The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing
Abstract
Unlike canonical pre-mRNAs, animal replication-dependent histone pre-mRNAs lack introns and are processed at the 3’-end by a mechanism distinct from cleavage and polyadenylation. They have a 3’ stem loop and histone downstream element (HDE) that are recognized by stem-loop binding protein (SLBP) and U7 snRNP, respectively. The N-terminal domain (NTD) of Lsm11, a component of U7 snRNP, interacts with FLASH NTD and these two proteins recruit the histone cleavage complex containing the CPSF-73 endonuclease for the cleavage reaction. Here, we determined crystal structures of FLASH NTD and found that it forms a coiled-coil dimer. Using solution light scattering, we characterized the stoichiometry of the FLASH NTD-Lsm11 NTD complex and found that it is a 2:1 heterotrimer, which is supported by observations from analytical ultracentrifugation and crosslinking.
- Authors:
-
[1]
- Columbia Univ., New York, NY (United States)
- National Yang-Ming Univ., Taipei (Taiwan)
- Univ. of North Carolina, Chapel Hill, NC (United States)
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)
- Sponsoring Org.:
- National Institutes of Health (NIH); Taiwan Ministry of Science and Technology (MOST); • National Institute of General Medical Sciences (NIGMS); Howard Hughes Medical Institute (HHMI); USDOE Office of Science (SC)
- OSTI Identifier:
- 1430295
- Grant/Contract Number:
- R35GM118093; S10OD012018; GM29832; 105-2320-B-010-012; 106-2320-B-010-013; S10 RR029205; AC02-06CH11357; AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS ONE
- Additional Journal Information:
- Journal Volume: 12; Journal Issue: 10; Journal ID: ISSN 1932-6203
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- ENGLISH
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Crystal structure; Dimers (Chemical physics); Histones; Sedimentation; Vector cloning; Crystals; Dimerization; Ultracentrifugation
Citation Formats
Aik, Wei Shen, Lin, Min-Han, Tan, Dazhi, Tripathy, Ashutosh, Marzluff, William F., Dominski, Zbigniew, Chou, Chi-Yuan, and Tong, Liang. The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing. United States: N. p., 2017.
Web. doi:10.1371/journal.pone.0186034.
Aik, Wei Shen, Lin, Min-Han, Tan, Dazhi, Tripathy, Ashutosh, Marzluff, William F., Dominski, Zbigniew, Chou, Chi-Yuan, & Tong, Liang. The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing. United States. https://doi.org/10.1371/journal.pone.0186034
Aik, Wei Shen, Lin, Min-Han, Tan, Dazhi, Tripathy, Ashutosh, Marzluff, William F., Dominski, Zbigniew, Chou, Chi-Yuan, and Tong, Liang. Wed .
"The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing". United States. https://doi.org/10.1371/journal.pone.0186034. https://www.osti.gov/servlets/purl/1430295.
@article{osti_1430295,
title = {The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing},
author = {Aik, Wei Shen and Lin, Min-Han and Tan, Dazhi and Tripathy, Ashutosh and Marzluff, William F. and Dominski, Zbigniew and Chou, Chi-Yuan and Tong, Liang},
abstractNote = {Unlike canonical pre-mRNAs, animal replication-dependent histone pre-mRNAs lack introns and are processed at the 3’-end by a mechanism distinct from cleavage and polyadenylation. They have a 3’ stem loop and histone downstream element (HDE) that are recognized by stem-loop binding protein (SLBP) and U7 snRNP, respectively. The N-terminal domain (NTD) of Lsm11, a component of U7 snRNP, interacts with FLASH NTD and these two proteins recruit the histone cleavage complex containing the CPSF-73 endonuclease for the cleavage reaction. Here, we determined crystal structures of FLASH NTD and found that it forms a coiled-coil dimer. Using solution light scattering, we characterized the stoichiometry of the FLASH NTD-Lsm11 NTD complex and found that it is a 2:1 heterotrimer, which is supported by observations from analytical ultracentrifugation and crosslinking.},
doi = {10.1371/journal.pone.0186034},
journal = {PLoS ONE},
number = 10,
volume = 12,
place = {United States},
year = {Wed Oct 11 00:00:00 EDT 2017},
month = {Wed Oct 11 00:00:00 EDT 2017}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 9 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Three Proteins of the U7-Specific Sm Ring Function as the Molecular Ruler To Determine the Site of 3'-End Processing in Mammalian Histone Pre-mRNA
journal, May 2009
- Yang, X. -c.; Torres, M. P.; Marzluff, W. F.
- Molecular and Cellular Biology, Vol. 29, Issue 15
Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing
journal, September 2003
- Pillai, R. S.
- Genes & Development, Vol. 17, Issue 18
Searching for FLASH domains
journal, October 1999
- Koonin, Eugene V.; Aravind, L.; Hofmann, Kay
- Nature, Vol. 401, Issue 6754
Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis
journal, May 2016
- Tatomer, Deirdre C.; Terzo, Esteban; Curry, Kaitlin P.
- The Journal of Cell Biology, Vol. 213, Issue 5
Molecular Architecture of the Human Pre-mRNA 3′ Processing Complex
journal, February 2009
- Shi, Yongsheng; Di Giammartino, Dafne Campigli; Taylor, Derek
- Molecular Cell, Vol. 33, Issue 3
FLASH is required for histone transcription and S-phase progression
journal, September 2006
- Barcaroli, D.; Bongiorno-Borbone, L.; Terrinoni, A.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 40
FLASH and NPAT positive but not Coilin positive Cajal bodies correlate with cell ploidy
journal, August 2008
- Bongiorno-Borbone, Lucilla; De Cola, Antonella; Vernole, Patrizia
- Cell Cycle, Vol. 7, Issue 15
Metazoan replication-dependent histone mRNAs: a distinct set of RNA polymerase II transcripts
journal, June 2005
- Marzluff, William F.
- Current Opinion in Cell Biology, Vol. 17, Issue 3
Four factors are required for 3'-end cleavage of pre-mRNAs.
journal, November 1989
- Takagaki, Y.; Ryner, L. C.; Manley, J. L.
- Genes & Development, Vol. 3, Issue 11
FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci
journal, April 2008
- Alm-Kristiansen, A. H.; Sæther, T.; Matre, V.
- Oncogene, Vol. 27, Issue 34
Mapping the Interaction Network of Key Proteins Involved in Histone mRNA Generation: A Hydrogen/Deuterium Exchange Study
journal, March 2016
- Skrajna, Aleksandra; Yang, Xiao-cui; Tarnowski, Krzysztof
- Journal of Molecular Biology, Vol. 428, Issue 6
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
journal, September 2000
- Zhao, J.
- Genes & Development, Vol. 14, Issue 18
Structure of Histone mRNA Stem-Loop, Human Stem-Loop Binding Protein, and 3'hExo Ternary Complex
journal, January 2013
- Tan, D.; Marzluff, W. F.; Dominski, Z.
- Science, Vol. 339, Issue 6117
Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments
journal, January 2011
- Hsieh, Yi-Hui; Chou, Chi-Yuan
- Journal of Biomedical Science, Vol. 18, Issue 1
Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main Protease
journal, December 2015
- Ho, Bo-Lin; Cheng, Shu-Chun; Shi, Lin
- PLOS ONE, Vol. 10, Issue 12
A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing
journal, January 2002
- Dominski, Z.
- Genes & Development, Vol. 16, Issue 1
On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation
journal, September 2003
- Schuck, Peter
- Analytical Biochemistry, Vol. 320, Issue 1
Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells
journal, October 2008
- Ghule, P. N.; Dominski, Z.; Yang, X. -c.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 44
Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay
journal, December 2012
- Hoefig, Kai P.; Rath, Nicola; Heinz, Gitta A.
- Nature Structural & Molecular Biology, Vol. 20, Issue 1
The Polyadenylation Factor CPSF-73 Is Involved in Histone-Pre-mRNA Processing
journal, October 2005
- Dominski, Zbigniew; Yang, Xiao-cui; Marzluff, William F.
- Cell, Vol. 123, Issue 1
FLASH, a Proapoptotic Protein Involved in Activation of Caspase-8, Is Essential for 3′ End Processing of Histone Pre-mRNAs
journal, October 2009
- Yang, Xiao-cui; Burch, Brandon D.; Yan, Yan
- Molecular Cell, Vol. 36, Issue 2
Integration, scaling, space-group assignment and post-refinement
journal, January 2010
- Kabsch, Wolfgang
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 133-144
Inference of Macromolecular Assemblies from Crystalline State
journal, September 2007
- Krissinel, Evgeny; Henrick, Kim
- Journal of Molecular Biology, Vol. 372, Issue 3
XDS
journal, January 2010
- Kabsch, Wolfgang
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2
Structural and functional characterization of MERS coronavirus papain-like protease
journal, January 2014
- Lin, Min-Han; Chuang, Shang-Ju; Chen, Chiao-Che
- Journal of Biomedical Science, Vol. 21, Issue 1
The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis
journal, April 1999
- Imai, Yuzuru; Kimura, Takaharu; Murakami, Akira
- Nature, Vol. 398, Issue 6730
Emergence of the β-CASP ribonucleases: Highly conserved and ubiquitous metallo-enzymes involved in messenger RNA maturation and degradation
journal, June 2013
- Dominski, Zbigniew; Carpousis, Agamemnon J.; Clouet-d'Orval, Béatrice
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Vol. 1829, Issue 6-7
Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's
journal, December 1987
- Mowry, K.; Steitz, J.
- Science, Vol. 238, Issue 4834
Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein
journal, October 2001
- Pillai, R. S.
- The EMBO Journal, Vol. 20, Issue 19
A Conserved Interaction That Is Essential for the Biogenesis of Histone Locus Bodies
journal, October 2014
- Yang, Xiao-cui; Sabath, Ivan; Kunduru, Lalitha
- Journal of Biological Chemistry, Vol. 289, Issue 49
A 3′ Exonuclease that Specifically Interacts with the 3′ End of Histone mRNA
journal, August 2003
- Dominski, Zbigniew; Yang, Xiao-cui; Kaygun, Handan
- Molecular Cell, Vol. 12, Issue 2
Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail
journal, November 2008
- Marzluff, William F.; Wagner, Eric J.; Duronio, Robert J.
- Nature Reviews Genetics, Vol. 9, Issue 11
The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing.
journal, December 1996
- Wang, Z. F.; Whitfield, M. L.; Ingledue, T. C.
- Genes & Development, Vol. 10, Issue 23
Deciphering key features in protein structures with the new ENDscript server
journal, April 2014
- Robert, Xavier; Gouet, Patrice
- Nucleic Acids Research, Vol. 42, Issue W1
Features and development of Coot
journal, March 2010
- Emsley, P.; Lohkamp, B.; Scott, W. G.
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila
journal, April 2011
- Burch, B. D.; Godfrey, A. C.; Gasdaska, P. Y.
- RNA, Vol. 17, Issue 6
PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010
- Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega
journal, January 2011
- Sievers, Fabian; Wilm, Andreas; Dineen, David
- Molecular Systems Biology, Vol. 7, Issue 1
U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3' end processing
journal, April 2005
- Azzouz, T. N.
- Nucleic Acids Research, Vol. 33, Issue 7
Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs
journal, November 2005
- Kolev, N. G.
- Genes & Development, Vol. 19, Issue 21
Mutation of Glu-166 Blocks the Substrate-Induced Dimerization of SARS Coronavirus Main Protease
journal, April 2010
- Cheng, Shu-Chun; Chang, Gu-Gang; Chou, Chi-Yuan
- Biophysical Journal, Vol. 98, Issue 7
U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem–loop binding protein
journal, March 2017
- Skrajna, Aleksandra; Yang, Xiao-cui; Bucholc, Katarzyna
- RNA, Vol. 23, Issue 6
Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease
journal, April 2012
- Chou, Ya-Wen; Cheng, Shu-Chun; Lai, Hsing-Yi
- Archives of Biochemistry and Biophysics, Vol. 520, Issue 2
A new bioinformatics analysis tools framework at EMBL-EBI
journal, May 2010
- Goujon, M.; McWilliam, H.; Li, W.
- Nucleic Acids Research, Vol. 38, Issue Web Server
Experimental phasing with SHELXC / D / E : combining chain tracing with density modification
journal, March 2010
- Sheldrick, George M.
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3′ processing of H3 pre-mRNA in the oocyte.
journal, July 1986
- Strub, K.; Birnstiel, M. L.
- The EMBO Journal, Vol. 5, Issue 7
A Genome-wide RNA Interference Screen Reveals that Variant Histones Are Necessary for Replication-Dependent Histone Pre-mRNA Processing
journal, November 2007
- Wagner, Eric J.; Burch, Brandon D.; Godfrey, Ashley C.
- Molecular Cell, Vol. 28, Issue 4
Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure.
journal, May 1990
- Hendrickson, W. A.; Horton, J. R.; LeMaster, D. M.
- The EMBO Journal, Vol. 9, Issue 5
FLASH Meets Nuclear Bodies: CD95 Receptor Signals via a Nuclear Pathway
journal, April 2007
- Krieghoff, Eva; Milovic-Holm, Kristijana; Hofmann, Thomas G.
- Cell Cycle, Vol. 6, Issue 7
Cell cycle-regulated phosphorylation of p220NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription
journal, September 2000
- Ma, T.
- Genes & Development, Vol. 14, Issue 18
[20] Processing of X-ray diffraction data collected in oscillation mode
book, January 1997
- Otwinowski, Zbyszek; Minor, Wladek
- Macromolecular Crystallography Part A, 307-326
Phaser crystallographic software
journal, July 2007
- McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
- Journal of Applied Crystallography, Vol. 40, Issue 4
Protein secondary structure prediction based on position-specific scoring matrices 1 1Edited by G. Von Heijne
journal, September 1999
- Jones, David T.
- Journal of Molecular Biology, Vol. 292, Issue 2
PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
journal, December 2019
- Sharma, Deepti; De Falco, Louis; Padavattan, Sivaraman
- Nature Communications, Vol. 10, Issue 1
Cryo-EM structure of the respiratory syncytial virus RNA polymerase
journal, January 2020
- Cao, Dongdong; Gao, Yunrong; Roesler, Claire
- Nature Communications, Vol. 11, Issue 1
Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
journal, February 2021
- Tillu, Vikas A.; Rae, James; Gao, Ya
- Nature Communications, Vol. 12, Issue 1
FLASH, a Proapoptotic Protein Involved in Activation of Caspase-8, Is Essential for 3′ End Processing of Histone Pre-mRNAs
text, January 2009
- Yan, Yan,; Xiao-cui, Yang,; D., Burch, Brandon
- The University of North Carolina at Chapel Hill University Libraries
The Polyadenylation Factor CPSF-73 Is Involved in Histone-Pre-mRNA Processing
text, January 2005
- Xiao-cui, Yang,; F., Marzluff, William; Zbigniew, Dominski,
- The University of North Carolina at Chapel Hill University Libraries
Mapping the Interaction Network of Key Proteins Involved in Histone mRNA Generation: A Hydrogen/Deuterium Exchange Study
text, January 2016
- Aleksandra, Skrajna,; F., Marzluff, William; Xiao-Cui, Yang,
- The University of North Carolina at Chapel Hill University Libraries
Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila
text, January 2011
- R., Salzler, H.; Z., Dominski,; F., Marzluff, W.
- The University of North Carolina at Chapel Hill University Libraries
Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail
text, January 2008
- F., Marzluff, William; J., Wagner, Eric; J., Duronio, Robert
- The University of North Carolina at Chapel Hill University Libraries
Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis
text, January 2016
- Esteban, Terzo,; P., Curry, Kaitlin; J., Duronio, Robert
- The University of North Carolina at Chapel Hill University Libraries
A Conserved Interaction That Is Essential for the Biogenesis of Histone Locus Bodies
text, January 2014
- Cui, Yang, Xiao; Lalitha, Kunduru,; F., Marzluff, William
- The University of North Carolina at Chapel Hill University Libraries
FLASH Is Required for the Endonucleolytic Cleavage of Histone Pre-mRNAs but Is Dispensable for the 5' Exonucleolytic Degradation of the Downstream Cleavage Product
text, January 2011
- I., Sabath,; L., Kunduru,; B., Xu,
- The University of North Carolina at Chapel Hill University Libraries
A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing
text, January 2002
- Z., Dominski,
- The University of North Carolina at Chapel Hill University Libraries
The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing.
text, January 1996
- Feng, Wang, Zeng; C., Ingledue III, Thomas; Zbigniew, Dominski,
- The University of North Carolina at Chapel Hill University Libraries
A Complex Containing the CPSF73 Endonuclease and Other Polyadenylation Factors Associates with U7 snRNP and Is Recruited to Histone Pre-mRNA for 3'-End Processing
text, January 2012
- F., Marzluff, W.; M., Dadlez,; J., Debski,
- The University of North Carolina at Chapel Hill University Libraries
Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells
text, January 2008
- B., Lian, J.; J., van Wijnen, A.; X. -c., Yang,
- The University of North Carolina at Chapel Hill University Libraries
A Genome-wide RNA Interference Screen Reveals that Variant Histones Are Necessary for Replication-Dependent Histone Pre-mRNA Processing
text, January 2007
- C., Godfrey, Ashley; R., Salzler, Harmony; J., Duronio, Robert
- The University of North Carolina at Chapel Hill University Libraries
A 3′ Exonuclease that Specifically Interacts with the 3′ End of Histone mRNA
text, January 2003
- Handan, Kaygun,; Michal, Dadlez,; Xiao-cui, Yang,
- The University of North Carolina at Chapel Hill University Libraries
PHENIX: a comprehensive Python-based system for macromolecular structure solution.
text, January 2010
- Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
- Apollo - University of Cambridge Repository
U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3' end processing
text, January 2005
- Azzouz, Teldja N.; Gruber, Andreas; Schümperli, Daniel
- Oxford University Press
Three Proteins of the U7-Specific Sm Ring Function as the Molecular Ruler To Determine the Site of 3'-End Processing in Mammalian Histone Pre-mRNA
text, January 2009
- P., Torres, M.; X. -c., Yang,; Z., Dominski,
- The University of North Carolina at Chapel Hill University Libraries
Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3′ processing of H3 pre-mRNA in the oocyte.
journal, July 1986
- Strub, K.; Birnstiel, M. L.
- The EMBO Journal, Vol. 5, Issue 7
Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease
journal, April 2012
- Chou, Ya-Wen; Cheng, Shu-Chun; Lai, Hsing-Yi
- Archives of Biochemistry and Biophysics, Vol. 520, Issue 2
Emergence of the β-CASP ribonucleases: Highly conserved and ubiquitous metallo-enzymes involved in messenger RNA maturation and degradation
journal, June 2013
- Dominski, Zbigniew; Carpousis, Agamemnon J.; Clouet-d'Orval, Béatrice
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Vol. 1829, Issue 6-7
Mutation of Glu-166 Blocks the Substrate-Induced Dimerization of SARS Coronavirus Main Protease
journal, April 2010
- Cheng, Shu-Chun; Chang, Gu-Gang; Chou, Chi-Yuan
- Biophysical Journal, Vol. 98, Issue 7
Metazoan replication-dependent histone mRNAs: a distinct set of RNA polymerase II transcripts
journal, June 2005
- Marzluff, William F.
- Current Opinion in Cell Biology, Vol. 17, Issue 3
Inference of Macromolecular Assemblies from Crystalline State
journal, September 2007
- Krissinel, Evgeny; Henrick, Kim
- Journal of Molecular Biology, Vol. 372, Issue 3
Mapping the Interaction Network of Key Proteins Involved in Histone mRNA Generation: A Hydrogen/Deuterium Exchange Study
journal, March 2016
- Skrajna, Aleksandra; Yang, Xiao-cui; Tarnowski, Krzysztof
- Journal of Molecular Biology, Vol. 428, Issue 6
A Genome-wide RNA Interference Screen Reveals that Variant Histones Are Necessary for Replication-Dependent Histone Pre-mRNA Processing
journal, November 2007
- Wagner, Eric J.; Burch, Brandon D.; Godfrey, Ashley C.
- Molecular Cell, Vol. 28, Issue 4
Molecular Architecture of the Human Pre-mRNA 3′ Processing Complex
journal, February 2009
- Shi, Yongsheng; Di Giammartino, Dafne Campigli; Taylor, Derek
- Molecular Cell, Vol. 33, Issue 3
The stem-loop binding protein forms a highly stable and specific complex with the 3′ stem-loop of histone mRNAs
journal, January 2001
- Battle, Daniel J.; Doudna, Jennifer A.
- RNA, Vol. 7, Issue 1
The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis
journal, April 1999
- Imai, Yuzuru; Kimura, Takaharu; Murakami, Akira
- Nature, Vol. 398, Issue 6730
FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci
journal, April 2008
- Alm-Kristiansen, A. H.; Sæther, T.; Matre, V.
- Oncogene, Vol. 27, Issue 34
FLASH is required for histone transcription and S-phase progression
journal, September 2006
- Barcaroli, D.; Bongiorno-Borbone, L.; Terrinoni, A.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 40
Structural and Functional Variations in Human Apolipoprotein E3 and E4
journal, March 2006
- Chou, Chi-Yuan; Jen, Wei-Ping; Hsieh, Yi-Hui
- Journal of Biological Chemistry, Vol. 281, Issue 19
Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein
journal, October 2001
- Pillai, R. S.
- The EMBO Journal, Vol. 20, Issue 19
U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3' end processing
journal, April 2005
- Azzouz, T. N.
- Nucleic Acids Research, Vol. 33, Issue 7
Deciphering key features in protein structures with the new ENDscript server
journal, April 2014
- Robert, Xavier; Gouet, Patrice
- Nucleic Acids Research, Vol. 42, Issue W1
Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing
journal, September 2003
- Pillai, R. S.
- Genes & Development, Vol. 17, Issue 18
Four factors are required for 3'-end cleavage of pre-mRNAs.
journal, November 1989
- Takagaki, Y.; Ryner, L. C.; Manley, J. L.
- Genes & Development, Vol. 3, Issue 11
Cell cycle-regulated phosphorylation of p220NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription
journal, September 2000
- Ma, T.
- Genes & Development, Vol. 14, Issue 18
A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing
journal, January 2002
- Dominski, Z.
- Genes & Development, Vol. 16, Issue 1
Mechanism for controlling the monomer–dimer conversion of SARS coronavirus main protease
journal, April 2013
- Wu, Cheng-Guo; Cheng, Shu-Chun; Chen, Shiang-Chuan
- Acta Crystallographica Section D Biological Crystallography, Vol. 69, Issue 5
Structural basis for catalysis and ubiquitin recognition by the Severe acute respiratory syndrome coronavirus papain-like protease
journal, January 2014
- Chou, Chi-Yuan; Lai, Hsing-Yi; Chen, Hung-Yi
- Acta Crystallographica Section D Biological Crystallography, Vol. 70, Issue 2
Interaction of FLASH with Arsenite Resistance Protein 2 Is Involved in Cell Cycle Progression at S Phase
journal, June 2009
- Kiriyama, M.; Kobayashi, Y.; Saito, M.
- Molecular and Cellular Biology, Vol. 29, Issue 17
A Complex Containing the CPSF73 Endonuclease and Other Polyadenylation Factors Associates with U7 snRNP and Is Recruited to Histone Pre-mRNA for 3'-End Processing
journal, October 2012
- Yang, X. -C.; Sabath, I.; Debski, J.
- Molecular and Cellular Biology, Vol. 33, Issue 1
FLASH Is Required for the Endonucleolytic Cleavage of Histone Pre-mRNAs but Is Dispensable for the 5' Exonucleolytic Degradation of the Downstream Cleavage Product
journal, January 2011
- Yang, X. -c.; Xu, B.; Sabath, I.
- Molecular and Cellular Biology, Vol. 31, Issue 7
The Cyclin E/Cdk2 Substrate p220NPAT Is Required for S-Phase Entry, Histone Gene Expression, and Cajal Body Maintenance in Human Somatic Cells
journal, November 2003
- Ye, X.; Wei, Y.; Nalepa, G.
- Molecular and Cellular Biology, Vol. 23, Issue 23
Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments
journal, January 2011
- Hsieh, Yi-Hui; Chou, Chi-Yuan
- Journal of Biomedical Science, Vol. 18, Issue 1
Structural and functional characterization of MERS coronavirus papain-like protease
journal, January 2014
- Lin, Min-Han; Chuang, Shang-Ju; Chen, Chiao-Che
- Journal of Biomedical Science, Vol. 21, Issue 1
U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem–loop binding protein
journal, March 2017
- Skrajna, Aleksandra; Yang, Xiao-cui; Bucholc, Katarzyna
- RNA, Vol. 23, Issue 6
Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main Protease
journal, December 2015
- Ho, Bo-Lin; Cheng, Shu-Chun; Shi, Lin
- PLOS ONE, Vol. 10, Issue 12
Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail
text, January 2008
- F., Marzluff, William; J., Wagner, Eric; J., Duronio, Robert
- The University of North Carolina at Chapel Hill University Libraries
A Conserved Interaction That Is Essential for the Biogenesis of Histone Locus Bodies
text, January 2014
- Cui, Yang, Xiao; Lalitha, Kunduru,; F., Marzluff, William
- The University of North Carolina at Chapel Hill University Libraries
Structure of Histone mRNA Stem-Loop, Human Stem-Loop Binding Protein, and 3'hExo Ternary Complex
text, January 2013
- Z., Dominski,; D., Tan,; F., Marzluff, W.
- The University of North Carolina at Chapel Hill University Libraries
PHENIX: a comprehensive Python-based system for macromolecular structure solution.
text, January 2010
- Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
- Apollo - University of Cambridge Repository
FLASH Meets Nuclear Bodies: CD95 Receptor Signals via a Nuclear Pathway
journal, April 2007
- Krieghoff, Eva; Milovic-Holm, Kristijana; Hofmann, Thomas G.
- Cell Cycle, Vol. 6, Issue 7
FLASH and NPAT positive but not Coilin positive Cajal bodies correlate with cell ploidy
journal, August 2008
- Bongiorno-Borbone, Lucilla; De Cola, Antonella; Vernole, Patrizia
- Cell Cycle, Vol. 7, Issue 15
Works referencing / citing this record:
Composition and processing activity of a semi-recombinant holo U7 snRNP
journal, December 2019
- Bucholc, Katarzyna; Aik, Wei Shen; Yang, Xiao-cui
- Nucleic Acids Research, Vol. 48, Issue 3
Structure of an active human histone pre-mRNA 3′-end processing machinery
journal, February 2020
- Sun, Yadong; Zhang, Yixiao; Aik, Wei Shen
- Science, Vol. 367, Issue 6478
Composition and processing activity of a semi-recombinant holo U7 snRNP
journal, December 2019
- Bucholc, Katarzyna; Aik, Wei Shen; Yang, Xiao-cui
- Nucleic Acids Research, Vol. 48, Issue 3