Dynamic Neutron Scattering by Biological Systems
Abstract
Dynamic neutron scattering directly probes motions in biological systems on femtosecond to microsecond timescales. When combined with molecular dynamics simulation and normal mode analysis, detailed descriptions of the forms and frequencies of motions can be derived. We examine vibrations in proteins, the temperature dependence of protein motions, and concepts describing the rich variety of motions detectable using neutrons in biological systems at physiological temperatures. In conclusion, new techniques for deriving information on collective motions using coherent scattering are also reviewed.
- Authors:
-
[1];
[1];
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
- Shanghai Jiao Tong Univ., Shanghai (China)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1459310
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Annual Review of Biophysics
- Additional Journal Information:
- Journal Volume: 47; Journal Issue: 1; Journal ID: ISSN 1936-122X
- Publisher:
- Annual Reviews
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; dynamics; biomolecules; neutron scattering; MD simulation
Citation Formats
Smith, Jeremy C., Tan, Pan, Petridis, Loukas, and Hong, Liang. Dynamic Neutron Scattering by Biological Systems. United States: N. p., 2018.
Web. doi:10.1146/annurev-biophys-070317-033358.
Smith, Jeremy C., Tan, Pan, Petridis, Loukas, & Hong, Liang. Dynamic Neutron Scattering by Biological Systems. United States. https://doi.org/10.1146/annurev-biophys-070317-033358
Smith, Jeremy C., Tan, Pan, Petridis, Loukas, and Hong, Liang. Wed .
"Dynamic Neutron Scattering by Biological Systems". United States. https://doi.org/10.1146/annurev-biophys-070317-033358. https://www.osti.gov/servlets/purl/1459310.
@article{osti_1459310,
title = {Dynamic Neutron Scattering by Biological Systems},
author = {Smith, Jeremy C. and Tan, Pan and Petridis, Loukas and Hong, Liang},
abstractNote = {Dynamic neutron scattering directly probes motions in biological systems on femtosecond to microsecond timescales. When combined with molecular dynamics simulation and normal mode analysis, detailed descriptions of the forms and frequencies of motions can be derived. We examine vibrations in proteins, the temperature dependence of protein motions, and concepts describing the rich variety of motions detectable using neutrons in biological systems at physiological temperatures. In conclusion, new techniques for deriving information on collective motions using coherent scattering are also reviewed.},
doi = {10.1146/annurev-biophys-070317-033358},
journal = {Annual Review of Biophysics},
number = 1,
volume = 47,
place = {United States},
year = {Wed Mar 21 00:00:00 EDT 2018},
month = {Wed Mar 21 00:00:00 EDT 2018}
}
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