Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2
Abstract
Recent studies reported miR-497 exhibited inhibitory effects in various cancers. However, whether miR-497 is involved in inhibiting angiogenesis, which is critical for tumor growth and metastasis, is still unknown. The purpose of this study was to investigate the potential role of miR-497 in tumor angiogenesis. In this work, cell proliferation and apoptosis analyses were conducted to explore the potential function of miR-497 in HUVECs by using MTT and TUNEL assays. Western blotting (WB) was employed to validate the downstream targets of miR-497. Furthermore, in order to disclose the role of miR-497 on angiogenesis, VEGFR2-luc transgenic mice were treated with miR-497 mimic and applied to monitor tumor angiogenesis and growth by in vivo bioluminescent imaging (BLI). The results demonstrated that overexpression of miR-497 showed inhibitory effects on VEGFR2 activation and downstream Raf/MEK/ERK signal pathways in vitro and in vivo. Moreover, overexpression of miR-497 effectively induced HUVECs apoptosis by targeting VEGFR2 and downstream PI3K/AKT signaling pathway. Furthermore, miR-497 exhibited anti-angiogenesis and anti-tumor effects in the VEGFR2-luc breast tumor model proven by BLI, WB and immunohistochemistry analysis. In summary, miR-497 inhibits tumor angiogenesis and growth via targeting VEGFR2, indicating miR-497 can be explored as a potential drug candidate for cancer therapy.
- Authors:
-
- College of Heilongjiang Province, Harbin, Heilongjiang (China). Key Laboratory of Molecular Imaging; Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang (China). Department of Cardiology; Stanford Univ., CA (United States). Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program
- Third Hospital of Harbin Medical University, Harbin, Heilongjiang (China). Department of Anesthesiology
- College of Heilongjiang Province, Harbin, Heilongjiang (China). Key Laboratory of Molecular Imaging; Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang (China). Department of Radiology
- Second Hospital of Harbin Medical University, Harbin, Heilongjiang (China). Department of Cardiology
- Stanford Univ., CA (United States). Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program
- Harbin Medical University, Daqing, Heilongjiang (China). College of Pharmacy
- Publication Date:
- Research Org.:
- Stanford Univ., CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1440561
- Grant/Contract Number:
- SC0008397
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Scientific Reports
- Additional Journal Information:
- Journal Volume: 5; Journal Issue: 1; Journal ID: ISSN 2045-2322
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Tu, Yingfeng, Liu, Li, Zhao, Dongliang, Liu, Youbin, Ma, Xiaowei, Fan, Yuhua, Wan, Lin, Huang, Tao, Cheng, Zhen, and Shen, Baozhong. Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2. United States: N. p., 2015.
Web. doi:10.1038/srep13827.
Tu, Yingfeng, Liu, Li, Zhao, Dongliang, Liu, Youbin, Ma, Xiaowei, Fan, Yuhua, Wan, Lin, Huang, Tao, Cheng, Zhen, & Shen, Baozhong. Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2. United States. https://doi.org/10.1038/srep13827
Tu, Yingfeng, Liu, Li, Zhao, Dongliang, Liu, Youbin, Ma, Xiaowei, Fan, Yuhua, Wan, Lin, Huang, Tao, Cheng, Zhen, and Shen, Baozhong. Tue .
"Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2". United States. https://doi.org/10.1038/srep13827. https://www.osti.gov/servlets/purl/1440561.
@article{osti_1440561,
title = {Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2},
author = {Tu, Yingfeng and Liu, Li and Zhao, Dongliang and Liu, Youbin and Ma, Xiaowei and Fan, Yuhua and Wan, Lin and Huang, Tao and Cheng, Zhen and Shen, Baozhong},
abstractNote = {Recent studies reported miR-497 exhibited inhibitory effects in various cancers. However, whether miR-497 is involved in inhibiting angiogenesis, which is critical for tumor growth and metastasis, is still unknown. The purpose of this study was to investigate the potential role of miR-497 in tumor angiogenesis. In this work, cell proliferation and apoptosis analyses were conducted to explore the potential function of miR-497 in HUVECs by using MTT and TUNEL assays. Western blotting (WB) was employed to validate the downstream targets of miR-497. Furthermore, in order to disclose the role of miR-497 on angiogenesis, VEGFR2-luc transgenic mice were treated with miR-497 mimic and applied to monitor tumor angiogenesis and growth by in vivo bioluminescent imaging (BLI). The results demonstrated that overexpression of miR-497 showed inhibitory effects on VEGFR2 activation and downstream Raf/MEK/ERK signal pathways in vitro and in vivo. Moreover, overexpression of miR-497 effectively induced HUVECs apoptosis by targeting VEGFR2 and downstream PI3K/AKT signaling pathway. Furthermore, miR-497 exhibited anti-angiogenesis and anti-tumor effects in the VEGFR2-luc breast tumor model proven by BLI, WB and immunohistochemistry analysis. In summary, miR-497 inhibits tumor angiogenesis and growth via targeting VEGFR2, indicating miR-497 can be explored as a potential drug candidate for cancer therapy.},
doi = {10.1038/srep13827},
journal = {Scientific Reports},
number = 1,
volume = 5,
place = {United States},
year = {Tue Sep 08 00:00:00 EDT 2015},
month = {Tue Sep 08 00:00:00 EDT 2015}
}
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Works referenced in this record:
MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer
journal, June 2012
- Guo, S. T.; Jiang, C. C.; Wang, G. P.
- Oncogene, Vol. 32, Issue 15
Endothelial cells and VEGF in vascular development
journal, December 2005
- Coultas, Leigh; Chawengsaksophak, Kallayanee; Rossant, Janet
- Nature, Vol. 438, Issue 7070
MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis
journal, March 2010
- Cha, Shih-Ting; Chen, Pai-Sheng; Johansson, Gunnar
- Cancer Research, Vol. 70, Issue 7
MicroRNA expression profiles classify human cancers
journal, June 2005
- Lu, Jun; Getz, Gad; Miska, Eric A.
- Nature, Vol. 435, Issue 7043
Cell-specific effects of miR-221/222 in vessels: Molecular mechanism and therapeutic application
journal, January 2012
- Liu, Xiaojun; Cheng, Yunhui; Yang, Jian
- Journal of Molecular and Cellular Cardiology, Vol. 52, Issue 1
MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers
journal, May 2013
- Qian, Xu; Yu, Jing; Yin, Yu
- Cell Cycle, Vol. 12, Issue 9
Vascular endothelial growth factor regulates primate choroid-retinal endothelial cell proliferation and tube formation through PI3K/Akt and MEK/ERK dependent signaling
journal, June 2013
- Jin, Jing; Yuan, Fei; Shen, Min-qian
- Molecular and Cellular Biochemistry, Vol. 381, Issue 1-2
MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression
journal, December 2007
- Lee, D. Y.; Deng, Z.; Wang, C. -H.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 51
Identification and angiogenic role of the novel tumor endothelial marker CLEC14A
journal, June 2011
- Mura, M.; Swain, R. K.; Zhuang, X.
- Oncogene, Vol. 31, Issue 3
MicroRNA-221 Induces Cell Survival and Cisplatin Resistance through PI3K/Akt Pathway in Human Osteosarcoma
journal, January 2013
- Zhao, Guangyi; Cai, Chengkui; Yang, Tongtao
- PLoS ONE, Vol. 8, Issue 1
Predicting the Effects of Anti-angiogenic Agents Targeting Specific VEGF Isoforms
journal, May 2012
- Finley, Stacey D.; Popel, Aleksander S.
- The AAPS Journal, Vol. 14, Issue 3
The Critical Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis
journal, January 2012
- Amini, A.; Masoumi Moghaddam, S.; L. Morris, D.
- Current Cancer Drug Targets, Vol. 12, Issue 1
Lactadherin promotes VEGF-dependent neovascularization
journal, April 2005
- Silvestre, Jean-Sébastien; Théry, Clotilde; Hamard, Ghislaine
- Nature Medicine, Vol. 11, Issue 5
miR-497 induces apoptosis of breast cancer cells by targeting Bcl-w
journal, December 2011
- Shen, Lei; Li, Jia; Xu, Liping
- Experimental and Therapeutic Medicine, Vol. 3, Issue 3
miR-21-mediated tumor growth
journal, October 2006
- Si, M-L; Zhu, S.; Wu, H.
- Oncogene, Vol. 26, Issue 19
MicroRNA 497 modulates interleukin 1 signalling via the MAPK/ERK pathway
journal, October 2012
- Zheng, Dongling; Radziszewska, Anna; Woo, Patricia
- FEBS Letters, Vol. 586, Issue 23
MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis
journal, April 2010
- Nicoli, Stefania; Standley, Clive; Walker, Paul
- Nature, Vol. 464, Issue 7292
The novel miR-9500 regulates the proliferation and migration of human lung cancer cells by targeting Akt1
journal, March 2014
- Yoo, J. K.; Jung, H. Y.; Lee, J. M.
- Cell Death & Differentiation, Vol. 21, Issue 7
The shaping and functional consequences of the microRNA landscape in breast cancer
journal, May 2013
- Dvinge, Heidi; Git, Anna; Gräf, Stefan
- Nature, Vol. 497, Issue 7449
Tocotrienols Target PI3K/Akt Signaling in Anti-Breast Cancer Therapy
journal, July 2013
- Sylvester, Paul; Ayoub, Nehad
- Anti-Cancer Agents in Medicinal Chemistry, Vol. 13, Issue 7
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer
journal, July 2013
- Chatterjee, Sampurna; Heukamp, Lukas C.; Siobal, Maike
- Journal of Clinical Investigation, Vol. 123, Issue 7
Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways
journal, July 2013
- Law, Alice Y. S.; Wong, Chris K. C.
- Molecular and Cellular Endocrinology, Vol. 374, Issue 1-2
TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer
journal, September 2011
- Shih, M-C; Chen, J-Y; Wu, Y-C
- Oncogene, Vol. 31, Issue 19
MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1
journal, January 2013
- Creevey, Laura; Ryan, Jacqueline; Harvey, Harry
- Molecular Cancer, Vol. 12, Issue 1
Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor
journal, February 2008
- Hata, Yasuaki; Miura, Muneki; Nakao, Shintaro
- Japanese Journal of Ophthalmology, Vol. 52, Issue 1
Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises
journal, August 2008
- Yap, Timothy A.; Garrett, Michelle D.; Walton, Mike I.
- Current Opinion in Pharmacology, Vol. 8, Issue 4
Downregulation of miR-497 promotes tumor growth and angiogenesis by targeting HDGF in non-small cell lung cancer
journal, June 2013
- Zhao, Wen-yan; Wang, Yan; An, Zhong-jun
- Biochemical and Biophysical Research Communications, Vol. 435, Issue 3
Tracking angiogenesis induced by skin wounding and contact hypersensitivity using a Vegfr2-luciferase transgenic mouse
journal, January 2004
- Zhang, Ning; Fang, Zuxu; Contag, Pamela R.
- Blood, Vol. 103, Issue 2
Assessment of multiparametric MRI in a human glioma model to monitor cytotoxic and anti-angiogenic drug effects
journal, December 2010
- Lemasson, Benjamin; Christen, Thomas; Tizon, Xavier
- NMR in Biomedicine, Vol. 24, Issue 5
Akt1 in Endothelial Cell and Angiogenesis
journal, March 2006
- Somanath, Payaningal R.; Razorenova, Olga V.; Chen, Juhua
- Cell Cycle, Vol. 5, Issue 5
In Vivo Monitoring of Angiogenesis Inhibition via Down-Regulation of Mir-21 in a VEGFR2-Luc Murine Breast Cancer Model Using Bioluminescent Imaging
journal, August 2013
- Zhao, Dongliang; Tu, Yingfeng; Wan, Lin
- PLoS ONE, Vol. 8, Issue 8
MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8
journal, October 2010
- Fang, L.; Deng, Z.; Shatseva, T.
- Oncogene, Vol. 30, Issue 7
Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase
journal, February 2013
- Awazu, Yoshiko; Mizutani, Akio; Nagase, Yoshinori
- Cancer Science, Vol. 104, Issue 4
Inhibition of Tumor Endothelial ERK Activation, Angiogenesis, and Tumor Growth by Sorafenib (BAY43-9006)
journal, November 2006
- Murphy, Danielle A.; Makonnen, Sosina; Lassoued, Wiem
- The American Journal of Pathology, Vol. 169, Issue 5
MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth
journal, June 2013
- Zhou, Bisheng; Ma, Ruihua; Si, Wenxia
- Cancer Letters, Vol. 333, Issue 2
miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2
journal, January 2011
- Zhu, Wei; Zhu, DanXia; Lu, Shiqiang
- Medical Oncology, Vol. 29, Issue 1
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer
journal, March 2013
- Chatterjee, Sampurna; Heukamp, Lukas C.; Siobal, Maike
- Journal of Clinical Investigation, Vol. 123, Issue 4
Vascular endothelial growth factor regulates primate choroid-retinal endothelial cell proliferation and tube formation through PI3K/Akt and MEK/ERK dependent signaling
journal, June 2013
- Jin, Jing; Yuan, Fei; Shen, Min-qian
- Molecular and Cellular Biochemistry, Vol. 381, Issue 1-2
miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2
journal, January 2011
- Zhu, Wei; Zhu, DanXia; Lu, Shiqiang
- Medical Oncology, Vol. 29, Issue 1
MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth
journal, June 2013
- Zhou, Bisheng; Ma, Ruihua; Si, Wenxia
- Cancer Letters, Vol. 333, Issue 2
MicroRNA 497 modulates interleukin 1 signalling via the MAPK/ERK pathway
journal, October 2012
- Zheng, Dongling; Radziszewska, Anna; Woo, Patricia
- FEBS Letters, Vol. 586, Issue 23
The novel miR-9500 regulates the proliferation and migration of human lung cancer cells by targeting Akt1
journal, March 2014
- Yoo, J. K.; Jung, H. Y.; Lee, J. M.
- Cell Death & Differentiation, Vol. 21, Issue 7
The shaping and functional consequences of the microRNA landscape in breast cancer
journal, May 2013
- Dvinge, Heidi; Git, Anna; Gräf, Stefan
- Nature, Vol. 497, Issue 7449
MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8
journal, October 2010
- Fang, L.; Deng, Z.; Shatseva, T.
- Oncogene, Vol. 30, Issue 7
Identification and angiogenic role of the novel tumor endothelial marker CLEC14A
journal, June 2011
- Mura, M.; Swain, R. K.; Zhuang, X.
- Oncogene, Vol. 31, Issue 3
TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer
journal, September 2011
- Shih, M-C; Chen, J-Y; Wu, Y-C
- Oncogene, Vol. 31, Issue 19
MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer
journal, June 2012
- Guo, S. T.; Jiang, C. C.; Wang, G. P.
- Oncogene, Vol. 32, Issue 15
miR-21-mediated tumor growth
journal, October 2006
- Si, M-L; Zhu, S.; Wu, H.
- Oncogene, Vol. 26, Issue 19
MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression
journal, December 2007
- Lee, D. Y.; Deng, Z.; Wang, C. -H.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 51
miR-497 and miR-302b Regulate Ethanol-induced Neuronal Cell Death through BCL2 Protein and Cyclin D2
journal, August 2011
- Yadav, Sanjay; Pandey, Ankita; Shukla, Aruna
- Journal of Biological Chemistry, Vol. 286, Issue 43
Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase
journal, February 2013
- Awazu, Yoshiko; Mizutani, Akio; Nagase, Yoshinori
- Cancer Science, Vol. 104, Issue 4
Editor's Note: MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis
journal, July 2019
- Cha, Shih-Ting; Chen, Pai-Sheng; Johansson, Gunnar
- Cancer Research, Vol. 79, Issue 14
Whole-Body Optical Imaging in Animal Models to Assess Cancer Development and Progression
journal, June 2007
- Kaijzel, E. L.; van der Pluijm, G.; Lowik, C. W. G. M.
- Clinical Cancer Research, Vol. 13, Issue 12
Analysis of MiR-195 and MiR-497 Expression, Regulation and Role in Breast Cancer
journal, February 2011
- Li, D.; Zhao, Y.; Liu, C.
- Clinical Cancer Research, Vol. 17, Issue 7
Non-invasive imaging for studying anti-angiogenic therapy effects
journal, January 2013
- Ehling, Josef; Lammers, Twan; Kiessling, Fabian
- Thrombosis and Haemostasis, Vol. 109, Issue 03
Thanks be to Zebrafish
journal, September 2010
- Williams, Ruth
- Circulation Research, Vol. 107, Issue 5
MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1
journal, January 2013
- Creevey, Laura; Ryan, Jacqueline; Harvey, Harry
- Molecular Cancer, Vol. 12, Issue 1
The Critical Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis
journal, January 2012
- Amini, A.; Masoumi Moghaddam, S.; L. Morris, D.
- Current Cancer Drug Targets, Vol. 12, Issue 1
Tocotrienols Target PI3K/Akt Signaling in Anti-Breast Cancer Therapy
journal, July 2013
- Sylvester, Paul; Ayoub, Nehad
- Anti-Cancer Agents in Medicinal Chemistry, Vol. 13, Issue 7
Inhibition of Tumor Endothelial ERK Activation, Angiogenesis, and Tumor Growth by Sorafenib (BAY43-9006)
journal, November 2006
- Murphy, Danielle A.; Makonnen, Sosina; Lassoued, Wiem
- The American Journal of Pathology, Vol. 169, Issue 5
miR-497 induces apoptosis of breast cancer cells by targeting Bcl-w
journal, December 2011
- Shen, Lei; Li, Jia; Xu, Liping
- Experimental and Therapeutic Medicine, Vol. 3, Issue 3
Akt1 in Endothelial Cell and Angiogenesis
journal, March 2006
- Somanath, Payaningal R.; Razorenova, Olga V.; Chen, Juhua
- Cell Cycle, Vol. 5, Issue 5
Works referencing / citing this record:
Regulation of tumor angiogenesis by microRNAs: State of the art: GORADEL et al.
journal, August 2018
- Goradel, Nasser H.; Mohammadi, Nejad; Haghi-Aminjan, Hamed
- Journal of Cellular Physiology, Vol. 234, Issue 2
A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis
journal, December 2018
- Farzaneh Behelgardi, Maryam; Zahri, Saber; Mashayekhi, Farhad
- Scientific Reports, Vol. 8, Issue 1
Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model
journal, January 2020
- Jeong, Kyeongsoo; Yu, Yeong Jun; You, Jae Young
- Lab on a Chip, Vol. 20, Issue 3
PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186
journal, March 2017
- Ma, Yawen; Wang, Ping; Xue, Yixue
- Tumor Biology, Vol. 39, Issue 3
New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications
journal, February 2018
- Wang, Ye; Wang, Liya; Chen, Cheng
- Molecular Cancer, Vol. 17, Issue 1
MicroRNA-497 Induces Apoptosis and Suppresses Proliferation via the Bcl-2/Bax-Caspase9-Caspase3 Pathway and Cyclin D2 Protein in HUVECs
journal, December 2016
- Wu, Ridong; Tang, Shi; Wang, Mian
- PLOS ONE, Vol. 11, Issue 12
miR-206/133b Cluster: A Weapon against Lung Cancer?
journal, September 2017
- Pan, Jing-Yu; Sun, Cheng-Cao; Bi, Zhuo-Yue
- Molecular Therapy - Nucleic Acids, Vol. 8
A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis
journal, December 2018
- Farzaneh Behelgardi, Maryam; Zahri, Saber; Mashayekhi, Farhad
- Scientific Reports, Vol. 8, Issue 1
miR‐15a/15b Cluster Modulates Survival of Mesenchymal Stem Cells to Improve Its Therapeutic Efficacy of Myocardial Infarction
journal, January 2019
- Tu, Yingfeng; Qiu, Yan; Liu, Li
- Journal of the American Heart Association, Vol. 8, Issue 1
New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications
journal, February 2018
- Wang, Ye; Wang, Liya; Chen, Cheng
- Molecular Cancer, Vol. 17, Issue 1
MicroRNA-497 Induces Apoptosis and Suppresses Proliferation via the Bcl-2/Bax-Caspase9-Caspase3 Pathway and Cyclin D2 Protein in HUVECs
journal, December 2016
- Wu, Ridong; Tang, Shi; Wang, Mian
- PLOS ONE, Vol. 11, Issue 12
Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway
journal, October 2017
- Li, Ming; Yu, Xinfang; Li, Wei
- Oncotarget, Vol. 9, Issue 1
MicroRNAs in cancer metastasis and angiogenesis
journal, December 2017
- Lou, Weiyang; Liu, Jingxing; Gao, Yanjia
- Oncotarget, Vol. 8, Issue 70