Enzyme-activated intracellular drug delivery with tubule clay nanoformulation
Abstract
Fabrication of stimuli-triggered drug delivery vehicle is is an important milestone in treating cancer. Here we demonstrate the selective anticancer drug delivery into human cells with biocompatible 50-nm diameter halloysite nanotube carriers. Physically-adsorbed dextrin end stoppers secure the intercellular release of brilliant green. Drug-loaded nanotubes penetrate through the cellular membranes and their uptake efficiency depends on the cells growth rate. Intercellular glycosyl hydrolases-mediated decomposition of the dextrin tube-end stoppers triggers the release of the lumen-loaded brilliant green, which allowed for preferable elimination of human lung carcinoma cells (А549) as compared with hepatoma cells (Hep3b). In conclusion, the enzyme-activated intracellular delivery of brilliant green using dextrin-coated halloysite nanotubes is a promising platform for anticancer treatment.
- Authors:
-
- Kazan Federal Univ., Kazan (Russian Federation). Bionanotechnology Lab.
- Louisiana Tech Univ., Ruston, LA (United States). Inst. for Micromanufacturing
- Kazan Federal Univ., Kazan (Russian Federation). Bionanotechnology Lab.; Louisiana Tech Univ., Ruston, LA (United States). Inst. for Micromanufacturing
- Publication Date:
- Research Org.:
- Louisiana Tech Univ., Ruston, LA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1454260
- Grant/Contract Number:
- SC0012432
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Scientific Reports
- Additional Journal Information:
- Journal Volume: 5; Journal Issue: 1; Journal ID: ISSN 2045-2322
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Dzamukova, Maria R., Naumenko, Ekaterina A., Lvov, Yuri M., and Fakhrullin, Rawil F. Enzyme-activated intracellular drug delivery with tubule clay nanoformulation. United States: N. p., 2015.
Web. doi:10.1038/srep10560.
Dzamukova, Maria R., Naumenko, Ekaterina A., Lvov, Yuri M., & Fakhrullin, Rawil F. Enzyme-activated intracellular drug delivery with tubule clay nanoformulation. United States. https://doi.org/10.1038/srep10560
Dzamukova, Maria R., Naumenko, Ekaterina A., Lvov, Yuri M., and Fakhrullin, Rawil F. Fri .
"Enzyme-activated intracellular drug delivery with tubule clay nanoformulation". United States. https://doi.org/10.1038/srep10560. https://www.osti.gov/servlets/purl/1454260.
@article{osti_1454260,
title = {Enzyme-activated intracellular drug delivery with tubule clay nanoformulation},
author = {Dzamukova, Maria R. and Naumenko, Ekaterina A. and Lvov, Yuri M. and Fakhrullin, Rawil F.},
abstractNote = {Fabrication of stimuli-triggered drug delivery vehicle is is an important milestone in treating cancer. Here we demonstrate the selective anticancer drug delivery into human cells with biocompatible 50-nm diameter halloysite nanotube carriers. Physically-adsorbed dextrin end stoppers secure the intercellular release of brilliant green. Drug-loaded nanotubes penetrate through the cellular membranes and their uptake efficiency depends on the cells growth rate. Intercellular glycosyl hydrolases-mediated decomposition of the dextrin tube-end stoppers triggers the release of the lumen-loaded brilliant green, which allowed for preferable elimination of human lung carcinoma cells (А549) as compared with hepatoma cells (Hep3b). In conclusion, the enzyme-activated intracellular delivery of brilliant green using dextrin-coated halloysite nanotubes is a promising platform for anticancer treatment.},
doi = {10.1038/srep10560},
journal = {Scientific Reports},
number = 1,
volume = 5,
place = {United States},
year = {Fri May 15 00:00:00 EDT 2015},
month = {Fri May 15 00:00:00 EDT 2015}
}
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