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This content will become publicly available on March 29, 2019

Title: Aggregate Exposure Pathways in Support of Risk Assessment

Over time, risk assessment has shifted from establishing relationships between exposure to a single chemical and a resulting adverse health outcome, to evaluation of multiple chemicals and disease outcomes simultaneously. As a result, there is an increasing need to better understand the complex mechanisms that influence risk of chemical and non-chemical stressors, beginning at their source and ending at a biological endpoint relevant to human or ecosystem health risk assessment. Just as the Adverse Outcome Pathway (AOP) framework has emerged as a means of providing insight into mechanism-based toxicity, the exposure science community has seen the recent introduction of the Aggregate Exposure Pathway (AEP) framework. AEPs aid in making exposure data applicable to the FAIR (i.e., findable, accessible, interoperable, and reusable) principle, especially by (1) organizing continuous flow of disjointed exposure information;(2) identifying data gaps, to focus resources on acquiring the most relevant data; (3) optimizing use and repurposing of existing exposure data; and (4) facilitating interoperability among predictive models. Herein, we discuss integration of the AOP and AEP frameworks and how such integration can improve confidence in both traditional and cumulative risk assessment approaches.
Authors:
 [1] ;  [2] ; ORCiD logo [3] ;  [4] ;  [5] ;  [1]
  1. US Environmental Protection Agency (EPA), Durham, NC (United States). National Exposure Research Lab.
  2. Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
  3. US Environmental Protection Agency (EPA), Durham, NC (United States). National Health and Environmental Effects Research Lab.
  4. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Health Effects and Exposure Science
  5. European Commission, Ispra (Italy). Joint Research Centre, Directorate Health, Consumers and Reference Materials
Publication Date:
Grant/Contract Number:
AC05-76RL01830
Type:
Accepted Manuscript
Journal Name:
Current Opinion in Toxicology
Additional Journal Information:
Journal Name: Current Opinion in Toxicology; Journal ID: ISSN 2468-2020
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE; USEPA
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; Aggregate Exposure Pathway; risk assessment; Adverse Outcome Pathway
OSTI Identifier:
1432517