Engineering the Bacterial Microcompartment Domain for Molecular Scaffolding Applications
Abstract
As synthetic biology advances the intricacy of engineered biological systems, the importance of spatial organization within the cellular environment must not be marginalized. Increasingly, biological engineers are investigating means to control spatial organization within the cell, mimicking strategies used by natural pathways to increase flux and reduce cross-talk. A modular platform for constructing a diverse set of defined, programmable architectures would greatly assist in improving yields from introduced metabolic pathways and increasing insulation of other heterologous systems. Here, we review recent research on the shell proteins of bacterial microcompartments and discuss their potential application as “building blocks” for a range of customized intracellular scaffolds. As a result, we summarize the state of knowledge on the self-assembly of BMC shell proteins and discuss future avenues of research that will be important to realize the potential of BMC shell proteins as predictively assembling and programmable biological materials for bioengineering.
- Authors:
-
- Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Computational Sciences and Engineering; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
- Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Biophysics and Integrated Bioimaging Division
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1399948
- Alternate Identifier(s):
- OSTI ID: 1687363
- Grant/Contract Number:
- AC05-00OR22725; FG02-91ER20021
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Frontiers in Microbiology
- Additional Journal Information:
- Journal Volume: 8; Journal ID: ISSN 1664-302X
- Publisher:
- Frontiers Research Foundation
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; scaffold; synthetic biology; bacterial microcompartment; shell proteins; BMC; spatial organization; metabolic engineering; self-assembly
Citation Formats
Young, Eric J., Burton, Rodney, Mahalik, Jyoti P., Sumpter, Bobby G., Fuentes-Cabrera, Miguel, Kerfeld, Cheryl A., and Ducat, Daniel C. Engineering the Bacterial Microcompartment Domain for Molecular Scaffolding Applications. United States: N. p., 2017.
Web. doi:10.3389/fmicb.2017.01441.
Young, Eric J., Burton, Rodney, Mahalik, Jyoti P., Sumpter, Bobby G., Fuentes-Cabrera, Miguel, Kerfeld, Cheryl A., & Ducat, Daniel C. Engineering the Bacterial Microcompartment Domain for Molecular Scaffolding Applications. United States. https://doi.org/10.3389/fmicb.2017.01441
Young, Eric J., Burton, Rodney, Mahalik, Jyoti P., Sumpter, Bobby G., Fuentes-Cabrera, Miguel, Kerfeld, Cheryl A., and Ducat, Daniel C. Mon .
"Engineering the Bacterial Microcompartment Domain for Molecular Scaffolding Applications". United States. https://doi.org/10.3389/fmicb.2017.01441. https://www.osti.gov/servlets/purl/1399948.
@article{osti_1399948,
title = {Engineering the Bacterial Microcompartment Domain for Molecular Scaffolding Applications},
author = {Young, Eric J. and Burton, Rodney and Mahalik, Jyoti P. and Sumpter, Bobby G. and Fuentes-Cabrera, Miguel and Kerfeld, Cheryl A. and Ducat, Daniel C.},
abstractNote = {As synthetic biology advances the intricacy of engineered biological systems, the importance of spatial organization within the cellular environment must not be marginalized. Increasingly, biological engineers are investigating means to control spatial organization within the cell, mimicking strategies used by natural pathways to increase flux and reduce cross-talk. A modular platform for constructing a diverse set of defined, programmable architectures would greatly assist in improving yields from introduced metabolic pathways and increasing insulation of other heterologous systems. Here, we review recent research on the shell proteins of bacterial microcompartments and discuss their potential application as “building blocks” for a range of customized intracellular scaffolds. As a result, we summarize the state of knowledge on the self-assembly of BMC shell proteins and discuss future avenues of research that will be important to realize the potential of BMC shell proteins as predictively assembling and programmable biological materials for bioengineering.},
doi = {10.3389/fmicb.2017.01441},
journal = {Frontiers in Microbiology},
number = ,
volume = 8,
place = {United States},
year = {Mon Jul 31 00:00:00 EDT 2017},
month = {Mon Jul 31 00:00:00 EDT 2017}
}
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Encapsulation as a Strategy for the Design of Biological Compartmentalization
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Bacterial microcompartments and the modular construction of microbial metabolism
journal, January 2015
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Spatial organization of enzymes for metabolic engineering
journal, May 2012
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Employing bacterial microcompartment technology to engineer a shell-free enzyme-aggregate for enhanced 1,2-propanediol production in Escherichia coli
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Protein Assembly: Versatile Approaches to Construct Highly Ordered Nanostructures
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Protein Calligraphy: A New Concept Begins To Take Shape
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Theoretical Study of the Initial Stages of Self-Assembly of a Carboxysome’s Facet
journal, March 2016
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Evidence for Improved Encapsulated Pathway Behavior in a Bacterial Microcompartment through Shell Protein Engineering
journal, June 2017
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- ACS Synthetic Biology, Vol. 6, Issue 10
Interenzyme Substrate Diffusion for an Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures
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Channeling by Proximity: The Catalytic Advantages of Active Site Colocalization Using Brownian Dynamics
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Solution Structure of a Bacterial Microcompartment Targeting Peptide and Its Application in the Construction of an Ethanol Bioreactor
journal, November 2013
- Lawrence, Andrew D.; Frank, Stefanie; Newnham, Sarah
- ACS Synthetic Biology, Vol. 3, Issue 7
Engineering Bacterial Microcompartment Shells: Chimeric Shell Proteins and Chimeric Carboxysome Shells
journal, July 2014
- Cai, Fei; Sutter, Markus; Bernstein, Susan L.
- ACS Synthetic Biology, Vol. 4, Issue 4
Enzyme clustering accelerates processing of intermediates through metabolic channeling
journal, September 2014
- Castellana, Michele; Wilson, Maxwell Z.; Xu, Yifan
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Substrate channelling as an approach to cascade reactions
journal, March 2016
- Wheeldon, Ian; Minteer, Shelley D.; Banta, Scott
- Nature Chemistry, Vol. 8, Issue 4
Natural strategies for the spatial optimization of metabolism in synthetic biology
journal, May 2012
- Agapakis, Christina M.; Boyle, Patrick M.; Silver, Pamela A.
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Genetic encoding of DNA nanostructures and their self-assembly in living bacteria
journal, April 2016
- Elbaz, Johann; Yin, Peng; Voigt, Christopher A.
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Undesired usage and the robust self-assembly of heterogeneous structures
journal, February 2015
- Murugan, Arvind; Zou, James; Brenner, Michael P.
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