Bioinspired Universal Flexible Elastomer‐Based Microchannels
Abstract
Abstract Flexible and stretchable microscale fluidic devices have a broad range of potential applications, ranging from electronic wearable devices for convenient digital lifestyle to biomedical devices. However, simple ways to achieve stable flexible and stretchable fluidic microchannels with dynamic liquid transport have been challenging because every application for elastomeric microchannels is restricted by their complex fabrication process and limited material selection. Here, a universal strategy for building microfluidic devices that possess exceptionally stable and stretching properties is shown. The devices exhibit superior mechanical deformability, including high strain (967%) and recovery ability, where applications as both strain sensor and pressure‐flow regulating device are demonstrated. Various microchannels are combined with organic, inorganic, and metallic materials as stable composite microfluidics. Furthermore, with surface chemical modification these stretchable microfluidic devices can also obtain antifouling property to suit for a broad range of industrial and biomedical applications.
- Authors:
-
- Bionic and Soft Matter Research Institute College of Physical Science and Technology Xiamen University 361005 Xiamen China
- Department of Mechanical and Electrical Engineering Xiamen University 361005 Xiamen China
- College of Chemistry and Chemical Engineering, and Collaborative Innovation Center of Chemistry for Energy Materials, and State Key Laboratory of Physical Chemistry of Solid Surfaces, and Pen‐Tung Sah Institute of Micro‐Nano Science and Technology Xiamen University 361005 Xiamen China
- Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge MA 02138 USA
- Biomaterials Innovation Research Center Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA
- Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge MA 02138 USA, Biomaterials Innovation Research Center Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA
- Department of Chemistry and Chemical Biology Harvard University Cambridge MA 02138 USA
- Wyss Institute for Biologically Inspired Engineering Harvard University Cambridge MA 02138 USA, Department of Chemistry and Chemical Biology Harvard University Cambridge MA 02138 USA
- Bionic and Soft Matter Research Institute College of Physical Science and Technology Xiamen University 361005 Xiamen China, College of Chemistry and Chemical Engineering, and Collaborative Innovation Center of Chemistry for Energy Materials, and State Key Laboratory of Physical Chemistry of Solid Surfaces, and Pen‐Tung Sah Institute of Micro‐Nano Science and Technology Xiamen University 361005 Xiamen China
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1416642
- Grant/Contract Number:
- DE‐AR0000326; DE‐SC0005247
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Small
- Additional Journal Information:
- Journal Name: Small Journal Volume: 14 Journal Issue: 18; Journal ID: ISSN 1613-6810
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Germany
- Language:
- English
Citation Formats
Wu, Feng, Chen, Songyue, Chen, Baiyi, Wang, Miao, Min, Lingli, Alvarenga, Jack, Ju, Jie, Khademhosseini, Ali, Yao, Yuxing, Zhang, Yu Shrike, Aizenberg, Joanna, and Hou, Xu. Bioinspired Universal Flexible Elastomer‐Based Microchannels. Germany: N. p., 2018.
Web. doi:10.1002/smll.201702170.
Wu, Feng, Chen, Songyue, Chen, Baiyi, Wang, Miao, Min, Lingli, Alvarenga, Jack, Ju, Jie, Khademhosseini, Ali, Yao, Yuxing, Zhang, Yu Shrike, Aizenberg, Joanna, & Hou, Xu. Bioinspired Universal Flexible Elastomer‐Based Microchannels. Germany. https://doi.org/10.1002/smll.201702170
Wu, Feng, Chen, Songyue, Chen, Baiyi, Wang, Miao, Min, Lingli, Alvarenga, Jack, Ju, Jie, Khademhosseini, Ali, Yao, Yuxing, Zhang, Yu Shrike, Aizenberg, Joanna, and Hou, Xu. Thu .
"Bioinspired Universal Flexible Elastomer‐Based Microchannels". Germany. https://doi.org/10.1002/smll.201702170.
@article{osti_1416642,
title = {Bioinspired Universal Flexible Elastomer‐Based Microchannels},
author = {Wu, Feng and Chen, Songyue and Chen, Baiyi and Wang, Miao and Min, Lingli and Alvarenga, Jack and Ju, Jie and Khademhosseini, Ali and Yao, Yuxing and Zhang, Yu Shrike and Aizenberg, Joanna and Hou, Xu},
abstractNote = {Abstract Flexible and stretchable microscale fluidic devices have a broad range of potential applications, ranging from electronic wearable devices for convenient digital lifestyle to biomedical devices. However, simple ways to achieve stable flexible and stretchable fluidic microchannels with dynamic liquid transport have been challenging because every application for elastomeric microchannels is restricted by their complex fabrication process and limited material selection. Here, a universal strategy for building microfluidic devices that possess exceptionally stable and stretching properties is shown. The devices exhibit superior mechanical deformability, including high strain (967%) and recovery ability, where applications as both strain sensor and pressure‐flow regulating device are demonstrated. Various microchannels are combined with organic, inorganic, and metallic materials as stable composite microfluidics. Furthermore, with surface chemical modification these stretchable microfluidic devices can also obtain antifouling property to suit for a broad range of industrial and biomedical applications.},
doi = {10.1002/smll.201702170},
journal = {Small},
number = 18,
volume = 14,
place = {Germany},
year = {Thu Jan 11 00:00:00 EST 2018},
month = {Thu Jan 11 00:00:00 EST 2018}
}
https://doi.org/10.1002/smll.201702170
Web of Science
Works referenced in this record:
Fabrication of microfluidic systems in poly(dimethylsiloxane)
journal, January 2000
- McDonald, J. Cooper; Duffy, David C.; Anderson, Janelle R.
- Electrophoresis, Vol. 21, Issue 1
A Strategy for the Construction of Controlled, Three-Dimensional, Multilayered, Tissue-Like Structures
journal, August 2012
- Gong, Peiyuan; Zheng, Wenfu; Huang, Zhuo
- Advanced Functional Materials, Vol. 23, Issue 1
Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin
journal, April 2014
- Xu, Sheng; Zhang, Yihui; Jia, Lin
- Science, Vol. 344, Issue 6179
A Strategy for Depositing Different Types of Cells in Three Dimensions to Mimic Tubular Structures in Tissues
journal, January 2012
- Yuan, Bo; Jin, Yu; Sun, Yi
- Advanced Materials, Vol. 24, Issue 7
An ultra-lightweight design for imperceptible plastic electronics
journal, July 2013
- Kaltenbrunner, Martin; Sekitani, Tsuyoshi; Reeder, Jonathan
- Nature, Vol. 499, Issue 7459
Soft Stylus Probes for Scanning Electrochemical Microscopy
journal, August 2009
- Cortés-Salazar, Fernando; Träuble, Markus; Li, Fei
- Analytical Chemistry, Vol. 81, Issue 16
Tumour-on-a-chip provides an optical window into nanoparticle tissue transport
journal, October 2013
- Albanese, Alexandre; Lam, Alan K.; Sykes, Edward A.
- Nature Communications, Vol. 4, Issue 1
Stretchable silicon nanoribbon electronics for skin prosthesis
journal, December 2014
- Kim, Jaemin; Lee, Mincheol; Shim, Hyung Joon
- Nature Communications, Vol. 5, Issue 1
Pursuing prosthetic electronic skin
journal, July 2016
- Chortos, Alex; Liu, Jia; Bao, Zhenan
- Nature Materials, Vol. 15, Issue 9
The pressure drop along rectangular microchannels containing bubbles
journal, January 2007
- Fuerstman, Michael J.; Lai, Ann; Thurlow, Meghan E.
- Lab on a Chip, Vol. 7, Issue 11
Interplay between materials and microfluidics
journal, April 2017
- Hou, Xu; Zhang, Yu Shrike; Santiago, Grissel Trujillo-de
- Nature Reviews Materials, Vol. 2, Issue 5
Soft Matter-Regulated Active Nanovalves Locally Self-Assembled in Femtoliter Nanofluidic Channels
journal, January 2016
- Xu, Yan; Shinomiya, Misato; Harada, Atsushi
- Advanced Materials, Vol. 28, Issue 11
Stretchable GaAs Photovoltaics with Designs That Enable High Areal Coverage
journal, January 2011
- Lee, Jongho; Wu, Jian; Shi, Mingxing
- Advanced Materials, Vol. 23, Issue 8
In-Plane Deformation Mechanics for Highly Stretchable Electronics
journal, December 2016
- Su, Yewang; Ping, Xuecheng; Yu, Ki Jun
- Advanced Materials, Vol. 29, Issue 8
Omnidirectional Printing of 3D Microvascular Networks
journal, March 2011
- Wu, Willie; DeConinck, Adam; Lewis, Jennifer A.
- Advanced Materials, Vol. 23, Issue 24
Microstructure fabrication with a CO 2 laser system
journal, October 2003
- Snakenborg, Detlef; Klank, Henning; Kutter, Jörg P.
- Journal of Micromechanics and Microengineering, Vol. 14, Issue 2
Ultrastretchable, transparent triboelectric nanogenerator as electronic skin for biomechanical energy harvesting and tactile sensing
journal, May 2017
- Pu, Xiong; Liu, Mengmeng; Chen, Xiangyu
- Science Advances, Vol. 3, Issue 5
Analog-to-digital drug screening
journal, February 2012
- Wootton, Robert C. R.; deMello, Andrew J.
- Nature, Vol. 483, Issue 7387
Bioinspired Multicompartmental Microfibers from Microfluidics
journal, June 2014
- Cheng, Yao; Zheng, Fuyin; Lu, Jie
- Advanced Materials, Vol. 26, Issue 30
Skin-inspired hydrogel–elastomer hybrids with robust interfaces and functional microstructures
journal, June 2016
- Yuk, Hyunwoo; Zhang, Teng; Parada, German Alberto
- Nature Communications, Vol. 7, Issue 1
Wearable and Washable Conductors for Active Textiles
journal, July 2017
- Le Floch, Paul; Yao, Xi; Liu, Qihan
- ACS Applied Materials & Interfaces, Vol. 9, Issue 30
Fabrication of Flexible Neural Probes With Built-In Microfluidic Channels by Thermal Bonding of Parylene
journal, January 2006
- Ziegler, Dominik; Suzuki, Takafumi; Takeuchi, Shoji
- Journal of Microelectromechanical Systems, Vol. 15, Issue 6
Microfluidic technologies for accelerating the clinical translation of nanoparticles
journal, October 2012
- Valencia, Pedro M.; Farokhzad, Omid C.; Karnik, Rohit
- Nature Nanotechnology, Vol. 7, Issue 10
Microfluidics-Based in Vivo Mimetic Systems for the Study of Cellular Biology
journal, February 2014
- Kim, Donghyuk; Wu, Xiaojie; Young, Ashlyn T.
- Accounts of Chemical Research, Vol. 47, Issue 4
Oscillatory flow in microchannels
journal, June 2004
- Morris, Christopher J.; Forster, Fred K.
- Experiments in Fluids, Vol. 36, Issue 6
Embedded Template-Assisted Fabrication of Complex Microchannels in PDMS and Design of a Microfluidic Adhesive
journal, November 2006
- Verma, Mohan K. S.; Majumder, Abhijit; Ghatak, Animangsu
- Langmuir, Vol. 22, Issue 24
Stretchable Microfluidic Radiofrequency Antennas
journal, April 2010
- Kubo, Masahiro; Li, Xiaofeng; Kim, Choongik
- Advanced Materials, Vol. 22, Issue 25, p. 2749-2752
Microfluidics: reframing biological enquiry
journal, August 2015
- Duncombe, Todd A.; Tentori, Augusto M.; Herr, Amy E.
- Nature Reviews Molecular Cell Biology, Vol. 16, Issue 9
Whole-Teflon microfluidic chips
journal, May 2011
- Ren, K.; Dai, W.; Zhou, J.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 20
When Microfluidic Devices Go Bad
journal, November 2005
- Mukhopadhyay, Rajendrani
- Analytical Chemistry, Vol. 77, Issue 21
Biological implications of polydimethylsiloxane-based microfluidic cell culture
journal, January 2009
- Regehr, Keil J.; Domenech, Maribella; Koepsel, Justin T.
- Lab on a Chip, Vol. 9, Issue 15
New Peptidomimetic Polymers for Antifouling Surfaces
journal, June 2005
- Statz, Andrea R.; Meagher, Robert J.; Barron, Annelise E.
- Journal of the American Chemical Society, Vol. 127, Issue 22
Triple-State Liquid-Based Microfluidic Tactile Sensor with High Flexibility, Durability, and Sensitivity
journal, March 2016
- Yeo, Joo Chuan; Yu, Jiahao
- ACS Sensors, Vol. 1, Issue 5
Recent Developments in Microfluidics for Cell Studies
journal, February 2014
- Xiong, Bin; Ren, Kangning; Shu, Yiwei
- Advanced Materials, Vol. 26, Issue 31
Supercritical microfluidics: Opportunities in flow-through chemistry and materials science
journal, June 2012
- Marre, S.; Roig, Y.; Aymonier, C.
- The Journal of Supercritical Fluids, Vol. 66
The origins and the future of microfluidics
journal, July 2006
- Whitesides, George M.
- Nature, Vol. 442, Issue 7101, p. 368-373
Camouflage and Display for Soft Machines
journal, August 2012
- Morin, S. A.; Shepherd, R. F.; Kwok, S. W.
- Science, Vol. 337, Issue 6096, p. 828-832
Self-Adjusting, Polymeric Multilayered Roll that can Keep the Shapes of the Blood Vessel Scaffolds during Biodegradation
journal, May 2017
- Cheng, Shiyu; Jin, Yu; Wang, Nuoxin
- Advanced Materials, Vol. 29, Issue 28
Soft lithography for micro- and nanoscale patterning
journal, February 2010
- Qin, Dong; Xia, Younan; Whitesides, George M.
- Nature Protocols, Vol. 5, Issue 3
Advances in engineering hydrogels
journal, May 2017
- Zhang, Yu Shrike; Khademhosseini, Ali
- Science, Vol. 356, Issue 6337
The present and future role of microfluidics in biomedical research
journal, March 2014
- Sackmann, Eric K.; Fulton, Anna L.; Beebe, David J.
- Nature, Vol. 507, Issue 7491
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle
journal, March 2017
- Xiao, Shuo; Coppeta, Jonathan R.; Rogers, Hunter B.
- Nature Communications, Vol. 8, Issue 1
Polyimide-based microfluidic devices
journal, January 2001
- Metz, Stefan; Holzer, Raphael; Renaud, Philippe
- Lab on a Chip, Vol. 1, Issue 1
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
journal, January 2013
- Wagner, Ilka; Materne, Eva-Maria; Brincker, Sven
- Lab on a Chip, Vol. 13, Issue 18
On the Physical Equilibrium of Small Blood Vessels
journal, January 1951
- Burton, Alan C.
- American Journal of Physiology-Legacy Content, Vol. 164, Issue 2
Enhancing flow boiling and antifouling with nanometer titanium dioxide coating surfaces
journal, January 2007
- Liu, Ming-Yan; Wang, Hong; Wang, Yan
- AIChE Journal, Vol. 53, Issue 5
Developing optofluidic technology through the fusion of microfluidics and optics
journal, July 2006
- Psaltis, Demetri; Quake, Stephen R.; Yang, Changhuei
- Nature, Vol. 442, Issue 7101
Microfluidics—downsizing large-scale biology
journal, August 2001
- Mitchell, Peter
- Nature Biotechnology, Vol. 19, Issue 8
Microfluidic diagnostic technologies for global public health
journal, July 2006
- Yager, Paul; Edwards, Thayne; Fu, Elain
- Nature, Vol. 442, Issue 7101, p. 412-418
Reactive particle precipitation in liquid microchannel flow
journal, January 2008
- Kockmann, N.; Kastner, J.; Woias, P.
- Chemical Engineering Journal, Vol. 135
Highly deformable liquid-state heterojunction sensors
journal, September 2014
- Ota, Hiroki; Chen, Kevin; Lin, Yongjing
- Nature Communications, Vol. 5, Issue 1