Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix

Mastren, Tara; Radchenko, Valery; Engle, Jonathan W.; Weidner, John W.; Owens, Allison; Wyant, Lance E.; Copping, Roy; Brugh, Mark; Nortier, F. Meiring; Birnbaum, Eva R.; John, Kevin D.; Fassbender, Michael E.

doi:10.1016/j.aca.2017.10.020

Title: Chromatographic separation of the theranostic radionuclide ¹¹¹Ag from a proton irradiated thorium matrix

Journal Article · Mon Oct 30 00:00:00 UTC 2017 · Analytica Chimica Acta

DOI: https://doi.org/10.1016/j.aca.2017.10.020 · OSTI ID:1409773

Mastren, Tara ^[1]; Radchenko, Valery ^[1]; Engle, Jonathan W. ^[1]; Weidner, John W. ^[1]; Owens, Allison ^[2]; Wyant, Lance E. ^[2]; Copping, Roy ^[2]; Brugh, Mark ^[1]; Nortier, F. Meiring ^[1]; Birnbaum, Eva R. ^[1]; John, Kevin D. ^[1];

^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Nuclear Security and Isotope Technology Division

Column chromatographic methods have been developed to separate no-carrier-added ¹¹¹Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing ²²⁵Ac separation design. In this paper, we report the separation of ¹¹¹Ag both prior and subsequent to ²²⁵Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R₃P = S) and alkyl phosphine oxides (R₃P = O). The recovery yield of ¹¹¹Ag was 93 ± 9% with a radiochemical purity of 99.9% (prior) and 87 ± 9% with a radiochemical purity of 99.9% (subsequent to) ²²⁵Ac recovery. Both processes were successfully performed with insignificant impacts on ²²⁵Ac yields or quality. Measured equilibrium distribution coefficients for silver and ruthenium (a residual contaminant) on CL resin in hydrochloric and nitric acid media are reported, to the best of our knowledge, for the first time. Finally and additionally, measured cross sections for the production of ¹¹¹Ag and ^110mAg for the ²³²Th(p,f)^110m,111Ag reactions are reported within.

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Research Organization:: Los Alamos National Laboratory (LANL); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: LANL Laboratory Directed Research and Development (LDRD) Program; USDOE; USDOE Office of Science (SC), Nuclear Physics (NP); USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)

Grant/Contract Number:: AC05-00OR22725; AC52-06NA25396

OSTI ID:: 1409773

Report Number(s):: LA-UR-17-23917

Journal Information:: Analytica Chimica Acta, Journal Name: Analytica Chimica Acta Vol. 998; ISSN 0003-2670

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf Huang, Yaoyao; Hu, Yang; Chen, Lvcun PLOS ONE, Vol. 13, Issue 3 https://doi.org/10.1371/journal.pone.0193659	journal	March 2018
Defining Processing Times for Accelerator Produced 225Ac and Other Isotopes from Proton Irradiated Thorium Fitzsimmons, Jonathan; Griswold, Justin; Medvedev, Dmitri Molecules, Vol. 24, Issue 6 https://doi.org/10.3390/molecules24061095	journal	March 2019

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111Ag
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CL resin
nuclear reaction cross sections
proton irradiation
theranostic
thorium target

Title: Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix

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References (33)

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Title: Chromatographic separation of the theranostic radionuclide ¹¹¹Ag from a proton irradiated thorium matrix