restraints
journal, November 2007

  • Grishaev, Alexander; Tugarinov, Vitali; Kay, Lewis E.
  • Journal of Biomolecular NMR, Vol. 40, Issue 2
  • DOI: 10.1007/s10858-007-9211-5

Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
journal, December 2007

  • Wells, James A.; McClendon, Christopher L.
  • Nature, Vol. 450, Issue 7172
  • DOI: 10.1038/nature06526

Super-Resolution in Solution X-Ray Scattering and Its Applications to Structural Systems Biology
journal, May 2013


Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
journal, April 2011

  • Rochel, Natacha; Ciesielski, Fabrice; Godet, Julien
  • Nature Structural & Molecular Biology, Vol. 18, Issue 5
  • DOI: 10.1038/nsmb.2054

Development and testing of a general amber force field
journal, January 2004

  • Wang, Junmei; Wolf, Romain M.; Caldwell, James W.
  • Journal of Computational Chemistry, Vol. 25, Issue 9
  • DOI: 10.1002/jcc.20035

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
journal, October 2017


Structure of a Biologically Active Estrogen Receptor-Coactivator Complex on DNA
journal, March 2015


Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA
journal, February 2014

  • Lou, Xiaohua; Toresson, Gudrun; Benod, Cindy
  • Nature Structural & Molecular Biology, Vol. 21, Issue 3
  • DOI: 10.1038/nsmb.2778

International Union of Pharmacology. LXIV. Estrogen Receptors
journal, November 2006

  • Dahlman-Wright, Karin; Cavailles, Vincent; Fuqua, Suzanne A.
  • Pharmacological Reviews, Vol. 58, Issue 4
  • DOI: 10.1124/pr.58.4.8

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
journal, May 2017

  • Zehir, Ahmet; Benayed, Ryma; Shah, Ronak H.
  • Nature Medicine, Vol. 23, Issue 6
  • DOI: 10.1038/nm.4333

Protein Footprinting Comes of Age: Mass Spectrometry for Biophysical Structure Assessment
journal, March 2017


A modified TIP3P water potential for simulation with Ewald summation
journal, November 2004

  • Price, Daniel J.; Brooks, Charles L.
  • The Journal of Chemical Physics, Vol. 121, Issue 20
  • DOI: 10.1063/1.1808117

Quantitative Mapping of Protein Structure by Hydroxyl Radical Footprinting-Mediated Structural Mass Spectrometry: A Protection Factor Analysis
journal, January 2015

  • Huang, Wei; Ravikumar, Krishnakumar M.; Chance, Mark R.
  • Biophysical Journal, Vol. 108, Issue 1
  • DOI: 10.1016/j.bpj.2014.11.013

Toward Improved Description of DNA Backbone: Revisiting Epsilon and Zeta Torsion Force Field Parameters
journal, April 2013

  • Zgarbová, Marie; Luque, F. Javier; Šponer, Jiří
  • Journal of Chemical Theory and Computation, Vol. 9, Issue 5
  • DOI: 10.1021/ct400154j

Multidomain integration in the structure of the HNF-4α nuclear receptor complex
journal, March 2013

  • Chandra, Vikas; Huang, Pengxiang; Potluri, Nalini
  • Nature, Vol. 495, Issue 7441
  • DOI: 10.1038/nature11966

Multidomain assembled states of Hck tyrosine kinase in solution
journal, August 2010

  • Yang, S.; Blachowicz, L.; Makowski, L.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 36
  • DOI: 10.1073/pnas.1004569107

Radiolytic Protein Footprinting with mass Spectrometry to Probe the Structure of Macromolecular Complexes
journal, June 2006


ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
journal, July 2015

  • Maier, James A.; Martinez, Carmenza; Kasavajhala, Koushik
  • Journal of Chemical Theory and Computation, Vol. 11, Issue 8
  • DOI: 10.1021/acs.jctc.5b00255

Crystal Structure of a Mutant hERα Ligand-binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism
journal, February 2001

  • Gangloff, Monique; Ruff, Marc; Eiler, Sylvia
  • Journal of Biological Chemistry, Vol. 276, Issue 18
  • DOI: 10.1074/jbc.M009870200

Evaluating conformational free energies: The colony energy and its application to the problem of loop prediction
journal, May 2002

  • Xiang, Z.; Soto, C. S.; Honig, B.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 11
  • DOI: 10.1073/pnas.102179699

Theoretical modeling of multiprotein complexes by iSPOT: Integration of small-angle X-ray scattering, hydroxyl radical footprinting, and computational docking
journal, December 2016

  • Huang, Wei; Ravikumar, Krishnakumar M.; Parisien, Marc
  • Journal of Structural Biology, Vol. 196, Issue 3
  • DOI: 10.1016/j.jsb.2016.08.001

2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update
journal, August 2017

  • Trewhella, Jill; Duff, Anthony P.; Durand, Dominique
  • Acta Crystallographica Section D Structural Biology, Vol. 73, Issue 9
  • DOI: 10.1107/S2059798317011597

Integrative structure modeling with the Integrative Modeling Platform: Integrative Structure Modeling with IMP
journal, October 2017

  • Webb, Benjamin; Viswanath, Shruthi; Bonomi, Massimiliano
  • Protein Science, Vol. 27, Issue 1
  • DOI: 10.1002/pro.3311

Quantitative Protein Topography Analysis and High-Resolution Structure Prediction Using Hydroxyl Radical Labeling and Tandem-Ion Mass Spectrometry (MS)
journal, February 2015

  • Kaur, Parminder; Kiselar, Janna; Yang, Sichun
  • Molecular & Cellular Proteomics, Vol. 14, Issue 4
  • DOI: 10.1074/mcp.O114.044362

Structural and Functional Impacts of ER Coactivator Sequential Recruitment
journal, September 2017


The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer
journal, October 1988


The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes
journal, February 2016

  • van Zundert, G. C. P.; Rodrigues, J. P. G. L. M.; Trellet, M.
  • Journal of Molecular Biology, Vol. 428, Issue 4
  • DOI: 10.1016/j.jmb.2015.09.014

A New Vector for High-Throughput, Ligation-Independent Cloning Encoding a Tobacco Etch Virus Protease Cleavage Site
journal, June 2002

  • Stols, Lucy; Gu, Minyi; Dieckman, Lynda
  • Protein Expression and Purification, Vol. 25, Issue 1
  • DOI: 10.1006/prep.2001.1603

Cross-talk between the ligand- and DNA-binding domains of estrogen receptor: ERα Domain Cross-Talk
journal, August 2013

  • Huang, Wei; Greene, Geoffrey L.; Ravikumar, Krishnakumar M.
  • Proteins: Structure, Function, and Bioinformatics, Vol. 81, Issue 11
  • DOI: 10.1002/prot.24331

Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS)
journal, October 2013

  • Graewert, Melissa A.; Svergun, Dmitri I.
  • Current Opinion in Structural Biology, Vol. 23, Issue 5
  • DOI: 10.1016/j.sbi.2013.06.007

Automated analysis of interatomic contacts in proteins
journal, April 1999


Functional domains of the human estrogen receptor
journal, December 1987


DNASU plasmid and PSI:Biology-Materials repositories: resources to accelerate biological research
journal, November 2013

  • Seiler, Catherine Y.; Park, Jin G.; Sharma, Amit
  • Nucleic Acids Research, Vol. 42, Issue D1
  • DOI: 10.1093/nar/gkt1060