Nudge-nudge, WNK-WNK (kinases), say no more?
Abstract
Contents Summary 35 I Overview of animal and plant WNK kinases 35 II. Structure: domains and topology 36 III. Phylogeny–evolutionary relationships 41 IV. Plant WNK kinase distribution and regulation of WNK expression and activity 41 V. Functions of WNK family members in physiology and development 41 VI. Say no more? Still many questions to be answered 45 Acknowledgements 46 References 46 Summary WITH NO LYSINE ( WNK ) kinases are serine/threonine kinases uniquely characterized by an anomalous placement of a catalytic lysine, hence their moniker. In animals, WNK protein kinases play critical roles in protein trafficking of components that mediate renal ion transport processes and regulate osmoregulation of cell volume. In plants, the WNK kinase gene family is larger and more diverse. Recent studies revealed WNK kinase roles in orchestrating the trafficking of an ion channel, a lipid kinase complex in animals, and a heterotrimeric G protein signaling component in plants that is necessary for signal transduction. For this reason, new attention is geared toward investigating the mechanisms adopted by WNK kinases to nudge intracellular proteins to their destinations. In this review, the functions of WNK kinases in protein trafficking are derived from what we have learned from the modelmore »
- Authors:
-
- Univ. of North Carolina, Chapel Hill, NC (United States); National Univ. of Singapore (Singapore)
- National Univ. of Singapore (Singapore)
- Univ. of North Carolina, Chapel Hill, NC (United States)
- Publication Date:
- Research Org.:
- University of North Carolina, Chapel Hill, NC (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1609602
- Alternate Identifier(s):
- OSTI ID: 1457494
- Grant/Contract Number:
- FG02-05ER15671; DE‐FG02‐05er15671
- Resource Type:
- Accepted Manuscript
- Journal Name:
- New Phytologist
- Additional Journal Information:
- Journal Volume: 220; Journal Issue: 1; Journal ID: ISSN 0028-646X
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; plant sciences; circadian; flowering; protein trafficking; regulator of G signaling; WNK kinase
Citation Formats
Cao-Pham, Anh H., Urano, Daisuke, Ross-Elliott, Timothy J., and Jones, Alan M. Nudge-nudge, WNK-WNK (kinases), say no more?. United States: N. p., 2018.
Web. doi:10.1111/nph.15276.
Cao-Pham, Anh H., Urano, Daisuke, Ross-Elliott, Timothy J., & Jones, Alan M. Nudge-nudge, WNK-WNK (kinases), say no more?. United States. https://doi.org/10.1111/nph.15276
Cao-Pham, Anh H., Urano, Daisuke, Ross-Elliott, Timothy J., and Jones, Alan M. Wed .
"Nudge-nudge, WNK-WNK (kinases), say no more?". United States. https://doi.org/10.1111/nph.15276. https://www.osti.gov/servlets/purl/1609602.
@article{osti_1609602,
title = {Nudge-nudge, WNK-WNK (kinases), say no more?},
author = {Cao-Pham, Anh H. and Urano, Daisuke and Ross-Elliott, Timothy J. and Jones, Alan M.},
abstractNote = {Contents Summary 35 I Overview of animal and plant WNK kinases 35 II. Structure: domains and topology 36 III. Phylogeny–evolutionary relationships 41 IV. Plant WNK kinase distribution and regulation of WNK expression and activity 41 V. Functions of WNK family members in physiology and development 41 VI. Say no more? Still many questions to be answered 45 Acknowledgements 46 References 46 Summary WITH NO LYSINE ( WNK ) kinases are serine/threonine kinases uniquely characterized by an anomalous placement of a catalytic lysine, hence their moniker. In animals, WNK protein kinases play critical roles in protein trafficking of components that mediate renal ion transport processes and regulate osmoregulation of cell volume. In plants, the WNK kinase gene family is larger and more diverse. Recent studies revealed WNK kinase roles in orchestrating the trafficking of an ion channel, a lipid kinase complex in animals, and a heterotrimeric G protein signaling component in plants that is necessary for signal transduction. For this reason, new attention is geared toward investigating the mechanisms adopted by WNK kinases to nudge intracellular proteins to their destinations. In this review, the functions of WNK kinases in protein trafficking are derived from what we have learned from the model organism Arabidopsis thaliana . To place this new idea in context, we provide the predicted WNK kinase structures, their predicted expression patterns, a speculated evolutionary pathway, and the regulatory roles of plant WNK s in transport processes and other physiologies. We brazenly predict that the WNK kinases in both plants and animals will soon be recognized as a nexus for trafficking‐based signal transduction.},
doi = {10.1111/nph.15276},
journal = {New Phytologist},
number = 1,
volume = 220,
place = {United States},
year = {Wed Jun 27 00:00:00 EDT 2018},
month = {Wed Jun 27 00:00:00 EDT 2018}
}
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