Aggregate Exposure Pathways in Support of Risk Assessment

Tan, Yu-Mei; Leonard, Jeremy A.; Edwards, Stephen; Teeguarden, Justin; Paini, Alicia; Egeghy, Peter

doi:10.1016/j.cotox.2018.03.006

Title: Aggregate Exposure Pathways in Support of Risk Assessment

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Abstract

Over time, risk assessment has shifted from establishing relationships between exposure to a single chemical and a resulting adverse health outcome, to evaluation of multiple chemicals and disease outcomes simultaneously. As a result, there is an increasing need to better understand the complex mechanisms that influence risk of chemical and non-chemical stressors, beginning at their source and ending at a biological endpoint relevant to human or ecosystem health risk assessment. Just as the Adverse Outcome Pathway (AOP) framework has emerged as a means of providing insight into mechanism-based toxicity, the exposure science community has seen the recent introduction of the Aggregate Exposure Pathway (AEP) framework. AEPs aid in making exposure data applicable to the FAIR (i.e., findable, accessible, interoperable, and reusable) principle, especially by (1) organizing continuous flow of disjointed exposure information;(2) identifying data gaps, to focus resources on acquiring the most relevant data; (3) optimizing use and repurposing of existing exposure data; and (4) facilitating interoperability among predictive models. Herein, we discuss integration of the AOP and AEP frameworks and how such integration can improve confidence in both traditional and cumulative risk assessment approaches.

Authors:

Tan, Yu-Mei ^[1]; Leonard, Jeremy A. ^[2];

^[3]; Teeguarden, Justin ^[4]; Paini, Alicia ^[5]; Egeghy, Peter ^[1]

US Environmental Protection Agency (EPA), Durham, NC (United States). National Exposure Research Lab.
Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
US Environmental Protection Agency (EPA), Durham, NC (United States). National Health and Environmental Effects Research Lab.
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Health Effects and Exposure Science
European Commission, Ispra (Italy). Joint Research Centre, Directorate Health, Consumers and Reference Materials

Publication Date:: Thu Mar 29 00:00:00 EDT 2018

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE; USEPA

OSTI Identifier:: 1432517

Alternate Identifier(s):: OSTI ID: 1781148

Grant/Contract Number:: AC05-76RL01830; AC05-76RLO 1830

Resource Type:: Accepted Manuscript

Journal Name:: Current Opinion in Toxicology

Additional Journal Information:: Journal Volume: 9; Journal ID: ISSN 2468-2020

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; Aggregate Exposure Pathway; risk assessment; Adverse Outcome Pathway

Citation Formats


                    Tan, Yu-Mei, Leonard, Jeremy A., Edwards, Stephen, Teeguarden, Justin, Paini, Alicia, and Egeghy, Peter. Aggregate Exposure Pathways in Support of Risk Assessment.  United States: N. p., 2018. 
Web.  doi:10.1016/j.cotox.2018.03.006.

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                    Tan, Yu-Mei, Leonard, Jeremy A., Edwards, Stephen, Teeguarden, Justin, Paini, Alicia, & Egeghy, Peter. Aggregate Exposure Pathways in Support of Risk Assessment.  United States.  https://doi.org/10.1016/j.cotox.2018.03.006

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                    Tan, Yu-Mei, Leonard, Jeremy A., Edwards, Stephen, Teeguarden, Justin, Paini, Alicia, and Egeghy, Peter. Thu .  
"Aggregate Exposure Pathways in Support of Risk Assessment".  United States.  https://doi.org/10.1016/j.cotox.2018.03.006.  https://www.osti.gov/servlets/purl/1432517.

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@article{osti_1432517,

  title        = {Aggregate Exposure Pathways in Support of Risk Assessment},

  author       = {Tan, Yu-Mei and Leonard, Jeremy A. and Edwards, Stephen and Teeguarden, Justin and Paini, Alicia and Egeghy, Peter},

  abstractNote = {Over time, risk assessment has shifted from establishing relationships between exposure to a single chemical and a resulting adverse health outcome, to evaluation of multiple chemicals and disease outcomes simultaneously. As a result, there is an increasing need to better understand the complex mechanisms that influence risk of chemical and non-chemical stressors, beginning at their source and ending at a biological endpoint relevant to human or ecosystem health risk assessment. Just as the Adverse Outcome Pathway (AOP) framework has emerged as a means of providing insight into mechanism-based toxicity, the exposure science community has seen the recent introduction of the Aggregate Exposure Pathway (AEP) framework. AEPs aid in making exposure data applicable to the FAIR (i.e., findable, accessible, interoperable, and reusable) principle, especially by (1) organizing continuous flow of disjointed exposure information;(2) identifying data gaps, to focus resources on acquiring the most relevant data; (3) optimizing use and repurposing of existing exposure data; and (4) facilitating interoperability among predictive models. Herein, we discuss integration of the AOP and AEP frameworks and how such integration can improve confidence in both traditional and cumulative risk assessment approaches.},

  doi          = {10.1016/j.cotox.2018.03.006},

  journal      = {Current Opinion in Toxicology},

  number       = ,

  volume       = 9,

  place        = {United States},

  year         = {Thu Mar 29 00:00:00 EDT 2018},

  month        = {Thu Mar 29 00:00:00 EDT 2018}

}

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