Human age and skin physiology shape diversity and abundance of Archaea on skin

Moissl-Eichinger, Christine; Probst, Alexander J.; Birarda, Giovanni; Auerbach, Anna; Koskinen, Kaisa; Wolf, Peter; Holman, Hoi-Ying N.

doi:10.1038/s41598-017-04197-4

Title: Human age and skin physiology shape diversity and abundance of Archaea on skin

Journal Article · Thu Jun 22 04:00:00 UTC 2017 · Scientific Reports

DOI: https://doi.org/10.1038/s41598-017-04197-4 · OSTI ID:1408493

Moissl-Eichinger, Christine ^[1]; Probst, Alexander J. ^[2];

^[3]; Auerbach, Anna ^[4]; Koskinen, Kaisa ^[1]; Wolf, Peter ^[5]; Holman, Hoi-Ying N. ^[6]

Medical Univ. of Graz, Graz (Austria). Dept. of Internal Medicine; BioTechMed-Graz, Graz (Austria)
Univ. of California, Berkeley, CA (United States). Dept. of Earth and Planetary Science
Elettra - Sincrotrone Trieste, Strada Statale, Trieste (Italy); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Berkeley Synchrotron Infrared Structural Biology Program
Univ. of Regensburg (Germany). Dept. of Microbiology and Archaea Center
Medical Univ. of Graz, Graz (Austria). Dept. of Dermatology
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Berkeley Synchrotron Infrared Structural Biology Program

The human skin microbiome acts as an important barrier protecting our body from pathogens and other environmental influences. Recent investigations have provided evidence that Archaea are a constant but highly variable component of the human skin microbiome, yet factors that determine their abundance changes are unknown. Here, we tested the hypothesis that the abundance of archaea on human skin is influenced by human age and skin physiology by quantitative PCR of 51 different skin samples taken from human subjects of various age. Our results reveal that archaea are more abundant in human subjects either older than 60 years or younger than 12 years as compared to middle-aged human subjects. These results, together with results obtained from spectroscopy analysis, allowed us gain first insights into a potential link of lower sebum levels and lipid content and thus reduced skin moisture with an increase in archaeal signatures. In conclusion, amplicon sequencing of selected samples revealed the prevalence of specific eury- and mainly thaumarchaeal taxa, represented by a core archaeome of the human skin.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1408493

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 7; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Interactive metagenomic visualization in a Web browser Ondov, Brian D.; Bergman, Nicholas H.; Phillippy, Adam M. BMC Bioinformatics, Vol. 12, Issue 1 https://doi.org/10.1186/1471-2105-12-385	journal	September 2011
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Archaea on Human Skin Probst, Alexander J.; Auerbach, Anna K.; Moissl-Eichinger, Christine PLoS ONE, Vol. 8, Issue 6 https://doi.org/10.1371/journal.pone.0065388	journal	June 2013
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First Insights into the Diverse Human Archaeome: Specific Detection of Archaea in the Gastrointestinal Tract, Lung, and Nose and on Skin Koskinen, Kaisa; Pausan, Manuela R.; Perras, Alexandra K. mBio, Vol. 8, Issue 6 https://doi.org/10.1128/mbio.00824-17	journal	November 2017
Cross-Domain and Viral Interactions in the Microbiome Rowan-Nash, Aislinn D.; Korry, Benjamin J.; Mylonakis, Eleftherios Microbiology and Molecular Biology Reviews, Vol. 83, Issue 1 https://doi.org/10.1128/mmbr.00044-18	journal	January 2019
The Oral Archaeome: A Scoping Review Belmok, A.; de Cena, J. A.; Kyaw, C. M. Journal of Dental Research, Vol. 99, Issue 6 https://doi.org/10.1177/0022034520910435	journal	March 2020
Longitudinal development of the dust microbiome in a newly opened Norwegian kindergarten Nygaard, Anders B.; Charnock, Colin Microbiome, Vol. 6, Issue 1 https://doi.org/10.1186/s40168-018-0553-x	journal	September 2018
Exploring the Archaeome: Detection of Archaeal Signatures in the Human Body Pausan, Manuela R.; Csorba, Cintia; Singer, Georg Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.02796	journal	December 2019
Elevation is Associated with Human Skin Microbiomes Li, Huan; Wang, Yijie; Yu, Qiaoling Microorganisms, Vol. 7, Issue 12 https://doi.org/10.3390/microorganisms7120611	journal	November 2019

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