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Title: Dynamic Neutron Scattering by Biological Systems

Dynamic neutron scattering directly probes motions in biological systems on femtosecond to microsecond timescales. When combined with molecular dynamics simulation and normal mode analysis, detailed descriptions of the forms and frequencies of motions can be derived. We examine vibrations in proteins, the temperature dependence of protein motions, and concepts describing the rich variety of motions detectable using neutrons in biological systems at physiological temperatures. In conclusion, new techniques for deriving information on collective motions using coherent scattering are also reviewed.
Authors:
ORCiD logo [1] ;  [2] ; ORCiD logo [1] ;  [2]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
  2. Shanghai Jiao Tong Univ., Shanghai (China)
Publication Date:
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Annual Review of Biophysics
Additional Journal Information:
Journal Volume: 47; Journal Issue: 1; Journal ID: ISSN 1936-122X
Publisher:
Annual Reviews
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; dynamics; biomolecules; neutron scattering; MD simulation
OSTI Identifier:
1459310

Smith, Jeremy C., Tan, Pan, Petridis, Loukas, and Hong, Liang. Dynamic Neutron Scattering by Biological Systems. United States: N. p., Web. doi:10.1146/annurev-biophys-070317-033358.
Smith, Jeremy C., Tan, Pan, Petridis, Loukas, & Hong, Liang. Dynamic Neutron Scattering by Biological Systems. United States. doi:10.1146/annurev-biophys-070317-033358.
Smith, Jeremy C., Tan, Pan, Petridis, Loukas, and Hong, Liang. 2018. "Dynamic Neutron Scattering by Biological Systems". United States. doi:10.1146/annurev-biophys-070317-033358.
@article{osti_1459310,
title = {Dynamic Neutron Scattering by Biological Systems},
author = {Smith, Jeremy C. and Tan, Pan and Petridis, Loukas and Hong, Liang},
abstractNote = {Dynamic neutron scattering directly probes motions in biological systems on femtosecond to microsecond timescales. When combined with molecular dynamics simulation and normal mode analysis, detailed descriptions of the forms and frequencies of motions can be derived. We examine vibrations in proteins, the temperature dependence of protein motions, and concepts describing the rich variety of motions detectable using neutrons in biological systems at physiological temperatures. In conclusion, new techniques for deriving information on collective motions using coherent scattering are also reviewed.},
doi = {10.1146/annurev-biophys-070317-033358},
journal = {Annual Review of Biophysics},
number = 1,
volume = 47,
place = {United States},
year = {2018},
month = {3}
}