Improvement of a mixture experiment model relating the component proportions to the size of nanonized itraconazole particles in extemporary suspensions
Abstract
A paper by Foglio Bonda et al. published previously in this journal (2016, Vol. 83, pp. 175–183) discussed the use of mixture experiment design and modeling methods to study how the proportions of three components in an extemporaneous oral suspension affected the mean diameter of drug particles (Zave). The three components were itraconazole (ITZ), Tween 20 (TW20), and Methocel® E5 (E5). This commentary addresses some errors and other issues in the previous paper, and also discusses an improved model relating proportions of ITZ, TW20, and E5 to Zave. The improved model contains six of the 10 terms in the full-cubic mixture model, which were selected using a different cross-validation procedure than used in the previous paper. In conclusion, compared to the four-term model presented in the previous paper, the improved model fit the data better, had excellent cross-validation performance, and the predicted Zave of a validation point was within model uncertainty of the measured value.
- Authors:
-
[1];
- Univ. degli Studi del Piemonte Orientale "A. Avogadro," Novara (Italy). Dipartimento di Scienze del Farmaco
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1425500
- Report Number(s):
- PNNL-SA-123916
Journal ID: ISSN 0928-0987; PII: S0928098718301209
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- European Journal of Pharmaceutical Sciences
- Additional Journal Information:
- Journal Volume: 117; Journal ID: ISSN 0928-0987
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 77 NANOSCIENCE AND NANOTECHNOLOGY; Drug nanosuspension; Drug particle size; Mixture experiment design; Mixture experiment model; Cross-validated regression analysis
Citation Formats
Pattarino, Franco, Piepel, Greg, and Rinaldi, Maurizio. Improvement of a mixture experiment model relating the component proportions to the size of nanonized itraconazole particles in extemporary suspensions. United States: N. p., 2018.
Web. doi:10.1016/J.EJPS.2018.03.005.
Pattarino, Franco, Piepel, Greg, & Rinaldi, Maurizio. Improvement of a mixture experiment model relating the component proportions to the size of nanonized itraconazole particles in extemporary suspensions. United States. https://doi.org/10.1016/J.EJPS.2018.03.005
Pattarino, Franco, Piepel, Greg, and Rinaldi, Maurizio. Sat .
"Improvement of a mixture experiment model relating the component proportions to the size of nanonized itraconazole particles in extemporary suspensions". United States. https://doi.org/10.1016/J.EJPS.2018.03.005. https://www.osti.gov/servlets/purl/1425500.
@article{osti_1425500,
title = {Improvement of a mixture experiment model relating the component proportions to the size of nanonized itraconazole particles in extemporary suspensions},
author = {Pattarino, Franco and Piepel, Greg and Rinaldi, Maurizio},
abstractNote = {A paper by Foglio Bonda et al. published previously in this journal (2016, Vol. 83, pp. 175–183) discussed the use of mixture experiment design and modeling methods to study how the proportions of three components in an extemporaneous oral suspension affected the mean diameter of drug particles (Zave). The three components were itraconazole (ITZ), Tween 20 (TW20), and Methocel® E5 (E5). This commentary addresses some errors and other issues in the previous paper, and also discusses an improved model relating proportions of ITZ, TW20, and E5 to Zave. The improved model contains six of the 10 terms in the full-cubic mixture model, which were selected using a different cross-validation procedure than used in the previous paper. In conclusion, compared to the four-term model presented in the previous paper, the improved model fit the data better, had excellent cross-validation performance, and the predicted Zave of a validation point was within model uncertainty of the measured value.},
doi = {10.1016/J.EJPS.2018.03.005},
journal = {European Journal of Pharmaceutical Sciences},
number = ,
volume = 117,
place = {United States},
year = {Sat Mar 03 00:00:00 EST 2018},
month = {Sat Mar 03 00:00:00 EST 2018}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 1 work
Citation information provided by
Web of Science
Web of Science
Figures / Tables:
Table 1: Component settings (mass fractions) of the mixture design formulations
All figures and tables
(5 total)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Nanonized itraconazole powders for extemporary oral suspensions: Role of formulation components studied by a mixture design
journal, February 2016
- Foglio Bonda, Andrea; Rinaldi, Maurizio; Segale, Lorena
- European Journal of Pharmaceutical Sciences, Vol. 83
Test Statistics for Mixture Models
journal, November 1974
- Marquardt, Donald W.; Snee, Ronald D.
- Technometrics, Vol. 16, Issue 4
Works referencing / citing this record:
Effects of sugar composition on shelf life of hard candy: Optimization study using D‐optimal mixture design of experiments
journal, June 2019
- Spanemberg, Flavio E. M.; Korzenowski, André L.; Sellitto, Miguel A.
- Journal of Food Process Engineering, Vol. 42, Issue 6
Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.