Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I
Abstract
Curcumin is a polyphenolic phytonutrient that has antineurodegenerative properties. Here, we investigated the anti-amyloidogenic properties of curcumin. Following incubation with curcumin, intrinsic tryptophan fluorescence emission of apolipoprotein (apo) A-I was strongly quenched. At the same time, curcumin fluorescence emission was enhanced. The fluorescence emission spectra of curcumin in the presence of amyloid-like aggregates formed by methionine-oxidized (ox) apoA-I varied, depending on whether curcumin was added before, or after, aggregate formation. The impact of curcumin on the structure of the aggregating material was revealed by the lower amount of β-structure in ox-apoA-I amyloid-like aggregates formed in the presence of curcumin, compared to aggregates formed without curcumin. However, the kinetics of ox-apoA-I amyloid-like aggregate formation was not altered by the presence of curcumin. Moreover, electron microscopy analysis detected no discernable differences in amyloid morphology when ox-apoA-I amyloid-like aggregates were formed in the presence or absence of curcumin. In conclusion, curcumin interacts with apoA-I and alters the structure of ox-apoA-I amyloid-like aggregates yet does not diminish the propensity of ox-apoA-I to form aggregates.
- Authors:
-
- Univ. of California, Berkeley, CA (United States). Dept. of Nutritional Sciences and Toxicology
- Children's Hospital Oakland Research Inst., Oakland, CA (United States); Univ. of Tehran (Iran). Dept. of Biotechnology and College of Science
- Children's Hospital Oakland Research Inst., Oakland, CA (United States)
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). The Molecular Foundry
- Univ. of California, Berkeley, CA (United States). Dept. of Nutritional Sciences and Toxicology; Children's Hospital Oakland Research Inst., Oakland, CA (United States); Univ. of Nevada, Reno, NV (United States). Dept. of Biochemistry and Molecular Biology
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH)
- OSTI Identifier:
- 1416461
- Alternate Identifier(s):
- OSTI ID: 1416605; OSTI ID: 1433116
- Grant/Contract Number:
- AC02-05CH11231; R37‐HL64159; R01‐HL113059; HL115153; GM104427
- Resource Type:
- Published Article
- Journal Name:
- FEBS Open Bio
- Additional Journal Information:
- Journal Name: FEBS Open Bio Journal Volume: 8 Journal Issue: 2; Journal ID: ISSN 2211-5463
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Netherlands
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; amyloid‐like aggregate; Apolipoprotein A‐I; curcumin; electron microscopy; fluorescence spectroscopy; methionine oxidation
Citation Formats
Krishnamoorthy, Aparna, Tavoosi, Narjes, Chan, Gary K. L., Liu, Jianfang, Ren, Gang, Cavigiolio, Giorgio, and Ryan, Robert O. Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I. Netherlands: N. p., 2018.
Web. doi:10.1002/2211-5463.12372.
Krishnamoorthy, Aparna, Tavoosi, Narjes, Chan, Gary K. L., Liu, Jianfang, Ren, Gang, Cavigiolio, Giorgio, & Ryan, Robert O. Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I. Netherlands. https://doi.org/10.1002/2211-5463.12372
Krishnamoorthy, Aparna, Tavoosi, Narjes, Chan, Gary K. L., Liu, Jianfang, Ren, Gang, Cavigiolio, Giorgio, and Ryan, Robert O. Wed .
"Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I". Netherlands. https://doi.org/10.1002/2211-5463.12372.
@article{osti_1416461,
title = {Effect of curcumin on amyloid-like aggregates generated from methionine-oxidized apolipoprotein A-I},
author = {Krishnamoorthy, Aparna and Tavoosi, Narjes and Chan, Gary K. L. and Liu, Jianfang and Ren, Gang and Cavigiolio, Giorgio and Ryan, Robert O.},
abstractNote = {Curcumin is a polyphenolic phytonutrient that has antineurodegenerative properties. Here, we investigated the anti-amyloidogenic properties of curcumin. Following incubation with curcumin, intrinsic tryptophan fluorescence emission of apolipoprotein (apo) A-I was strongly quenched. At the same time, curcumin fluorescence emission was enhanced. The fluorescence emission spectra of curcumin in the presence of amyloid-like aggregates formed by methionine-oxidized (ox) apoA-I varied, depending on whether curcumin was added before, or after, aggregate formation. The impact of curcumin on the structure of the aggregating material was revealed by the lower amount of β-structure in ox-apoA-I amyloid-like aggregates formed in the presence of curcumin, compared to aggregates formed without curcumin. However, the kinetics of ox-apoA-I amyloid-like aggregate formation was not altered by the presence of curcumin. Moreover, electron microscopy analysis detected no discernable differences in amyloid morphology when ox-apoA-I amyloid-like aggregates were formed in the presence or absence of curcumin. In conclusion, curcumin interacts with apoA-I and alters the structure of ox-apoA-I amyloid-like aggregates yet does not diminish the propensity of ox-apoA-I to form aggregates.},
doi = {10.1002/2211-5463.12372},
journal = {FEBS Open Bio},
number = 2,
volume = 8,
place = {Netherlands},
year = {Wed Jan 10 00:00:00 EST 2018},
month = {Wed Jan 10 00:00:00 EST 2018}
}
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https://doi.org/10.1002/2211-5463.12372
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